Regulation of translation initiation in eukaryotes: mechanisms and biological targets.

Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP. Cell (2010) 17.87

The mechanism of eukaryotic translation initiation and principles of its regulation. Nat Rev Mol Cell Biol (2010) 11.19

Ribosome profiling of mouse embryonic stem cells reveals the complexity and dynamics of mammalian proteomes. Cell (2011) 10.56

Eukaryotic stress granules: the ins and outs of translation. Mol Cell (2009) 6.09

RNA processing and its regulation: global insights into biological networks. Nat Rev Genet (2010) 5.34

Translational control in cancer. Nat Rev Cancer (2010) 4.59

Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster. Cell Metab (2010) 4.44

Global signatures of protein and mRNA expression levels. Mol Biosyst (2009) 4.43

The ribosome profiling strategy for monitoring translation in vivo by deep sequencing of ribosome-protected mRNA fragments. Nat Protoc (2012) 4.41

Ribosome-mediated specificity in Hox mRNA translation and vertebrate tissue patterning. Cell (2011) 4.26

A parsimonious model for gene regulation by miRNAs. Science (2011) 3.79

High-resolution view of the yeast meiotic program revealed by ribosome profiling. Science (2011) 3.53

The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC. Nat Struct Mol Biol (2012) 3.42

Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells. Cell Metab (2009) 3.28

Angiogenin-induced tRNA fragments inhibit translation initiation. Mol Cell (2011) 3.23

Specialized ribosomes: a new frontier in gene regulation and organismal biology. Nat Rev Mol Cell Biol (2012) 2.91

Regulation of TFEB and V-ATPases by mTORC1. EMBO J (2011) 2.84

Tight coordination of protein translation and HSF1 activation supports the anabolic malignant state. Science (2013) 2.79

Global mapping of translation initiation sites in mammalian cells at single-nucleotide resolution. Proc Natl Acad Sci U S A (2012) 2.79

mTOR complex 2 signaling and functions. Cell Cycle (2011) 2.66

RNA targets of wild-type and mutant FET family proteins. Nat Struct Mol Biol (2011) 2.46

mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide. EMBO J (2010) 2.35

The Arc of synaptic memory. Exp Brain Res (2009) 2.30

Eukaryotic initiation factor 2 phosphorylation and translational control in metabolism. Adv Nutr (2012) 2.27

Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch. Nature (2014) 2.20

A mechanistic overview of translation initiation in eukaryotes. Nat Struct Mol Biol (2012) 2.17

N(6)-methyladenosine Modulates Messenger RNA Translation Efficiency. Cell (2015) 2.15

Cellular IRES-mediated translation: the war of ITAFs in pathophysiological states. Cell Cycle (2011) 2.15

Phosphorylation of eIF2 facilitates ribosomal bypass of an inhibitory upstream ORF to enhance CHOP translation. J Biol Chem (2011) 2.12

Viral subversion of the host protein synthesis machinery. Nat Rev Microbiol (2011) 2.07

All things must pass: contrasts and commonalities in eukaryotic and bacterial mRNA decay. Nat Rev Mol Cell Biol (2010) 2.07

Immunogenetics. Dynamic profiling of the protein life cycle in response to pathogens. Science (2015) 2.06

Ribosome profiling reveals pervasive translation outside of annotated protein-coding genes. Cell Rep (2014) 2.04

MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice. J Clin Invest (2010) 2.04

Translation initiator EIF4G1 mutations in familial Parkinson disease. Am J Hum Genet (2011) 2.00

Cryo-EM structure and rRNA model of a translating eukaryotic 80S ribosome at 5.5-A resolution. Proc Natl Acad Sci U S A (2010) 1.99

Reversible RNA adenosine methylation in biological regulation. Trends Genet (2012) 1.93

Where is mTOR and what is it doing there? J Cell Biol (2013) 1.91

Tristetraprolin (TTP): interactions with mRNA and proteins, and current thoughts on mechanisms of action. Biochim Biophys Acta (2013) 1.90

Translational control by changes in poly(A) tail length: recycling mRNAs. Nat Struct Mol Biol (2012) 1.89

Role for mammalian target of rapamycin complex 1 signaling in neuroadaptations underlying alcohol-related disorders. Proc Natl Acad Sci U S A (2010) 1.88

The dynamic N(1)-methyladenosine methylome in eukaryotic messenger RNA. Nature (2016) 1.88

OASL1 inhibits translation of the type I interferon-regulating transcription factor IRF7. Nat Immunol (2013) 1.87

RPS25 is essential for translation initiation by the Dicistroviridae and hepatitis C viral IRESs. Genes Dev (2009) 1.87

Widespread regulation of translation by elongation pausing in heat shock. Mol Cell (2013) 1.85

Cotranslational response to proteotoxic stress by elongation pausing of ribosomes. Mol Cell (2013) 1.83

The Circadian Protein BMAL1 Regulates Translation in Response to S6K1-Mediated Phosphorylation. Cell (2015) 1.83

C. elegans detects pathogen-induced translational inhibition to activate immune signaling. Cell Host Microbe (2012) 1.79

DENR-MCT-1 promotes translation re-initiation downstream of uORFs to control tissue growth. Nature (2014) 1.78

Gene expression regulation by upstream open reading frames and human disease. PLoS Genet (2013) 1.76

Molecular architecture of the 40S⋅eIF1⋅eIF3 translation initiation complex. Cell (2014) 1.76

Ubiquitously transcribed genes use alternative polyadenylation to achieve tissue-specific expression. Genes Dev (2013) 1.74

Spatially restricting gene expression by local translation at synapses. Trends Neurosci (2010) 1.74

NRF2 Promotes Tumor Maintenance by Modulating mRNA Translation in Pancreatic Cancer. Cell (2016) 1.74

The eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress. Mol Biol Cell (2011) 1.73

Genome-wide search for novel human uORFs and N-terminal protein extensions using ribosomal footprinting. Genome Res (2012) 1.73

Remote control of gene function by local translation. Cell (2014) 1.72

Translational control in cancer etiology. Cold Spring Harb Perspect Biol (2013) 1.71

Localization of eukaryote-specific ribosomal proteins in a 5.5-Å cryo-EM map of the 80S eukaryotic ribosome. Proc Natl Acad Sci U S A (2010) 1.68

Protective coupling of mitochondrial function and protein synthesis via the eIF2α kinase GCN-2. PLoS Genet (2012) 1.67

The pioneer round of translation: features and functions. Cell (2010) 1.66

RNAi screening implicates a SKN-1-dependent transcriptional response in stress resistance and longevity deriving from translation inhibition. PLoS Genet (2010) 1.66

Structural basis for the inhibition of the eukaryotic ribosome. Nature (2014) 1.65

Imaging protein synthesis in cells and tissues with an alkyne analog of puromycin. Proc Natl Acad Sci U S A (2011) 1.65

5'-3'-UTR interactions regulate p53 mRNA translation and provide a target for modulating p53 induction after DNA damage. Genes Dev (2010) 1.64

Regulation of amino acid, nucleotide, and phosphate metabolism in Saccharomyces cerevisiae. Genetics (2012) 1.64

RNAs: regulators of bacterial virulence. Nat Rev Microbiol (2010) 1.63

BDNF activates mTOR to regulate GluR1 expression required for memory formation. PLoS One (2009) 1.63

Translational coregulation of 5'TOP mRNAs by TIA-1 and TIAR. Genes Dev (2011) 1.62

Bridging IRES elements in mRNAs to the eukaryotic translation apparatus. Biochim Biophys Acta (2009) 1.62

Stress-specific composition, assembly and kinetics of stress granules in Saccharomyces cerevisiae. J Cell Sci (2010) 1.58

An oxygen-regulated switch in the protein synthesis machinery. Nature (2012) 1.56

Fibrotic extracellular matrix activates a profibrotic positive feedback loop. J Clin Invest (2014) 1.54

IRESite--a tool for the examination of viral and cellular internal ribosome entry sites. Nucleic Acids Res (2009) 1.54

Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers. Proc Natl Acad Sci U S A (2013) 1.53

IL-6- and NGF-induced rapid control of protein synthesis and nociceptive plasticity via convergent signaling to the eIF4F complex. J Neurosci (2010) 1.52

Both transcriptional regulation and translational control of ATF4 are central to the integrated stress response. J Biol Chem (2010) 1.51

The p38/MK2-driven exchange between tristetraprolin and HuR regulates AU-rich element-dependent translation. PLoS Genet (2012) 1.50

mRNP granules. Assembly, function, and connections with disease. RNA Biol (2014) 1.50

Autophagy and innate immunity: triggering, targeting and tuning. Semin Cell Dev Biol (2010) 1.49

In vivo and transcriptome-wide identification of RNA binding protein target sites. Mol Cell (2011) 1.47

Genome-wide identification and quantitative analysis of cleaved tRNA fragments induced by cellular stress. J Biol Chem (2012) 1.47

Targeting cap-dependent translation blocks converging survival signals by AKT and PIM kinases in lymphoma. J Exp Med (2011) 1.45

Translation dynamics of single mRNAs in live cells and neurons. Science (2016) 1.45

Molecular view of 43 S complex formation and start site selection in eukaryotic translation initiation. J Biol Chem (2010) 1.44

The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability. Sci Signal (2015) 1.44

Bidirectional regulation of P body formation mediated by eIF4F complex formation in sensory neurons. Neurosci Lett (2013) 1.44

mTOR complexes in neurodevelopmental and neuropsychiatric disorders. Nat Neurosci (2013) 1.43

Phosphorylation of Nrf2 at multiple sites by MAP kinases has a limited contribution in modulating the Nrf2-dependent antioxidant response. PLoS One (2009) 1.42

Molecular architecture of a eukaryotic translational initiation complex. Science (2013) 1.41

ERK and AKT signaling cooperate to translationally regulate survivin expression for metastatic progression of colorectal cancer. Oncogene (2013) 1.40

Translation of 5' leaders is pervasive in genes resistant to eIF2 repression. Elife (2015) 1.40

The new face of the old molecules: crustin Pm4 and transglutaminase type I serving as rnps down-regulate astakine-mediated hematopoiesis. PLoS One (2013) 1.40

Life span extension via eIF4G inhibition is mediated by posttranscriptional remodeling of stress response gene expression in C. elegans. Cell Metab (2011) 1.39

Translational control in cellular and developmental processes. Nat Rev Genet (2012) 1.39

RNA regulons in Hox 5' UTRs confer ribosome specificity to gene regulation. Nature (2014) 1.38

Key contribution of CPEB4-mediated translational control to cancer progression. Nat Med (2011) 1.37

The 5'-7-methylguanosine cap on eukaryotic mRNAs serves both to stimulate canonical translation initiation and to block an alternative pathway. Mol Cell (2010) 1.35

Specific SKN-1/Nrf stress responses to perturbations in translation elongation and proteasome activity. PLoS Genet (2011) 1.35

Ribosome profiling reveals post-transcriptional buffering of divergent gene expression in yeast. Genome Res (2013) 1.35

The impact of microRNAs on protein output. Nature (2008) 32.39

Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Nat Rev Genet (2008) 32.08

Widespread changes in protein synthesis induced by microRNAs. Nature (2008) 31.44

A microRNA in a multiple-turnover RNAi enzyme complex. Science (2002) 23.36

Specificity of microRNA target selection in translational repression. Genes Dev (2004) 21.14

Switching from repression to activation: microRNAs can up-regulate translation. Science (2007) 17.00

Argonaute2, a link between genetic and biochemical analyses of RNAi. Science (2001) 15.32

Single-stranded antisense siRNAs guide target RNA cleavage in RNAi. Cell (2002) 14.37

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. Nature (2004) 12.36

Structure of the 70S ribosome complexed with mRNA and tRNA. Science (2006) 12.25

RNA regulons: coordination of post-transcriptional events. Nat Rev Genet (2007) 10.12

P bodies and the control of mRNA translation and degradation. Mol Cell (2007) 9.98

Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells. Proc Natl Acad Sci U S A (2004) 7.03

mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events. Cell (2005) 6.71

Extensive association of functionally and cytotopically related mRNAs with Puf family RNA-binding proteins in yeast. PLoS Biol (2004) 6.38

Stress granules: the Tao of RNA triage. Trends Biochem Sci (2008) 6.27

S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth. Science (2006) 5.94

GW182 interaction with Argonaute is essential for miRNA-mediated translational repression and mRNA decay. Nat Struct Mol Biol (2008) 5.57

Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans. Aging Cell (2007) 5.51

Spatial regulation of beta-actin translation by Src-dependent phosphorylation of ZBP1. Nature (2005) 5.29

Dendritic protein synthesis, synaptic plasticity, and memory. Cell (2006) 5.18

The roles of individual eukaryotic translation initiation factors in ribosomal scanning and initiation codon selection. Genes Dev (2002) 4.96

Translational control of long-lasting synaptic plasticity and memory. Neuron (2009) 4.77

Higher-order substrate recognition of eIF2alpha by the RNA-dependent protein kinase PKR. Cell (2005) 4.41

Let-7 microRNA-mediated mRNA deadenylation and translational repression in a mammalian cell-free system. Genes Dev (2007) 4.35

Translational control by MAPK signaling in long-term synaptic plasticity and memory. Cell (2004) 4.34

MicroRNA inhibition of translation initiation in vitro by targeting the cap-binding complex eIF4F. Science (2007) 4.33

Following translation by single ribosomes one codon at a time. Nature (2008) 4.14

An mRNA m7G cap binding-like motif within human Ago2 represses translation. Cell (2007) 4.03

Quantitative analysis of Argonaute protein reveals microRNA-dependent localization to stress granules. Proc Natl Acad Sci U S A (2006) 4.02

Mammalian poly(A)-binding protein is a eukaryotic translation initiation factor, which acts via multiple mechanisms. Genes Dev (2005) 3.92

Structural roles for human translation factor eIF3 in initiation of protein synthesis. Science (2005) 3.91

The transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor 4A binding protein that inhibits translation. Mol Cell Biol (2003) 3.90

Lifespan regulation by evolutionarily conserved genes essential for viability. PLoS Genet (2007) 3.83

Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans. Aging Cell (2007) 3.78

Drosophila miR2 induces pseudo-polysomes and inhibits translation initiation. Nature (2007) 3.77

Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation. EMBO J (2004) 3.69

New modes of translational control in development, behavior, and disease. Mol Cell (2007) 3.60

Dissecting eIF4E action in tumorigenesis. Genes Dev (2007) 3.53

Ribosome loading onto the mRNA cap is driven by conformational coupling between eIF4G and eIF4E. Cell (2003) 3.46

eIF2alpha phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory. Cell (2007) 3.46

The eukaryotic translation initiation factors eIF1 and eIF1A induce an open conformation of the 40S ribosome. Mol Cell (2007) 3.44

Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G. Cell (2007) 3.21

Cap-dependent translation initiation in eukaryotes is regulated by a molecular mimic of eIF4G. Mol Cell (1999) 3.21

Lipoxygenase mRNA silencing in erythroid differentiation: The 3'UTR regulatory complex controls 60S ribosomal subunit joining. Cell (2001) 3.19

A hierarchical network controls protein translation during murine embryonic stem cell self-renewal and differentiation. Cell Stem Cell (2008) 3.18

The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP. Cell (2008) 3.10

Dissociation of eIF1 from the 40S ribosomal subunit is a key step in start codon selection in vivo. Genes Dev (2007) 3.08

eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans. Nature (2007) 3.07

Maskin is a CPEB-associated factor that transiently interacts with elF-4E. Mol Cell (1999) 3.05

Therapeutic suppression of translation initiation factor eIF4E expression reduces tumor growth without toxicity. J Clin Invest (2007) 3.01

14-3-3sigma controls mitotic translation to facilitate cytokinesis. Nature (2007) 2.98

Colocalization of transcription and translation within cytoplasmic poxvirus factories coordinates viral expression and subjugates host functions. Cell Host Microbe (2007) 2.97

Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency. Nature (2008) 2.95

Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2. J Clin Invest (2007) 2.86

Pi release from eIF2, not GTP hydrolysis, is the step controlled by start-site selection during eukaryotic translation initiation. Mol Cell (2005) 2.81

MicroRNAs and viral infection. Mol Cell (2005) 2.81

A new paradigm for translational control: inhibition via 5'-3' mRNA tethering by Bicoid and the eIF4E cognate 4EHP. Cell (2005) 2.80

Bruno acts as a dual repressor of oskar translation, promoting mRNA oligomerization and formation of silencing particles. Cell (2006) 2.77

Expression of constitutively active CREB protein facilitates the late phase of long-term potentiation by enhancing synaptic capture. Cell (2002) 2.77

Translational control of hippocampal synaptic plasticity and memory by the eIF2alpha kinase GCN2. Nature (2005) 2.67

4E-binding protein 1: a key molecular "funnel factor" in human cancer with clinical implications. Cancer Res (2007) 2.67

Drosophila cup is an eIF4E binding protein that associates with Bruno and regulates oskar mRNA translation in oogenesis. Dev Cell (2004) 2.66

In vivo imaging of oskar mRNA transport reveals the mechanism of posterior localization. Cell (2008) 2.63

A conformational change in the eukaryotic translation preinitiation complex and release of eIF1 signal recognition of the start codon. Mol Cell (2005) 2.61

Topology and regulation of the human eIF4A/4G/4H helicase complex in translation initiation. Cell (2009) 2.60

Recycling of eukaryotic posttermination ribosomal complexes. Cell (2007) 2.57

Structural basis for messenger RNA movement on the ribosome. Nature (2006) 2.55

Opposing polymerase-deadenylase activities regulate cytoplasmic polyadenylation. Mol Cell (2006) 2.45

A hypoxia-controlled cap-dependent to cap-independent translation switch in breast cancer. Mol Cell (2007) 2.44

Structure of the 30S translation initiation complex. Nature (2008) 2.43

Epigenetic activation of a subset of mRNAs by eIF4E explains its effects on cell proliferation. PLoS One (2007) 2.35

The translation repressor 4E-BP2 is critical for eIF4F complex formation, synaptic plasticity, and memory in the hippocampus. J Neurosci (2005) 2.33

Structure of the ribosome-bound cricket paralysis virus IRES RNA. Nat Struct Mol Biol (2006) 2.32

Translation factors promote the formation of two states of the closed-loop mRNP. Nature (2008) 2.31

Ribosomal position and contacts of mRNA in eukaryotic translation initiation complexes. EMBO J (2008) 2.26

Crystal structure of the yeast eIF4A-eIF4G complex: an RNA-helicase controlled by protein-protein interactions. Proc Natl Acad Sci U S A (2008) 2.24

The yeast eIF3 subunits TIF32/a, NIP1/c, and eIF5 make critical connections with the 40S ribosome in vivo. Genes Dev (2003) 2.21

Smaug recruits the CCR4/POP2/NOT deadenylase complex to trigger maternal transcript localization in the early Drosophila embryo. Curr Biol (2005) 2.18

Viral IRES RNA structures and ribosome interactions. Trends Biochem Sci (2008) 2.17

Translational control of maternal Cyclin B mRNA by Nanos in the Drosophila germline. Development (2007) 2.16

Translation initiation on mammalian mRNAs with structured 5'UTRs requires DExH-box protein DHX29. Cell (2008) 2.11

The TORrid affairs of viruses: effects of mammalian DNA viruses on the PI3K-Akt-mTOR signalling pathway. Nat Rev Microbiol (2008) 2.08

Phosphorylation of the eukaryotic translation initiation factor eIF4E contributes to its transformation and mRNA transport activities. Cancer Res (2004) 2.06

daf-16 protects the nematode Caenorhabditis elegans during food deprivation. J Gerontol A Biol Sci Med Sci (2006) 2.06

Cap-independent translation is required for starvation-induced differentiation in yeast. Science (2007) 2.05

N- and C-terminal residues of eIF1A have opposing effects on the fidelity of start codon selection. EMBO J (2007) 2.03

Drosophila Cup is an eIF4E-binding protein that functions in Smaug-mediated translational repression. EMBO J (2003) 2.03

Eukaryotic translation initiation factor 4E availability controls the switch between cap-dependent and internal ribosomal entry site-mediated translation. Mol Cell Biol (2005) 1.99

Oskar allows nanos mRNA translation in Drosophila embryos by preventing its deadenylation by Smaug/CCR4. Development (2006) 1.97

The fidelity of translation initiation: reciprocal activities of eIF1, IF3 and YciH. EMBO J (2005) 1.96

A dual inhibitory mechanism restricts msl-2 mRNA translation for dosage compensation in Drosophila. Cell (2005) 1.91

Bicaudal-C recruits CCR4-NOT deadenylase to target mRNAs and regulates oogenesis, cytoskeletal organization, and its own expression. Dev Cell (2007) 1.88

Eukaryotic initiation factor 6 is rate-limiting in translation, growth and transformation. Nature (2008) 1.85

tRNA-mRNA mimicry drives translation initiation from a viral IRES. Nat Struct Mol Biol (2007) 1.84

Divergent tRNA-like element supports initiation, elongation, and termination of protein biosynthesis. Proc Natl Acad Sci U S A (2003) 1.83

CPEB interacts with an ovary-specific eIF4E and 4E-T in early Xenopus oocytes. J Biol Chem (2007) 1.79

Ribosome occupancy of the yeast CPA1 upstream open reading frame termination codon modulates nonsense-mediated mRNA decay. Mol Cell (2005) 1.79

eIF3j is located in the decoding center of the human 40S ribosomal subunit. Mol Cell (2007) 1.78

Eukaryotic translation initiation machinery can operate in a bacterial-like mode without eIF2. Nat Struct Mol Biol (2008) 1.77

Nuclear surveillance and degradation of hypomodified initiator tRNAMet in S. cerevisiae. Genes Dev (2004) 4.61

New modes of translational control in development, behavior, and disease. Mol Cell (2007) 3.60

Dissociation of eIF1 from the 40S ribosomal subunit is a key step in start codon selection in vivo. Genes Dev (2007) 3.08

Gcn5 promotes acetylation, eviction, and methylation of nucleosomes in transcribed coding regions. Mol Cell (2007) 2.71

Translational control by TOR and TAP42 through dephosphorylation of eIF2alpha kinase GCN2. Genes Dev (2003) 2.39

Development and characterization of a reconstituted yeast translation initiation system. RNA (2002) 2.27

A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II. Mol Cell (2004) 2.27

Phosphorylated Pol II CTD recruits multiple HDACs, including Rpd3C(S), for methylation-dependent deacetylation of ORF nucleosomes. Mol Cell (2010) 2.26

The yeast eIF3 subunits TIF32/a, NIP1/c, and eIF5 make critical connections with the 40S ribosome in vivo. Genes Dev (2003) 2.21

Domains of eIF1A that mediate binding to eIF2, eIF3 and eIF5B and promote ternary complex recruitment in vivo. EMBO J (2003) 2.12

Interactions of eukaryotic translation initiation factor 3 (eIF3) subunit NIP1/c with eIF1 and eIF5 promote preinitiation complex assembly and regulate start codon selection. Mol Cell Biol (2004) 2.09

Phosphorylation of the Pol II CTD by KIN28 enhances BUR1/BUR2 recruitment and Ser2 CTD phosphorylation near promoters. Mol Cell (2009) 2.08

Functions of eIF3 downstream of 48S assembly impact AUG recognition and GCN4 translational control. EMBO J (2004) 2.05

Exome sequencing identifies recurrent somatic mutations in EIF1AX and SF3B1 in uveal melanoma with disomy 3. Nat Genet (2013) 2.05

N- and C-terminal residues of eIF1A have opposing effects on the fidelity of start codon selection. EMBO J (2007) 2.03

A multiplicity of coactivators is required by Gcn4p at individual promoters in vivo. Mol Cell Biol (2003) 1.88

Direct eIF2-eIF3 contact in the multifactor complex is important for translation initiation in vivo. EMBO J (2002) 1.82

Linking high-resolution metabolic flux phenotypes and transcriptional regulation in yeast modulated by the global regulator Gcn4p. Proc Natl Acad Sci U S A (2009) 1.79

Eukaryotic translation initiation factor 3 (eIF3) and eIF2 can promote mRNA binding to 40S subunits independently of eIF4G in yeast. Mol Cell Biol (2006) 1.75

The eIF1A C-terminal domain promotes initiation complex assembly, scanning and AUG selection in vivo. EMBO J (2005) 1.68

Simultaneous recruitment of coactivators by Gcn4p stimulates multiple steps of transcription in vivo. Mol Cell Biol (2005) 1.68

eIF3a cooperates with sequences 5' of uORF1 to promote resumption of scanning by post-termination ribosomes for reinitiation on GCN4 mRNA. Genes Dev (2008) 1.67

The essential ATP-binding cassette protein RLI1 functions in translation by promoting preinitiation complex assembly. J Biol Chem (2004) 1.65

eIF1 controls multiple steps in start codon recognition during eukaryotic translation initiation. J Mol Biol (2009) 1.59

Regulatory elements in eIF1A control the fidelity of start codon selection by modulating tRNA(i)(Met) binding to the ribosome. Genes Dev (2010) 1.54

A triad of subunits from the Gal11/tail domain of Srb mediator is an in vivo target of transcriptional activator Gcn4p. Mol Cell Biol (2004) 1.53

The essential vertebrate ABCE1 protein interacts with eukaryotic initiation factors. J Biol Chem (2006) 1.52

The Spt4p subunit of yeast DSIF stimulates association of the Paf1 complex with elongating RNA polymerase II. Mol Cell Biol (2006) 1.52

An array of coactivators is required for optimal recruitment of TATA binding protein and RNA polymerase II by promoter-bound Gcn4p. Mol Cell Biol (2004) 1.51

NuA4 lysine acetyltransferase Esa1 is targeted to coding regions and stimulates transcription elongation with Gcn5. Mol Cell Biol (2009) 1.51

Interdependent recruitment of SAGA and Srb mediator by transcriptional activator Gcn4p. Mol Cell Biol (2005) 1.47

The yeast eukaryotic initiation factor 4G (eIF4G) HEAT domain interacts with eIF1 and eIF5 and is involved in stringent AUG selection. Mol Cell Biol (2003) 1.46

In vivo stabilization of preinitiation complexes by formaldehyde cross-linking. Methods Enzymol (2007) 1.46

Structural basis for autoinhibition and mutational activation of eukaryotic initiation factor 2alpha protein kinase GCN2. J Biol Chem (2005) 1.44

Functional interactions between yeast translation eukaryotic elongation factor (eEF) 1A and eEF3. J Biol Chem (2002) 1.43

Sus1 is recruited to coding regions and functions during transcription elongation in association with SAGA and TREX2. Genes Dev (2008) 1.39

The 5'-7-methylguanosine cap on eukaryotic mRNAs serves both to stimulate canonical translation initiation and to block an alternative pathway. Mol Cell (2010) 1.35

Recruitment of SWI/SNF by Gcn4p does not require Snf2p or Gcn5p but depends strongly on SWI/SNF integrity, SRB mediator, and SAGA. Mol Cell Biol (2003) 1.33

The C-terminal region of eukaryotic translation initiation factor 3a (eIF3a) promotes mRNA recruitment, scanning, and, together with eIF3j and the eIF3b RNA recognition motif, selection of AUG start codons. Mol Cell Biol (2010) 1.31

Functional elements in initiation factors 1, 1A, and 2β discriminate against poor AUG context and non-AUG start codons. Mol Cell Biol (2011) 1.22

Depletion of eIF4G from yeast cells narrows the range of translational efficiencies genome-wide. BMC Genomics (2011) 1.19

Genetic identification of yeast 18S rRNA residues required for efficient recruitment of initiator tRNA(Met) and AUG selection. Genes Dev (2008) 1.19

Multiple elements in the eIF4G1 N-terminus promote assembly of eIF4G1•PABP mRNPs in vivo. EMBO J (2010) 1.18

Ribosomal protein L33 is required for ribosome biogenesis, subunit joining, and repression of GCN4 translation. Mol Cell Biol (2007) 1.16

Interaction of the RNP1 motif in PRT1 with HCR1 promotes 40S binding of eukaryotic initiation factor 3 in yeast. Mol Cell Biol (2006) 1.15

Yeast cap binding complex impedes recruitment of cleavage factor IA to weak termination sites. Mol Cell Biol (2007) 1.14

The C-terminal domain of eukaryotic initiation factor 5 promotes start codon recognition by its dynamic interplay with eIF1 and eIF2β. Cell Rep (2012) 1.13

Coordinated movements of eukaryotic translation initiation factors eIF1, eIF1A, and eIF5 trigger phosphate release from eIF2 in response to start codon recognition by the ribosomal preinitiation complex. J Biol Chem (2013) 1.11

Specific domains in yeast translation initiation factor eIF4G strongly bias RNA unwinding activity of the eIF4F complex toward duplexes with 5'-overhangs. J Biol Chem (2012) 1.07

Mutations that bypass tRNA binding activate the intrinsically defective kinase domain in GCN2. Genes Dev (2002) 1.05

Serine 577 is phosphorylated and negatively affects the tRNA binding and eIF2alpha kinase activities of GCN2. J Biol Chem (2002) 1.04

A sterol-binding protein integrates endosomal lipid metabolism with TOR signaling and nitrogen sensing. Cell (2012) 1.01

IMPACT, a protein preferentially expressed in the mouse brain, binds GCN1 and inhibits GCN2 activation. J Biol Chem (2005) 1.00

YIH1 is an actin-binding protein that inhibits protein kinase GCN2 and impairs general amino acid control when overexpressed. J Biol Chem (2004) 1.00

Activator Gcn4 employs multiple segments of Med15/Gal11, including the KIX domain, to recruit mediator to target genes in vivo. J Biol Chem (2009) 1.00

Pol II CTD kinases Bur1 and Kin28 promote Spt5 CTR-independent recruitment of Paf1 complex. EMBO J (2012) 0.98

Disrupting vesicular trafficking at the endosome attenuates transcriptional activation by Gcn4. Mol Cell Biol (2008) 0.97

Snf1 promotes phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2 by activating Gcn2 and inhibiting phosphatases Glc7 and Sit4. Mol Cell Biol (2010) 0.97

Recruitment of the ArgR/Mcm1p repressor is stimulated by the activator Gcn4p: a self-checking activation mechanism. Proc Natl Acad Sci U S A (2004) 0.96

Yeast eIF4B binds to the head of the 40S ribosomal subunit and promotes mRNA recruitment through its N-terminal and internal repeat domains. RNA (2012) 0.95

Polyribosome binding by GCN1 is required for full activation of eukaryotic translation initiation factor 2{alpha} kinase GCN2 during amino acid starvation. J Biol Chem (2005) 0.94

Conserved residues in yeast initiator tRNA calibrate initiation accuracy by regulating preinitiation complex stability at the start codon. Genes Dev (2014) 0.93

β-Hairpin loop of eukaryotic initiation factor 1 (eIF1) mediates 40 S ribosome binding to regulate initiator tRNA(Met) recruitment and accuracy of AUG selection in vivo. J Biol Chem (2013) 0.93

The novel ATP-binding cassette protein ARB1 is a shuttling factor that stimulates 40S and 60S ribosome biogenesis. Mol Cell Biol (2005) 0.93

Enhanced eIF1 binding to the 40S ribosome impedes conformational rearrangements of the preinitiation complex and elevates initiation accuracy. RNA (2013) 0.92

Archaeal aIF2B interacts with eukaryotic translation initiation factors eIF2alpha and eIF2Balpha: Implications for aIF2B function and eIF2B regulation. J Mol Biol (2009) 0.92

Evidence that eukaryotic translation elongation factor 1A (eEF1A) binds the Gcn2 protein C terminus and inhibits Gcn2 activity. J Biol Chem (2011) 0.91

GCN2 whets the appetite for amino acids. Mol Cell (2005) 0.89

A network of hydrophobic residues impeding helix alphaC rotation maintains latency of kinase Gcn2, which phosphorylates the alpha subunit of translation initiation factor 2. Mol Cell Biol (2008) 0.89

Analysis and reconstitution of translation initiation in vitro. Methods Enzymol (2002) 0.89

The beta/Gcd7 subunit of eukaryotic translation initiation factor 2B (eIF2B), a guanine nucleotide exchange factor, is crucial for binding eIF2 in vivo. Mol Cell Biol (2010) 0.88

An upstream ORF with non-AUG start codon is translated in vivo but dispensable for translational control of GCN4 mRNA. Nucleic Acids Res (2011) 0.87

Activator Gcn4p and Cyc8p/Tup1p are interdependent for promoter occupancy at ARG1 in vivo. Mol Cell Biol (2005) 0.87

Identification of compounds that decrease the fidelity of start codon recognition by the eukaryotic translational machinery. RNA (2011) 0.86

Yeast arginine methyltransferase Hmt1p regulates transcription elongation and termination by methylating Npl3p. Nucleic Acids Res (2010) 0.85

Yeast eukaryotic initiation factor 4B (eIF4B) enhances complex assembly between eIF4A and eIF4G in vivo. J Biol Chem (2012) 0.85

YeastBook: an encyclopedia of the reference eukaryotic cell. Genetics (2011) 0.84

Vps factors are required for efficient transcription elongation in budding yeast. Genetics (2013) 0.84

Guanine nucleotide pool imbalance impairs multiple steps of protein synthesis and disrupts GCN4 translational control in Saccharomyces cerevisiae. Genetics (2010) 0.83

eIF2alpha kinases provide a new solution to the puzzle of substrate specificity. Nat Struct Mol Biol (2005) 0.83

Identification and characterization of functionally critical, conserved motifs in the internal repeats and N-terminal domain of yeast translation initiation factor 4B (yeIF4B). J Biol Chem (2013) 0.82

Gcn1 and actin binding to Yih1: implications for activation of the eIF2 kinase GCN2. J Biol Chem (2011) 0.82

Cotranscriptional recruitment of yeast TRAMP complex to intronic sequences promotes optimal pre-mRNA splicing. Nucleic Acids Res (2013) 0.80

Overexpression of eukaryotic translation elongation factor 3 impairs Gcn2 protein activation. J Biol Chem (2012) 0.79

Measuring dynamic changes in histone modifications and nucleosome density during activated transcription in budding yeast. Methods Mol Biol (2012) 0.78

Mcm1p binding sites in ARG1 positively regulate Gcn4p binding and SWI/SNF recruitment. Biochem Biophys Res Commun (2009) 0.77

Interplay between GCN2 and GCN4 expression, translation elongation factor 1 mutations and translational fidelity in yeast. Nucleic Acids Res (2005) 0.77

Targeting translation in hypoxic tumors. ACS Chem Biol (2006) 0.76

Eukaryotic translation initiation factor eIF5 promotes the accuracy of start codon recognition by regulating Pi release and conformational transitions of the preinitiation complex. Nucleic Acids Res (2015) 0.75