Published in J Am Chem Soc on September 22, 2010
Peptoid-based PET imaging of vascular endothelial growth factor receptor (VEGFR) expression. Am J Nucl Med Mol Imaging (2011) 1.01
Novel genetic approach for in vivo vascular imaging in mice. Circ Res (2012) 0.92
Caspase-responsive smart gadolinium-based contrast agent for magnetic resonance imaging of drug-induced apoptosis. Chem Sci (2014) 0.90
Synthesis and Evaluation of Gd(III) -Based Magnetic Resonance Contrast Agents for Molecular Imaging of Prostate-Specific Membrane Antigen. Angew Chem Int Ed Engl (2015) 0.87
Discrete nanomolecular polyhedral borane scaffold supporting multiple gadolinium(III) complexes as a high performance MRI contrast agent. Inorg Chem (2012) 0.83
Molecular MRI differentiation of VEGF receptor-2 levels in C6 and RG2 glioma models. Am J Nucl Med Mol Imaging (2013) 0.81
Positron emission tomography imaging of vascular endothelial growth factor receptor expression with (61)Cu-labeled lysine-tagged VEGF121. Mol Pharm (2012) 0.81
Design of a novel class of protein-based magnetic resonance imaging contrast agents for the molecular imaging of cancer biomarkers. Wiley Interdiscip Rev Nanomed Nanobiotechnol (2013) 0.79
On-Bead Two-Color (OBTC) Cell Screen for Direct Identification of Highly Selective Cell Surface Receptor Ligands. Curr Protoc Chem Biol (2012) 0.79
Imaging free zinc levels in vivo - what can be learned? Inorganica Chim Acta (2012) 0.78
Unbiased Selection of Peptide-Peptoid Hybrids Specific for Lung Cancer Compared to Normal Lung Epithelial Cells. ACS Chem Biol (2015) 0.78
cRGD peptide-conjugated icosahedral closo-B12(2-) core carrying multiple Gd3+-DOTA chelates for α(v)β3 integrin-targeted tumor imaging (MRI). Inorg Chem (2013) 0.78
Targeted delivery of gold nanoparticle contrast agents for reporting gene detection by magnetic resonance imaging. Chem Commun (Camb) (2015) 0.78
GRPR-targeted Protein Contrast Agents for Molecular Imaging of Receptor Expression in Cancers by MRI. Sci Rep (2015) 0.77
Cyclization of peptoids by formation of boronate esters. Tetrahedron Lett (2011) 0.77
Macromolecular Imaging Agents Containing Lanthanides: Can Conceptual Promise Lead to Clinical Potential? Macromolecules (2012) 0.77
Identification of lipid-phosphatidylserine (PS) as the target of unbiasedly selected cancer specific peptide-peptoid hybrid PPS1. Oncotarget (2016) 0.77
Development of a large peptoid-DOTA combinatorial library. Biopolymers (2016) 0.75
Target binding improves relaxivity in aptamer-gadolinium conjugates. J Biol Inorg Chem (2012) 0.75
OKN-007 decreases VEGFR-2 levels in a preclinical GL261 mouse glioma model. Am J Nucl Med Mol Imaging (2015) 0.75
Multimodal Genetic Approach for Molecular Imaging of Vasculature in a Mouse Model of Melanoma. Mol Imaging Biol (2016) 0.75
Influence of molecular parameters and increasing magnetic field strength on relaxivity of gadolinium- and manganese-based T1 contrast agents. Contrast Media Mol Imaging (2009) 2.48
A peptoid "antibody surrogate" that antagonizes VEGF receptor 2 activity. J Am Chem Soc (2008) 2.47
Vascular endothelial growth factor localization in the adult. Am J Pathol (2006) 2.20
Macromolecules, dendrimers, and nanomaterials in magnetic resonance imaging: the interplay between size, function, and pharmacokinetics. Chem Rev (2010) 1.82
Peptide-based probes for targeted molecular imaging. Biochemistry (2010) 1.43
Inhibition of vascular endothelial growth factor reduces angiogenesis and modulates immune cell infiltration of orthotopic breast cancer xenografts. Mol Cancer Ther (2009) 1.40
The detection limit of a Gd3+-based T1 agent is substantially reduced when targeted to a protein microdomain. Magn Reson Imaging (2008) 1.33
A peptide targeted contrast agent specific to fibrin-fibronectin complexes for cancer molecular imaging with MRI. Bioconjug Chem (2008) 1.29
Targeted gadolinium-loaded dendrimer nanoparticles for tumor-specific magnetic resonance contrast enhancement. Int J Nanomedicine (2008) 1.28
The impact of rigidity and water exchange on the relaxivity of a dendritic MRI contrast agent. Chemistry (2002) 1.26
Large relaxivity enhancement of paramagnetic lipid nanoparticles by restricting the local motions of the Gd(III) chelates. J Am Chem Soc (2010) 1.19
Gadolinium-conjugated dendrimer nanoclusters as a tumor-targeted T1 magnetic resonance imaging contrast agent. Angew Chem Int Ed Engl (2010) 1.19
PAMAM dendrimer-based contrast agents for MR imaging of Her-2/neu receptors by a three-step pretargeting approach. Magn Reson Med (2008) 1.13
Cellular labeling with Gd(III) chelates: only high thermodynamic stabilities prevent the cells acting as 'sponges' of Gd3+ ions. Contrast Media Mol Imaging (2006) 0.94
Noninvasive monitoring of HPMA copolymer-RGDfK conjugates by magnetic resonance imaging. Pharm Res (2009) 0.91
Gd-functionalised Au nanoparticles as targeted contrast agents in MRI: relaxivity enhancement by polyelectrolyte coating. Chem Commun (Camb) (2009) 0.83
Recruitment of a 19S proteasome subcomplex to an activated promoter. Science (2002) 4.01
Hypoxia-inducible factor 1alpha induces fibrosis and insulin resistance in white adipose tissue. Mol Cell Biol (2009) 3.96
Comparative in vivo stability of copper-64-labeled cross-bridged and conventional tetraazamacrocyclic complexes. J Med Chem (2004) 3.57
Identification of candidate IgG biomarkers for Alzheimer's disease via combinatorial library screening. Cell (2011) 3.01
Isolation of protein ligands from large peptoid libraries. J Am Chem Soc (2003) 2.80
A peptoid "antibody surrogate" that antagonizes VEGF receptor 2 activity. J Am Chem Soc (2008) 2.47
Soluble Eph A receptors inhibit tumor angiogenesis and progression in vivo. Oncogene (2002) 2.41
Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth. Nat Med (2009) 2.39
Dichotomous effects of VEGF-A on adipose tissue dysfunction. Proc Natl Acad Sci U S A (2012) 2.24
Angiogenic role of LYVE-1-positive macrophages in adipose tissue. Circ Res (2007) 2.22
Monitoring response to anticancer therapy by targeting microbubbles to tumor vasculature. Clin Cancer Res (2007) 2.19
Role of DAB2IP in modulating epithelial-to-mesenchymal transition and prostate cancer metastasis. Proc Natl Acad Sci U S A (2010) 2.16
Enhanced expression of SPARC/osteonectin in the tumor-associated stroma of non-small cell lung cancer is correlated with markers of hypoxia/acidity and with poor prognosis of patients. Cancer Res (2003) 2.08
Non-nuclear estrogen receptor alpha signaling promotes cardiovascular protection but not uterine or breast cancer growth in mice. J Clin Invest (2010) 1.90
Preparation and biological evaluation of copper-64-labeled tyr3-octreotate using a cross-bridged macrocyclic chelator. Clin Cancer Res (2004) 1.89
Microwave-assisted solid-phase synthesis of peptoids. Org Lett (2002) 1.81
Seamless bead to microarray screening: rapid identification of the highest affinity protein ligands from large combinatorial libraries. Chem Biol (2010) 1.67
Physical and functional association of RNA polymerase II and the proteasome. Proc Natl Acad Sci U S A (2004) 1.61
Vascular endothelial growth factor receptor 2 mediates macrophage infiltration into orthotopic pancreatic tumors in mice. Cancer Res (2008) 1.61
Macrophage-derived SPARC bridges tumor cell-extracellular matrix interactions toward metastasis. Cancer Res (2008) 1.61
Systematic identification of molecular subtype-selective vulnerabilities in non-small-cell lung cancer. Cell (2013) 1.60
Chemistry of periodate-mediated cross-linking of 3,4-dihydroxylphenylalanine-containing molecules to proteins. J Am Chem Soc (2006) 1.60
MRI detection of paramagnetic chemical exchange effects in mice kidneys in vivo. Magn Reson Med (2007) 1.57
Molecular consequences of silencing mutant K-ras in pancreatic cancer cells: justification for K-ras-directed therapy. Mol Cancer Res (2005) 1.57
A high-throughput assay for assessing the cell permeability of combinatorial libraries. Nat Biotechnol (2005) 1.54
Enhanced growth of pancreatic tumors in SPARC-null mice is associated with decreased deposition of extracellular matrix and reduced tumor cell apoptosis. Mol Cancer Res (2004) 1.54
Lack of host SPARC enhances vascular function and tumor spread in an orthotopic murine model of pancreatic carcinoma. Dis Model Mech (2009) 1.53
Cytokine levels correlate with immune cell infiltration after anti-VEGF therapy in preclinical mouse models of breast cancer. PLoS One (2009) 1.53
Proteolytic turnover of the Gal4 transcription factor is not required for function in vivo. Nature (2006) 1.49
A biomimetic polyketide-inspired approach to small-molecule ligand discovery. Nat Chem (2011) 1.49
Peptoids as potential therapeutics. Curr Opin Mol Ther (2009) 1.49
Smac mimetic increases chemotherapy response and improves survival in mice with pancreatic cancer. Cancer Res (2010) 1.48
Genome-wide analysis of human HSF1 signaling reveals a transcriptional program linked to cellular adaptation and survival. Mol Biosyst (2006) 1.47
Target identification in chemical genetics: the (often) missing link. Chem Biol (2004) 1.47
Quantitative evaluation of the relative cell permeability of peptoids and peptides. J Am Chem Soc (2007) 1.44
Pharmacological characterization of 40 human melanocortin-4 receptor polymorphisms with the endogenous proopiomelanocortin-derived agonists and the agouti-related protein (AGRP) antagonist. Biochemistry (2006) 1.42
Luminescent gold nanoparticles with efficient renal clearance. Angew Chem Int Ed Engl (2011) 1.41
The VEGF family in cancer and antibody-based strategies for their inhibition. MAbs (2011) 1.41
Tumor VEGF:VEGFR2 autocrine feed-forward loop triggers angiogenesis in lung cancer. J Clin Invest (2013) 1.41
SPARC: a matricellular regulator of tumorigenesis. J Cell Commun Signal (2009) 1.41
Inhibition of vascular endothelial growth factor reduces angiogenesis and modulates immune cell infiltration of orthotopic breast cancer xenografts. Mol Cancer Ther (2009) 1.40
27-Hydroxycholesterol promotes cell-autonomous, ER-positive breast cancer growth. Cell Rep (2013) 1.39
A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth. Nat Commun (2013) 1.37
Loss of SPARC-mediated VEGFR-1 suppression after injury reveals a novel antiangiogenic activity of VEGF-A. J Clin Invest (2006) 1.36
Identification of a peptoid inhibitor of the proteasome 19S regulatory particle. J Am Chem Soc (2007) 1.36
64Cu-labeled folate-conjugated shell cross-linked nanoparticles for tumor imaging and radiotherapy: synthesis, radiolabeling, and biologic evaluation. J Nucl Med (2005) 1.35
The detection limit of a Gd3+-based T1 agent is substantially reduced when targeted to a protein microdomain. Magn Reson Imaging (2008) 1.33
Protein "fingerprinting" in complex mixtures with peptoid microarrays. Proc Natl Acad Sci U S A (2005) 1.33
Synthesis and screening of stereochemically diverse combinatorial libraries of peptide tertiary amides. Chem Biol (2013) 1.32
The role of the proteasomal ATPases and activator monoubiquitylation in regulating Gal4 binding to promoters. Genes Dev (2006) 1.32
Progestin-dependent progression of human breast tumor xenografts: a novel model for evaluating antitumor therapeutics. Cancer Res (2007) 1.31
Effect of rapamycin alone and in combination with antiangiogenesis therapy in an orthotopic model of human pancreatic cancer. Clin Cancer Res (2004) 1.31
Vascular endothelial growth factor induces proliferation of breast cancer cells and inhibits the anti-proliferative activity of anti-hormones. Endocr Relat Cancer (2006) 1.31
The role of Cdk5 in neuroendocrine thyroid cancer. Cancer Cell (2013) 1.30
A nonproteolytic function of the 19S regulatory subunit of the 26S proteasome is required for efficient activated transcription by human RNA polymerase II. Biochemistry (2002) 1.30
A cell-permeable synthetic transcription factor mimic. Angew Chem Int Ed Engl (2007) 1.29
Widespread, but non-identical, association of proteasomal 19 and 20 S proteins with yeast chromatin. J Biol Chem (2006) 1.27
On-resonance low B1 pulses for imaging of the effects of PARACEST agents. J Magn Reson (2005) 1.26
RHOA-FAK is a required signaling axis for the maintenance of KRAS-driven lung adenocarcinomas. Cancer Discov (2013) 1.25
SPARC regulates TGF-beta1-dependent signaling in primary glomerular mesangial cells. J Cell Biochem (2004) 1.24
Periodate-triggered cross-linking of DOPA-containing peptide-protein complexes. J Am Chem Soc (2004) 1.24
Increased expression of Cyr61 (CCN1) identified in peritoneal metastases from human pancreatic cancer. J Am Coll Surg (2005) 1.23
Comparison of kinetic models for analysis of pyruvate-to-lactate exchange by hyperpolarized 13 C NMR. NMR Biomed (2012) 1.23
Glucose metabolism via the pentose phosphate pathway, glycolysis and Krebs cycle in an orthotopic mouse model of human brain tumors. NMR Biomed (2012) 1.23
Genomic studies of transcription factor-DNA interactions. Curr Opin Chem Biol (2005) 1.21
Quantum dots as a visual aid for screening bead-bound combinatorial libraries. Chembiochem (2003) 1.20
Targeting vascular endothelium with avidin microbubbles. Ultrasound Med Biol (2005) 1.19
BIBF 1120 (nintedanib), a triple angiokinase inhibitor, induces hypoxia but not EMT and blocks progression of preclinical models of lung and pancreatic cancer. Mol Cancer Ther (2013) 1.19
Noninvasive evaluation of liver metabolism by 2H and 13C NMR isotopomer analysis of human urine. Anal Biochem (2003) 1.18
Anti-VEGF-A therapy reduces lymphatic vessel density and expression of VEGFR-3 in an orthotopic breast tumor model. Int J Cancer (2007) 1.18
The role of the size and number of polyethylene glycol chains in the biodistribution and tumor localization of triazine dendrimers. Mol Pharm (2008) 1.18
Design and synthesis of a cell-permeable synthetic transcription factor mimic. J Comb Chem (2007) 1.17
Identification of Gal4 activation domain-binding proteins in the 26S proteasome by periodate-triggered cross-linking. Mol Biosyst (2005) 1.15
Imparting multivalency to a bifunctional chelator: a scaffold design for targeted PET imaging probes. Angew Chem Int Ed Engl (2009) 1.14
Near-infrared emitting radioactive gold nanoparticles with molecular pharmacokinetics. Angew Chem Int Ed Engl (2012) 1.14
Transplantation of mesenchymal stem cells from young donors delays aging in mice. Sci Rep (2011) 1.13
Steroid receptor coactivator-3 expression in lung cancer and its role in the regulation of cancer cell survival and proliferation. Cancer Res (2010) 1.13
SMAC mimetic (JP1201) sensitizes non-small cell lung cancers to multiple chemotherapy agents in an IAP-dependent but TNF-α-independent manner. Cancer Res (2011) 1.13
r84, a novel therapeutic antibody against mouse and human VEGF with potent anti-tumor activity and limited toxicity induction. PLoS One (2010) 1.13
Incorporation of heterocycles into the backbone of peptoids to generate diverse peptoid-inspired one bead one compound libraries. ACS Comb Sci (2012) 1.11
Malignant progression and blockade of angiogenesis in a murine transgenic model of neuroblastoma. Cancer Res (2007) 1.11
Fibulin-5, an integrin-binding matricellular protein: its function in development and disease. J Cell Commun Signal (2009) 1.11
Utility of redundant combinatorial libraries in distinguishing high and low quality screening hits. ACS Comb Sci (2014) 1.10
High-throughput evaluation of relative cell permeability between peptoids and peptides. Bioorg Med Chem (2008) 1.09
Forced expression of MMP9 rescues the loss of angiogenesis and abrogates metastasis of pancreatic tumors triggered by the absence of host SPARC. Exp Biol Med (Maywood) (2008) 1.08
Lack of "immunological fitness" during fasting in metabolically challenged animals. J Lipid Res (2012) 1.08
Physical and functional interactions of monoubiquitylated transactivators with the proteasome. J Biol Chem (2008) 1.08
Magnetic resonance imaging detects a specific peptide-protein binding event. J Am Chem Soc (2002) 1.08
Acyl hydrazides as peptoid sub-monomers. Chem Commun (Camb) (2011) 1.07
Label transfer chemistry for the characterization of protein-protein interactions. J Am Chem Soc (2007) 1.07
Discovery of peptoid ligands for anti-aquaporin 4 antibodies. Chem Biol (2013) 1.07
Frequent detection of infectious xenotropic murine leukemia virus (XMLV) in human cultures established from mouse xenografts. Cancer Biol Ther (2011) 1.06
K-Ras promotes angiogenesis mediated by immortalized human pancreatic epithelial cells through mitogen-activated protein kinase signaling pathways. Mol Cancer Res (2009) 1.06
Modulating endogenous NQO1 levels identifies key regulatory mechanisms of action of β-lapachone for pancreatic cancer therapy. Clin Cancer Res (2011) 1.06
The proteasomal ATPase complex is required for stress-induced transcription in yeast. Nucleic Acids Res (2006) 1.06
Phosphorylation of Akt and ERK1/2 is required for VEGF-A/VEGFR2-induced proliferation and migration of lymphatic endothelium. PLoS One (2011) 1.06
TGF-β and αvβ6 integrin act in a common pathway to suppress pancreatic cancer progression. Cancer Res (2012) 1.06
Semaphorin 3B inhibits the phosphatidylinositol 3-kinase/Akt pathway through neuropilin-1 in lung and breast cancer cells. Cancer Res (2008) 1.05