| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Biological, clinical and population relevance of 95 loci for blood lipids.
|
Nature
|
2010
|
28.21
|
|
2
|
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
|
Nat Genet
|
2010
|
23.08
|
|
3
|
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
|
Nature
|
2010
|
20.01
|
|
4
|
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.
|
Nat Genet
|
2010
|
17.89
|
|
5
|
Vitamin D deficiency and risk of cardiovascular disease.
|
Circulation
|
2008
|
13.39
|
|
6
|
Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study.
|
Lancet
|
2012
|
12.10
|
|
7
|
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.
|
Nat Genet
|
2012
|
11.09
|
|
8
|
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.
|
Nat Genet
|
2010
|
7.94
|
|
9
|
Large-scale association analysis identifies new risk loci for coronary artery disease.
|
Nat Genet
|
2012
|
7.59
|
|
10
|
Use of multiple biomarkers to improve the prediction of death from cardiovascular causes.
|
N Engl J Med
|
2008
|
7.33
|
|
11
|
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge.
|
Nat Genet
|
2010
|
6.66
|
|
12
|
C-reactive protein, fibrinogen, and cardiovascular disease prediction.
|
N Engl J Med
|
2012
|
6.39
|
|
13
|
Genomic inflation factors under polygenic inheritance.
|
Eur J Hum Genet
|
2011
|
4.89
|
|
14
|
Impact of body mass index and the metabolic syndrome on the risk of cardiovascular disease and death in middle-aged men.
|
Circulation
|
2009
|
4.78
|
|
15
|
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.
|
Nat Genet
|
2012
|
4.73
|
|
16
|
GWAS of 126,559 individuals identifies genetic variants associated with educational attainment.
|
Science
|
2013
|
4.71
|
|
17
|
Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies.
|
Lancet
|
2012
|
4.63
|
|
18
|
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
|
Nat Genet
|
2012
|
4.37
|
|
19
|
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
|
Nat Genet
|
2014
|
4.13
|
|
20
|
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.
|
Nat Genet
|
2010
|
3.37
|
|
21
|
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
|
Nat Genet
|
2013
|
3.25
|
|
22
|
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.
|
PLoS Genet
|
2012
|
3.21
|
|
23
|
Common variants associated with plasma triglycerides and risk for coronary artery disease.
|
Nat Genet
|
2013
|
2.92
|
|
24
|
Plasma parathyroid hormone and the risk of cardiovascular mortality in the community.
|
Circulation
|
2009
|
2.85
|
|
25
|
Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits.
|
PLoS Genet
|
2013
|
2.83
|
|
26
|
FTO genotype is associated with phenotypic variability of body mass index.
|
Nature
|
2012
|
2.77
|
|
27
|
Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile.
|
Nat Genet
|
2011
|
2.73
|
|
28
|
Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts.
|
PLoS Med
|
2013
|
2.73
|
|
29
|
CUBN is a gene locus for albuminuria.
|
J Am Soc Nephrol
|
2011
|
2.70
|
|
30
|
Higher fibroblast growth factor-23 increases the risk of all-cause and cardiovascular mortality in the community.
|
Kidney Int
|
2012
|
2.61
|
|
31
|
Risk of thromboembolic diseases in men with prostate cancer: results from the population-based PCBaSe Sweden.
|
Lancet Oncol
|
2010
|
2.56
|
|
32
|
Genetically determined height and coronary artery disease.
|
N Engl J Med
|
2015
|
2.24
|
|
33
|
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.
|
Diabetes
|
2011
|
2.21
|
|
34
|
Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: a meta-analysis of 14 cohort studies.
|
Diabetes Care
|
2010
|
2.14
|
|
35
|
Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.
|
Nat Genet
|
2012
|
2.12
|
|
36
|
Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data.
|
JAMA
|
2009
|
2.10
|
|
37
|
Nationwide cohort study of risk of ischemic heart disease in patients with celiac disease.
|
Circulation
|
2011
|
1.85
|
|
38
|
Cardiac troponin-I and risk of heart failure: a community-based cohort study.
|
Eur Heart J
|
2009
|
1.78
|
|
39
|
Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.
|
Nat Genet
|
2013
|
1.72
|
|
40
|
A genome-wide association search for type 2 diabetes genes in African Americans.
|
PLoS One
|
2012
|
1.72
|
|
41
|
The role of adiposity in cardiometabolic traits: a Mendelian randomization analysis.
|
PLoS Med
|
2013
|
1.70
|
|
42
|
The Swedish Twin Registry: establishment of a biobank and other recent developments.
|
Twin Res Hum Genet
|
2012
|
1.65
|
|
43
|
Absolute and relative risk of cardiovascular disease in men with prostate cancer: results from the Population-Based PCBaSe Sweden.
|
J Clin Oncol
|
2010
|
1.62
|
|
44
|
Gene × physical activity interactions in obesity: combined analysis of 111,421 individuals of European ancestry.
|
PLoS Genet
|
2013
|
1.51
|
|
45
|
Genome-wide association studies of obesity and metabolic syndrome.
|
Mol Cell Endocrinol
|
2012
|
1.49
|
|
46
|
Interplay of overweight and insulin resistance on hypertension development.
|
J Hypertens
|
2014
|
1.48
|
|
47
|
Plasma beta amyloid and the risk of Alzheimer disease and dementia in elderly men: a prospective, population-based cohort study.
|
Arch Neurol
|
2008
|
1.46
|
|
48
|
Parity and risk of later-life maternal cardiovascular disease.
|
Am Heart J
|
2010
|
1.41
|
|
49
|
LifeGene--a large prospective population-based study of global relevance.
|
Eur J Epidemiol
|
2010
|
1.38
|
|
50
|
Birth characteristics and subsequent risks of maternal cardiovascular disease: effects of gestational age and fetal growth.
|
Circulation
|
2011
|
1.34
|
|
51
|
Multilocus genetic risk scores for coronary heart disease prediction.
|
Arterioscler Thromb Vasc Biol
|
2013
|
1.32
|
|
52
|
Evidence of a causal relationship between adiponectin levels and insulin sensitivity: a Mendelian randomization study.
|
Diabetes
|
2012
|
1.27
|
|
53
|
Biomarkers of extracellular matrix metabolism (MMP-9 and TIMP-1) and risk of stroke, myocardial infarction, and cause-specific mortality: cohort study.
|
PLoS One
|
2011
|
1.26
|
|
54
|
Insulin sensitivity measured with euglycemic clamp is independently associated with glomerular filtration rate in a community-based cohort.
|
Diabetes Care
|
2008
|
1.26
|
|
55
|
Mendelian randomization studies do not support a causal role for reduced circulating adiponectin levels in insulin resistance and type 2 diabetes.
|
Diabetes
|
2013
|
1.25
|
|
56
|
Meta-analysis of gene-level associations for rare variants based on single-variant statistics.
|
Am J Hum Genet
|
2013
|
1.24
|
|
57
|
Risk associated with the metabolic syndrome versus the sum of its individual components.
|
Diabetes Care
|
2006
|
1.21
|
|
58
|
Impact of BMI and the metabolic syndrome on the risk of diabetes in middle-aged men.
|
Diabetes Care
|
2010
|
1.20
|
|
59
|
Polymorphisms in the SCD1 gene: associations with body fat distribution and insulin sensitivity.
|
Obesity (Silver Spring)
|
2007
|
1.18
|
|
60
|
Conjoint effects of serum calcium and phosphate on risk of total, cardiovascular, and noncardiovascular mortality in the community.
|
Arterioscler Thromb Vasc Biol
|
2009
|
1.18
|
|
61
|
Associations of variants in FTO and near MC4R with obesity traits in South Asian Indians.
|
Obesity (Silver Spring)
|
2012
|
1.14
|
|
62
|
Risk prediction measures for case-cohort and nested case-control designs: an application to cardiovascular disease.
|
Am J Epidemiol
|
2012
|
1.13
|
|
63
|
Total zinc intake may modify the glucose-raising effect of a zinc transporter (SLC30A8) variant: a 14-cohort meta-analysis.
|
Diabetes
|
2011
|
1.13
|
|
64
|
Serum FGF23 and risk of cardiovascular events in relation to mineral metabolism and cardiovascular pathology.
|
Clin J Am Soc Nephrol
|
2013
|
1.10
|
|
65
|
The combined contribution of albuminuria and glomerular filtration rate to the prediction of cardiovascular mortality in elderly men.
|
Nephrol Dial Transplant
|
2011
|
1.10
|
|
66
|
Cyclooxygenase-2 inhibitors and cardiovascular risk in a nation-wide cohort study after the withdrawal of rofecoxib.
|
Eur Heart J
|
2011
|
1.06
|
|
67
|
Differential white blood cell count and type 2 diabetes: systematic review and meta-analysis of cross-sectional and prospective studies.
|
PLoS One
|
2010
|
1.06
|
|
68
|
Relations of circulating resistin and adiponectin and cardiac structure and function: the Framingham Offspring Study.
|
Obesity (Silver Spring)
|
2011
|
1.05
|
|
69
|
Plasma parathyroid hormone and risk of congestive heart failure in the community.
|
Eur J Heart Fail
|
2010
|
1.05
|
|
70
|
Inference of the genetic architecture underlying BMI and height with the use of 20,240 sibling pairs.
|
Am J Hum Genet
|
2013
|
1.04
|
|
71
|
Meta-analysis investigating associations between healthy diet and fasting glucose and insulin levels and modification by loci associated with glucose homeostasis in data from 15 cohorts.
|
Am J Epidemiol
|
2012
|
1.03
|
|
72
|
Myocardial performance index, a Doppler-derived index of global left ventricular function, predicts congestive heart failure in elderly men.
|
Eur Heart J
|
2004
|
1.01
|
|
73
|
Subfertility and risk of later life maternal cardiovascular disease.
|
Hum Reprod
|
2011
|
1.01
|
|
74
|
Association between serum cathepsin S and mortality in older adults.
|
JAMA
|
2011
|
0.99
|
|
75
|
Clinical and genetic correlates of growth differentiation factor 15 in the community.
|
Clin Chem
|
2012
|
0.99
|
|
76
|
Identification of cis- and trans-acting genetic variants explaining up to half the variation in circulating vascular endothelial growth factor levels.
|
Circ Res
|
2011
|
0.97
|
|
77
|
Adiponectin and risk of congestive heart failure.
|
JAMA
|
2006
|
0.96
|
|
78
|
Alcohol intake, insulin resistance, and abdominal obesity in elderly men.
|
Obesity (Silver Spring)
|
2007
|
0.92
|
|
79
|
Adiponectin and cardiac geometry and function in elderly: results from two community-based cohort studies.
|
Eur J Endocrinol
|
2009
|
0.90
|
|
80
|
Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene.
|
J Clin Invest
|
2015
|
0.90
|
|
81
|
Urinary neutrophil gelatinase-associated lipocalin (NGAL) is associated with mortality in a community-based cohort of older Swedish men.
|
Atherosclerosis
|
2013
|
0.89
|
|
82
|
Sortilin receptor 1 predicts longitudinal cognitive change.
|
Neurobiol Aging
|
2013
|
0.89
|
|
83
|
Sensitivity Analyses for Robust Causal Inference from Mendelian Randomization Analyses with Multiple Genetic Variants.
|
Epidemiology
|
2017
|
0.88
|
|
84
|
Oxidative stress and inflammatory markers in relation to circulating levels of adiponectin.
|
Obesity (Silver Spring)
|
2013
|
0.88
|
|
85
|
A detailed cardiovascular characterization of obesity without the metabolic syndrome.
|
Arterioscler Thromb Vasc Biol
|
2011
|
0.88
|
|
86
|
Higher magnesium intake is associated with lower fasting glucose and insulin, with no evidence of interaction with select genetic loci, in a meta-analysis of 15 CHARGE Consortium Studies.
|
J Nutr
|
2013
|
0.88
|
|
87
|
DNA mismatch repair gene MSH6 implicated in determining age at natural menopause.
|
Hum Mol Genet
|
2013
|
0.88
|
|
88
|
Urinary kidney injury molecule 1 and incidence of heart failure in elderly men.
|
Eur J Heart Fail
|
2012
|
0.87
|
|
89
|
Breastfeeding in infancy and adult cardiovascular disease risk factors.
|
Am J Med
|
2009
|
0.87
|
|
90
|
Relations of circulating vitamin D concentrations with left ventricular geometry and function.
|
Eur J Heart Fail
|
2012
|
0.87
|
|
91
|
A genome-wide assessment of variability in human serum metabolism.
|
Hum Mutat
|
2013
|
0.86
|
|
92
|
FTO genetic variants and risk of obesity and type 2 diabetes: a meta-analysis of 28,394 Indians.
|
Obesity (Silver Spring)
|
2013
|
0.86
|
|
93
|
Inflammation, oxidative stress, glomerular filtration rate, and albuminuria in elderly men: a cross-sectional study.
|
BMC Res Notes
|
2012
|
0.86
|
|
94
|
Serum cathepsin S is associated with decreased insulin sensitivity and the development of type 2 diabetes in a community-based cohort of elderly men.
|
Diabetes Care
|
2012
|
0.86
|
|
95
|
Genome-wide and gene-based association implicates FRMD6 in Alzheimer disease.
|
Hum Mutat
|
2012
|
0.86
|
|
96
|
No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels.
|
Diabetes
|
2012
|
0.86
|
|
97
|
Familial effects on ischemic stroke: the role of sibling kinship, sex, and age of onset.
|
Circ Cardiovasc Genet
|
2012
|
0.85
|
|
98
|
Valvular osteoclasts in calcification and aortic valve stenosis severity.
|
Int J Cardiol
|
2013
|
0.85
|
|
99
|
Genetic determinants of mortality. Can findings from genome-wide association studies explain variation in human mortality?
|
Hum Genet
|
2013
|
0.85
|
|
100
|
Clinical depression, antidepressant use and risk of future cardiovascular disease.
|
Eur J Epidemiol
|
2013
|
0.85
|
|
101
|
Global DNA hypermethylation is associated with high serum levels of persistent organic pollutants in an elderly population.
|
Environ Int
|
2013
|
0.85
|
|
102
|
Serum endostatin and risk of mortality in the elderly: findings from 2 community-based cohorts.
|
Arterioscler Thromb Vasc Biol
|
2013
|
0.83
|
|
103
|
Persistent organic pollutants and inflammatory markers in a cross-sectional study of elderly swedish people: the PIVUS cohort.
|
Environ Health Perspect
|
2014
|
0.83
|
|
104
|
Cerebrovascular and ischemic heart disease in young adults born preterm: a population-based Swedish cohort study.
|
Eur J Epidemiol
|
2014
|
0.83
|
|
105
|
Association between glomerular filtration rate and endothelial function in an elderly community cohort.
|
Atherosclerosis
|
2012
|
0.81
|
|
106
|
Smokeless tobacco (snus) and risk of heart failure: results from two Swedish cohorts.
|
Eur J Prev Cardiol
|
2011
|
0.81
|
|
107
|
Associations of circulating adiponectin with measures of vascular function and morphology.
|
J Clin Endocrinol Metab
|
2010
|
0.80
|
|
108
|
Genetic variants from lipid-related pathways and risk for incident myocardial infarction.
|
PLoS One
|
2013
|
0.79
|
|
109
|
Rediscovery rate estimation for assessing the validation of significant findings in high-throughput studies.
|
Brief Bioinform
|
2014
|
0.78
|
|
110
|
Association between circulating endostatin, hypertension duration, and hypertensive target-organ damage.
|
Hypertension
|
2013
|
0.78
|
|
111
|
Genetic variation in the dimethylarginine dimethylaminohydrolase 1 gene (DDAH1) is related to asymmetric dimethylarginine (ADMA) levels, but not to endothelium-dependent vasodilation.
|
Vasc Med
|
2013
|
0.77
|
|
112
|
Genetic variation in the CYP2B6 gene is related to circulating 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) concentrations: an observational population-based study.
|
Environ Health
|
2014
|
0.77
|
|
113
|
Circulating biomarkers in cardiovascular disease.
|
Dis Markers
|
2009
|
0.77
|
|
114
|
Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene.
|
J Clin Invest
|
2016
|
0.76
|
|
115
|
The Expressed Genome in Cardiovascular Diseases and Stroke: Refinement, Diagnosis, and Prediction: A Scientific Statement From the American Heart Association.
|
Circ Cardiovasc Genet
|
2017
|
0.76
|
|
116
|
The leukotriene receptor antagonist montelukast and aortic stenosis.
|
Br J Clin Pharmacol
|
2013
|
0.75
|
|
117
|
Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.
|
PLoS Genet
|
2016
|
0.75
|
|
118
|
Large-scale genome-wide association studies consortia: blessing, burden, or necessity?
|
Circ Cardiovasc Genet
|
2010
|
0.75
|
|
119
|
Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function.
|
J Clin Invest
|
2017
|
0.75
|
|
120
|
Utilizing twins as controls for non-twin case-materials in genome wide association studies.
|
PLoS One
|
2013
|
0.75
|
|
121
|
Influence of a prudent diet on circulating cathepsin S in humans.
|
Nutr J
|
2014
|
0.75
|
|
122
|
Erratum: Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation.
|
Nat Genet
|
2017
|
0.75
|
|
123
|
New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475 000 Individuals.
|
Circ Cardiovasc Genet
|
2017
|
0.75
|
|
124
|
Correction: Effect of Insulin Resistance on Monounsaturated Fatty Acid Levels: A Multi-cohort Non-targeted Metabolomics and Mendelian Randomization Study.
|
PLoS Genet
|
2017
|
0.75
|
|
125
|
Erratum: Genetic loci associated with heart rate variability and their effects on cardiac disease risk.
|
Nat Commun
|
2017
|
0.75
|