Published in Nat Genet on August 12, 2012
Genetic studies of body mass index yield new insights for obesity biology. Nature (2015) 8.27
Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Nat Genet (2013) 8.24
Clinical interpretation and implications of whole-genome sequencing. JAMA (2014) 7.24
The metabochip, a custom genotyping array for genetic studies of metabolic, cardiovascular, and anthropometric traits. PLoS Genet (2012) 6.15
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet (2012) 4.73
Loss-of-function mutations in SLC30A8 protect against type 2 diabetes. Nat Genet (2014) 4.24
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet (2014) 4.13
HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials. Lancet (2014) 3.94
An atlas of genetic correlations across human diseases and traits. Nat Genet (2015) 3.90
LD Score regression distinguishes confounding from polygenicity in genome-wide association studies. Nat Genet (2015) 3.82
Chromatin marks identify critical cell types for fine mapping complex trait variants. Nat Genet (2012) 3.67
Association between circulating 25-hydroxyvitamin D and incident type 2 diabetes: a mendelian randomisation study. Lancet Diabetes Endocrinol (2014) 3.61
Rare-variant association analysis: study designs and statistical tests. Am J Hum Genet (2014) 3.42
New genetic loci link adipose and insulin biology to body fat distribution. Nature (2015) 3.38
Bayesian refinement of association signals for 14 loci in 3 common diseases. Nat Genet (2012) 3.31
A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease. Nat Genet (2015) 2.84
Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity. Diabetes (2013) 2.70
Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future. Lancet (2013) 2.66
Polygenic type 2 diabetes prediction at the limit of common variant detection. Diabetes (2014) 2.52
Epigenome-wide association of DNA methylation markers in peripheral blood from Indian Asians and Europeans with incident type 2 diabetes: a nested case-control study. Lancet Diabetes Endocrinol (2015) 2.46
Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants. Nat Genet (2014) 2.38
Genetic Variation Determines PPARγ Function and Anti-diabetic Drug Response In Vivo. Cell (2015) 2.31
Mapping DNA methylation across development, genotype and schizophrenia in the human frontal cortex. Nat Neurosci (2015) 2.31
Genetically determined height and coronary artery disease. N Engl J Med (2015) 2.24
Gene-lifestyle interaction and type 2 diabetes: the EPIC interact case-cohort study. PLoS Med (2014) 2.22
Type 2 diabetes in East Asians: similarities and differences with populations in Europe and the United States. Ann N Y Acad Sci (2013) 2.15
Genome-wide patterns of selection in 230 ancient Eurasians. Nature (2015) 2.09
Partitioning heritability by functional annotation using genome-wide association summary statistics. Nat Genet (2015) 2.05
A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes. Nature (2014) 1.89
The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study. PLoS Genet (2015) 1.87
Realizing the promise of cancer predisposition genes. Nature (2014) 1.84
Genetic evidence for a normal-weight "metabolically obese" phenotype linking insulin resistance, hypertension, coronary artery disease, and type 2 diabetes. Diabetes (2014) 1.77
The Genome of the Netherlands: design, and project goals. Eur J Hum Genet (2013) 1.68
Large-scale genomics unveils the genetic architecture of psychiatric disorders. Nat Neurosci (2014) 1.64
Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis. Lancet Diabetes Endocrinol (2015) 1.64
Methodological challenges in mendelian randomization. Epidemiology (2014) 1.61
Methylation QTLs in the developing brain and their enrichment in schizophrenia risk loci. Nat Neurosci (2015) 1.60
Cell-type, allelic, and genetic signatures in the human pancreatic beta cell transcriptome. Genome Res (2013) 1.58
Statistical colocalization of genetic risk variants for related autoimmune diseases in the context of common controls. Nat Genet (2015) 1.56
Instrumental variable estimation in a survival context. Epidemiology (2015) 1.56
Myocardial Infarction-Associated SNP at 6p24 Interferes With MEF2 Binding and Associates With PHACTR1 Expression Levels in Human Coronary Arteries. Arterioscler Thromb Vasc Biol (2015) 1.54
Mouse-human experimental epigenetic analysis unmasks dietary targets and genetic liability for diabetic phenotypes. Cell Metab (2015) 1.52
Exome sequencing and complex disease: practical aspects of rare variant association studies. Hum Mol Genet (2012) 1.52
Using published data in Mendelian randomization: a blueprint for efficient identification of causal risk factors. Eur J Epidemiol (2015) 1.51
The impact of phenotypic and genetic heterogeneity on results of genome wide association studies of complex diseases. PLoS One (2013) 1.51
A Type 1 Diabetes Genetic Risk Score Can Aid Discrimination Between Type 1 and Type 2 Diabetes in Young Adults. Diabetes Care (2015) 1.50
TM6SF2 is a regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content. Proc Natl Acad Sci U S A (2014) 1.49
Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin. Nat Genet (2016) 1.48
Causal Assessment of Serum Urate Levels in Cardiometabolic Diseases Through a Mendelian Randomization Study. J Am Coll Cardiol (2016) 1.46
Phenotypic Characterization of Genetically Lowered Human Lipoprotein(a) Levels. J Am Coll Cardiol (2016) 1.46
Genetic variants primarily associated with type 2 diabetes are related to coronary artery disease risk. Atherosclerosis (2015) 1.46
A population genetic signal of polygenic adaptation. PLoS Genet (2014) 1.46
The cancer-associated FGFR4-G388R polymorphism enhances pancreatic insulin secretion and modifies the risk of diabetes. Cell Metab (2013) 1.45
Biomarkers for type 2 diabetes and impaired fasting glucose using a nontargeted metabolomics approach. Diabetes (2013) 1.44
The genetic architecture of type 2 diabetes. Nature (2016) 1.43
Whole-exome sequencing of 2,000 Danish individuals and the role of rare coding variants in type 2 diabetes. Am J Hum Genet (2013) 1.43
Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer. Nat Genet (2014) 1.41
Power estimation and sample size determination for replication studies of genome-wide association studies. BMC Genomics (2016) 1.41
Molecular mechanisms underlying variations in lung function: a systems genetics analysis. Lancet Respir Med (2015) 1.40
Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism. Proc Natl Acad Sci U S A (2014) 1.40
Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci. Nat Genet (2015) 1.39
Super-enhancers delineate disease-associated regulatory nodes in T cells. Nature (2015) 1.39
Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age. Hum Mol Genet (2014) 1.39
Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms. Cell (2017) 1.38
Evaluating empirical bounds on complex disease genetic architecture. Nat Genet (2013) 1.37
Genetic screening for the risk of type 2 diabetes: worthless or valuable? Diabetes Care (2013) 1.34
Oxidative stress, insulin resistance, dyslipidemia and type 2 diabetes mellitus. World J Diabetes (2015) 1.33
Detection and interpretation of shared genetic influences on 42 human traits. Nat Genet (2016) 1.32
Developmental regulation of human cortex transcription and its clinical relevance at single base resolution. Nat Neurosci (2014) 1.31
Fast and accurate imputation of summary statistics enhances evidence of functional enrichment. Bioinformatics (2014) 1.31
GPA: a statistical approach to prioritizing GWAS results by integrating pleiotropy and annotation. PLoS Genet (2014) 1.29
Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility. Nat Commun (2015) 1.27
Novel locus including FGF21 is associated with dietary macronutrient intake. Hum Mol Genet (2013) 1.27
Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes. PLoS Genet (2014) 1.27
Identification of type 2 diabetes subgroups through topological analysis of patient similarity. Sci Transl Med (2015) 1.27
Association of a low-frequency variant in HNF1A with type 2 diabetes in a Latino population. JAMA (2014) 1.22
Association between a genetic variant related to glutamic acid metabolism and coronary heart disease in individuals with type 2 diabetes. JAMA (2013) 1.22
Novel Observations From Next-Generation RNA Sequencing of Highly Purified Human Adult and Fetal Islet Cell Subsets. Diabetes (2015) 1.21
Sixty-five common genetic variants and prediction of type 2 diabetes. Diabetes (2014) 1.21
Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores. Am J Hum Genet (2015) 1.21
Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters. Cell (2016) 1.20
Combining information on multiple instrumental variables in Mendelian randomization: comparison of allele score and summarized data methods. Stat Med (2015) 1.20
Gene-environment and gene-treatment interactions in type 2 diabetes: progress, pitfalls, and prospects. Diabetes Care (2013) 1.20
Bioenergetics in human evolution and disease: implications for the origins of biological complexity and the missing genetic variation of common diseases. Philos Trans R Soc Lond B Biol Sci (2013) 1.19
GLIS3, a susceptibility gene for type 1 and type 2 diabetes, modulates pancreatic beta cell apoptosis via regulation of a splice variant of the BH3-only protein Bim. PLoS Genet (2013) 1.19
Genetics of type 2 diabetes-pitfalls and possibilities. Genes (Basel) (2015) 1.16
Recent advances in understanding the genetic architecture of type 2 diabetes. Hum Mol Genet (2015) 1.16
Type 2 diabetes: prevalence and relevance of genetic and acquired factors for its prediction. Dtsch Arztebl Int (2013) 1.16
Pleiotropy analysis of quantitative traits at gene level by multivariate functional linear models. Genet Epidemiol (2015) 1.16
Obesity genomics: assessing the transferability of susceptibility loci across diverse populations. Genome Med (2013) 1.13
I'm eating for two: parental dietary effects on offspring metabolism. Cell (2015) 1.11
TCF7L2 is a master regulator of insulin production and processing. Hum Mol Genet (2014) 1.10
Genetic Drivers of Epigenetic and Transcriptional Variation in Human Immune Cells. Cell (2016) 1.10
Laying a solid foundation for Manhattan--'setting the functional basis for the post-GWAS era'. Trends Genet (2014) 1.10
Explaining additional genetic variation in complex traits. Trends Genet (2014) 1.08
Association mapping across numerous traits reveals patterns of functional variation in maize. PLoS Genet (2014) 1.08
Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance. Nat Genet (2016) 1.08
Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus. PLoS Genet (2015) 1.08
Association of a 62 Variants Type 2 Diabetes Genetic Risk Score With Markers of Subclinical Atherosclerosis: A Transethnic, Multicenter Study. Circ Cardiovasc Genet (2015) 1.07
Shared common variants in prostate cancer and blood lipids. Int J Epidemiol (2014) 1.06
A map of human genome variation from population-scale sequencing. Nature (2010) 121.13
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
Genomic control for association studies. Biometrics (1999) 64.39
SIFT: Predicting amino acid changes that affect protein function. Nucleic Acids Res (2003) 52.26
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet (2008) 35.06
Common SNPs explain a large proportion of the heritability for human height. Nat Genet (2010) 35.02
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science (2007) 32.97
Integrating common and rare genetic variation in diverse human populations. Nature (2010) 32.30
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Genetics of gene expression and its effect on disease. Nature (2008) 21.35
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nat Genet (2009) 16.53
Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet (2008) 15.94
Rare variants create synthetic genome-wide associations. PLoS Biol (2010) 14.43
A common inversion under selection in Europeans. Nat Genet (2005) 13.66
Type 2 diabetes: principles of pathogenesis and therapy. Lancet (2005) 10.71
A human phenome-interactome network of protein complexes implicated in genetic disorders. Nat Biotechnol (2007) 9.90
Estimating missing heritability for disease from genome-wide association studies. Am J Hum Genet (2011) 8.95
SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations. Nat Genet (2008) 8.63
Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia. Nat Genet (1999) 8.53
Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions. PLoS Genet (2009) 8.39
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
Parental origin of sequence variants associated with complex diseases. Nature (2009) 7.21
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet (2010) 6.66
Mechanisms of disease:Molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes. Nat Rev Mol Cell Biol (2008) 6.23
Proteins encoded in genomic regions associated with immune-mediated disease physically interact and suggest underlying biology. PLoS Genet (2011) 6.20
The metabochip, a custom genotyping array for genetic studies of metabolic, cardiovascular, and anthropometric traits. PLoS Genet (2012) 6.15
Common inherited variation in mitochondrial genes is not enriched for associations with type 2 diabetes or related glycemic traits. PLoS Genet (2010) 5.79
Exhaustive allelic transmission disequilibrium tests as a new approach to genome-wide association studies. Nat Genet (2004) 5.78
Heterogeneity in meta-analyses of genome-wide association investigations. PLoS One (2007) 5.77
Common genetic variation near MC4R is associated with waist circumference and insulin resistance. Nat Genet (2008) 5.55
Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits. Nat Genet (2012) 5.55
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet (2012) 4.73
The genetic interpretation of area under the ROC curve in genomic profiling. PLoS Genet (2010) 4.58
Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. Nat Genet (2011) 4.50
Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis. Nat Genet (2012) 4.41
Statistical methods for identifying differentially expressed genes in DNA microarrays. Methods Mol Biol (2003) 4.28
Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways. Diabetes (2010) 4.07
A large-scale analysis of tissue-specific pathology and gene expression of human disease genes and complexes. Proc Natl Acad Sci U S A (2008) 3.57
Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci. Nat Genet (2011) 3.46
Consistent association of type 2 diabetes risk variants found in europeans in diverse racial and ethnic groups. PLoS Genet (2010) 3.27
A genome-wide association study identifies susceptibility variants for type 2 diabetes in Han Chinese. PLoS Genet (2010) 3.25
Genetic variants at 2q24 are associated with susceptibility to type 2 diabetes. Hum Mol Genet (2010) 3.24
A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B. Nat Genet (2010) 2.81
The emerging genetic architecture of type 2 diabetes. Cell Metab (2008) 2.77
Identification of new genetic risk variants for type 2 diabetes. PLoS Genet (2010) 2.62
Comparing strategies to fine-map the association of common SNPs at chromosome 9p21 with type 2 diabetes and myocardial infarction. Nat Genet (2011) 2.42
Adipocytokines and insulin resistance. J Clin Endocrinol Metab (2004) 2.16
Induction of human beta-cell proliferation and engraftment using a single G1/S regulatory molecule, cdk6. Diabetes (2010) 2.12
Epidemiological evidence for the links between sleep, circadian rhythms and metabolism. Obes Rev (2009) 1.83
Meta-analysis of sex-specific genome-wide association studies. Genet Epidemiol (2010) 1.56
TCF7L2 variants are associated with increased proinsulin/insulin ratios but not obesity traits in the Framingham Heart Study. Diabetologia (2009) 1.33
Vitamin D insufficiency and diabetes risks. Curr Drug Targets (2011) 1.27
Initial sequencing and comparative analysis of the mouse genome. Nature (2002) 96.15
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature (2007) 75.09
Finding the missing heritability of complex diseases. Nature (2009) 67.95
Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc Natl Acad Sci U S A (2009) 54.68
PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet (2003) 53.59
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science (2007) 51.70
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science (2007) 43.16
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science (2007) 37.88
A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature (2007) 35.08
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet (2008) 35.06
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science (2007) 32.97
Integrating common and rare genetic variation in diverse human populations. Nature (2010) 32.30
Heart disease and stroke statistics--2011 update: a report from the American Heart Association. Circulation (2010) 30.07
Genome-wide association study identifies novel breast cancer susceptibility loci. Nature (2007) 29.23
A high-resolution recombination map of the human genome. Nat Genet (2002) 28.66
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat Genet (2008) 25.83
Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. N Engl J Med (2006) 23.83
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35