Lin Leng

Author PubWeight™ 124.07‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment. Nat Med 2007 5.28
2 CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex. Immunity 2006 3.38
3 Macrophage migration inhibitory factor stimulates AMP-activated protein kinase in the ischaemic heart. Nature 2008 2.96
4 Inhibition of macrophage migration inhibitory factor or its receptor (CD74) attenuates growth and invasion of DU-145 prostate cancer cells. J Immunol 2006 2.09
5 Macrophage migration inhibitory factor promotes intestinal tumorigenesis. Gastroenterology 2005 2.05
6 Macrophage migration inhibitory factor (MIF) exerts antifibrotic effects in experimental liver fibrosis via CD74. Proc Natl Acad Sci U S A 2011 1.85
7 High expression of inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (iPFK-2; PFKFB3) in human cancers. Cancer Res 2002 1.84
8 Macrophage migration inhibitory factor induces B cell survival by activation of a CD74-CD44 receptor complex. J Biol Chem 2007 1.71
9 A critical role for the host mediator macrophage migration inhibitory factor in the pathogenesis of malarial anemia. J Exp Med 2006 1.61
10 Abrogation of macrophage migration inhibitory factor decreases West Nile virus lethality by limiting viral neuroinvasion. J Clin Invest 2007 1.57
11 Impaired macrophage migration inhibitory factor-AMP-activated protein kinase activation and ischemic recovery in the senescent heart. Circulation 2010 1.56
12 Macrophage migration inhibitory factor is released from pituitary folliculo-stellate-like cells by endotoxin and dexamethasone and attenuates the steroid-induced inhibition of interleukin 6 release. Endocrinology 2004 1.54
13 Rapid and transient activation of the ERK MAPK signalling pathway by macrophage migration inhibitory factor (MIF) and dependence on JAB1/CSN5 and Src kinase activity. Cell Signal 2005 1.53
14 A novel, macrophage migration inhibitory factor suicide substrate inhibits motility and growth of lung cancer cells. Cancer Res 2008 1.49
15 MIF deficiency reduces chronic inflammation in white adipose tissue and impairs the development of insulin resistance, glucose intolerance, and associated atherosclerotic disease. Circ Res 2009 1.49
16 Cardiac macrophage migration inhibitory factor inhibits JNK pathway activation and injury during ischemia/reperfusion. J Clin Invest 2009 1.48
17 IL-8 secreted in a macrophage migration-inhibitory factor- and CD74-dependent manner regulates B cell chronic lymphocytic leukemia survival. Proc Natl Acad Sci U S A 2007 1.47
18 A tautomerase-null macrophage migration-inhibitory factor (MIF) gene knock-in mouse model reveals that protein interactions and not enzymatic activity mediate MIF-dependent growth regulation. Mol Cell Biol 2009 1.43
19 Discovery of human macrophage migration inhibitory factor (MIF)-CD74 antagonists via virtual screening. J Med Chem 2009 1.39
20 Macrophage migration inhibitory factor promoter polymorphisms and the clinical expression of scleroderma. Arthritis Rheum 2006 1.35
21 Reduction of the aortic inflammatory response in spontaneous atherosclerosis by blockade of macrophage migration inhibitory factor (MIF). Atherosclerosis 2006 1.31
22 The D-dopachrome tautomerase (DDT) gene product is a cytokine and functional homolog of macrophage migration inhibitory factor (MIF). Proc Natl Acad Sci U S A 2011 1.29
23 Macrophage migration inhibitory factor and autism spectrum disorders. Pediatrics 2008 1.27
24 The Golgi-associated protein p115 mediates the secretion of macrophage migration inhibitory factor. J Immunol 2009 1.25
25 Simultaneous detection of microsatellite repeats and SNPs in the macrophage migration inhibitory factor (MIF) gene by thin-film biosensor chips and application to rural field studies. Nucleic Acids Res 2005 1.24
26 Macrophage migration inhibitory factor contributes to the immune escape of ovarian cancer by down-regulating NKG2D. J Immunol 2008 1.23
27 Acute lung injury induced by lipopolysaccharide is independent of complement activation. J Immunol 2008 1.22
28 The influence of macrophage migration inhibitory factor gene polymorphisms on outcome from community-acquired pneumonia. FASEB J 2009 1.22
29 Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast. Proc Natl Acad Sci U S A 2010 1.21
30 Macrophage migration inhibitory factor: an intracellular inhibitor of angiotensin II-induced increases in neuronal activity. J Neurosci 2004 1.20
31 The proinflammatory cytokine macrophage migration inhibitory factor regulates glucose metabolism during systemic inflammation. J Immunol 2007 1.18
32 Macrophage migration inhibitory factor induces MMP-9 expression in macrophages via the MEK-ERK MAP kinase pathway. J Interferon Cytokine Res 2007 1.18
33 Stat1 and CD74 overexpression is co-dependent and linked to increased invasion and lymph node metastasis in triple-negative breast cancer. J Proteomics 2011 1.16
34 Structural and functional characterization of a secreted hookworm Macrophage Migration Inhibitory Factor (MIF) that interacts with the human MIF receptor CD74. J Biol Chem 2007 1.14
35 Dual effect of the macrophage migration inhibitory factor gene on the development and severity of human systemic lupus erythematosus. Arthritis Rheum 2011 1.13
36 Macrophage migration inhibitory factor promotes cell death and aggravates neurologic deficits after experimental stroke. J Cereb Blood Flow Metab 2010 1.13
37 Activation of the JNK signalling pathway by macrophage migration inhibitory factor (MIF) and dependence on CXCR4 and CD74. Cell Signal 2010 1.12
38 Macrophage migration inhibitory factor upregulates angiogenic factors and correlates with clinical measures in rheumatoid arthritis. J Rheumatol 2007 1.11
39 MIF (macrophage migration inhibitory factor) promoter polymorphisms and susceptibility to severe malarial anemia. J Infect Dis 2009 1.11
40 Autoimmune diseases: MIF as a therapeutic target. Expert Opin Ther Targets 2010 1.10
41 A Leishmania ortholog of macrophage migration inhibitory factor modulates host macrophage responses. J Immunol 2008 1.09
42 CD74 induces TAp63 expression leading to B-cell survival. Blood 2007 1.08
43 Receptor agonists of macrophage migration inhibitory factor. Bioorg Med Chem Lett 2010 1.06
44 Macrophage migration inhibitory factor (MIF) is critical for the host resistance against Toxoplasma gondii. FASEB J 2008 1.04
45 A role for macrophage migration inhibitory factor in the neonatal respiratory distress syndrome. J Immunol 2008 1.04
46 Partial MHC class II constructs inhibit MIF/CD74 binding and downstream effects. Eur J Immunol 2013 1.04
47 TAp63 regulates VLA-4 expression and chronic lymphocytic leukemia cell migration to the bone marrow in a CD74-dependent manner. J Immunol 2010 1.03
48 Tumor growth-promoting properties of macrophage migration inhibitory factor. Curr Pharm Des 2008 1.03
49 Limiting cardiac ischemic injury by pharmacological augmentation of macrophage migration inhibitory factor-AMP-activated protein kinase signal transduction. Circulation 2013 1.02
50 Macrophage migration inhibitory factor (MIF) is a critical mediator of the innate immune response to Mycobacterium tuberculosis. Proc Natl Acad Sci U S A 2013 1.00
51 The conformational flexibility of the carboxy terminal residues 105-114 is a key modulator of the catalytic activity and stability of macrophage migration inhibitory factor. Biochemistry 2008 1.00
52 Sex steroid regulation of macrophage migration inhibitory factor in normal and inflamed colon in the female rat. Gastroenterology 2006 0.99
53 Optimization of N-benzyl-benzoxazol-2-ones as receptor antagonists of macrophage migration inhibitory factor (MIF). Bioorg Med Chem Lett 2010 0.99
54 Macrophage migration inhibitory factor plays a permissive role in the maintenance of cardiac contractile function under starvation through regulation of autophagy. Cardiovasc Res 2013 0.98
55 Null mutation for macrophage migration inhibitory factor (MIF) is associated with less aggressive bladder cancer in mice. BMC Cancer 2007 0.98
56 A new class of isothiocyanate-based irreversible inhibitors of macrophage migration inhibitory factor. Biochemistry 2009 0.98
57 Macrophage migration inhibitory factor enzymatic activity, lung inflammation, and cystic fibrosis. Am J Respir Crit Care Med 2012 0.97
58 CD74-dependent deregulation of the tumor suppressor scribble in human epithelial and breast cancer cells. Neoplasia 2013 0.97
59 Null mutation in macrophage migration inhibitory factor prevents muscle cell loss and fibrosis in partial bladder outlet obstruction. Am J Physiol Renal Physiol 2006 0.97
60 Evidence for a role of macrophage migration inhibitory factor in vascular disease. Arterioscler Thromb Vasc Biol 2004 0.96
61 Drug repositioning and pharmacophore identification in the discovery of hookworm MIF inhibitors. Chem Biol 2011 0.96
62 The role of macrophage migration inhibitory factor in autoimmune liver disease. Hepatology 2013 0.95
63 A Plasmodium-encoded cytokine suppresses T-cell immunity during malaria. Proc Natl Acad Sci U S A 2012 0.94
64 Cutting edge: Deficiency of macrophage migration inhibitory factor impairs murine airway allergic responses. J Immunol 2006 0.94
65 MIF produced by bone marrow-derived macrophages contributes to teratoma progression after embryonic stem cell transplantation. Cancer Res 2012 0.93
66 Structural and kinetic analyses of macrophage migration inhibitory factor active site interactions. Biochemistry 2009 0.92
67 Ribosomal protein S19 interacts with macrophage migration inhibitory factor and attenuates its pro-inflammatory function. J Biol Chem 2009 0.92
68 A critical regulatory role for macrophage migration inhibitory factor in hyperoxia-induced injury in the developing murine lung. PLoS One 2013 0.92
69 Glycoxidized LDL increases lectin-like oxidized low density lipoprotein receptor-1 in diabetes mellitus. Atherosclerosis 2008 0.91
70 Macrophage migration inhibitory factor is released as a complex with alpha1-inhibitor-3 in the intraluminal fluid during bladder inflammation in the rat. J Urol 2005 0.91
71 c-Met and its ligand hepatocyte growth factor/scatter factor regulate mature B cell survival in a pathway induced by CD74. J Immunol 2010 0.91
72 Soluble lectin-like oxidized low density lipoprotein receptor-1 in type 2 diabetes mellitus. J Lipid Res 2008 0.91
73 Enhanced expression of receptor for advanced glycation end-products is associated with low circulating soluble isoforms of the receptor in Type 2 diabetes. Clin Sci (Lond) 2011 0.90
74 Human cytomegalovirus paralyzes macrophage motility through down-regulation of chemokine receptors, reorganization of the cytoskeleton, and release of macrophage migration inhibitory factor. J Immunol 2009 0.90
75 CD74 is a survival receptor on colon epithelial cells. World J Gastroenterol 2010 0.90
76 Small molecular modulation of macrophage migration inhibitory factor in the hyperoxia-induced mouse model of bronchopulmonary dysplasia. Respir Res 2013 0.89
77 Elevated levels of macrophage migration inhibitory factor (MIF) in the plasma of HIV-1-infected patients and in HIV-1-infected cell cultures: a relevant role on viral replication. Virology 2010 0.89
78 Macrophage migration inhibitory factor inhibits osteoclastogenesis. Bone 2009 0.89
79 The cytokine midkine and its receptor RPTPζ regulate B cell survival in a pathway induced by CD74. J Immunol 2011 0.89
80 Validity of LupusQoL-China for the assessment of health related quality of life in Chinese patients with systemic lupus erythematosus. PLoS One 2013 0.88
81 Virtual screening and optimization yield low-nanomolar inhibitors of the tautomerase activity of Plasmodium falciparum macrophage migration inhibitory factor. J Med Chem 2012 0.88
82 MIF intersubunit disulfide mutant antagonist supports activation of CD74 by endogenous MIF trimer at physiologic concentrations. Proc Natl Acad Sci U S A 2013 0.88
83 Increased TLR4 expression and downstream cytokine production in immunosuppressed adults compared to non-immunosuppressed adults. PLoS One 2010 0.87
84 Association of macrophage migration inhibitory factor (MIF) polymorphisms with risk of meningitis from Streptococcus pneumoniae. Cytokine 2011 0.86
85 The vestigial enzyme D-dopachrome tautomerase protects the heart against ischemic injury. J Clin Invest 2014 0.86
86 Evidence for vascular macrophage migration inhibitory factor in destabilization of human atherosclerotic plaques. Cardiovasc Res 2005 0.86
87 Role of macrophage migration inhibitory factor in the Th2 immune response to epicutaneous sensitization. J Clin Immunol 2011 0.85
88 Functional polymorphisms in the gene encoding macrophage migration inhibitory factor are associated with Gram-negative bacteremia in older adults. J Infect Dis 2013 0.85
89 Role of macrophage migration inhibitory factor in the regulatory T cell response of tumor-bearing mice. J Immunol 2012 0.85
90 Macrophage migration inhibitory factor deficiency in chronic obstructive pulmonary disease. Am J Physiol Lung Cell Mol Physiol 2014 0.85
91 Benzisothiazolones as modulators of macrophage migration inhibitory factor. Bioorg Med Chem Lett 2011 0.85
92 A novel allosteric inhibitor of macrophage migration inhibitory factor (MIF). J Biol Chem 2012 0.84
93 Receptor for advanced glycation endproducts (RAGE) deficiency protects against MPTP toxicity. Neurobiol Aging 2012 0.84
94 Amyloid fibril formation by macrophage migration inhibitory factor. Biochem Biophys Res Commun 2005 0.84
95 A role for the B-cell CD74/macrophage migration inhibitory factor pathway in the immunomodulation of systemic lupus erythematosus by a therapeutic tolerogenic peptide. Immunology 2010 0.84
96 A genetic role for macrophage migration inhibitory factor (MIF) in adult-onset Still's disease. Arthritis Res Ther 2013 0.83
97 Macrophage migration inhibitory factor manipulation and evaluation in tumoral hypoxic adaptation. Methods Enzymol 2007 0.81
98 Macrophage migration inhibitory factor: a downregulator of early T cell-dependent IFN-gamma responses in Plasmodium chabaudi adami (556 KA)-infected mice. J Immunol 2011 0.80
99 Macrophage migration inhibitory factor anti-thrombin III complexes are decreased in bladder cancer patient serum: Complex formation as a mechanism of inactivation. Cancer Lett 2009 0.80
100 DNA vaccination against macrophage migration inhibitory factor improves atopic dermatitis in murine models. J Allergy Clin Immunol 2009 0.80
101 Fully automated biometry of in situ intraocular lenses using long scan depth spectral-domain optical coherence tomography. Eye Contact Lens 2014 0.79
102 Transcription factor ICBP90 regulates the MIF promoter and immune susceptibility locus. J Clin Invest 2016 0.79
103 Macrophage-derived, macrophage migration inhibitory factor (MIF) is necessary to induce disease in the K/BxN serum-induced model of arthritis. Rheumatol Int 2013 0.79
104 Macrophage migration inhibitory factor increases neuronal delayed rectifier K+ current. J Neurophysiol 2005 0.79
105 Selective preservation of bone marrow mature recirculating but not marginal zone B cells in murine models of chronic inflammation. PLoS One 2010 0.79
106 Characterization of Neospora caninum macrophage migration inhibitory factor. Exp Parasitol 2013 0.77
107 Crystallographic and receptor binding characterization of Plasmodium falciparum macrophage migration inhibitory factor complexed to two potent inhibitors. J Med Chem 2014 0.77
108 Automatic biometry of the anterior segment during accommodation imaged by optical coherence tomography. Eye Contact Lens 2014 0.76
109 Preliminary associations between childhood neglect, MIF, and cortisol: potential pathways to long-term disease risk. Dev Psychobiol 2014 0.76
110 Agreement of corneal epithelial profiles produced by automated segmentation of SD-OCT images having different optical resolutions. Eye Contact Lens 2014 0.76
111 A critical role for the host mediator macrophage migration inhibitory factor in the pathogenesis of malarial anemia. J Exp Med 2015 0.75