Helicobacter pylori HtrA is a new secreted virulence factor that cleaves E-cadherin to disrupt intercellular adhesion.

PubWeight™: 1.54‹?› | Rank: Top 4%

🔗 View Article (PMC 2948180)

Published in EMBO Rep on September 03, 2010

Authors

Benjamin Hoy1, Martin Löwer, Christiane Weydig, Gert Carra, Nicole Tegtmeyer, Tim Geppert, Peter Schröder, Norbert Sewald, Steffen Backert, Gisbert Schneider, Silja Wessler

Author Affiliations

1: Junior Research Group, Paul-Ehrlich Institute, Langen, Germany.

Articles citing this

Role of the cag-pathogenicity island encoded type IV secretion system in Helicobacter pylori pathogenesis. FEBS J (2011) 1.68

Analysis of surface-exposed outer membrane proteins in Helicobacter pylori. J Bacteriol (2014) 1.45

Distinct roles of secreted HtrA proteases from gram-negative pathogens in cleaving the junctional protein and tumor suppressor E-cadherin. J Biol Chem (2012) 1.31

Chlamydia trachomatis secretion of proteases for manipulating host signaling pathways. Front Microbiol (2011) 1.14

Pathobiology of Helicobacter pylori-Induced Gastric Cancer. Gastroenterology (2015) 1.13

Molecular mechanisms of gastric epithelial cell adhesion and injection of CagA by Helicobacter pylori. Cell Commun Signal (2011) 1.13

The functional interplay of Helicobacter pylori factors with gastric epithelial cells induces a multi-step process in pathogenesis. Cell Commun Signal (2013) 1.11

Helicobacter pylori in gastric carcinogenesis: mechanisms. Gastroenterol Clin North Am (2013) 1.11

Bacterial proteolytic complexes as therapeutic targets. Nat Rev Drug Discov (2012) 1.08

Proteomic analysis of Vibrio cholerae outer membrane vesicles. Proc Natl Acad Sci U S A (2014) 1.06

Rapid paracellular transmigration of Campylobacter jejuni across polarized epithelial cells without affecting TER: role of proteolytic-active HtrA cleaving E-cadherin but not fibronectin. Gut Pathog (2012) 1.06

Comparative whole genome sequence analysis of the carcinogenic bacterial model pathogen Helicobacter felis. Genome Biol Evol (2011) 1.05

The role of serine protease HtrA in acute ulcerative enterocolitis and extra-intestinal immune responses during Campylobacter jejuni infection of gnotobiotic IL-10 deficient mice. Front Cell Infect Microbiol (2014) 1.05

Bacterial outer membrane vesicles in disease and preventive medicine. Semin Immunopathol (2010) 1.05

Transmigration route of Campylobacter jejuni across polarized intestinal epithelial cells: paracellular, transcellular or both? Cell Commun Signal (2013) 1.01

The HtrA protease from Streptococcus pneumoniae digests both denatured proteins and the competence-stimulating peptide. J Biol Chem (2012) 0.98

Comparative genomics of Helicobacter pylori and the human-derived Helicobacter bizzozeronii CIII-1 strain reveal the molecular basis of the zoonotic nature of non-pylori gastric Helicobacter infections in humans. BMC Genomics (2011) 0.95

"Targeted disruption of the epithelial-barrier by Helicobacter pylori". Cell Commun Signal (2011) 0.92

Growth phase-dependent composition of the Helicobacter pylori exoproteome. J Proteomics (2015) 0.92

Enteric bacterial proteases in inflammatory bowel disease- pathophysiology and clinical implications. World J Gastroenterol (2013) 0.91

Helicobacter pylori CagA: From Pathogenic Mechanisms to Its Use as an Anti-Cancer Vaccine. Front Immunol (2013) 0.91

The impact of serine protease HtrA in apoptosis, intestinal immune responses and extra-intestinal histopathology during Campylobacter jejuni infection of infant mice. Gut Pathog (2014) 0.91

Helicobacter pylori bacteria alter the p53 stress response via ERK-HDM2 pathway. Oncotarget (2015) 0.89

Signal transduction of Helicobacter pylori during interaction with host cell protein receptors of epithelial and immune cells. Gut Microbes (2013) 0.89

The HtrA protease of Borrelia burgdorferi degrades outer membrane protein BmpD and chemotaxis phosphatase CheX. Mol Microbiol (2013) 0.87

Inhibitors of Helicobacter pylori protease HtrA found by 'virtual ligand' screening combat bacterial invasion of epithelia. PLoS One (2011) 0.87

Campylobacter jejuni serine protease HtrA plays an important role in heat tolerance, oxygen resistance, host cell adhesion, invasion, and transmigration. Eur J Microbiol Immunol (Bp) (2015) 0.86

How Listeria monocytogenes organizes its surface for virulence. Front Cell Infect Microbiol (2014) 0.86

The protease inhibitor JO146 demonstrates a critical role for CtHtrA for Chlamydia trachomatis reversion from penicillin persistence. Front Cell Infect Microbiol (2013) 0.86

Extracellular secretion of protease HtrA from Campylobacter jejuni is highly efficient and independent of its protease activity and flagellum. Eur J Microbiol Immunol (Bp) (2013) 0.85

Alzheimer's Disease: APP, Gamma Secretase, APOE, CLU, CR1, PICALM, ABCA7, BIN1, CD2AP, CD33, EPHA1, and MS4A2, and Their Relationships with Herpes Simplex, C. Pneumoniae, Other Suspect Pathogens, and the Immune System. Int J Alzheimers Dis (2011) 0.84

Helicobacter pylori-induced alteration of epithelial cell signaling and polarity: a possible mechanism of gastric carcinoma etiology and disparity. Cytoskeleton (Hoboken) (2013) 0.84

Identification of E-cadherin signature motifs functioning as cleavage sites for Helicobacter pylori HtrA. Sci Rep (2016) 0.83

The stability and activity of recombinant Helicobacter pylori HtrA under stress conditions. J Basic Microbiol (2012) 0.83

Electron microscopic, genetic and protein expression analyses of Helicobacter acinonychis strains from a Bengal tiger. PLoS One (2013) 0.83

Genome-wide association analysis of avian resistance to Campylobacter jejuni colonization identifies risk locus spanning the CDH13 gene. G3 (Bethesda) (2013) 0.83

Structural and functional aspects of the Helicobacter pylori secretome. World J Gastroenterol (2014) 0.82

Draft genome sequences of six enterohepatic helicobacter species isolated from humans and one from rhesus macaques. Genome Announc (2014) 0.82

Systematic analysis of phosphotyrosine antibodies recognizing single phosphorylated EPIYA-motifs in CagA of Western-type Helicobacter pylori strains. PLoS One (2014) 0.81

Characterisation of worldwide Helicobacter pylori strains reveals genetic conservation and essentiality of serine protease HtrA. Mol Microbiol (2015) 0.81

Borrelia burgdorferi HtrA may promote dissemination and irritation. Mol Microbiol (2013) 0.81

The LA loop as an important regulatory element of the HtrA (DegP) protease from Escherichia coli: structural and functional studies. J Biol Chem (2014) 0.80

Effect of Helicobacter pylori on gastric epithelial cells. World J Gastroenterol (2014) 0.79

Comparative proteomic analysis of the membrane proteins of two Haemophilus parasuis strains to identify proteins that may help in habitat adaptation and pathogenesis. Proteome Sci (2014) 0.79

HtrA Is Important for Stress Resistance and Virulence in Haemophilus parasuis. Infect Immun (2016) 0.79

Helicobacter pylori-induced posttranscriptional regulation of H-K-ATPase α-subunit gene expression by miRNA. Am J Physiol Gastrointest Liver Physiol (2014) 0.78

Outer membrane vesicles of Tannerella forsythia: biogenesis, composition, and virulence. Mol Oral Microbiol (2015) 0.78

Microevolution of Virulence-Related Genes in Helicobacter pylori Familial Infection. PLoS One (2015) 0.78

Borrelia burgdorferi HtrA: evidence for twofold proteolysis of outer membrane protein p66. Mol Microbiol (2015) 0.77

HtrA, a Temperature- and Stationary Phase-Activated Protease Involved in Maturation of a Key Microbial Virulence Determinant, Facilitates Borrelia burgdorferi Infection in Mammalian Hosts. Infect Immun (2016) 0.77

Calcium binding protects E-cadherin from cleavage by Helicobacter pylori HtrA. Gut Pathog (2016) 0.77

Impact of Helicobacter pylori on the healing process of the gastric barrier. World J Gastroenterol (2016) 0.76

Inhibiting Helicobacter pylori HtrA protease by addressing a computationally predicted allosteric ligand binding site. Chem Sci (2014) 0.76

Proteolytic Activities Expressed by Gastrointestinal Pathogens Bacillus cereus, Listeria monocytogenes and Enterococcus faecium in Different Growth Phases. (2015) 0.76

HtrA-mediated E-cadherin cleavage is limited to DegP and DegQ homologs expressed by gram-negative pathogens. Cell Commun Signal (2016) 0.76

Type IV Secretion and Signal Transduction of Helicobacter pylori CagA through Interactions with Host Cell Receptors. Toxins (Basel) (2017) 0.75

Digital PCR identifies changes in CDH1 (E-cadherin) transcription pattern in intestinal-type gastric cancer. Oncotarget (2016) 0.75

Proteolysis in Helicobacter pylori-Induced Gastric Cancer. Toxins (Basel) (2017) 0.75

Bacterial serine protease HtrA as a promising new target for antimicrobial therapy? Cell Commun Signal (2017) 0.75

Production, secretion and purification of a correctly folded staphylococcal antigen in Lactococcus lactis. Microb Cell Fact (2015) 0.75

Insights into the Cyanobacterial Deg/HtrA Proteases. Front Plant Sci (2016) 0.75

Linkages between oral commensal bacteria and atherosclerotic plaques in coronary artery disease patients. NPJ Biofilms Microbiomes (2016) 0.75

Role of caspase-3/E-cadherin in helicobacter pylori-induced apoptosis of gastric epithelial cells. Oncotarget (2017) 0.75

Pseudomonas aeruginosa ExlA and Serratia marcescens ShlA trigger cadherin cleavage by promoting calcium influx and ADAM10 activation. PLoS Pathog (2017) 0.75

Overexpression of serine protease HtrA enhances disruption of adherens junctions, paracellular transmigration and type IV secretion of CagA by Helicobacter pylori. Gut Pathog (2017) 0.75

Articles cited by this

Basic local alignment search tool. J Mol Biol (1990) 659.07

Helicobacter pylori and gastrointestinal tract adenocarcinomas. Nat Rev Cancer (2002) 10.19

Disruption of the epithelial apical-junctional complex by Helicobacter pylori CagA. Science (2003) 5.23

ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation. Proc Natl Acad Sci U S A (2005) 3.57

Release of an invasion promoter E-cadherin fragment by matrilysin and stromelysin-1. J Cell Sci (2001) 3.51

Helicobacter pylori VacA, a paradigm for toxin multifunctionality. Nat Rev Microbiol (2005) 3.25

Global transposon mutagenesis and essential gene analysis of Helicobacter pylori. J Bacteriol (2004) 3.25

Structural basis for the regulated protease and chaperone function of DegP. Nature (2008) 2.56

Helicobacter pylori CagA interacts with E-cadherin and deregulates the beta-catenin signal that promotes intestinal transdifferentiation in gastric epithelial cells. Oncogene (2007) 2.34

Intracellular, intercellular, and stromal invasion of gastric mucosa, preneoplastic lesions, and cancer by Helicobacter pylori. Gastroenterology (2007) 1.98

The role of human HtrA1 in arthritic disease. J Biol Chem (2005) 1.91

Selective increase of the permeability of polarized epithelial cell monolayers by Helicobacter pylori vacuolating toxin. J Clin Invest (1998) 1.89

Activation of DegP chaperone-protease via formation of large cage-like oligomers upon binding to substrate proteins. Proc Natl Acad Sci U S A (2008) 1.68

Proteases in bacterial pathogenesis. Res Microbiol (2009) 1.62

Primary structure of a putative serine protease specific for IGF-binding proteins. FEBS Lett (1996) 1.46

Helicobacter pylori dysregulation of gastric epithelial tight junctions by urease-mediated myosin II activation. Gastroenterology (2008) 1.41

Molecular mechanisms of epithelial-barrier disruption by Helicobacter pylori. Trends Microbiol (2008) 1.30

p120 and Kaiso regulate Helicobacter pylori-induced expression of matrix metalloproteinase-7. Mol Biol Cell (2008) 1.15

Structure, function and regulation of the conserved serine proteases DegP and DegS of Escherichia coli. Res Microbiol (2009) 1.12

E-cadherin in gastric cancer. World J Gastroenterol (2006) 1.11

Prediction of extracellular proteases of the human pathogen Helicobacter pylori reveals proteolytic activity of the Hp1018/19 protein HtrA. PLoS One (2008) 1.10

CagA-independent disruption of adherence junction complexes involves E-cadherin shedding and implies multiple steps in Helicobacter pylori pathogenicity. Exp Cell Res (2007) 1.08

Ectodomain shedding of E-cadherin and c-Met is induced by Helicobacter pylori infection. Exp Cell Res (2009) 1.07

Articles by these authors

Exploiting the mutanome for tumor vaccination. Cancer Res (2012) 4.45

Designing antimicrobial peptides: form follows function. Nat Rev Drug Discov (2011) 4.16

Helicobacter exploits integrin for type IV secretion and kinase activation. Nature (2007) 4.02

Src is the kinase of the Helicobacter pylori CagA protein in vitro and in vivo. J Biol Chem (2002) 3.47

NF-kappaB activation and potentiation of proinflammatory responses by the Helicobacter pylori CagA protein. Proc Natl Acad Sci U S A (2005) 2.52

Induction of TLR-2 and TLR-5 expression by Helicobacter pylori switches cagPAI-dependent signalling leading to the secretion of IL-8 and TNF-α. PLoS One (2011) 2.29

Biological impact of freezing Plk1 in its inactive conformation in cancer cells. Cell Cycle (2010) 2.18

Fate of primary cells at the G₁/S boundary after polo-like kinase 1 inhibition by SBE13. Cell Cycle (2011) 2.11

Comparison of support vector machine and artificial neural network systems for drug/nondrug classification. J Chem Inf Comput Sci (2003) 2.02

Helicobacter pylori HopH (OipA) and bacterial pathogenicity: genetic and functional genomic analysis of hopH gene polymorphisms. J Infect Dis (2006) 2.02

PocketPicker: analysis of ligand binding-sites with shape descriptors. Chem Cent J (2007) 1.90

Functional analysis of the Helicobacter pylori cag pathogenicity island reveals both VirD4-CagA-dependent and VirD4-CagA-independent mechanisms. Infect Immun (2002) 1.84

Support vector machine applications in bioinformatics. Appl Bioinformatics (2003) 1.78

Molecular mechanisms and kinetics between DNA and DNA binding ligands. Biophys J (2004) 1.74

Activation of Abl by Helicobacter pylori: a novel kinase for CagA and crucial mediator of host cell scattering. Gastroenterology (2007) 1.70

Role of the cag-pathogenicity island encoded type IV secretion system in Helicobacter pylori pathogenesis. FEBS J (2011) 1.68

Development of a virtual screening method for identification of "frequent hitters" in compound libraries. J Med Chem (2002) 1.63

The Helicobacter pylori CagA protein induces cortactin dephosphorylation and actin rearrangement by c-Src inactivation. EMBO J (2003) 1.60

A constituent of green tea, epigallocatechin-3-gallate, activates endothelial nitric oxide synthase by a phosphatidylinositol-3-OH-kinase-, cAMP-dependent protein kinase-, and Akt-dependent pathway and leads to endothelial-dependent vasorelaxation. J Biol Chem (2003) 1.59

Specific entry of Helicobacter pylori into cultured gastric epithelial cells via a zipper-like mechanism. Infect Immun (2002) 1.59

The versatility of Helicobacter pylori CagA effector protein functions: The master key hypothesis. Helicobacter (2010) 1.59

c-Src and c-Abl kinases control hierarchic phosphorylation and function of the CagA effector protein in Western and East Asian Helicobacter pylori strains. J Clin Invest (2012) 1.53

Prediction of type III secretion signals in genomes of gram-negative bacteria. PLoS One (2009) 1.50

Digital genome-wide ncRNA expression, including SnoRNAs, across 11 human tissues using polyA-neutral amplification. PLoS One (2010) 1.42

Antibody-drug conjugates in tumor therapy. Pharm Pat Anal (2012) 1.38

Host cell interactome of tyrosine-phosphorylated bacterial proteins. Cell Host Microbe (2009) 1.36

Distinct roles of secreted HtrA proteases from gram-negative pathogens in cleaving the junctional protein and tumor suppressor E-cadherin. J Biol Chem (2012) 1.31

An unusual ERAD-like complex is targeted to the apicoplast of Plasmodium falciparum. Eukaryot Cell (2009) 1.31

Molecular mechanisms of epithelial-barrier disruption by Helicobacter pylori. Trends Microbiol (2008) 1.30

Properties and prediction of mitochondrial transit peptides from Plasmodium falciparum. Mol Biochem Parasitol (2003) 1.28

Importance of EGF receptor, HER2/Neu and Erk1/2 kinase signalling for host cell elongation and scattering induced by the Helicobacter pylori CagA protein: antagonistic effects of the vacuolating cytotoxin VacA. Cell Microbiol (2008) 1.25

Role of the small Rho GTPases Rac1 and Cdc42 in host cell invasion of Campylobacter jejuni. Cell Microbiol (2007) 1.24

A small fibronectin-mimicking protein from bacteria induces cell spreading and focal adhesion formation. J Biol Chem (2010) 1.19

Biochemical and functional characterization of Helicobacter pylori vesicles. Mol Microbiol (2010) 1.18

Emerging roles of Abl family tyrosine kinases in microbial pathogenesis. Trends Biochem Sci (2008) 1.16

p120 and Kaiso regulate Helicobacter pylori-induced expression of matrix metalloproteinase-7. Mol Biol Cell (2008) 1.15

Antibacterial endiandric acid derivatives from Beilschmiedia anacardioides. Phytochemistry (2009) 1.14

Molecular mechanisms of gastric epithelial cell adhesion and injection of CagA by Helicobacter pylori. Cell Commun Signal (2011) 1.13

Impact of conformational flexibility on three-dimensional similarity searching using correlation vectors. J Chem Inf Model (2006) 1.13

Species-specific inhibition of APOBEC3C by the prototype foamy virus protein bet. J Biol Chem (2008) 1.12

Serine phosphorylation of cortactin controls focal adhesion kinase activity and cell scattering induced by Helicobacter pylori. Cell Host Microbe (2011) 1.12

Processing and classification of chemical data inspired by insect olfaction. Proc Natl Acad Sci U S A (2007) 1.12

Predicting olfactory receptor neuron responses from odorant structure. Chem Cent J (2007) 1.12

The functional interplay of Helicobacter pylori factors with gastric epithelial cells induces a multi-step process in pathogenesis. Cell Commun Signal (2013) 1.11

Helicobacter pylori CagL activates ADAM17 to induce repression of the gastric H, K-ATPase alpha subunit. Gastroenterology (2010) 1.11

Scaffold diversity of natural products: inspiration for combinatorial library design. Nat Prod Rep (2008) 1.10

The Helicobacter pylori CagA protein disrupts matrix adhesion of gastric epithelial cells by dephosphorylation of vinculin. Cell Microbiol (2007) 1.10

Prediction of extracellular proteases of the human pathogen Helicobacter pylori reveals proteolytic activity of the Hp1018/19 protein HtrA. PLoS One (2008) 1.10

Helicobacter pylori CagL dependent induction of gastrin expression via a novel αvβ5-integrin-integrin linked kinase signalling complex. Gut (2012) 1.10

A virtual screening method for prediction of the HERG potassium channel liability of compound libraries. Chembiochem (2002) 1.10

Cortactin: an Achilles' heel of the actin cytoskeleton targeted by pathogens. Trends Microbiol (2005) 1.09

CagA-independent disruption of adherence junction complexes involves E-cadherin shedding and implies multiple steps in Helicobacter pylori pathogenicity. Exp Cell Res (2007) 1.08

Helicobacter pylori stimulates host cyclooxygenase-2 gene transcription: critical importance of MEK/ERK-dependent activation of USF1/-2 and CREB transcription factors. Cell Microbiol (2003) 1.07

Helicobacter pylori induces AGS cell motility and elongation via independent signaling pathways. Infect Immun (2004) 1.07

Correction: Induction of TLR-2 and TLR-5 Expression by Helicobacter pylori Switches cagPAI-Dependent Signalling Leading to the Secretion of IL-8 and TNF-α. PLoS One (2015) 1.06

Scaffold-hopping potential of ligand-based similarity concepts. ChemMedChem (2006) 1.04

Enteropathogenic Escherichia coli subverts phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate upon epithelial cell infection. Mol Biol Cell (2008) 1.03

Host epithelial cell invasion by Campylobacter jejuni: trigger or zipper mechanism? Front Cell Infect Microbiol (2012) 1.03

The cytotoxic necrotizing factors from Yersinia pseudotuberculosis and from Escherichia coli bind to different cellular receptors but take the same route to the cytosol. Infect Immun (2007) 1.03

Kernel approach to molecular similarity based on iterative graph similarity. J Chem Inf Model (2007) 1.03

Uptake, degradation and chiral discrimination of N-acyl-D/L-homoserine lactones by barley (Hordeum vulgare) and yam bean (Pachyrhizus erosus) plants. Anal Bioanal Chem (2007) 1.02

The Cag pathogenicity island and interaction between TLR2/NOD2 and NLRP3 regulate IL-1β production in Helicobacter pylori infected dendritic cells. Eur J Immunol (2013) 1.02

Helicobacter pylori stimulates host vascular endothelial growth factor-A (vegf-A) gene expression via MEK/ERK-dependent activation of Sp1 and Sp3. FASEB J (2003) 1.02

Nuclear export is evolutionarily conserved in CVC paired-like homeobox proteins and influences protein stability, transcriptional activation, and extracellular secretion. Mol Cell Biol (2005) 1.02

Major host factors involved in epithelial cell invasion of Campylobacter jejuni: role of fibronectin, integrin beta1, FAK, Tiam-1, and DOCK180 in activating Rho GTPase Rac1. Front Cell Infect Microbiol (2011) 1.01

Transmigration route of Campylobacter jejuni across polarized intestinal epithelial cells: paracellular, transcellular or both? Cell Commun Signal (2013) 1.01

Bioactive constituents of the stem bark of Beilschmiedia zenkeri. J Nat Prod (2009) 1.01

Review and outlook: from single nanoparticles to self-assembled monolayers and granular GMR sensors. Beilstein J Nanotechnol (2010) 1.01

The Helicobacter pylori CagA protein induces tyrosine dephosphorylation of ezrin. Proteomics (2004) 1.01

Delineation of a carcinogenic Helicobacter pylori proteome. Mol Cell Proteomics (2009) 1.00

Pseudoreceptor models in drug design: bridging ligand- and receptor-based virtual screening. Nat Rev Drug Discov (2008) 1.00

A helical RGD motif promoting cell adhesion: crystal structures of the Helicobacter pylori type IV secretion system pilus protein CagL. Structure (2013) 0.99

How Helicobacter pylori infection controls gastric acid secretion. J Gastroenterol (2012) 0.99

Phenotype-based high-content chemical library screening identifies statins as inhibitors of in vivo lymphangiogenesis. Proc Natl Acad Sci U S A (2012) 0.99

Adhesion, invasion, and agglutination mediated by two trimeric autotransporters in the human uropathogen Proteus mirabilis. Infect Immun (2010) 0.99