Inhibiting Helicobacter pylori HtrA protease by addressing a computationally predicted allosteric ligand binding site.

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Published in Chem Sci on June 30, 2014

Authors

Anna Maria Perna1, Felix Reisen1, Thomas P Schmidt2, Tim Geppert1, Max Pillong1, Martin Weisel3, Benjamin Hoy2, Philip C Simister4, Stephan M Feller5, Silja Wessler2, Gisbert Schneider1

Author Affiliations

1: Swiss Federal Institute of Technology (ETH), Department of Chemistry and Applied Biosciences, 8093 Zurich, Switzerland.
2: University of Salzburg, Department of Molecular Biology, 5020 Salzburg, Austria.
3: Goethe-University, Institute of Organic Chemistry and Chemical Biology, 60322 Frankfurt, Germany.
4: University of Oxford, Department of Oncology, Weatherall Institute of Molecular Medicine, OX3 9DS Oxford, UK.
5: University of Oxford, Department of Oncology, Weatherall Institute of Molecular Medicine, OX3 9DS Oxford, UK ; Martin-Luther-University Halle-Wittenberg, Institute of Molecular Medicine, 06120 Halle, Germany.

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