Published in Nat Rev Microbiol on April 01, 2005
Role of Helicobacter Pylori and Its Toxins in Lung and Digestive System Diseases | NCT00366509
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From array-based hybridization of Helicobacter pylori isolates to the complete genome sequence of an isolate associated with MALT lymphoma. BMC Genomics (2010) 1.16
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Prediction of extracellular proteases of the human pathogen Helicobacter pylori reveals proteolytic activity of the Hp1018/19 protein HtrA. PLoS One (2008) 1.10
Helicobacter pylori vacuolating cytotoxin A (VacA) engages the mitochondrial fission machinery to induce host cell death. Proc Natl Acad Sci U S A (2011) 1.08
Functional antagonism between Helicobacter pylori CagA and vacuolating toxin VacA in control of the NFAT signaling pathway in gastric epithelial cells. Proc Natl Acad Sci U S A (2005) 1.08
Gastrointestinal malignancy and the microbiome. Gastroenterology (2014) 1.07
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Molecular evolution of the Helicobacter pylori vacuolating toxin gene vacA. J Bacteriol (2010) 1.06
Helicobacter pylori VacA induces programmed necrosis in gastric epithelial cells. Infect Immun (2011) 1.05
Helicobacter pylori VacA disrupts apical membrane-cytoskeletal interactions in gastric parietal cells. J Biol Chem (2008) 1.04
Low-density lipoprotein receptor-related protein-1 (LRP1) mediates autophagy and apoptosis caused by Helicobacter pylori VacA. J Biol Chem (2012) 1.03
Endosome-mitochondria juxtaposition during apoptosis induced by H. pylori VacA. Cell Death Differ (2010) 1.03
The role of viral and bacterial pathogens in gastrointestinal cancer. J Cell Physiol (2008) 1.02
Polymorphisms in the intermediate region of VacA impact Helicobacter pylori-induced disease development. J Clin Microbiol (2010) 1.02
Diversity of VacA intermediate region among Helicobacter pylori strains from several regions of the world. J Clin Microbiol (2010) 1.01
Cholesterol depletion reduces Helicobacter pylori CagA translocation and CagA-induced responses in AGS cells. Infect Immun (2008) 1.01
Characterization of two Campylobacter jejuni strains for use in volunteer experimental-infection studies. Infect Immun (2008) 1.00
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A Tale of Two Toxins: Helicobacter Pylori CagA and VacA Modulate Host Pathways that Impact Disease. Front Microbiol (2010) 1.00
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How Helicobacter pylori infection controls gastric acid secretion. J Gastroenterol (2012) 0.99
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Helicobacter pylori VacA toxin/subunit p34: targeting of an anion channel to the inner mitochondrial membrane. PLoS Pathog (2010) 0.95
Clustering of Helicobacter pylori VacA in lipid rafts, mediated by its receptor, receptor-like protein tyrosine phosphatase beta, is required for intoxication in AZ-521 Cells. Infect Immun (2006) 0.95
Helicobacter pylori initiates the stringent response upon nutrient and pH downshift. J Bacteriol (2006) 0.95
Sequence divergence and conservation in genomes of Helicobacter cetorum strains from a dolphin and a whale. PLoS One (2013) 0.93
Helicobacter pylori VacA subdomain required for intracellular toxin activity and assembly of functional oligomeric complexes. Infect Immun (2008) 0.92
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A changing gastric environment leads to adaptation of lipopolysaccharide variants in Helicobacter pylori populations during colonization. PLoS One (2009) 0.91
Bacterial chemotaxis modulates host cell apoptosis to establish a T-helper cell, type 17 (Th17)-dominant immune response in Helicobacter pylori infection. Proc Natl Acad Sci U S A (2011) 0.91
Resistance of primary murine CD4+ T cells to Helicobacter pylori vacuolating cytotoxin. Infect Immun (2006) 0.91
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Role of connexin 43 in Helicobacter pylori VacA-induced cell death. Infect Immun (2013) 0.89
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Vitamin B6 is required for full motility and virulence in Helicobacter pylori. MBio (2010) 0.88
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CagA and VacA polymorphisms do not correlate with severity of histopathological lesions in Helicobacter pylori-infected Greek children. J Clin Microbiol (2009) 0.88
CagA and VacA polymorphisms are associated with distinct pathological features in Helicobacter pylori-infected adults with peptic ulcer and non-peptic ulcer disease. J Clin Microbiol (2010) 0.88
In vivo sequence variation in HopZ, a phase-variable outer membrane protein of Helicobacter pylori. Infect Immun (2012) 0.88
Helicobacter pylori Diversity and Gastric Cancer Risk. MBio (2016) 0.88
Ceramide and Toll-like receptor 4 are mobilized into membrane rafts in response to Helicobacter pylori infection in gastric epithelial cells. Infect Immun (2012) 0.87
Reconstitution of Helicobacter pylori VacA toxin from purified components. Biochemistry (2010) 0.87
Helicobacter pylori CagA activates NF-kappaB by targeting TAK1 for TRAF6-mediated Lys 63 ubiquitination. EMBO Rep (2009) 1.63
Adaptation of aerobic respiration to low O2 environments. Proc Natl Acad Sci U S A (2011) 1.63
Selective inhibitor of endosomal trafficking pathways exploited by multiple toxins and viruses. Proc Natl Acad Sci U S A (2013) 1.60
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Effect of Helicobacter pylori's vacuolating cytotoxin on the autophagy pathway in gastric epithelial cells. Autophagy (2009) 1.45
Helicobacter pylori vacuolating cytotoxin enters cells, localizes to the mitochondria, and induces mitochondrial membrane permeability changes correlated to toxin channel activity. Cell Microbiol (2004) 1.36
Plasma membrane cholesterol modulates cellular vacuolation induced by the Helicobacter pylori vacuolating cytotoxin. Infect Immun (2002) 1.20
Transition State Structure for the Hydrolysis of NAD Catalyzed by Diphtheria Toxin. J Am Chem Soc (1997) 1.20
Cellular vacuolation and mitochondrial cytochrome c release are independent outcomes of Helicobacter pylori vacuolating cytotoxin activity that are each dependent on membrane channel formation. J Biol Chem (2003) 1.18
Sphingomyelin functions as a novel receptor for Helicobacter pylori VacA. PLoS Pathog (2008) 1.13
Vacuolating cytotoxin and variants in Atg16L1 that disrupt autophagy promote Helicobacter pylori infection in humans. Gastroenterology (2012) 1.12
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Helicobacter pylori vacuolating cytotoxin A (VacA) engages the mitochondrial fission machinery to induce host cell death. Proc Natl Acad Sci U S A (2011) 1.08
Mechanism of inhibition of Bacillus anthracis spore outgrowth by the lantibiotic nisin. ACS Chem Biol (2011) 1.06
Cytolethal distending toxin family members are differentially affected by alterations in host glycans and membrane cholesterol. J Biol Chem (2010) 1.06
Order-disorder-order transitions mediate the activation of cholera toxin. J Mol Biol (2008) 0.99
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Functional complementation reveals the importance of intermolecular monomer interactions for Helicobacter pylori VacA vacuolating activity. Mol Microbiol (2002) 0.95
Fluorescence resonance energy transfer microscopy of the Helicobacter pylori vacuolating cytotoxin within mammalian cells. Infect Immun (2002) 0.92
Membrane interaction of Pasteurella multocida toxin involves sphingomyelin. FEBS J (2011) 0.92
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Functional comparison of the two Bacillus anthracis glutamate racemases. J Bacteriol (2007) 0.92
Helicobacter pylori VacA subdomain required for intracellular toxin activity and assembly of functional oligomeric complexes. Infect Immun (2008) 0.92
Determinants of catalytic power and ligand binding in glutamate racemase. J Am Chem Soc (2009) 0.91
Characterization of a cytotoxic factor in culture filtrates of Serratia marcescens. Infect Immun (2002) 0.89
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High-throughput, single-cell analysis of macrophage interactions with fluorescently labeled Bacillus anthracis spores. Appl Environ Microbiol (2008) 0.87
Sphingomyelin is important for the cellular entry and intracellular localization of Helicobacter pylori VacA. Cell Microbiol (2010) 0.86
Activation of the abundant nuclear factor poly(ADP-ribose) polymerase-1 by Helicobacter pylori. Proc Natl Acad Sci U S A (2009) 0.84
Exploiting Enzyme Plasticity in Virtual Screening: High Efficiency Inhibitors of Glutamate Racemase. ACS Med Chem Lett (2010) 0.84
Cellular interactions of the cytolethal distending toxins from Escherichia coli and Haemophilus ducreyi. J Biol Chem (2013) 0.84
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The mechanism of Bacillus anthracis intracellular germination requires multiple and highly diverse genetic loci. Infect Immun (2008) 0.83
Helicobacter pylori activation of PARP-1: usurping a versatile regulator of host cellular health. Gut Microbes (2011) 0.79
Helicobacter pylori activates NF-κB by inducing Ubc13-mediated ubiquitination of lysine 158 of TAK1. J Cell Biochem (2013) 0.79
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