PubRank

Josephine M Egan

Author PubWeight™ 137.44‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet 2010 17.89
2 Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet 2010 6.66
3 Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1. Proc Natl Acad Sci U S A 2007 4.62
4 A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet 2012 4.37
5 Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways. Diabetes 2010 4.07
6 Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet 2012 3.21
7 Diabetes impairs hippocampal function through glucocorticoid-mediated effects on new and mature neurons. Nat Neurosci 2008 3.11
8 The role of incretins in glucose homeostasis and diabetes treatment. Pharmacol Rev 2008 2.73
9 Mechanisms of action of glucagon-like peptide 1 in the pancreas. Pharmacol Ther 2006 2.71
10 Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats. Hippocampus 2008 2.44
11 Adipocytokines and the metabolic syndrome among older persons with and without obesity: the InCHIANTI study. Clin Endocrinol (Oxf) 2010 2.24
12 Human duodenal enteroendocrine cells: source of both incretin peptides, GLP-1 and GIP. Am J Physiol Endocrinol Metab 2005 2.18
13 GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism. Proc Natl Acad Sci U S A 2009 2.15
14 A genome-wide association study reveals variants in ARL15 that influence adiponectin levels. PLoS Genet 2009 2.09
15 Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction. Proc Natl Acad Sci U S A 2008 1.97
16 Modulation of taste sensitivity by GLP-1 signaling. J Neurochem 2008 1.89
17 SRT1720 improves survival and healthspan of obese mice. Sci Rep 2011 1.81
18 Clear detection of ADIPOQ locus as the major gene for plasma adiponectin: results of genome-wide association analyses including 4659 European individuals. Atherosclerosis 2009 1.78
19 miR-130 suppresses adipogenesis by inhibiting peroxisome proliferator-activated receptor gamma expression. Mol Cell Biol 2010 1.75
20 A genome-wide association search for type 2 diabetes genes in African Americans. PLoS One 2012 1.72
21 The effect of intermittent energy and carbohydrate restriction v. daily energy restriction on weight loss and metabolic disease risk markers in overweight women. Br J Nutr 2013 1.56
22 Protection and reversal of excitotoxic neuronal damage by glucagon-like peptide-1 and exendin-4. J Pharmacol Exp Ther 2002 1.51
23 Glucagon-like peptide-1 decreases endogenous amyloid-beta peptide (Abeta) levels and protects hippocampal neurons from death induced by Abeta and iron. J Neurosci Res 2003 1.45
24 Pharmacological agents that directly modulate insulin secretion. Pharmacol Rev 2003 1.45
25 Incretin-based therapies in type 2 diabetes mellitus. J Clin Endocrinol Metab 2008 1.45
26 Bitter taste receptors influence glucose homeostasis. PLoS One 2008 1.44
27 A novel neurotrophic property of glucagon-like peptide 1: a promoter of nerve growth factor-mediated differentiation in PC12 cells. J Pharmacol Exp Ther 2002 1.43
28 Exendin-4 improves glycemic control, ameliorates brain and pancreatic pathologies, and extends survival in a mouse model of Huntington's disease. Diabetes 2008 1.42
29 Plasma adiponectin and leptin levels, body composition, and glucose utilization in adult women with wide ranges of age and obesity. Diabetes Care 2003 1.37
30 Circulating brain-derived neurotrophic factor and indices of metabolic and cardiovascular health: data from the Baltimore Longitudinal Study of Aging. PLoS One 2010 1.32
31 Cannabinoids inhibit insulin receptor signaling in pancreatic β-cells. Diabetes 2011 1.26
32 RNA-binding protein HuD controls insulin translation. Mol Cell 2012 1.25
33 Peptide YY is secreted after oral glucose administration in a gender-specific manner. J Clin Endocrinol Metab 2005 1.25
34 Quadriceps strength, quadriceps power, and gait speed in older U.S. adults with diabetes mellitus: results from the National Health and Nutrition Examination Survey, 1999-2002. J Am Geriatr Soc 2013 1.23
35 Ubiquitination is involved in glucose-mediated downregulation of GIP receptors in islets. Am J Physiol Endocrinol Metab 2007 1.22
36 Exogenous glucose-dependent insulinotropic polypeptide worsens post prandial hyperglycemia in type 2 diabetes. Diabetes 2009 1.20
37 Vasoactive intestinal peptide-null mice demonstrate enhanced sweet taste preference, dysglycemia, and reduced taste bud leptin receptor expression. Diabetes 2010 1.16
38 Resveratrol improves adipose insulin signaling and reduces the inflammatory response in adipose tissue of rhesus monkeys on high-fat, high-sugar diet. Cell Metab 2013 1.14
39 Perinatal exercise improves glucose homeostasis in adult offspring. Am J Physiol Endocrinol Metab 2012 1.13
40 Effects of 3 months of continuous subcutaneous administration of glucagon-like peptide 1 in elderly patients with type 2 diabetes. Diabetes Care 2003 1.12
41 Relationship of serum fibroblast growth factor 21 with abnormal glucose metabolism and insulin resistance: the Baltimore Longitudinal Study of Aging. J Clin Endocrinol Metab 2012 1.09
42 Diabetes and altered glucose metabolism with aging. Endocrinol Metab Clin North Am 2013 1.09
43 Insulin and glucagon regulate pancreatic α-cell proliferation. PLoS One 2011 1.08
44 Glucagon signaling modulates sweet taste responsiveness. FASEB J 2010 1.08
45 Conserved and differential effects of dietary energy intake on the hippocampal transcriptomes of females and males. PLoS One 2008 1.07
46 Influence of leptin, adiponectin, and resistin on the association between abdominal adiposity and arterial stiffness. Am J Hypertens 2010 1.05
47 Resveratrol prevents β-cell dedifferentiation in nonhuman primates given a high-fat/high-sugar diet. Diabetes 2013 1.04
48 Glucose and insulin measurements from the oral glucose tolerance test and mortality prediction. Diabetes Care 2008 1.03
49 Ghrelin is produced in taste cells and ghrelin receptor null mice show reduced taste responsivity to salty (NaCl) and sour (citric acid) tastants. PLoS One 2010 1.01
50 The importance of the nine-amino acid C-terminal sequence of exendin-4 for binding to the GLP-1 receptor and for biological activity. Regul Pept 2003 1.01
51 GLP-1 (9-36) amide, cleavage product of GLP-1 (7-36) amide, is a glucoregulatory peptide. Obesity (Silver Spring) 2008 1.01
52 Association of hormonal dysregulation with metabolic syndrome in older women: data from the InCHIANTI study. Am J Physiol Endocrinol Metab 2006 1.00
53 Therapeutic perspectives for the treatment of Huntington's disease: treating the whole body. Histol Histopathol 2008 0.99
54 Cannabinoids induce pancreatic β-cell death by directly inhibiting insulin receptor activation. Sci Signal 2012 0.97
55 Exendin-4 differentiation of a human pancreatic duct cell line into endocrine cells: involvement of PDX-1 and HNF3beta transcription factors. J Cell Physiol 2002 0.97
56 Hyperinsulinemic hypoglycemia after Roux-en-Y gastric bypass: unraveling the role of gut hormonal and pancreatic endocrine dysfunction. J Surg Res 2010 0.97
57 Hormones in the naso-oropharynx: endocrine modulation of taste and smell. Trends Endocrinol Metab 2009 0.96
58 Exendin-4 pharmacodynamics: insights from the hyperglycemic clamp technique. J Pharmacol Exp Ther 2004 0.96
59 Transferrin fusion technology: a novel approach to prolonging biological half-life of insulinotropic peptides. J Pharmacol Exp Ther 2010 0.96
60 Hormonal response to a mixed-meal challenge after reversal of gastric bypass for hypoglycemia. J Clin Endocrinol Metab 2013 0.94
61 Glucagon-like peptide 1 modulates calcium responses to glutamate and membrane depolarization in hippocampal neurons. J Neurochem 2003 0.94
62 Glucose tolerance, glucose utilization and insulin secretion in ageing. Novartis Found Symp 2002 0.94
63 Reduced energy intake: the secret to a long and healthy life? IBS J Sci 2007 0.93
64 Elevated plasma glucose-dependent insulinotropic polypeptide associates with hyperinsulinemia in impaired glucose tolerance. Diabetes Care 2004 0.93
65 Cross-sectional evidence of a signaling pathway from bone homeostasis to glucose metabolism. J Clin Endocrinol Metab 2011 0.93
66 Notch signaling in pancreatic endocrine cell and diabetes. Biochem Biophys Res Commun 2009 0.92
67 Euglycemic agent-mediated hypothalamic transcriptomic manipulation in the N171-82Q model of Huntington disease is related to their physiological efficacy. J Biol Chem 2012 0.91
68 Caloric restriction: impact upon pituitary function and reproduction. Ageing Res Rev 2008 0.91
69 Denatonium induces secretion of glucagon-like peptide-1 through activation of bitter taste receptor pathways. Diabetologia 2014 0.89
70 Age-related changes in mouse taste bud morphology, hormone expression, and taste responsivity. J Gerontol A Biol Sci Med Sci 2011 0.86
71 Vismodegib, an antagonist of hedgehog signaling, directly alters taste molecular signaling in taste buds. Cancer Med 2014 0.85
72 The glucoregulatory benefits of glucagon-like peptide-1 (7-36) amide infusion during intensive insulin therapy in critically ill surgical patients: a pilot study. Crit Care Med 2014 0.85
73 Effect of glucagon-like peptide 1 (7-36 amide) on insulin-mediated glucose uptake in patients with type 1 diabetes. Diabetes Care 2003 0.84
74 Is longitudinal pulse pressure a better predictor of 24-hour urinary albumin excretion than other indices of blood pressure? Hypertension 2009 0.84
75 In vivo biological activity of exendin (1-30). Endocrine 2005 0.82
76 Roles of hormones in taste signaling. Results Probl Cell Differ 2010 0.81
77 GIP contributes to islet trihormonal abnormalities in type 2 diabetes. J Clin Endocrinol Metab 2014 0.81
78 Pancreas++: automated quantification of pancreatic islet cells in microscopy images. Front Physiol 2013 0.80
79 Selective contribution of regional adiposity, skeletal muscle, and adipokines to glucose disposal in older adults. J Am Geriatr Soc 2012 0.79
80 Identification of CB1/CB2 ligands from Zanthoxylum bungeanum. J Nat Prod 2013 0.79
81 To be or not to be--obese. Endocrinology 2011 0.79
82 Assessment of insulin sensitivity and secretion indices from oral glucose tolerance testing in subjects with fasting euglycemia but impaired 2-hour plasma glucose. Metabolism 2003 0.79
83 Role and development of GLP-1 receptor agonists in the management of diabetes. Diabetes Metab Syndr Obes 2009 0.78
84 Sustained exendin-4 secretion through gene therapy targeting salivary glands in two different rodent models of obesity/type 2 diabetes. PLoS One 2012 0.78
85 Contribution of nonesterified fatty acids to insulin resistance in the elderly with normal fasting but diabetic 2-hour postchallenge plasma glucose levels: the Baltimore Longitudinal Study of Aging. Metabolism 2007 0.77
86 High-dose isoflavones do not improve metabolic and inflammatory parameters in androgen-deprived men with prostate cancer. J Androl 2010 0.76
87 Targeting Stem Cells in Chronic Myeloid Leukemia with a PPAR-γ Agonist. N Engl J Med 2015 0.75