Published in PLoS One on September 14, 2010
The endocrinology of food intake. Nat Rev Endocrinol (2013) 1.03
Salivary PYY: a putative bypass to satiety. PLoS One (2011) 0.92
Peptide regulators of peripheral taste function. Semin Cell Dev Biol (2013) 0.87
Age-related changes in mouse taste bud morphology, hormone expression, and taste responsivity. J Gerontol A Biol Sci Med Sci (2011) 0.86
Vismodegib, an antagonist of hedgehog signaling, directly alters taste molecular signaling in taste buds. Cancer Med (2014) 0.85
Endocrine taste cells. Br J Nutr (2014) 0.84
Altered lipid and salt taste responsivity in ghrelin and GOAT null mice. PLoS One (2013) 0.82
Taste perception, associated hormonal modulation, and nutrient intake. Nutr Rev (2015) 0.81
Longitudinal analysis of calorie restriction on rat taste bud morphology and expression of sweet taste modulators. J Gerontol A Biol Sci Med Sci (2013) 0.81
The endocrinology of taste receptors. Nat Rev Endocrinol (2015) 0.80
Metabolic hormones in saliva: origins and functions. Oral Dis (2012) 0.80
Glucagon-like peptide-1 is specifically involved in sweet taste transmission. FASEB J (2015) 0.80
Proceedings of the 2015 A.S.P.E.N. Research Workshop-Taste Signaling: Impact on Food Selection, Intake, and Health. JPEN J Parenter Enteral Nutr (2015) 0.78
The development of sweet taste: From biology to hedonics. Rev Endocr Metab Disord (2016) 0.78
Higher TNF-α, IGF-1, and Leptin Levels are Found in Tasters than Non-Tasters. Front Endocrinol (Lausanne) (2014) 0.78
Sweet taste perception not altered after acute sleep deprivation in healthy young men. Somnologie (Berl) (2013) 0.77
Differential effects of ghrelin antagonists on alcohol drinking and reinforcement in mouse and rat models of alcohol dependence. Neuropharmacology (2015) 0.77
Acute one-cigarette smoking decreases ghrelin hormone in saliva: a pilot study. Int J Endocrinol (2014) 0.76
Characterization of Ghrelin O-Acyltransferase (GOAT) in goldfish (Carassius auratus). PLoS One (2017) 0.75
Therapeutic Potential of Targeting the Ghrelin Pathway. Int J Mol Sci (2017) 0.75
Cyclic-AMP regulates postnatal development of neural and behavioral responses to NaCl in rats. PLoS One (2017) 0.75
Overdominance effect of the bovine ghrelin receptor (GHSR1a)-DelR242 locus on growth in Japanese Shorthorn weaner bulls: heterozygote advantage in bull selection and molecular mechanisms. G3 (Bethesda) (2014) 0.75
Molecular mechanisms of taste recognition: considerations about the role of saliva. Int J Mol Sci (2015) 0.75
Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature (1999) 17.72
A role for ghrelin in the central regulation of feeding. Nature (2001) 8.12
The receptors and cells for mammalian taste. Nature (2006) 6.32
A receptor in pituitary and hypothalamus that functions in growth hormone release. Science (1996) 5.45
Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. Cell (2008) 5.10
The cells and logic for mammalian sour taste detection. Nature (2006) 4.65
Concurrent versus individual binding of HuR and AUF1 to common labile target mRNAs. EMBO J (2004) 4.45
Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocr Rev (2004) 3.79
Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells. J Clin Invest (2004) 3.70
Ghrelin octanoylation mediated by an orphan lipid transferase. Proc Natl Acad Sci U S A (2008) 3.41
Transient receptor potential family members PKD1L3 and PKD2L1 form a candidate sour taste receptor. Proc Natl Acad Sci U S A (2006) 3.24
Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor. Proc Natl Acad Sci U S A (2004) 2.99
The cells and peripheral representation of sodium taste in mice. Nature (2010) 2.80
Deletion of ghrelin impairs neither growth nor appetite. Mol Cell Biol (2003) 2.73
Absence of ghrelin protects against early-onset obesity. J Clin Invest (2005) 2.53
"Type III" cells of rat taste buds: immunohistochemical and ultrastructural studies of neuron-specific enolase, protein gene product 9.5, and serotonin. J Comp Neurol (2001) 2.28
Human duodenal enteroendocrine cells: source of both incretin peptides, GLP-1 and GIP. Am J Physiol Endocrinol Metab (2005) 2.18
Breadth of tuning and taste coding in mammalian taste buds. J Neurosci (2007) 2.06
Nucleoside triphosphate diphosphohydrolase-2 is the ecto-ATPase of type I cells in taste buds. J Comp Neurol (2006) 2.04
Salt taste transduction occurs through an amiloride-sensitive sodium transport pathway. Science (1984) 2.02
A high-throughput screening procedure for identifying mice with aberrant taste and oromotor function. Chem Senses (2002) 2.01
Modulation of taste sensitivity by GLP-1 signaling. J Neurochem (2008) 1.89
Ghrelin--a hormone with multiple functions. Front Neuroendocrinol (2004) 1.88
Two members of the TRPP family of ion channels, Pkd1l3 and Pkd2l1, are co-expressed in a subset of taste receptor cells. J Neurochem (2006) 1.83
Taste recognition: food for thought. Neuron (2005) 1.68
Amiloride-sensitive channels in type I fungiform taste cells in mouse. BMC Neurosci (2008) 1.65
Autocrine and paracrine roles for ATP and serotonin in mouse taste buds. J Neurosci (2009) 1.64
The candidate sour taste receptor, PKD2L1, is expressed by type III taste cells in the mouse. Chem Senses (2007) 1.63
Growth hormone releasing peptide (ghrelin) is synthesized and secreted by cardiomyocytes. Cardiovasc Res (2004) 1.60
Intragastric infusion of denatonium conditions flavor aversions and delays gastric emptying in rodents. Physiol Behav (2007) 1.44
Cell communication in taste buds. Cell Mol Life Sci (2006) 1.38
Membrane currents in taste cells of the rat fungiform papilla. Evidence for two types of Ca currents and inhibition of K currents by saccharin. J Gen Physiol (1990) 1.38
Epithelial Na+ channel subunits in rat taste cells: localization and regulation by aldosterone. J Comp Neurol (1999) 1.37
Expression, physiological action, and coexpression patterns of neuropeptide Y in rat taste-bud cells. Proc Natl Acad Sci U S A (2005) 1.35
Light and dark cells of rat vallate taste buds are morphologically distinct cell types. J Comp Neurol (1997) 1.34
Discrimination of taste qualities among mouse fungiform taste bud cells. J Physiol (2009) 1.30
On the processing of proghrelin to ghrelin. J Biol Chem (2006) 1.27
Expression and physiological actions of cholecystokinin in rat taste receptor cells. J Neurosci (2002) 1.25
Co-expression patterns of the neuropeptides vasoactive intestinal peptide and cholecystokinin with the transduction molecules alpha-gustducin and T1R2 in rat taste receptor cells. Neuroscience (2005) 1.20
Vasoactive intestinal peptide-null mice demonstrate enhanced sweet taste preference, dysglycemia, and reduced taste bud leptin receptor expression. Diabetes (2010) 1.16
Identification of ghrelin in human saliva: production by the salivary glands and potential role in proliferation of oral keratinocytes. Clin Chem (2005) 1.15
Synaptobrevin-2-like immunoreactivity is associated with vesicles at synapses in rat circumvallate taste buds. J Comp Neurol (2004) 1.13
Taste sensitivities to PROP and PTC vary independently in mice. Chem Senses (2003) 1.13
Inhibition by amiloride of chorda tympani responses evoked by monovalent salts. Brain Res (1985) 1.13
Molecular analysis of rat pituitary and hypothalamic growth hormone secretagogue receptors. Mol Endocrinol (1997) 1.12
NaCl responsive taste cells in the mouse fungiform taste buds. Neuroscience (2009) 1.12
The relative affective potency of glycine, L-serine and sucrose as assessed by a brief-access taste test in inbred strains of mice. Chem Senses (2004) 1.12
Cell lineage and differentiation in taste buds. Arch Histol Cytol (2006) 1.12
Modulation of taste sensitivity by GLP-1 signaling in taste buds. Ann N Y Acad Sci (2009) 1.12
A brief-access test for bitter taste in mice. Chem Senses (2002) 1.11
Ghrelin tissue distribution: comparison between gene and protein expression. J Endocrinol Invest (2006) 1.08
Detection of NaCl and KCl in TRPV1 knockout mice. Chem Senses (2006) 1.07
The active ion transport properties of canine lingual epithelia in vitro. Implications for gustatory transduction. J Gen Physiol (1984) 1.01
Qualitative and quantitative differences between taste buds of the rat and mouse. BMC Neurosci (2007) 1.00
Systemic administration of ghrelin increases extracellular dopamine in the shell but not the core subdivision of the nucleus accumbens. Neurochem Int (2008) 0.98
Hormones in the naso-oropharynx: endocrine modulation of taste and smell. Trends Endocrinol Metab (2009) 0.96
Ghrelin O-acyltransferase (GOAT) has a preference for n-hexanoyl-CoA over n-octanoyl-CoA as an acyl donor. Biochem Biophys Res Commun (2009) 0.92
Temporal changes in NCAM immunoreactivity during taste cell differentiation and cell lineage relationships in taste buds. Chem Senses (2005) 0.90
Using biosensors to detect the release of serotonin from taste buds during taste stimulation. Arch Ital Biol (2005) 0.87
The discovery of ghrelin--a personal memory. Regul Pept (2007) 0.86
Ghrelin receptor signaling: a promising therapeutic target for metabolic syndrome and cognitive dysfunction. CNS Neurol Disord Drug Targets (2010) 0.85
Expression of amiloride-sensitive epithelial sodium channels in mouse taste cells after chorda tympani nerve crush. Chem Senses (2005) 0.85
Localization of amiloride-sensitive sodium current and voltage-gated calcium currents in rat fungiform taste cells. J Neurophysiol (2007) 0.83
Nitric oxide modulates sodium taste via a cGMP-independent pathway. Dev Neurobiol (2007) 0.79
Ghrelin in the human myometrium. Reprod Biol Endocrinol (2010) 0.79
Expression of ENaC subunits in sensory nerve endings in the rat larynx. Neurosci Lett (2006) 0.78
An immunohistochemical study of the localization and developmental expression of ghrelin and its functional receptor in the ovine placenta. Reprod Biol Endocrinol (2007) 0.78
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet (2010) 6.66
The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron (2003) 6.05
Sirt1 protects against high-fat diet-induced metabolic damage. Proc Natl Acad Sci U S A (2008) 5.21
Morbidity and mortality of laparoscopic gastrectomy versus open gastrectomy for gastric cancer: an interim report--a phase III multicenter, prospective, randomized Trial (KLASS Trial). Ann Surg (2010) 4.89
Long-term results of laparoscopic gastrectomy for gastric cancer: a large-scale case-control and case-matched Korean multicenter study. J Clin Oncol (2014) 4.79
Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1. Proc Natl Acad Sci U S A (2007) 4.62
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet (2012) 4.37
Ghrelin controls hippocampal spine synapse density and memory performance. Nat Neurosci (2006) 4.25
Obesity is associated with hypothalamic injury in rodents and humans. J Clin Invest (2011) 4.17
Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways. Diabetes (2010) 4.07
UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals. Nature (2008) 3.91
Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite. J Clin Invest (2006) 3.81
The E-NTPDase family of ectonucleotidases: Structure function relationships and pathophysiological significance. Purinergic Signal (2006) 3.52
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
CD39 is the dominant Langerhans cell-associated ecto-NTPDase: modulatory roles in inflammation and immune responsiveness. Nat Med (2002) 3.18
Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice. Cell Metab (2006) 3.14
Diabetes impairs hippocampal function through glucocorticoid-mediated effects on new and mature neurons. Nat Neurosci (2008) 3.11
Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor. Proc Natl Acad Sci U S A (2004) 2.99
The central melanocortin system directly controls peripheral lipid metabolism. J Clin Invest (2007) 2.97
Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin. Cell Metab (2008) 2.89
BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders. Trends Neurosci (2004) 2.76
Osteopontin mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance in mice. J Clin Invest (2007) 2.73
The role of incretins in glucose homeostasis and diabetes treatment. Pharmacol Rev (2008) 2.73
Deletion of ghrelin impairs neither growth nor appetite. Mol Cell Biol (2003) 2.73
Mechanisms of action of glucagon-like peptide 1 in the pancreas. Pharmacol Ther (2006) 2.71
Targeted disruption of cd73/ecto-5'-nucleotidase alters thromboregulation and augments vascular inflammatory response. Circ Res (2004) 2.68
Transforming growth factor-beta and substrate stiffness regulate portal fibroblast activation in culture. Hepatology (2007) 2.53
Laparoscopic transumbilical single-port appendectomy: initial experience and comparison with three-port appendectomy. Surg Laparosc Endosc Percutan Tech (2010) 2.53
"Control" laboratory rodents are metabolically morbid: why it matters. Proc Natl Acad Sci U S A (2010) 2.50
Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats. Hippocampus (2008) 2.44
GOAT links dietary lipids with the endocrine control of energy balance. Nat Med (2009) 2.42
Alternate day calorie restriction improves clinical findings and reduces markers of oxidative stress and inflammation in overweight adults with moderate asthma. Free Radic Biol Med (2006) 2.32
Apo-ghrelin receptor forms heteromers with DRD2 in hypothalamic neurons and is essential for anorexigenic effects of DRD2 agonism. Neuron (2012) 2.30
Mutations in NR4A2 associated with familial Parkinson disease. Nat Genet (2002) 2.27
Adipocytokines and the metabolic syndrome among older persons with and without obesity: the InCHIANTI study. Clin Endocrinol (Oxf) (2010) 2.24
Consuming fructose-sweetened beverages increases body adiposity in mice. Obes Res (2005) 2.18
Human duodenal enteroendocrine cells: source of both incretin peptides, GLP-1 and GIP. Am J Physiol Endocrinol Metab (2005) 2.18
GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism. Proc Natl Acad Sci U S A (2009) 2.15
Glucose and weight control in mice with a designed ghrelin O-acyltransferase inhibitor. Science (2010) 2.12
A genome-wide association study reveals variants in ARL15 that influence adiponectin levels. PLoS Genet (2009) 2.09
Nucleoside triphosphate diphosphohydrolase-2 is the ecto-ATPase of type I cells in taste buds. J Comp Neurol (2006) 2.04
Prophylactic treatment with paroxetine ameliorates behavioral deficits and retards the development of amyloid and tau pathologies in 3xTgAD mice. Exp Neurol (2007) 2.04
Synaptic input organization of the melanocortin system predicts diet-induced hypothalamic reactive gliosis and obesity. Proc Natl Acad Sci U S A (2010) 2.04
Ghrelin action in the brain controls adipocyte metabolism. J Clin Invest (2006) 2.03
Ghrelin suppresses glucose-stimulated insulin secretion and deteriorates glucose tolerance in healthy humans. Diabetes (2010) 2.01
Sirtuin 1 and sirtuin 3: physiological modulators of metabolism. Physiol Rev (2012) 1.99
Totally laparoscopic gastrectomy with various types of intracorporeal anastomosis using laparoscopic linear staplers: preliminary experience. Surg Endosc (2008) 1.99
Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets. Nat Med (2011) 1.97
Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction. Proc Natl Acad Sci U S A (2008) 1.97
Caloric restriction and intermittent fasting: two potential diets for successful brain aging. Ageing Res Rev (2006) 1.94
A molecular mechanism that stabilizes cooperative secretions in Pseudomonas aeruginosa. Mol Microbiol (2010) 1.91
Exposure to elevated levels of dietary fat attenuates psychostimulant reward and mesolimbic dopamine turnover in the rat. Behav Neurosci (2008) 1.90
Modulation of taste sensitivity by GLP-1 signaling. J Neurochem (2008) 1.89
Long-term outcomes after laparoscopy-assisted gastrectomy for advanced gastric cancer: a large-scale multicenter retrospective study. Surg Endosc (2011) 1.85
Voluntary exercise and caloric restriction enhance hippocampal dendritic spine density and BDNF levels in diabetic mice. Hippocampus (2009) 1.84
Ghrelin promotes thymopoiesis during aging. J Clin Invest (2007) 1.83
Simultaneous deletion of ghrelin and its receptor increases motor activity and energy expenditure. Am J Physiol Gastrointest Liver Physiol (2007) 1.83
SRT1720 improves survival and healthspan of obese mice. Sci Rep (2011) 1.81
A new glucagon and GLP-1 co-agonist eliminates obesity in rodents. Nat Chem Biol (2009) 1.79
Clear detection of ADIPOQ locus as the major gene for plasma adiponectin: results of genome-wide association analyses including 4659 European individuals. Atherosclerosis (2009) 1.78
miR-130 suppresses adipogenesis by inhibiting peroxisome proliferator-activated receptor gamma expression. Mol Cell Biol (2010) 1.75
Cannabinoids, opioids and eating behavior: the molecular face of hedonism? Brain Res Rev (2005) 1.75
Adipocyte LDL receptor-related protein-1 expression modulates postprandial lipid transport and glucose homeostasis in mice. J Clin Invest (2007) 1.73
Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans. Sci Transl Med (2013) 1.72
A genome-wide association search for type 2 diabetes genes in African Americans. PLoS One (2012) 1.72
A neural signaling triumvirate that influences ageing and age-related disease: insulin/IGF-1, BDNF and serotonin. Ageing Res Rev (2004) 1.68
Des-acyl ghrelin induces food intake by a mechanism independent of the growth hormone secretagogue receptor. Endocrinology (2006) 1.67
Blue blocker glasses impede the capacity of bright light to suppress melatonin production. J Pineal Res (2006) 1.64
Characterization of adult ghrelin and ghrelin receptor knockout mice under positive and negative energy balance. Endocrinology (2007) 1.64
The candidate sour taste receptor, PKD2L1, is expressed by type III taste cells in the mouse. Chem Senses (2007) 1.63
Improved long-term quality of life in patients with laparoscopy-assisted distal gastrectomy with jejunal pouch interposition for early gastric cancer. Ann Surg Oncol (2010) 1.61
Sex-dependent metabolic, neuroendocrine, and cognitive responses to dietary energy restriction and excess. Endocrinology (2007) 1.59
Cooperation between brain and islet in glucose homeostasis and diabetes. Nature (2013) 1.59
GLP-1R responsiveness predicts individual gastric bypass efficacy on glucose tolerance in rats. Diabetes (2013) 1.58
The effect of intermittent energy and carbohydrate restriction v. daily energy restriction on weight loss and metabolic disease risk markers in overweight women. Br J Nutr (2013) 1.56
Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesity. J Neurosci (2009) 1.54
Impaired glucose tolerance in rats fed low-carbohydrate, high-fat diets. Am J Physiol Endocrinol Metab (2013) 1.54
Toward male individualization with rapidly mutating y-chromosomal short tandem repeats. Hum Mutat (2014) 1.53
KSR2 is an essential regulator of AMP kinase, energy expenditure, and insulin sensitivity. Cell Metab (2009) 1.53
The origins of diversity and specificity in g protein-coupled receptor signaling. J Pharmacol Exp Ther (2005) 1.53
Ghrelin amplifies dopamine signaling by cross talk involving formation of growth hormone secretagogue receptor/dopamine receptor subtype 1 heterodimers. Mol Endocrinol (2006) 1.53
Targeted estrogen delivery reverses the metabolic syndrome. Nat Med (2012) 1.51
Protection and reversal of excitotoxic neuronal damage by glucagon-like peptide-1 and exendin-4. J Pharmacol Exp Ther (2002) 1.51
An age-dependent interaction with leptin unmasks ghrelin's bone-protective effects. Endocrinology (2012) 1.50