Published in Postgrad Med on September 01, 2010
Inflammasomes in neuroinflammation and changes in brain function: a focused review. Front Neurosci (2014) 1.26
A novel pharmacologic inhibitor of the NLRP3 inflammasome limits myocardial injury after ischemia-reperfusion in the mouse. J Cardiovasc Pharmacol (2014) 0.99
Activation of inflammasomes in podocyte injury of mice on the high fat diet: Effects of ASC gene deletion and silencing. Biochim Biophys Acta (2014) 0.98
The Importance of NLRP3 Inflammasome in Heart Failure. J Card Fail (2015) 0.88
Sirt1 restrains lung inflammasome activation in a murine model of sepsis. Am J Physiol Lung Cell Mol Physiol (2015) 0.88
Danger- and pathogen-associated molecular patterns recognition by pattern-recognition receptors and ion channels of the transient receptor potential family triggers the inflammasome activation in immune cells and sensory neurons. J Neuroinflammation (2015) 0.83
Vasculitis and long standing ankylosing spondylitis in a patient with familial Mediterranean fever. J Res Med Sci (2014) 0.77
Whole Transcriptome Analysis (RNA Sequencing) of Peripheral Blood Mononuclear Cells of Vitiligo Patients. Dermatopathology (Basel) (2014) 0.75
Nanoparticle fullerol alleviates radiculopathy via NLRP3 inflammasome and neuropeptides. Nanomedicine (2017) 0.75
The plant immune system. Nature (2006) 33.70
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature (2001) 33.12
A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature (2001) 28.24
Innate immune recognition. Annu Rev Immunol (2001) 26.65
Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature (2006) 24.43
Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat Immunol (2008) 16.65
Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica. Science (2008) 16.54
NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. Immunity (2004) 13.55
The inflammasomes: guardians of the body. Annu Rev Immunol (2009) 12.89
Interleukin-1-receptor antagonist in type 2 diabetes mellitus. N Engl J Med (2007) 11.62
Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome. Nat Genet (2001) 9.34
Thioredoxin-interacting protein links oxidative stress to inflammasome activation. Nat Immunol (2009) 9.24
Ancient missense mutations in a new member of the RoRet gene family are likely to cause familial Mediterranean fever. The International FMF Consortium. Cell (1997) 7.43
The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA. Immunity (2009) 6.37
Neonatal-onset multisystem inflammatory disease responsive to interleukin-1beta inhibition. N Engl J Med (2006) 6.17
Horror autoinflammaticus: the molecular pathophysiology of autoinflammatory disease (*). Annu Rev Immunol (2009) 5.91
Familial Mediterranean fever. A survey of 470 cases and review of the literature. Am J Med (1967) 5.88
CARD15 mutations in Blau syndrome. Nat Genet (2001) 5.79
The Nalp3 inflammasome is essential for the development of silicosis. Proc Natl Acad Sci U S A (2008) 5.59
Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets. J Clin Invest (2002) 5.52
CARD15/NOD2 mutational analysis and genotype-phenotype correlation in 612 patients with inflammatory bowel disease. Am J Hum Genet (2002) 5.31
Use of canakinumab in the cryopyrin-associated periodic syndrome. N Engl J Med (2009) 5.19
De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases. Arthritis Rheum (2002) 4.98
Chronic infantile neurological cutaneous and articular syndrome is caused by mutations in CIAS1, a gene highly expressed in polymorphonuclear cells and chondrocytes. Am J Hum Genet (2002) 4.84
The NLR gene family: a standard nomenclature. Immunity (2008) 4.77
Mechanisms in the pathogenesis of asbestosis and silicosis. Am J Respir Crit Care Med (1998) 4.72
A pilot study of IL-1 inhibition by anakinra in acute gout. Arthritis Res Ther (2007) 4.65
Gout. Lancet (2009) 4.33
Prevention of cold-associated acute inflammation in familial cold autoinflammatory syndrome by interleukin-1 receptor antagonist. Lancet (2004) 4.23
NALP1 in vitiligo-associated multiple autoimmune disease. N Engl J Med (2007) 3.99
Interleukin-1-receptor antagonist in the Muckle-Wells syndrome. N Engl J Med (2003) 3.86
Glyburide inhibits the Cryopyrin/Nalp3 inflammasome. J Cell Biol (2009) 3.85
Cryopyrin and pyrin activate caspase-1, but not NF-kappaB, via ASC oligomerization. Cell Death Differ (2006) 3.77
Intracellular DNA recognition. Nat Rev Immunol (2010) 3.70
Mutations in MVK, encoding mevalonate kinase, cause hyperimmunoglobulinaemia D and periodic fever syndrome. Nat Genet (1999) 3.35
The clinical continuum of cryopyrinopathies: novel CIAS1 mutations in North American patients and a new cryopyrin model. Arthritis Rheum (2007) 2.88
A chronic, infantile, neurological, cutaneous and articular (CINCA) syndrome. A specific entity analysed in 30 patients. Scand J Rheumatol Suppl (1987) 2.62
The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1beta production. Proc Natl Acad Sci U S A (2006) 2.59
Association of mutations in the NALP3/CIAS1/PYPAF1 gene with a broad phenotype including recurrent fever, cold sensitivity, sensorineural deafness, and AA amyloidosis. Arthritis Rheum (2002) 2.58
Urticaria, deafness, and amyloidosis: a new heredo-familial syndrome. Q J Med (1962) 2.50
A proposed classification of the immunological diseases. PLoS Med (2006) 2.43
New mutations of CIAS1 that are responsible for Muckle-Wells syndrome and familial cold urticaria: a novel mutation underlies both syndromes. Am J Hum Genet (2002) 2.39
Familial cold autoinflammatory syndrome: phenotype and genotype of an autosomal dominant periodic fever. J Allergy Clin Immunol (2001) 2.33
Schnitzler syndrome: beyond the case reports: review and follow-up of 94 patients with an emphasis on prognosis and treatment. Semin Arthritis Rheum (2007) 2.32
Pyrin binds the PSTPIP1/CD2BP1 protein, defining familial Mediterranean fever and PAPA syndrome as disorders in the same pathway. Proc Natl Acad Sci U S A (2003) 2.30
Mutations in CD2BP1 disrupt binding to PTP PEST and are responsible for PAPA syndrome, an autoinflammatory disorder. Hum Mol Genet (2002) 2.27
Cryopyrin-induced interleukin 1beta secretion in monocytic cells: enhanced activity of disease-associated mutants and requirement for ASC. J Biol Chem (2004) 2.26
Interaction between pyrin and the apoptotic speck protein (ASC) modulates ASC-induced apoptosis. J Biol Chem (2001) 2.12
NLR, the nucleotide-binding domain leucine-rich repeat containing gene family. Curr Opin Immunol (2008) 2.09
Mutations in NALP12 cause hereditary periodic fever syndromes. Proc Natl Acad Sci U S A (2008) 2.06
Familial granulomatous arthritis, iritis, and rash. J Pediatr (1985) 1.90
The NLRP3 inflammasome: a sensor of immune danger signals. Semin Immunol (2009) 1.81
Arthropathy with rash, chronic meningitis, eye lesions, and mental retardation. J Pediatr (1981) 1.79
Hyperimmunoglobulinemia D and periodic fever syndrome. The clinical spectrum in a series of 50 patients. International Hyper-IgD Study Group. Medicine (Baltimore) (1994) 1.78
A recently recognised chronic inflammatory disease of early onset characterised by the triad of rash, central nervous system involvement and arthropathy. Clin Exp Rheumatol (2001) 1.63
Functional consequences of NOD2 (CARD15) mutations. Inflamm Bowel Dis (2006) 1.57
HMG-CoA reductase inhibition induces IL-1beta release through Rac1/PI3K/PKB-dependent caspase-1 activation. Blood (2008) 1.54
Effect of etanercept and anakinra on inflammatory attacks in the hyper-IgD syndrome: introducing a vaccination provocation model. Neth J Med (2005) 1.48
Anakinra for flares of pyogenic arthritis in PAPA syndrome. Rheumatology (Oxford) (2005) 1.48
A pilot study to evaluate the safety and efficacy of the long-acting interleukin-1 inhibitor rilonacept (interleukin-1 Trap) in patients with familial cold autoinflammatory syndrome. Arthritis Rheum (2008) 1.46
Therapy of autoinflammatory syndromes. J Allergy Clin Immunol (2009) 1.45
A new autosomal dominant disorder of pyogenic sterile arthritis, pyoderma gangrenosum, and acne: PAPA syndrome. Mayo Clin Proc (1997) 1.40
Autoinflammation: the prominent role of IL-1 in monogenic autoinflammatory diseases and implications for common illnesses. J Allergy Clin Immunol (2009) 1.38
CARD15: a pleiotropic autoimmune gene that confers susceptibility to psoriatic arthritis. Am J Hum Genet (2003) 1.38
Anakinra is safe and effective in controlling hyperimmunoglobulinaemia D syndrome-associated febrile crisis. J Inherit Metab Dis (2006) 1.26
Targeted treatment of pyoderma gangrenosum in PAPA (pyogenic arthritis, pyoderma gangrenosum and acne) syndrome with the recombinant human interleukin-1 receptor antagonist anakinra. Br J Dermatol (2009) 1.26
The autoinflammatory syndromes. Curr Opin Allergy Clin Immunol (2002) 1.18
Arthropathy of neonatal onset multisystem inflammatory disease (NOMID/CINCA). Pediatr Radiol (2006) 1.17
Recognition of infantile-onset multisystem inflammatory disease as a unique entity. J Pediatr (1997) 1.15
CARD15/NOD2 mutations in Crohn's disease. Ann N Y Acad Sci (2006) 1.14
Successful treatment of resistant pseudogout with anakinra. Arthritis Rheum (2008) 1.13
Cryopyrin-associated periodic syndromes and autoinflammation. Clin Exp Dermatol (2007) 1.04
Monarch-1/PYPAF7 and other CATERPILLER (CLR, NOD, NLR) proteins with negative regulatory functions. Microbes Infect (2007) 1.01
Dramatic response to IL1-RA treatment in longstanding multidrug resistant Schnitzler's syndrome: a case report and literature review. Clin Rheumatol (2010) 0.98
Psoriatic arthritis and CARD15 gene polymorphisms: no evidence for association in the Italian population. J Invest Dermatol (2004) 0.90
Comparison of effects of soaps and synthetic detergents on hands of housewives; clinical method. AMA Arch Derm Syphilol (1953) 0.89
Dysfunctional inflammasome in Schnitzler's syndrome. Rheumatology (Oxford) (2009) 0.88
Muckle-Wells syndrome: clinical and histological skin findings compatible with cold air urticaria in a large kindred. Br J Dermatol (2004) 0.84
CARD15 mutations in patients with plaque-type psoriasis and psoriatic arthritis: lack of association. Arch Dermatol Res (2006) 0.82
Lack of genetic association of the three more common polymorphisms of CARD15 with psoriatic arthritis and psoriasis in a German cohort. Ann Rheum Dis (2004) 0.81
Cutting edge: Candida albicans hyphae formation triggers activation of the Nlrp3 inflammasome. J Immunol (2009) 2.18
Sensing pathogens and danger signals by the inflammasome. Curr Opin Immunol (2009) 1.91
Sensing damage by the NLRP3 inflammasome. Immunol Rev (2011) 1.69
Mechanism of NLRP3 inflammasome activation. Ann N Y Acad Sci (2014) 1.54
NFIL3/E4BP4 controls type 2 T helper cell cytokine expression. EMBO J (2011) 1.26
Control of innate and adaptive immunity by the inflammasome. Microbes Infect (2012) 0.97
Cutting edge: Nlrp10 is essential for protective antifungal adaptive immunity against Candida albicans. J Immunol (2012) 0.94
Francisella tularensis live vaccine strain folate metabolism and pseudouridine synthase gene mutants modulate macrophage caspase-1 activation. Infect Immun (2012) 0.86
Tim-1 regulates Th2 responses in an airway hypersensitivity model. Eur J Immunol (2012) 0.85
A SOCS-1 promoter variant is associated with total serum IgE levels. J Immunol (2011) 0.82
NLRC4 suppresses melanoma tumor progression independently of inflammasome activation. J Clin Invest (2016) 0.76