Published in Ann N Y Acad Sci on May 19, 2014
Primary Prevention of Infection by COVID-19 in Health Providers (PI-Covid-19) | NCT04420260
Inflammasomes: mechanism of action, role in disease, and therapeutics. Nat Med (2015) 2.59
The NLRP3 Inflammasome Mediates Inflammation Produced by Bladder Outlet Obstruction. J Urol (2015) 1.46
Initiation and perpetuation of NLRP3 inflammasome activation and assembly. Immunol Rev (2015) 1.18
Inflammasome activation leads to Caspase-1-dependent mitochondrial damage and block of mitophagy. Proc Natl Acad Sci U S A (2014) 1.11
Molecular mechanisms regulating NLRP3 inflammasome activation. Cell Mol Immunol (2015) 1.06
NLRP3 inflammasome and its inhibitors: a review. Front Pharmacol (2015) 0.99
Role of inflammasome activation in the pathophysiology of vascular diseases of the neurovascular unit. Antioxid Redox Signal (2014) 0.92
Activation of NLRP3 inflammasome by crystalline structures via cell surface contact. Sci Rep (2014) 0.90
Disruption of glycolytic flux is a signal for inflammasome signaling and pyroptotic cell death. Elife (2016) 0.90
NLRP3 inflammasome: activation and regulation in age-related macular degeneration. Mediators Inflamm (2015) 0.90
The Importance of NLRP3 Inflammasome in Heart Failure. J Card Fail (2015) 0.88
Fasting and refeeding differentially regulate NLRP3 inflammasome activation in human subjects. J Clin Invest (2015) 0.85
Advances in mechanisms and signaling pathways of carbon nanotube toxicity. Nanotoxicology (2015) 0.84
Evasion of inflammasome activation by microbial pathogens. J Clin Invest (2015) 0.84
Apoptosis, Necrosis, and Necroptosis in the Gut and Intestinal Homeostasis. Mediators Inflamm (2015) 0.83
The potential repertoire of the innate immune system in the bladder: expression of pattern recognition receptors in the rat bladder and a rat urothelial cell line (MYP3 cells). Int Urol Nephrol (2015) 0.82
The Inflammasome Adaptor ASC Induces Procaspase-8 Death Effector Domain Filaments. J Biol Chem (2015) 0.82
Mechanisms of NLRP3 inflammasome activation and its role in NSAID-induced enteropathy. Mucosal Immunol (2015) 0.82
The NLRP3 inflammasome is critically involved in the development of bronchopulmonary dysplasia. Nat Commun (2015) 0.82
Regulation and Function of the Nucleotide Binding Domain Leucine-Rich Repeat-Containing Receptor, Pyrin Domain-Containing-3 Inflammasome in Lung Disease. Am J Respir Cell Mol Biol (2016) 0.81
Multiple Cathepsins Promote Pro-IL-1β Synthesis and NLRP3-Mediated IL-1β Activation. J Immunol (2015) 0.81
Sterile signals generate weaker and delayed macrophage NLRP3 inflammasome responses relative to microbial signals. Cell Mol Immunol (2016) 0.81
A novel "complement-metabolism-inflammasome axis" as a key regulator of immune cell effector function. Eur J Immunol (2016) 0.81
K(+) regulates Ca(2+) to drive inflammasome signaling: dynamic visualization of ion flux in live cells. Cell Death Dis (2015) 0.80
A Role for the Inflammasome in Spontaneous Labor at Term. Am J Reprod Immunol (2016) 0.80
NLRP3 Inflammasome Activation by Viroporins of Animal Viruses. Viruses (2015) 0.79
Specific pathways mediating inflammasome activation by Candida parapsilosis. Sci Rep (2017) 0.78
NLRP3 regulates a non-canonical platform for caspase-8 activation during epithelial cell apoptosis. Cell Death Differ (2016) 0.78
Known unknowns of cardiolipin signaling: The best is yet to come. Biochim Biophys Acta (2016) 0.78
Cigarette smoke represses the innate immune response to asbestos. Physiol Rep (2015) 0.78
Complement-mediated 'bystander' damage initiates host NLRP3 inflammasome activation. J Cell Sci (2016) 0.78
Bidirectional Crosstalk between C5a Receptors and the NLRP3 Inflammasome in Macrophages and Monocytes. Mediators Inflamm (2016) 0.77
Activation of autophagy and nucleotide-binding domain leucine-rich repeat-containing-like receptor family, pyrin domain-containing 3 inflammasome during Leishmania infantum-associated glomerulonephritis. Am J Pathol (2015) 0.77
Species-specific engagement of human nucleotide oligomerization domain 2 (NOD)2 and Toll-like receptor (TLR) signalling upon intracellular bacterial infection: role of Crohn's associated NOD2 gene variants. Clin Exp Immunol (2015) 0.77
HMGB1 Induces an Inflammatory Response in the Chorioamniotic Membranes That Is Partially Mediated by the Inflammasome. Biol Reprod (2016) 0.76
CD36 Is Essential for Regulation of the Host Innate Response to Staphylococcus aureus α-Toxin-Mediated Dermonecrosis. J Immunol (2015) 0.76
NLRP3 Localizes to the Tubular Epithelium in Human Kidney and Correlates With Outcome in IgA Nephropathy. Sci Rep (2016) 0.76
Neutrophils Contribute to the Protection Conferred by ArtinM against Intracellular Pathogens: A Study on Leishmania major. PLoS Negl Trop Dis (2016) 0.76
Alum: an old dog with new tricks. Emerg Microbes Infect (2016) 0.76
Immune Complexes Indirectly Suppress the Generation of Th17 Responses In Vivo. PLoS One (2016) 0.76
The role of caloric load and mitochondrial homeostasis in the regulation of the NLRP3 inflammasome. Cell Mol Life Sci (2016) 0.76
The inflammasome: an emerging therapeutic oncotarget for cancer prevention. Oncotarget (2016) 0.76
Inflammation - Cause or Consequence of Heart Failure or Both? Curr Heart Fail Rep (2017) 0.76
Deletion of Nlrp3 Augments Survival during Polymicrobial Sepsis by Decreasing Autophagy and Enhancing Phagocytosis. J Immunol (2016) 0.75
Differences in Inflammatory Response Induced by Two Representatives of Clades of the Pandemic ST258 Klebsiella pneumoniae Clonal Lineage Producing KPC-Type Carbapenemases. PLoS One (2017) 0.75
Inflammasomes in the urinary tract: a disease-based review. Am J Physiol Renal Physiol (2016) 0.75
Apolipoprotein A-I gene transfer exerts immunomodulatory effects and reduces vascular inflammation and fibrosis in ob/ob mice. J Inflamm (Lond) (2016) 0.75
NLRP3 inflammasome activation mediates radiation-induced pyroptosis in bone marrow-derived macrophages. Cell Death Dis (2017) 0.75
Dental Calculus Stimulates Interleukin-1β Secretion by Activating NLRP3 Inflammasome in Human and Mouse Phagocytes. PLoS One (2016) 0.75
Unresolved issues in theories of autoimmune disease using myocarditis as a framework. J Theor Biol (2014) 0.75
17-oxo-DHA displays additive anti-inflammatory effects with fluticasone propionate and inhibits the NLRP3 inflammasome. Sci Rep (2016) 0.75
Potent NLRP3 inflammasome activation by the HIV reverse-transcriptase inhibitor abacavir. J Biol Chem (2017) 0.75
Cytochrome c Negatively Regulates NLRP3 Inflammasomes. PLoS One (2016) 0.75
Acute fasting inhibits central caspase-1 activity reducing anxiety-like behavior and increasing novel object and object location recognition. Metabolism (2017) 0.75
HIV-1 Tat Primes and Activates Microglial NLRP3 Inflammasome-Mediated Neuroinflammation. J Neurosci (2017) 0.75
Recent Advances of the NLRP3 Inflammasome in Central Nervous System Disorders. J Immunol Res (2016) 0.75
Exposure to nickel oxide nanoparticles induces pulmonary inflammation through NLRP3 inflammasome activation in rats. Int J Nanomedicine (2016) 0.75
Lack of Effect of Murine Astrovirus Infection on Dextran Sulfate-induced Colitis in NLRP3-deficient Mice. Comp Med (2017) 0.75
Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System. Cell Metab (2017) 0.75
NLRP3 mutation and cochlear autoinflammation cause syndromic and nonsyndromic hearing loss DFNA34 responsive to anakinra therapy. Proc Natl Acad Sci U S A (2017) 0.75
Bladder fibrosis during outlet obstruction is triggered through the NLRP3 inflammasome and the production of IL-1β. Am J Physiol Renal Physiol (2017) 0.75
Involvement of c-Abl Kinase in Microglial Activation of NLRP3 Inflammasome and Impairment in Autolysosomal System. J Neuroimmune Pharmacol (2017) 0.75
Human Parvovirus Infection of Human Airway Epithelia Induces Pyroptotic Cell Death via Inhibiting Apoptosis. J Virol (2017) 0.75
Mitochondrial DNA oxidation induces imbalanced activity of NLRP3/NLRP6 inflammasomes by activation of caspase-8 and BRCC36 in dry eye. J Autoimmun (2017) 0.75
Expression of urinary miRNAs targeting NLRs inflammasomes in bladder cancer. Onco Targets Ther (2017) 0.75
Uric acid activates NRLP3 inflammasome in an in-vivo model of epithelial to mesenchymal transition in the kidney. J Mol Histol (2017) 0.75
The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell (2002) 20.11
Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature (2004) 14.80
Immunological and inflammatory functions of the interleukin-1 family. Annu Rev Immunol (2009) 14.33
NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. Immunity (2004) 13.55
AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature (2009) 13.23
A role for mitochondria in NLRP3 inflammasome activation. Nature (2010) 13.21
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature (2008) 11.39
AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. Nature (2009) 10.83
Two CD95 (APO-1/Fas) signaling pathways. EMBO J (1998) 10.42
A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes. Nature (1992) 9.96
NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell (2011) 9.75
Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome. Nat Genet (2001) 9.34
Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat Immunol (2010) 9.02
Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration. Cell Death Differ (2007) 8.85
Regulation of progenitor cell proliferation and granulocyte function by microRNA-223. Nature (2008) 8.69
Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression. J Immunol (2009) 8.40
An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome. Nat Immunol (2009) 7.93
The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation. Cell Death Differ (2007) 7.74
Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin. Nat Genet (2006) 6.89
HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA. Science (2009) 6.59
Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity. Nature (2011) 6.38
The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus. Nature (2011) 6.21
Activation and regulation of the inflammasomes. Nat Rev Immunol (2013) 5.71
Activation of interferon-gamma inducing factor mediated by interleukin-1beta converting enzyme. Science (1997) 5.16
Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. Immunity (2012) 5.08
De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases. Arthritis Rheum (2002) 4.98
Chronic infantile neurological cutaneous and articular syndrome is caused by mutations in CIAS1, a gene highly expressed in polymorphonuclear cells and chondrocytes. Am J Hum Genet (2002) 4.84
The NLR gene family: a standard nomenclature. Immunity (2008) 4.77
Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction. Nat Immunol (2012) 4.72
IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection. Cell Host Microbe (2011) 4.01
Type I interferon inhibits interleukin-1 production and inflammasome activation. Immunity (2011) 3.97
K⁺ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter. Immunity (2013) 3.96
Glyburide inhibits the Cryopyrin/Nalp3 inflammasome. J Cell Biol (2009) 3.85
Intracellular DNA recognition. Nat Rev Immunol (2010) 3.70
Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production. Nat Immunol (2009) 3.58
Cytochrome c release from mitochondria proceeds by a two-step process. Proc Natl Acad Sci U S A (2002) 3.57
Caspase-1-dependent pore formation during pyroptosis leads to osmotic lysis of infected host macrophages. Cell Microbiol (2006) 3.44
Cutting edge: TNF-alpha mediates sensitization to ATP and silica via the NLRP3 inflammasome in the absence of microbial stimulation. J Immunol (2009) 3.32
Inflammasomes and their roles in health and disease. Annu Rev Cell Dev Biol (2012) 3.18
Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome. Nat Immunol (2013) 3.08
Cutting edge: reactive oxygen species inhibitors block priming, but not activation, of the NLRP3 inflammasome. J Immunol (2011) 3.05
The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. Nature (2012) 2.87
Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1. Cell (2007) 2.79
Cell volume regulation modulates NLRP3 inflammasome activation. Immunity (2012) 2.71
Gain-of-function Pyrin mutations induce NLRP3 protein-independent interleukin-1β activation and severe autoinflammation in mice. Immunity (2011) 2.69
A crucial function of SGT1 and HSP90 in inflammasome activity links mammalian and plant innate immune responses. Nat Immunol (2007) 2.68
T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes. Nature (2009) 2.59
Inflammasome activators induce interleukin-1α secretion via distinct pathways with differential requirement for the protease function of caspase-1. Immunity (2012) 2.57
Mitochondrial cardiolipin is required for Nlrp3 inflammasome activation. Immunity (2013) 2.45
Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome-dependent processing of IL-1β. Nat Immunol (2012) 2.34
Critical role for calcium mobilization in activation of the NLRP3 inflammasome. Proc Natl Acad Sci U S A (2012) 2.19
Signaling by ROS drives inflammasome activation. Eur J Immunol (2010) 2.13
Mitochondrial permeability transition in Ca(2+)-dependent apoptosis and necrosis. Cell Calcium (2011) 2.06
Cardiolipin provides an essential activating platform for caspase-8 on mitochondria. J Cell Biol (2008) 2.06
Non-transcriptional priming and deubiquitination regulate NLRP3 inflammasome activation. J Biol Chem (2012) 2.04
An NLRP7-containing inflammasome mediates recognition of microbial lipopeptides in human macrophages. Immunity (2012) 2.01
The adaptor MAVS promotes NLRP3 mitochondrial localization and inflammasome activation. Cell (2013) 1.93
Critical functions of priming and lysosomal damage for NLRP3 activation. Eur J Immunol (2010) 1.87
Deubiquitination of NLRP3 by BRCC3 critically regulates inflammasome activity. Mol Cell (2012) 1.72
Cutting edge: miR-223 and EBV miR-BART15 regulate the NLRP3 inflammasome and IL-1β production. J Immunol (2012) 1.71
Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock. Cell Res (2013) 1.54
Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors. Nat Commun (2012) 1.48
NALP1 influences susceptibility to human congenital toxoplasmosis, proinflammatory cytokine response, and fate of Toxoplasma gondii-infected monocytic cells. Infect Immun (2010) 1.46
Deubiquitinases regulate the activity of caspase-1 and interleukin-1β secretion via assembly of the inflammasome. J Biol Chem (2012) 1.40
Cutting edge: Mouse NAIP1 detects the type III secretion system needle protein. J Immunol (2013) 1.38
NLRP3 inflammasome activity is negatively controlled by miR-223. J Immunol (2012) 1.35
BID is cleaved by caspase-8 within a native complex on the mitochondrial membrane. Cell Death Differ (2010) 1.34
The complement membrane attack complex triggers intracellular Ca2+ fluxes leading to NLRP3 inflammasome activation. J Cell Sci (2013) 1.33
TRPM2 links oxidative stress to NLRP3 inflammasome activation. Nat Commun (2013) 1.32
Is mPTP the gatekeeper for necrosis, apoptosis, or both? Biochim Biophys Acta (2010) 1.32
Cellular inhibitors of apoptosis proteins cIAP1 and cIAP2 are required for efficient caspase-1 activation by the inflammasome. Immunity (2011) 1.28
Early changes in intramitochondrial cardiolipin distribution during apoptosis. Cell Growth Differ (2002) 1.25
Acute lipopolysaccharide priming boosts inflammasome activation independently of inflammasome sensor induction. Immunobiology (2012) 1.23
IRAK-1 bypasses priming and directly links TLRs to rapid NLRP3 inflammasome activation. Proc Natl Acad Sci U S A (2013) 1.19
An Update on PYRIN Domain-Containing Pattern Recognition Receptors: From Immunity to Pathology. Front Immunol (2013) 1.17
Cutting edge: TLR signaling licenses IRAK1 for rapid activation of the NLRP3 inflammasome. J Immunol (2013) 1.15
The mitochondrial antiviral protein MAVS associates with NLRP3 and regulates its inflammasome activity. J Immunol (2013) 1.10
Mitochondrial protein mitofusin 2 is required for NLRP3 inflammasome activation after RNA virus infection. Proc Natl Acad Sci U S A (2013) 0.99
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Cyclic-di-GMP and cyclic-di-AMP activate the NLRP3 inflammasome. EMBO Rep (2013) 0.96
An interaction between Bcl-xL and the voltage-dependent anion channel (VDAC) promotes mitochondrial Ca2+ uptake. J Biol Chem (2013) 0.95
Cytochrome c release from rat brain mitochondria is proportional to the mitochondrial functional deficit: implications for apoptosis and neurodegenerative disease. J Neurochem (2005) 0.89
Cutting edge: Candida albicans hyphae formation triggers activation of the Nlrp3 inflammasome. J Immunol (2009) 2.18
Sensing pathogens and danger signals by the inflammasome. Curr Opin Immunol (2009) 1.91
Sensing damage by the NLRP3 inflammasome. Immunol Rev (2011) 1.69
NFIL3/E4BP4 controls type 2 T helper cell cytokine expression. EMBO J (2011) 1.26
Control of innate and adaptive immunity by the inflammasome. Microbes Infect (2012) 0.97
Cutting edge: Nlrp10 is essential for protective antifungal adaptive immunity against Candida albicans. J Immunol (2012) 0.94
Inflammasome-mediated autoinflammatory disorders. Postgrad Med (2010) 0.90
Francisella tularensis live vaccine strain folate metabolism and pseudouridine synthase gene mutants modulate macrophage caspase-1 activation. Infect Immun (2012) 0.86
Tim-1 regulates Th2 responses in an airway hypersensitivity model. Eur J Immunol (2012) 0.85
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Incomplete TCR-β allelic exclusion accelerates spontaneous autoimmune arthritis in K/BxN TCR transgenic mice. Eur J Immunol (2012) 0.80
Fcγ receptor III and Fcγ receptor IV on macrophages drive autoimmune valvular carditis in mice. Arthritis Rheumatol (2014) 0.77
Autoantibody-mediated arthritis in the absence of C3 and activating Fcγ receptors: C5 is activated by the coagulation cascade. Arthritis Res Ther (2012) 0.77
NLRC4 suppresses melanoma tumor progression independently of inflammasome activation. J Clin Invest (2016) 0.76