Published in Nat Rev Drug Discov on June 01, 2012
AMPK, insulin resistance, and the metabolic syndrome. J Clin Invest (2013) 2.44
Sirtuin 3-dependent mitochondrial dynamic improvements protect against acute kidney injury. J Clin Invest (2015) 1.71
Pharmacological approaches to restore mitochondrial function. Nat Rev Drug Discov (2013) 1.66
SIRT3 deficiency exacerbates ischemia-reperfusion injury: implication for aged hearts. Am J Physiol Heart Circ Physiol (2014) 1.60
The SIRT1 activator SRT1720 extends lifespan and improves health of mice fed a standard diet. Cell Rep (2014) 1.42
SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease. Cell Rep (2013) 1.41
Drugs that modulate aging: the promising yet difficult path ahead. Transl Res (2013) 1.38
Pro-autophagic polyphenols reduce the acetylation of cytoplasmic proteins. Cell Cycle (2012) 1.27
Translating advances from the basic biology of aging into clinical application. Exp Gerontol (2012) 1.16
Preparing for an Aging World: Engaging Biogerontologists, Geriatricians, and the Society. J Gerontol A Biol Sci Med Sci (2015) 1.16
The sirtuin family's role in aging and age-associated pathologies. J Clin Invest (2013) 1.12
Protective effects of sirtuins in cardiovascular diseases: from bench to bedside. Eur Heart J (2015) 1.11
Crosstalk between Oxidative Stress and SIRT1: Impact on the Aging Process. Int J Mol Sci (2013) 1.07
SIRT1 but not its increased expression is essential for lifespan extension in caloric-restricted mice. Aging Cell (2013) 1.06
You're only as old as your arteries: translational strategies for preserving vascular endothelial function with aging. Physiology (Bethesda) (2014) 1.04
Epigenetic modifications in the pathogenesis of diabetic nephropathy. Semin Nephrol (2013) 1.02
Pharmacological modulation of circadian rhythms by synthetic activators of the deacetylase SIRT1. Proc Natl Acad Sci U S A (2013) 1.00
Aging exacerbates hypertension-induced cerebral microhemorrhages in mice: role of resveratrol treatment in vasoprotection. Aging Cell (2015) 0.97
ATGL-catalyzed lipolysis regulates SIRT1 to control PGC-1α/PPAR-α signaling. Diabetes (2015) 0.96
Sirtuins are evolutionarily conserved viral restriction factors. MBio (2014) 0.96
SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass. Aging Cell (2014) 0.94
SIRT1 in the brain-connections with aging-associated disorders and lifespan. Front Cell Neurosci (2015) 0.93
Emerging role of sirtuins on tumorigenesis: possible link between aging and cancer. BMB Rep (2013) 0.93
A healthier approach to clinical trials evaluating resveratrol for primary prevention of age‐related diseases in healthy populations. Aging (Albany NY) (2013) 0.93
Aging and brain rejuvenation as systemic events. J Neurochem (2014) 0.93
Resveratrol treatment rescues neurovascular coupling in aged mice: role of improved cerebromicrovascular endothelial function and downregulation of NADPH oxidase. Am J Physiol Heart Circ Physiol (2013) 0.93
Crystallographic structure of a small molecule SIRT1 activator-enzyme complex. Nat Commun (2015) 0.91
Enhanced longevity by ibuprofen, conserved in multiple species, occurs in yeast through inhibition of tryptophan import. PLoS Genet (2014) 0.91
Unique functional roles for class I and class II histone deacetylases in central nervous system development and function. Int J Dev Neurosci (2013) 0.90
Non-alcoholic steatohepatitis and hepatocellular carcinoma: implications for lycopene intervention. Nutrients (2013) 0.89
Sirtuin1 (Sirt1) promotes cortical bone formation by preventing β-catenin sequestration by FoxO transcription factors in osteoblast progenitors. J Biol Chem (2014) 0.88
SIRT1 polymorphism, long-term survival and glucose tolerance in the general population. PLoS One (2013) 0.88
Resveratrol induces vascular smooth muscle cell differentiation through stimulation of SirT1 and AMPK. PLoS One (2014) 0.88
Adaptive cellular stress pathways as therapeutic targets of dietary phytochemicals: focus on the nervous system. Pharmacol Rev (2014) 0.87
Dendritic cell SIRT1-HIF1α axis programs the differentiation of CD4+ T cells through IL-12 and TGF-β1. Proc Natl Acad Sci U S A (2015) 0.87
Thiomyristoyl peptides as cell-permeable Sirt6 inhibitors. Org Biomol Chem (2014) 0.87
Sirtuins, Cell Senescence, and Vascular Aging. Can J Cardiol (2015) 0.87
Resveratrol induces expression of the slow, oxidative phenotype in mdx mouse muscle together with enhanced activity of the SIRT1-PGC-1α axis. Am J Physiol Cell Physiol (2014) 0.86
Autophagy in ageing and ageing-associated diseases. Acta Pharmacol Sin (2013) 0.86
Molecular and metabolomic effects of voluntary running wheel activity on skeletal muscle in late middle-aged rats. Physiol Rep (2015) 0.86
Selective overexpression of human SIRT1 in adipose tissue enhances energy homeostasis and prevents the deterioration of insulin sensitivity with ageing in mice. Am J Transl Res (2013) 0.85
Sirtuins in neurodegenerative diseases: an update on potential mechanisms. Front Aging Neurosci (2013) 0.85
FOXO3a potentiates hTERT gene expression by activating c-MYC and extends the replicative life-span of human fibroblast. PLoS One (2014) 0.85
The expression and correlation of SIRT1 and Phospho-SIRT1 in colorectal cancer. Int J Clin Exp Med (2015) 0.84
Resveratrol Induced Premature Senescence Is Associated with DNA Damage Mediated SIRT1 and SIRT2 Down-Regulation. PLoS One (2015) 0.84
Secondary muscle pathology and metabolic dysregulation in adults with cerebral palsy. Am J Physiol Endocrinol Metab (2012) 0.83
Dietary restriction, mitochondrial function and aging: from yeast to humans. Biochim Biophys Acta (2015) 0.83
Neurohormetic phytochemicals: An evolutionary-bioenergetic perspective. Neurochem Int (2015) 0.83
SIRT1 enhances glucose tolerance by potentiating brown adipose tissue function. Mol Metab (2014) 0.83
Peptides and Pseudopeptides as SIRT6 Deacetylation Inhibitors. ACS Med Chem Lett (2012) 0.83
Decreased levels of proapoptotic factors and increased key regulators of mitochondrial biogenesis constitute new potential beneficial features of long-lived growth hormone receptor gene-disrupted mice. J Gerontol A Biol Sci Med Sci (2012) 0.83
Epigenetic linkage of aging, cancer and nutrition. J Exp Biol (2015) 0.83
Resveratrol Improves Survival and Prolongs Life Following Hemorrhagic Shock. Mol Med (2015) 0.83
Sirtuin1 Suppresses Osteoclastogenesis by Deacetylating FoxOs. Mol Endocrinol (2015) 0.83
Increased ghrelin signaling prolongs survival in mouse models of human aging through activation of sirtuin1. Mol Psychiatry (2016) 0.82
Overexpression of Sirtuin 6 suppresses cellular senescence and NF-κB mediated inflammatory responses in osteoarthritis development. Sci Rep (2015) 0.82
Mechanisms underlying the anti-aging and anti-tumor effects of lithocholic bile acid. Int J Mol Sci (2014) 0.82
Sirtuin Deacetylation Mechanism and Catalytic Role of the Dynamic Cofactor Binding Loop. J Phys Chem Lett (2013) 0.82
Preferential expression of PAPPA in human preadipocytes from omental fat. J Endocrinol (2014) 0.81
Defining the role of histone deacetylases in the inhibition of mammary carcinogenesis by dietary energy restriction (DER): effects of suberoylanilide hydroxamic acid (SAHA) and DER in a rat model. Cancer Prev Res (Phila) (2013) 0.81
Targeting sirtuins for the treatment of diabetes. Diabetes Manag (Lond) (2013) 0.79
Sirtuins, aging, and cardiovascular risks. Age (Dordr) (2015) 0.79
Biological impacts of resveratrol, quercetin, and N-acetylcysteine on oxidative stress in human gingival fibroblasts. J Clin Biochem Nutr (2015) 0.79
SIRT3 inhibits cell proliferation in human gastric cancer through down-regulation of Notch-1. Int J Clin Exp Med (2015) 0.78
PCH-2 regulates Caenorhabditis elegans lifespan. Aging (Albany NY) (2015) 0.78
Serum from calorie-restricted animals delays senescence and extends the lifespan of normal human fibroblasts in vitro. Aging (Albany NY) (2015) 0.78
Sirtuin 1 Regulates Dendritic Cell Activation and Autophagy during Respiratory Syncytial Virus-Induced Immune Responses. J Immunol (2015) 0.78
Myeloid cell sirtuin-1 expression does not alter host immune responses to Gram-negative endotoxemia or Gram-positive bacterial infection. PLoS One (2013) 0.78
Resveratrol serves as a protein-substrate interaction stabilizer in human SIRT1 activation. Sci Rep (2016) 0.77
Resveratrol Decreases TXNIP mRNA and Protein Nuclear Expressions With an Arterial Function Improvement in Old Mice. J Gerontol A Biol Sci Med Sci (2015) 0.77
SIRT6 protects against endothelial dysfunction and atherosclerosis in mice. Aging (Albany NY) (2016) 0.77
Estrogen-dependent dynamic profile of eNOS-DNA associations in prostate cancer. PLoS One (2013) 0.77
When Anti-Aging Studies Meet Cancer Chemoprevention: Can Anti-Aging Agent Kill Two Birds with One Blow? Curr Pharmacol Rep (2015) 0.77
Modulation of Replicative Lifespan in Cryptococcus neoformans: Implications for Virulence. Front Microbiol (2017) 0.76
Redox Signaling in Diabetic Nephropathy: Hypertrophy versus Death Choices in Mesangial Cells and Podocytes. Mediators Inflamm (2015) 0.76
Pharmacological Strategies to Retard Cardiovascular Aging. Circ Res (2016) 0.76
A crucial role of SUMOylation in modulating Sirt6 deacetylation of H3 at lysine 56 and its tumor suppressive activity. Oncogene (2016) 0.76
Mass spectrometry-based detection of protein acetylation. Methods Mol Biol (2013) 0.76
Reverse chemomodulatory effects of the SIRT1 activators resveratrol and SRT1720 in Ewing's sarcoma cells: resveratrol suppresses and SRT1720 enhances etoposide- and vincristine-induced anticancer activity. J Cancer Res Clin Oncol (2015) 0.76
In vitro caloric restriction induces protective genes and functional rejuvenation in senescent SAMP8 astrocytes. Aging Cell (2015) 0.76
Direct activation of ATM by resveratrol under oxidizing conditions. PLoS One (2014) 0.76
(Healthy) ageing: focus on iodothyronines. Int J Mol Sci (2013) 0.76
New Horizons: Dietary protein, ageing and the Okinawan ratio. Age Ageing (2016) 0.76
SILAC-MS Based Characterization of LPS and Resveratrol Induced Changes in Adipocyte Proteomics - Resveratrol as Ameliorating Factor on LPS Induced Changes. PLoS One (2016) 0.76
DNA damage, NF-κB and accelerated aging. Asian J Androl (2012) 0.76
Aging aggravates alcoholic liver injury and fibrosis in mice by downregulating Sirtuin 1 expression. J Hepatol (2016) 0.76
Sirtuins Function as the Modulators in Aging-related Diseases in Common or Respectively. Chin Med J (Engl) (2015) 0.75
SIRT6 suppresses mitochondrial defects and cell death via the NF-κB pathway in myocardial hypoxia/reoxygenation induced injury. Am J Transl Res (2016) 0.75
Regulation of Serine-Threonine Kinase Akt Activation by NAD(+)-Dependent Deacetylase SIRT7. Cell Rep (2017) 0.75
Adjunct Strategies for Tuberculosis Vaccines: Modulating Key Immune Cell Regulatory Mechanisms to Potentiate Vaccination. Front Immunol (2016) 0.75
Development of a lozenge for oral transmucosal delivery of trans-resveratrol in humans: proof of concept. PLoS One (2014) 0.75
SIRT1 Polymorphisms Associate with Seasonal Weight Variation, Depressive Disorders, and Diastolic Blood Pressure in the General Population. PLoS One (2015) 0.75
Dietary Phytochemicals in Neuroimmunoaging: A New Therapeutic Possibility for Humans? Front Pharmacol (2016) 0.75
Curcumin as therapeutics for the treatment of head and neck squamous cell carcinoma by activating SIRT1. Sci Rep (2015) 0.75
Resveratrol-induced antinociception is involved in calcium channels and calcium/caffeine-sensitive pools. Oncotarget (2016) 0.75
Sirtuin 2 regulates cellular iron homeostasis via deacetylation of transcription factor NRF2. J Clin Invest (2017) 0.75
Rho-kinase inhibition ameliorates metabolic disorders through activation of AMPK pathway in mice. PLoS One (2014) 0.75
Genetic and Functional Sequence Variants of the SIRT3 Gene Promoter in Myocardial Infarction. PLoS One (2016) 0.75
Myeloid Sirtuin 2 Expression Does Not Impact Long-Term Mycobacterium tuberculosis Control. PLoS One (2015) 0.75
SIRT1 plays a neuroprotective role in traumatic brain injury in rats via inhibiting the p38 MAPK pathway. Acta Pharmacol Sin (2016) 0.75
Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci (2001) 42.21
Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies. Lancet (2009) 26.09
Mortality in relation to smoking: 50 years' observations on male British doctors. BMJ (2004) 24.88
Resveratrol improves health and survival of mice on a high-calorie diet. Nature (2006) 20.91
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature (2000) 20.54
Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell (2006) 19.16
Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature (2005) 18.41
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature (2003) 17.52
Aging, natural death, and the compression of morbidity. N Engl J Med (1980) 17.40
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science (2004) 17.38
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell (2001) 15.97
Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell (2001) 15.05
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature (2001) 14.44
The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev (1999) 14.43
Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials. Lancet (2009) 13.64
Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science (2000) 12.98
Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov (2006) 11.77
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science (2004) 11.39
Wine, alcohol, platelets, and the French paradox for coronary heart disease. Lancet (1992) 11.12
Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J (2004) 11.00
Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science (1997) 10.90
Regulation of cellular metabolism by protein lysine acetylation. Science (2010) 10.55
Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature (2004) 10.36
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature (2004) 10.32
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature (2007) 10.21
Caloric restriction delays disease onset and mortality in rhesus monkeys. Science (2009) 9.84
Sir2 mediates longevity in the fly through a pathway related to calorie restriction. Proc Natl Acad Sci U S A (2004) 9.25
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc Natl Acad Sci U S A (2003) 9.14
Mammalian SIRT1 represses forkhead transcription factors. Cell (2004) 8.89
Mammalian sirtuins: biological insights and disease relevance. Annu Rev Pathol (2010) 8.55
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell (2006) 8.48
The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase. Mol Cell (2003) 8.34
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha. Proc Natl Acad Sci U S A (2007) 8.23
Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol Cell Biol (2007) 7.97
Long-term follow-up of the West of Scotland Coronary Prevention Study. N Engl J Med (2007) 7.96
Statins and all-cause mortality in high-risk primary prevention: a meta-analysis of 11 randomized controlled trials involving 65,229 participants. Arch Intern Med (2010) 7.49
Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration. Science (2004) 7.29
SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell (2006) 6.79
Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. Mol Biol Cell (2005) 6.79
The effect of retarded growth upon the length of life span and upon the ultimate body size. 1935. Nutrition (1992) 6.77
A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family. Proc Natl Acad Sci U S A (2000) 6.49
SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature (2010) 6.48
The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control. Cell (2008) 6.44
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab (2008) 6.22
SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span. Cell (2009) 6.09
SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. Nature (2008) 6.02
SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}. J Biol Chem (2005) 5.93
Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity. Biochem Biophys Res Commun (1999) 5.83
SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell (2008) 5.76
Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction. Cell (2010) 5.73
Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. Cell (2012) 5.71
SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell (2008) 5.68
Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci (2010) 5.54
Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt. Dev Cell (2008) 5.51
Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease. Science (2007) 5.49
Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation. Cell Metab (2008) 5.44
SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1. J Biol Chem (2010) 5.43
Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice. Cell Metab (2005) 5.39
The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis. Mol Cell Biol (2003) 5.38
SIRT1 transgenic mice show phenotypes resembling calorie restriction. Aging Cell (2007) 5.30
Substrate-specific activation of sirtuins by resveratrol. J Biol Chem (2005) 5.28
Sirt1 regulates aging and resistance to oxidative stress in the heart. Circ Res (2007) 5.23
Sirt1 protects against high-fat diet-induced metabolic damage. Proc Natl Acad Sci U S A (2008) 5.21
The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha. Cell (2010) 5.11
Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation. Cell Metab (2010) 4.97
Increase in activity during calorie restriction requires Sirt1. Science (2005) 4.90
SirT1 gain of function increases energy efficiency and prevents diabetes in mice. Cell Metab (2008) 4.89
Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1. Proc Natl Acad Sci U S A (2007) 4.87
Mechanism of human SIRT1 activation by resveratrol. J Biol Chem (2005) 4.86
The retardation of aging in mice by dietary restriction: longevity, cancer, immunity and lifetime energy intake. J Nutr (1986) 4.81
SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes. J Biol Chem (2005) 4.80
Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1. Science (2009) 4.80
SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis. EMBO J (2007) 4.66
Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila. Nature (2011) 4.48
A novel pathway regulates memory and plasticity via SIRT1 and miR-134. Nature (2010) 4.39
Retracted Increased muscle PGC-1alpha expression protects from sarcopenia and metabolic disease during aging. Proc Natl Acad Sci U S A (2009) 4.37
The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. PLoS One (2008) 4.32
A suppressor of mating-type locus mutations in Saccharomyces cerevisiae: evidence for and identification of cryptic mating-type loci. Genetics (1979) 4.30
Seminars in medicine of the Beth Israel Deaconess Medical Center. Caloric intake and aging. N Engl J Med (1997) 4.26
Resveratrol stimulates AMP kinase activity in neurons. Proc Natl Acad Sci U S A (2007) 4.24
Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase. Science (2011) 4.16
SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase. J Biol Chem (2008) 4.16
The sirtuin SIRT6 regulates lifespan in male mice. Nature (2012) 4.07
Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans. Aging Cell (2009) 4.01
In search of Methuselah: estimating the upper limits to human longevity. Science (1990) 3.99
SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase. Proc Natl Acad Sci U S A (2007) 3.94
SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle. Cell (2009) 3.91
Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate. Curr Biol (2006) 3.88
Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons. Nat Genet (2005) 3.75
Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. Cell Metab (2011) 3.69
SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. Cell Metab (2012) 3.69
SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation. J Biol Chem (2008) 3.66
SirT1 regulates energy metabolism and response to caloric restriction in mice. PLoS One (2008) 3.66
Regulation of hypoxia-inducible factor 2alpha signaling by the stress-responsive deacetylase sirtuin 1. Science (2009) 3.64
Retracted SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10. Cell (2010) 3.58
Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle. Cell Metab (2010) 3.46
FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1). J Biol Chem (2004) 3.39
AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol. Diabetes (2009) 3.39
Benefits of smoking cessation for longevity. Am J Public Health (2002) 3.38
SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons. Cell Metab (2008) 3.35
Resveratrol improves health and survival of mice on a high-calorie diet. Nature (2006) 20.91
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science (2004) 11.39
Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival. Cell (2007) 6.47
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab (2008) 6.22
Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci (2010) 5.54
Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study. Nature (2012) 5.00
The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. PLoS One (2008) 4.32
Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans. Sci Transl Med (2011) 3.84
SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. Cell Metab (2012) 3.69
Polypharmacy cutoff and outcomes: five or more medicines were used to identify community-dwelling older men at risk of different adverse outcomes. J Clin Epidemiol (2012) 3.57
Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science (2012) 3.52
Aging-induced phenotypic changes and oxidative stress impair coronary arteriolar function. Circ Res (2002) 3.51
Aging biology and geriatric clinical pharmacology. Pharmacol Rev (2004) 3.23
Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake. Proc Natl Acad Sci U S A (2003) 2.82
Metformin improves healthspan and lifespan in mice. Nat Commun (2013) 2.68
Resveratrol induces mitochondrial biogenesis in endothelial cells. Am J Physiol Heart Circ Physiol (2009) 2.65
Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy. Sci Transl Med (2012) 2.58
Dietary deprivation extends lifespan in Caenorhabditis elegans. Aging Cell (2006) 2.54
Inflammation and endothelial dysfunction during aging: role of NF-kappaB. J Appl Physiol (1985) (2008) 2.40
T lymphocytes interact with hepatocytes through fenestrations in murine liver sinusoidal endothelial cells. Hepatology (2006) 2.30
Mechanisms of vascular aging: new perspectives. J Gerontol A Biol Sci Med Sci (2010) 2.24
Cigarette smoke-induced proinflammatory alterations in the endothelial phenotype: role of NAD(P)H oxidase activation. Am J Physiol Heart Circ Physiol (2007) 2.20
Resveratrol attenuates TNF-alpha-induced activation of coronary arterial endothelial cells: role of NF-kappaB inhibition. Am J Physiol Heart Circ Physiol (2006) 2.19
Aging-induced proinflammatory shift in cytokine expression profile in coronary arteries. FASEB J (2003) 2.13
JNK1 phosphorylates SIRT1 and promotes its enzymatic activity. PLoS One (2009) 2.07
Vasculoprotective effects of anti-tumor necrosis factor-alpha treatment in aging. Am J Pathol (2007) 2.02
Age-related changes in the hepatic sinusoidal endothelium impede lipoprotein transfer in the rat. Hepatology (2005) 2.00
Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction. Proc Natl Acad Sci U S A (2008) 1.97
Loss of muscle strength, mass (sarcopenia), and quality (specific force) and its relationship with functional limitation and physical disability: the Concord Health and Ageing in Men Project. J Am Geriatr Soc (2010) 1.97
Development of calorie restriction mimetics as a prolongevity strategy. Ann N Y Acad Sci (2004) 1.92
Regulation of bone morphogenetic protein-2 expression in endothelial cells: role of nuclear factor-kappaB activation by tumor necrosis factor-alpha, H2O2, and high intravascular pressure. Circulation (2005) 1.91
Hepatocyte entry leads to degradation of autoreactive CD8 T cells. Proc Natl Acad Sci U S A (2011) 1.89
Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations. Am J Physiol Heart Circ Physiol (2008) 1.87
Bone morphogenetic protein-2 induces proinflammatory endothelial phenotype. Am J Pathol (2006) 1.86
Mitochondrial biogenesis and healthy aging. Exp Gerontol (2008) 1.85
SRT1720 improves survival and healthspan of obese mice. Sci Rep (2011) 1.81
Pain, frailty and comorbidity on older men: the CHAMP study. Pain (2008) 1.79
CB2-receptor stimulation attenuates TNF-alpha-induced human endothelial cell activation, transendothelial migration of monocytes, and monocyte-endothelial adhesion. Am J Physiol Heart Circ Physiol (2007) 1.77
Mechanisms underlying caloric restriction and lifespan regulation: implications for vascular aging. Circ Res (2008) 1.75
Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2. Am J Physiol Heart Circ Physiol (2010) 1.73
Atypical antipsychotic medications and risk of falls in residents of aged care facilities. J Am Geriatr Soc (2005) 1.73
Proinflammatory phenotype of coronary arteries promotes endothelial apoptosis in aging. Physiol Genomics (2004) 1.73
SIRT1 is essential for normal cognitive function and synaptic plasticity. J Neurosci (2010) 1.71
Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: role of circulating factors and SIRT1. Mech Ageing Dev (2009) 1.69
Testing the oxidative stress hypothesis of aging in primate fibroblasts: is there a correlation between species longevity and cellular ROS production? J Gerontol A Biol Sci Med Sci (2012) 1.69
Resveratrol improves endothelial function: role of TNF{alpha} and vascular oxidative stress. Arterioscler Thromb Vasc Biol (2009) 1.63
Resveratrol prevents monocrotaline-induced pulmonary hypertension in rats. Hypertension (2009) 1.63
Vascular superoxide and hydrogen peroxide production and oxidative stress resistance in two closely related rodent species with disparate longevity. Aging Cell (2007) 1.62
How fast does the Grim Reaper walk? Receiver operating characteristics curve analysis in healthy men aged 70 and over. BMJ (2011) 1.59
Drug Burden Index and physical function in older Australian men. Br J Clin Pharmacol (2009) 1.58
Age-associated learning and memory deficits in two mouse versions of the Stone T-maze. Neurobiol Aging (2012) 1.55
Endothelial function and vascular oxidative stress in long-lived GH/IGF-deficient Ames dwarf mice. Am J Physiol Heart Circ Physiol (2008) 1.55
The Relationship between fenestrations, sieve plates and rafts in liver sinusoidal endothelial cells. PLoS One (2012) 1.54
Ubiquitin-mediated proteolysis of HuR by heat shock. EMBO J (2009) 1.52
Medication withdrawal trials in people aged 65 years and older: a systematic review. Drugs Aging (2008) 1.51
Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile. Aging Cell (2013) 1.48
Benzodiazepines and risk of hip fractures in older people: a review of the evidence. CNS Drugs (2003) 1.47
Of mice and men: the benefits of caloric restriction, exercise, and mimetics. Ageing Res Rev (2011) 1.47
Mitochondria and cardiovascular aging. Circ Res (2012) 1.46
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Cockayne syndrome group B protein prevents the accumulation of damaged mitochondria by promoting mitochondrial autophagy. J Exp Med (2012) 1.42
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