Published in PLoS Genet on September 23, 2010
Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway. PLoS Genet (2012) 2.63
Epigenetic mechanisms in neurological disease. Nat Med (2012) 1.74
Every amino acid matters: essential contributions of histone variants to mammalian development and disease. Nat Rev Genet (2014) 1.62
Histone variants in metazoan development. Dev Cell (2010) 1.42
The presence of the Y-chromosome, not the absence of the second X-chromosome, alters the mRNA levels stored in the fully grown XY mouse oocyte. PLoS One (2012) 1.42
Regulating the chromatin landscape: structural and mechanistic perspectives. Annu Rev Biochem (2014) 1.29
Histone variant H3.3 maintains a decondensed chromatin state essential for mouse preimplantation development. Development (2013) 1.14
Histone H3.3 mutations: a variant path to cancer. Cancer Cell (2013) 1.07
The Daxx/Atrx Complex Protects Tandem Repetitive Elements during DNA Hypomethylation by Promoting H3K9 Trimethylation. Cell Stem Cell (2015) 1.02
Endogenous mammalian histone H3.3 exhibits chromatin-related functions during development. Epigenetics Chromatin (2013) 1.00
Atrx deficiency induces telomere dysfunction, endocrine defects, and reduced life span. J Clin Invest (2013) 0.98
Alpha thalassemia/mental retardation syndrome X-linked gene product ATRX is required for proper replication restart and cellular resistance to replication stress. J Biol Chem (2013) 0.98
Compromised genomic integrity impedes muscle growth after Atrx inactivation. J Clin Invest (2012) 0.92
Histone H3.3 maintains genome integrity during mammalian development. Genes Dev (2015) 0.91
Role of ATRX in chromatin structure and function: implications for chromosome instability and human disease. Reproduction (2011) 0.86
XNP/dATRX interacts with DREF in the chromatin to regulate gene expression. Nucleic Acids Res (2011) 0.85
ATRX induction by mutant huntingtin via Cdx2 modulates heterochromatin condensation and pathology in Huntington's disease. Cell Death Differ (2012) 0.84
Viral reprogramming of the Daxx histone H3.3 chaperone during early Epstein-Barr virus infection. J Virol (2014) 0.83
ATRX is required for maintenance of the neuroprogenitor cell pool in the embryonic mouse brain. Biol Open (2014) 0.81
ATRX contributes to epigenetic asymmetry and silencing of major satellite transcripts in the maternal genome of the mouse embryo. Development (2015) 0.81
Chromosomal instability in mammalian pre-implantation embryos: potential causes, detection methods, and clinical consequences. Cell Tissue Res (2015) 0.79
Identification of protein complexes that bind to histone H3 combinatorial modifications using super-SILAC and weighted correlation network analysis. Nucleic Acids Res (2015) 0.78
Transplantation of nucleoli into human zygotes: not as simple as expected? J Assist Reprod Genet (2011) 0.77
Point mutations in an epigenetic factor lead to multiple types of bone tumors: role of H3.3 histone variant in bone development and disease. Bonekey Rep (2015) 0.75
Mouse BRWD1 is critical for spermatid postmeiotic transcription and female meiotic chromosome stability. J Cell Biol (2014) 0.75
DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell (1999) 25.75
Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability. Cell (2001) 11.39
Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation. Chromosoma (1997) 11.04
Centromeres and kinetochores: from epigenetics to mitotic checkpoint signaling. Cell (2003) 9.90
To err (meiotically) is human: the genesis of human aneuploidy. Nat Rev Genet (2001) 9.08
Higher-order structure in pericentric heterochromatin involves a distinct pattern of histone modification and an RNA component. Nat Genet (2002) 5.86
Drosophila aurora B kinase is required for histone H3 phosphorylation and condensin recruitment during chromosome condensation and to organize the central spindle during cytokinesis. J Cell Biol (2001) 5.34
Requirement of heterochromatin for cohesion at centromeres. Science (2001) 5.02
Centromeric chromatin exhibits a histone modification pattern that is distinct from both euchromatin and heterochromatin. Nat Struct Mol Biol (2004) 4.95
Phosphorylation of histone H3 is required for proper chromosome condensation and segregation. Cell (1999) 4.83
Un ménage à quatre: the molecular biology of chromosome segregation in meiosis. Cell (2003) 4.82
The case for epigenetic effects on centromere identity and function. Trends Genet (1997) 4.57
HP1 and the dynamics of heterochromatin maintenance. Nat Rev Mol Cell Biol (2004) 4.38
Chromosome choreography: the meiotic ballet. Science (2003) 4.00
Mouse centric and pericentric satellite repeats form distinct functional heterochromatin. J Cell Biol (2004) 3.65
The ATRX syndrome protein forms a chromatin-remodeling complex with Daxx and localizes in promyelocytic leukemia nuclear bodies. Proc Natl Acad Sci U S A (2003) 3.52
Mutations in ATRX, encoding a SWI/SNF-like protein, cause diverse changes in the pattern of DNA methylation. Nat Genet (2000) 3.24
Transgenic RNAi reveals essential function for CTCF in H19 gene imprinting. Science (2004) 2.98
Human female meiosis: what makes a good egg go bad? Trends Genet (2008) 2.91
Transcriptional dysregulation in NIPBL and cohesin mutant human cells. PLoS Biol (2009) 2.89
A chromatin remodelling complex that loads cohesin onto human chromosomes. Nature (2002) 2.53
Cloning, expression and chromosome locations of the human DNMT3 gene family. Gene (1999) 2.33
PHD fingers in human diseases: disorders arising from misinterpreting epigenetic marks. Mutat Res (2008) 2.31
Localization of a putative transcriptional regulator (ATRX) at pericentromeric heterochromatin and the short arms of acrocentric chromosomes. Proc Natl Acad Sci U S A (1999) 2.24
Age-associated alteration of gene expression patterns in mouse oocytes. Hum Mol Genet (2004) 2.11
A novel transcription regulatory complex containing death domain-associated protein and the ATR-X syndrome protein. J Biol Chem (2004) 1.98
Unravelling heterochromatin: competition between positive and negative factors regulates accessibility. Trends Genet (2002) 1.93
Age-associated increase in aneuploidy and changes in gene expression in mouse eggs. Dev Biol (2008) 1.85
Loss of ATRX leads to chromosome cohesion and congression defects. J Cell Biol (2008) 1.79
Heterochromatin and ND10 are cell-cycle regulated and phosphorylation-dependent alternate nuclear sites of the transcription repressor Daxx and SWI/SNF protein ATRX. J Cell Sci (2004) 1.63
Effect of meiotic recombination on the production of aneuploid gametes in humans. Cytogenet Genome Res (2005) 1.61
ATRX, a member of the SNF2 family of helicase/ATPases, is required for chromosome alignment and meiotic spindle organization in metaphase II stage mouse oocytes. Dev Biol (2004) 1.60
Differential regulation of CENP-A and histone H3 phosphorylation in G2/M. J Cell Sci (2001) 1.58
Identification of sister chromatids by DNA template strand sequences. Nature (2009) 1.53
RNAi in mouse oocytes and preimplantation embryos: effectiveness of hairpin dsRNA. Biochem Biophys Res Commun (2001) 1.49
Heterochromatin protein 1 modifies mammalian PEV in a dose- and chromosomal-context-dependent manner. Nat Genet (1999) 1.40
Centromere mitotic recombination in mammalian cells. J Cell Biol (2008) 1.35
Centromeres become unstuck without heterochromatin. Trends Cell Biol (2002) 1.29
Major chromatin remodeling in the germinal vesicle (GV) of mammalian oocytes is dispensable for global transcriptional silencing but required for centromeric heterochromatin function. Dev Biol (2004) 1.28
Meiotic events at the centromeric heterochromatin: histone H3 phosphorylation, topoisomerase II alpha localization and chromosome condensation. Chromosoma (1999) 1.28
Analysis of mammalian proteins involved in chromatin modification reveals new metaphase centromeric proteins and distinct chromosomal distribution patterns. Hum Mol Genet (2003) 1.25
Basonuclin: a novel mammalian maternal-effect gene. Development (2006) 1.18
Studying chromosome instability in the mouse. Biochim Biophys Acta (2008) 1.17
Transgenic RNAi in mouse oocytes: a simple and fast approach to study gene function. Dev Biol (2003) 1.14
Epidermal growth factor enhances preimplantation developmental competence of maturing mouse oocytes. Hum Reprod (1999) 1.11
Alterations of PLCbeta1 in mouse eggs change calcium oscillatory behavior following fertilization. Dev Biol (2007) 1.10
DNA methylation promotes Aurora-B-driven phosphorylation of histone H3 in chromosomal subdomains. J Cell Sci (2006) 1.08
Association of ATRX with pericentric heterochromatin and the Y chromosome of neonatal mouse spermatogonia. BMC Mol Biol (2008) 1.02
ATRX marks the inactive X chromosome (Xi) in somatic cells and during imprinted X chromosome inactivation in trophoblast stem cells. Chromosoma (2008) 1.01
Pluripotency deficit in clones overcome by clone-clone aggregation: epigenetic complementation? EMBO J (2003) 0.99
Evidence of a high proportion of premature unbalanced separation of sister chromatids in the first polar bodies of women of advanced age. Hum Reprod (2006) 0.96
Proper chromatin condensation and maintenance of histone H3 phosphorylation during mouse oocyte meiosis requires protein phosphatase activity. Biol Reprod (2006) 0.91
On the origin of lateral asymmetry. Chromosoma (1996) 0.90
Number of centromeric signals in micronuclei and mechanisms of aneuploidy. Toxicol Lett (2006) 0.89
Persistence of histone H2AX phosphorylation after meiotic chromosome synapsis and abnormal centromere cohesion in poly (ADP-ribose) polymerase (Parp-1) null oocytes. Dev Biol (2009) 0.84
Mouse genetic models for aneuploidy induction in germ cells. Cytogenet Genome Res (2005) 0.81
Emergency prevention of extinction of a transgenic allele in a less-fertile transgenic mouse line by crossing with an inbred or outbred mouse strain coupled with assisted reproductive technologies. Reprod Fertil Dev (2007) 0.77
Derivation of oocytes from mouse embryonic stem cells. Science (2003) 4.03
Intercellular communication in the mammalian ovary: oocytes carry the conversation. Science (2002) 3.40
Zygote arrest 1 (Zar1) is a novel maternal-effect gene critical for the oocyte-to-embryo transition. Nat Genet (2003) 2.09
Roles of NPM2 in chromatin and nucleolar organization in oocytes and embryos. Science (2003) 1.78
Mouse SYCP2 is required for synaptonemal complex assembly and chromosomal synapsis during male meiosis. J Cell Biol (2006) 1.60
ATRX, a member of the SNF2 family of helicase/ATPases, is required for chromosome alignment and meiotic spindle organization in metaphase II stage mouse oocytes. Dev Biol (2004) 1.60
Major chromatin remodeling in the germinal vesicle (GV) of mammalian oocytes is dispensable for global transcriptional silencing but required for centromeric heterochromatin function. Dev Biol (2004) 1.28
Identification of Gasz, an evolutionarily conserved gene expressed exclusively in germ cells and encoding a protein with four ankyrin repeats, a sterile-alpha motif, and a basic leucine zipper. Mol Endocrinol (2002) 1.27
The mouse meiotic mutation mei1 disrupts chromosome synapsis with sexually dimorphic consequences for meiotic progression. Dev Biol (2002) 1.24
Association of ATRX with pericentric heterochromatin and the Y chromosome of neonatal mouse spermatogonia. BMC Mol Biol (2008) 1.02
ATRX marks the inactive X chromosome (Xi) in somatic cells and during imprinted X chromosome inactivation in trophoblast stem cells. Chromosoma (2008) 1.01
NEDD1 is crucial for meiotic spindle stability and accurate chromosome segregation in mammalian oocytes. Dev Biol (2010) 0.95
Protein kinase C delta (PKCdelta) interacts with microtubule organizing center (MTOC)-associated proteins and participates in meiotic spindle organization. Dev Biol (2008) 0.93
Postweaning exposure to dietary zearalenone, a mycotoxin, promotes premature onset of puberty and disrupts early pregnancy events in female mice. Toxicol Sci (2013) 0.91
H1FOO is coupled to the initiation of oocytic growth. Biol Reprod (2004) 0.88
Role of ATRX in chromatin structure and function: implications for chromosome instability and human disease. Reproduction (2011) 0.86
Histone hyperacetylation during meiosis interferes with large-scale chromatin remodeling, axial chromatid condensation and sister chromatid separation in the mammalian oocyte. Int J Dev Biol (2012) 0.85
Persistence of histone H2AX phosphorylation after meiotic chromosome synapsis and abnormal centromere cohesion in poly (ADP-ribose) polymerase (Parp-1) null oocytes. Dev Biol (2009) 0.84
Depletion of pericentrin in mouse oocytes disrupts microtubule organizing center function and meiotic spindle organization. Mol Reprod Dev (2014) 0.81
Chromatin configuration and epigenetic landscape at the sex chromosome bivalent during equine spermatogenesis. Chromosoma (2011) 0.80
Chromatin structure and ATRX function in mouse oocytes. Results Probl Cell Differ (2012) 0.79
Lymphoid-specific helicase (HELLS) is essential for meiotic progression in mouse spermatocytes. Biol Reprod (2011) 0.79
Role of polycomb group protein cbx2/m33 in meiosis onset and maintenance of chromosome stability in the Mammalian germline. Genes (Basel) (2011) 0.75