Published in Genes Dev on July 01, 2015
Chromosome missegregation during anaphase triggers p53 cell cycle arrest through histone H3.3 Ser31 phosphorylation. Nat Cell Biol (2016) 0.86
Variants of core histones and their roles in cell fate decisions, development and cancer. Nat Rev Mol Cell Biol (2017) 0.84
Histone H3.3 promotes IgV gene diversification by enhancing formation of AID-accessible single-stranded DNA. EMBO J (2016) 0.80
Neuroblastoma: oncogenic mechanisms and therapeutic exploitation of necroptosis. Cell Death Dis (2015) 0.79
The tale of a tail: histone H4 acetylation and the repair of DNA breaks. Philos Trans R Soc Lond B Biol Sci (2017) 0.79
New players in heterochromatin silencing: histone variant H3.3 and the ATRX/DAXX chaperone. Nucleic Acids Res (2016) 0.78
Hide and seek: how chromatin-based pathways silence retroelements in the mammalian germline. Curr Opin Genet Dev (2016) 0.77
Polo-like Kinase 1 as a potential therapeutic target in Diffuse Intrinsic Pontine Glioma. BMC Cancer (2016) 0.77
Epigenome Maintenance in Response to DNA Damage. Mol Cell (2016) 0.76
The complexity of epigenetic diseases. J Pathol (2015) 0.76
Touch, act and go: landing and operating on nucleosomes. EMBO J (2016) 0.76
The Histone Variant H3.3 Is Enriched at Drosophila Amplicon Origins but Does Not Mark Them for Activation. G3 (Bethesda) (2016) 0.75
Therapeutic Targeting of Histone Modifications in Adult and Pediatric High-Grade Glioma. Front Oncol (2017) 0.75
RNase P protein subunit Rpp29 represses histone H3.3 nucleosome deposition. Mol Biol Cell (2016) 0.75
H3.3 demarcates GC-rich coding and subtelomeric regions and serves as potential memory mark for virulence gene expression in Plasmodium falciparum. Sci Rep (2016) 0.75
Comparison of genome-scale DNA methylation profiles in hepatocellular carcinoma by viral status. Epigenetics (2016) 0.75
Investigation of the human H3.3B (H3F3B) gene expression as a novel marker in patients with colorectal cancer. J Gastrointest Oncol (2017) 0.75
Fast gapped-read alignment with Bowtie 2. Nat Methods (2012) 83.79
TopHat: discovering splice junctions with RNA-Seq. Bioinformatics (2009) 81.13
edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics (2009) 67.17
BEDTools: a flexible suite of utilities for comparing genomic features. Bioinformatics (2010) 53.23
DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J Biol Chem (1998) 28.13
Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse. Dev Biol (2002) 13.87
Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma. Nature (2012) 10.99
Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis. Cell (2004) 10.16
Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer. Nat Genet (2001) 9.55
Distinct factors control histone variant H3.3 localization at specific genomic regions. Cell (2010) 8.79
The regulation of INK4/ARF in cancer and aging. Cell (2006) 8.75
FAIRE (Formaldehyde-Assisted Isolation of Regulatory Elements) isolates active regulatory elements from human chromatin. Genome Res (2006) 7.72
Widespread recombinase expression using FLPeR (flipper) mice. Genesis (2001) 7.08
Extraction, purification and analysis of histones. Nat Protoc (2007) 6.25
The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2. EMBO J (1998) 6.08
H3.3/H2A.Z double variant-containing nucleosomes mark 'nucleosome-free regions' of active promoters and other regulatory regions. Nat Genet (2009) 5.82
Nucleosome assembly by a complex of CAF-1 and acetylated histones H3/H4. Cell (1996) 5.77
Purification and characterization of CAF-I, a human cell factor required for chromatin assembly during DNA replication in vitro. Cell (1989) 5.02
Centromeric chromatin exhibits a histone modification pattern that is distinct from both euchromatin and heterochromatin. Nat Struct Mol Biol (2004) 4.95
Histone H3.3 is enriched in covalent modifications associated with active chromatin. Proc Natl Acad Sci U S A (2004) 4.88
Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres. Proc Natl Acad Sci U S A (2010) 4.73
Genome-wide kinetics of nucleosome turnover determined by metabolic labeling of histones. Science (2010) 4.72
ChIP-seq: using high-throughput sequencing to discover protein-DNA interactions. Methods (2009) 4.69
Altered telomeres in tumors with ATRX and DAXX mutations. Science (2011) 4.60
ATR-X syndrome protein targets tandem repeats and influences allele-specific expression in a size-dependent manner. Cell (2010) 4.34
Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application. Nat Rev Drug Discov (2010) 4.25
Nucleosome stability mediated by histone variants H3.3 and H2A.Z. Genes Dev (2007) 4.19
The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3. Genes Dev (2010) 4.00
High-efficiency FLP and PhiC31 site-specific recombination in mammalian cells. PLoS One (2007) 3.84
Epigenetic memory of an active gene state depends on histone H3.3 incorporation into chromatin in the absence of transcription. Nat Cell Biol (2007) 3.71
Efficient gene modulation in mouse epiblast using a Sox2Cre transgenic mouse strain. Mech Dev (2002) 3.49
Extensive and orderly reprogramming of genome-wide chromatin modifications associated with specification and early development of germ cells in mice. Dev Biol (2005) 2.94
Stem-loop binding protein, the protein that binds the 3' end of histone mRNA, is cell cycle regulated by both translational and posttranslational mechanisms. Mol Cell Biol (2000) 2.90
Histone modifications defining active genes persist after transcriptional and mitotic inactivation. EMBO J (2004) 2.86
Reverse genetic screening reveals poor correlation between morpholino-induced and mutant phenotypes in zebrafish. Dev Cell (2014) 2.85
CHD1 motor protein is required for deposition of histone variant H3.3 into chromatin in vivo. Science (2007) 2.71
Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway. PLoS Genet (2012) 2.63
The causes and consequences of polyploidy in normal development and cancer. Annu Rev Cell Dev Biol (2011) 2.54
Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone. Nat Genet (2013) 2.53
The histone H3K79 methyltransferase Dot1L is essential for mammalian development and heterochromatin structure. PLoS Genet (2008) 2.35
Variant histone H3.3 is deposited at sites of nucleosomal displacement throughout transcribed genes while active histone modifications show a promoter-proximal bias. Genes Dev (2005) 2.26
Transcription in the absence of histone H3.3. Curr Biol (2009) 2.24
Expression pattern of the Brachyury gene in whole-mount TWis/TWis mutant embryos. Development (1991) 2.09
p21WAF1 and tumourigenesis: 20 years after. Curr Opin Oncol (2013) 2.06
The double face of the histone variant H3.3. Cell Res (2011) 2.00
Gene trapping methods for the identification and functional analysis of cell surface proteins in mice. Methods Enzymol (2000) 1.96
New functions for an old variant: no substitute for histone H3.3. Curr Opin Genet Dev (2010) 1.93
Frequent recombination in telomeric DNA may extend the proliferative life of telomerase-negative cells. Nucleic Acids Res (2004) 1.89
Ionizing radiation and busulfan induce premature senescence in murine bone marrow hematopoietic cells. Cancer Res (2003) 1.86
Loss of ATRX leads to chromosome cohesion and congression defects. J Cell Biol (2008) 1.79
Marking histone H3 variants: how, when and why? Trends Biochem Sci (2007) 1.72
Loss of Atrx affects trophoblast development and the pattern of X-inactivation in extraembryonic tissues. PLoS Genet (2006) 1.64
Hira-dependent histone H3.3 deposition facilitates PRC2 recruitment at developmental loci in ES cells. Cell (2013) 1.64
Rapid induction of alternative lengthening of telomeres by depletion of the histone chaperone ASF1. Nat Struct Mol Biol (2014) 1.62
H3.3 is deposited at centromeres in S phase as a placeholder for newly assembled CENP-A in G₁ phase. Nucleus (2011) 1.57
p53-Dependent and -independent functions of the Arf tumor suppressor. Cold Spring Harb Symp Quant Biol (2005) 1.56
Significant role for p16INK4a in p53-independent telomere-directed senescence. Curr Biol (2004) 1.55
Linking abnormal mitosis to the acquisition of DNA damage. J Cell Biol (2012) 1.48
Transcription recovery after DNA damage requires chromatin priming by the H3.3 histone chaperone HIRA. Cell (2013) 1.45
Transcriptional and developmental functions of the H3.3 histone variant in Drosophila. Curr Biol (2009) 1.44
Histone H3.3 is required for endogenous retroviral element silencing in embryonic stem cells. Nature (2015) 1.32
p53: guardian of ploidy. Mol Oncol (2011) 1.25
A retroviral gene trap insertion into the histone 3.3A gene causes partial neonatal lethality, stunted growth, neuromuscular deficits and male sub-fertility in transgenic mice. Hum Mol Genet (1999) 1.23
Genetic activities in micronuclei: is the DNA entrapped in micronuclei lost for the cell? Mutat Res (2010) 1.20
H3.3 actively marks enhancers and primes gene transcription via opening higher-ordered chromatin. Genes Dev (2013) 1.14
A developmental requirement for HIRA-dependent H3.3 deposition revealed at gastrulation in Xenopus. Cell Rep (2012) 1.14
Histone variant H3.3 maintains a decondensed chromatin state essential for mouse preimplantation development. Development (2013) 1.14
Histone H3 trimethylation at lysine 36 is associated with constitutive and facultative heterochromatin. Genome Res (2011) 1.13
Chd2 interacts with H3.3 to determine myogenic cell fate. EMBO J (2012) 1.12
HIRA dependent H3.3 deposition is required for transcriptional reprogramming following nuclear transfer to Xenopus oocytes. Epigenetics Chromatin (2012) 1.11
Loss of maternal ATRX results in centromere instability and aneuploidy in the mammalian oocyte and pre-implantation embryo. PLoS Genet (2010) 1.10
Progressive telomere dysfunction causes cytokinesis failure and leads to the accumulation of polyploid cells. PLoS Genet (2012) 1.09
Nucleosome assembly is required for nuclear pore complex assembly in mouse zygotes. Nat Struct Mol Biol (2014) 1.08
Alternative Lengthening of Telomeres is characterized by reduced compaction of telomeric chromatin. Nucleic Acids Res (2014) 1.05
DNA damage associated with mitosis and cytokinesis failure. Oncogene (2013) 1.04
Hira-mediated H3.3 incorporation is required for DNA replication and ribosomal RNA transcription in the mouse zygote. Dev Cell (2014) 1.04
Endogenous mammalian histone H3.3 exhibits chromatin-related functions during development. Epigenetics Chromatin (2013) 1.00
Atrx deficiency induces telomere dysfunction, endocrine defects, and reduced life span. J Clin Invest (2013) 0.98
CO-FISH, COD-FISH, ReD-FISH, SKY-FISH. Methods Mol Biol (2011) 0.97
PUMA, a critical mediator of cell death--one decade on from its discovery. Cell Mol Biol Lett (2012) 0.96
Neuronal death resulting from targeted disruption of the Snf2 protein ATRX is mediated by p53. J Neurosci (2008) 0.96
Evolution of histone H3: emergence of variants and conservation of post-translational modification sites. Biochem Cell Biol (2011) 0.95
Histone variant H3.3 is an essential maternal factor for oocyte reprogramming. Proc Natl Acad Sci U S A (2014) 0.94
Transcription in the absence of histone H3.2 and H3K4 methylation. Curr Biol (2012) 0.94
Contribution of the two genes encoding histone variant h3.3 to viability and fertility in mice. PLoS Genet (2015) 0.93
An essential role of variant histone H3.3 for ectomesenchyme potential of the cranial neural crest. PLoS Genet (2012) 0.93
Use of LysoTracker to detect programmed cell death in embryos and differentiating embryonic stem cells. J Vis Exp (2012) 0.90
Conditional allelic replacement applied to genes encoding the histone variant H3.3 in the mouse. Genesis (2013) 0.85
Dissecting the role of H3K64me3 in mouse pericentromeric heterochromatin. Nat Commun (2013) 0.83
Histone H3.3 regulates dynamic chromatin states during spermatogenesis. Development (2014) 0.83
Optimal histone H3 to linker histone H1 chromatin ratio is vital for mesodermal competence in Xenopus. Development (2013) 0.81
The ARF tumor suppressor prevents chromosomal instability and ensures mitotic checkpoint fidelity through regulation of Aurora B. Mol Biol Cell (2014) 0.79
TRF1 and TRF2 binding to telomeres is modulated by nucleosomal organization. Nucleic Acids Res (2015) 0.77