ATRX marks the inactive X chromosome (Xi) in somatic cells and during imprinted X chromosome inactivation in trophoblast stem cells.

PubWeight™: 1.01‹?› | Rank: Top 15%

🔗 View Article (PMC 2877807)

Published in Chromosoma on November 13, 2008

Authors

Claudia Baumann1, Rabindranath De La Fuente

Author Affiliations

1: Department of Clinical Studies, Center for Animal Transgenesis and Germ Cell Research, University of Pennsylvania, New Bolton Center, Kennett Square, PA, 19348, USA.

Articles citing this

Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres. Proc Natl Acad Sci U S A (2010) 4.73

Dynamic changes in paternal X-chromosome activity during imprinted X-chromosome inactivation in mice. Proc Natl Acad Sci U S A (2009) 1.56

Histone variants in metazoan development. Dev Cell (2010) 1.42

ATRX directs binding of PRC2 to Xist RNA and Polycomb targets. Cell (2014) 1.38

New and Xisting regulatory mechanisms of X chromosome inactivation. Curr Opin Genet Dev (2012) 1.23

Evolutionary diversity and developmental regulation of X-chromosome inactivation. Hum Genet (2011) 1.20

Loss of maternal ATRX results in centromere instability and aneuploidy in the mammalian oocyte and pre-implantation embryo. PLoS Genet (2010) 1.10

The demoiselle of X-inactivation: 50 years old and as trendy and mesmerising as ever. PLoS Genet (2011) 1.08

Advances in understanding chromosome silencing by the long non-coding RNA Xist. Philos Trans R Soc Lond B Biol Sci (2013) 1.04

ATRX: the case of a peculiar chromatin remodeler. Epigenetics (2012) 1.03

Lessons from comparative analysis of X-chromosome inactivation in mammals. Chromosome Res (2009) 1.03

Role of ATRX in chromatin structure and function: implications for chromosome instability and human disease. Reproduction (2011) 0.86

XCI in preimplantation mouse and human embryos: first there is remodelling…. Hum Genet (2011) 0.85

Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2. Nat Commun (2016) 0.78

The histone variant H3.3 claims its place in the crowded scene of epigenetics. Aging (Albany NY) (2017) 0.75

Articles cited by this

Gene action in the X-chromosome of the mouse (Mus musculus L.). Nature (1961) 23.98

Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. Nature (2001) 19.67

Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain. Nature (2001) 19.54

Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites. Cell (2002) 12.28

Role of histone H3 lysine 27 methylation in X inactivation. Science (2003) 9.85

Requirement for Xist in X chromosome inactivation. Nature (1996) 8.24

Promotion of trophoblast stem cell proliferation by FGF4. Science (1998) 8.02

Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains. Genes Dev (2003) 7.91

Establishment of histone h3 methylation on the inactive X chromosome requires transient recruitment of Eed-Enx1 polycomb group complexes. Dev Cell (2003) 7.11

Epigenetic dynamics of imprinted X inactivation during early mouse development. Science (2003) 5.80

Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivation. Dev Cell (2004) 5.72

XIST RNA paints the inactive X chromosome at interphase: evidence for a novel RNA involved in nuclear/chromosome structure. J Cell Biol (1996) 5.51

A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors. EMBO J (1996) 4.65

A shift from reversible to irreversible X inactivation is triggered during ES cell differentiation. Mol Cell (2000) 4.26

A chromosomal memory triggered by Xist regulates histone methylation in X inactivation. PLoS Biol (2004) 4.23

Methylation of histone H3 at Lys-9 is an early mark on the X chromosome during X inactivation. Cell (2001) 4.21

Dosage compensation in mammals: fine-tuning the expression of the X chromosome. Genes Dev (2006) 4.17

Histone macroH2A1 is concentrated in the inactive X chromosome of female mammals. Nature (1998) 3.93

Preferential inactivation of the paternally derived X chromosome in the extraembryonic membranes of the mouse. Nature (1975) 3.75

Replication timing and transcriptional control: beyond cause and effect. Curr Opin Cell Biol (2002) 3.68

Differentially methylated forms of histone H3 show unique association patterns with inactive human X chromosomes. Nat Genet (2001) 3.63

Reactivation of the paternal X chromosome in early mouse embryos. Science (2004) 3.59

Histone H3 lysine 9 methylation is an epigenetic imprint of facultative heterochromatin. Nat Genet (2001) 3.46

Mutations in ATRX, encoding a SWI/SNF-like protein, cause diverse changes in the pattern of DNA methylation. Nat Genet (2000) 3.24

Mutations in a putative global transcriptional regulator cause X-linked mental retardation with alpha-thalassemia (ATR-X syndrome). Cell (1995) 3.09

Synergism of Xist RNA, DNA methylation, and histone hypoacetylation in maintaining X chromosome inactivation. J Cell Biol (2001) 2.94

Time-sequence of human chromosome duplication. Nature (1962) 2.79

Mitotically stable association of polycomb group proteins eed and enx1 with the inactive x chromosome in trophoblast stem cells. Curr Biol (2002) 2.64

Imprinted X inactivation maintained by a mouse Polycomb group gene. Nat Genet (2001) 2.63

Conditional deletion of Xist disrupts histone macroH2A localization but not maintenance of X inactivation. Nat Genet (1999) 2.62

Evidence for de novo imprinted X-chromosome inactivation independent of meiotic inactivation in mice. Nature (2005) 2.46

Differential histone H3 Lys-9 and Lys-27 methylation profiles on the X chromosome. Mol Cell Biol (2004) 2.43

Derivation of embryonic stem cell lines. Methods Enzymol (1993) 2.41

Global hypomethylation of the genome in XX embryonic stem cells. Nat Genet (2005) 2.35

The human X-inactivation centre is not required for maintenance of X-chromosome inactivation. Nature (1994) 2.32

Localization of a putative transcriptional regulator (ATRX) at pericentromeric heterochromatin and the short arms of acrocentric chromosomes. Proc Natl Acad Sci U S A (1999) 2.24

Ring1b-mediated H2A ubiquitination associates with inactive X chromosomes and is involved in initiation of X inactivation. J Biol Chem (2004) 2.15

The Polycomb group protein EED is dispensable for the initiation of random X-chromosome inactivation. PLoS Genet (2006) 2.08

The Polycomb group protein Eed protects the inactive X-chromosome from differentiation-induced reactivation. Nat Cell Biol (2006) 1.97

Mutations in transcriptional regulator ATRX establish the functional significance of a PHD-like domain. Nat Genet (1997) 1.88

Establishment of transcriptional competence in early and late S phase. Nature (2002) 1.81

Loss of ATRX leads to chromosome cohesion and congression defects. J Cell Biol (2008) 1.79

Histone macroH2A1 is concentrated in the inactive X chromosome of female preimplantation mouse embryos. Development (2000) 1.66

Loss of Atrx affects trophoblast development and the pattern of X-inactivation in extraembryonic tissues. PLoS Genet (2006) 1.64

Histone macroH2A1.2 relocates to the inactive X chromosome after initiation and propagation of X-inactivation. J Cell Biol (1999) 1.64

ATRX, a member of the SNF2 family of helicase/ATPases, is required for chromosome alignment and meiotic spindle organization in metaphase II stage mouse oocytes. Dev Biol (2004) 1.60

Cell cycle-dependent phosphorylation of the ATRX protein correlates with changes in nuclear matrix and chromatin association. Hum Mol Genet (2000) 1.59

Developmentally regulated alterations in Polycomb repressive complex 1 proteins on the inactive X chromosome. J Cell Biol (2004) 1.57

Regional and temporal changes in the pattern of X-chromosome replication during the early post-implantation development of the female mouse. Chromosoma (1982) 1.57

Xist and the order of silencing. EMBO Rep (2007) 1.55

Poly(ADP-ribose) polymerase 1 is inhibited by a histone H2A variant, MacroH2A, and contributes to silencing of the inactive X chromosome. J Biol Chem (2007) 1.53

X-chromosome inactivation: a hypothesis linking ontogeny and phylogeny. Nat Rev Genet (2005) 1.52

Specific interaction between the XNP/ATR-X gene product and the SET domain of the human EZH2 protein. Hum Mol Genet (1998) 1.42

Integrated kinetics of X chromosome inactivation in differentiating embryonic stem cells. Cytogenet Genome Res (2002) 1.42

Quantitative colocalization analysis of confocal fluorescence microscopy images. Curr Protoc Cell Biol (2008) 1.41

X-chromosome inactivation: closing in on proteins that bind Xist RNA. Trends Genet (2002) 1.40

Histone H3 lysine 9 methylation occurs rapidly at the onset of random X chromosome inactivation. Curr Biol (2002) 1.36

Chromatin of the Barr body: histone and non-histone proteins associated with or excluded from the inactive X chromosome. Hum Mol Genet (2003) 1.28

RNA and protein actors in X-chromosome inactivation. Cold Spring Harb Symp Quant Biol (2006) 1.26

Xist function: bridging chromatin and stem cells. Trends Genet (2007) 1.22

Epigenetic landscape required for placental development. Cell Mol Life Sci (2007) 1.13

Promoter-specific hypoacetylation of X-inactivated genes. Proc Natl Acad Sci U S A (1999) 1.13

Epigenetic regulation of mammalian pericentric heterochromatin in vivo by HP1. Biochem Biophys Res Commun (2005) 1.10

Analysis of DNA replication during S-phase by means of dynamic chromosome banding at high resolution. Chromosoma (1990) 1.04

Association of ATRX with pericentric heterochromatin and the Y chromosome of neonatal mouse spermatogonia. BMC Mol Biol (2008) 1.02

Forming facultative heterochromatin: silencing of an X chromosome in mammalian females. Cell Mol Life Sci (2003) 0.99

Abnormal X: autosome ratio, but normal X chromosome inactivation in human triploid cultures. BMC Genet (2006) 0.94

Correlation between X-chromosome inactivation and cell differentiation in female preimplantation mouse embryos. Cytogenet Cell Genet (1985) 0.87

Articles by these authors

Derivation of oocytes from mouse embryonic stem cells. Science (2003) 4.03

Mouse SYCP2 is required for synaptonemal complex assembly and chromosomal synapsis during male meiosis. J Cell Biol (2006) 1.60

The mouse meiotic mutation mei1 disrupts chromosome synapsis with sexually dimorphic consequences for meiotic progression. Dev Biol (2002) 1.24

Loss of maternal ATRX results in centromere instability and aneuploidy in the mammalian oocyte and pre-implantation embryo. PLoS Genet (2010) 1.10

Association of ATRX with pericentric heterochromatin and the Y chromosome of neonatal mouse spermatogonia. BMC Mol Biol (2008) 1.02

H1FOO is coupled to the initiation of oocytic growth. Biol Reprod (2004) 0.88

Histone hyperacetylation during meiosis interferes with large-scale chromatin remodeling, axial chromatid condensation and sister chromatid separation in the mammalian oocyte. Int J Dev Biol (2012) 0.85

Persistence of histone H2AX phosphorylation after meiotic chromosome synapsis and abnormal centromere cohesion in poly (ADP-ribose) polymerase (Parp-1) null oocytes. Dev Biol (2009) 0.84

Chromatin configuration and epigenetic landscape at the sex chromosome bivalent during equine spermatogenesis. Chromosoma (2011) 0.80

Lymphoid-specific helicase (HELLS) is essential for meiotic progression in mouse spermatocytes. Biol Reprod (2011) 0.79

Role of polycomb group protein cbx2/m33 in meiosis onset and maintenance of chromosome stability in the Mammalian germline. Genes (Basel) (2011) 0.75