Published in J Am Soc Nephrol on October 07, 2010
A SPAK isoform switch modulates renal salt transport and blood pressure. Cell Metab (2011) 1.79
Perspective of future drugs targeting sterile 20/SPS1-related proline/alanine-rich kinase for blood pressure control. World J Cardiol (2015) 0.75
Ablation of Potassium-Chloride Cotransporter Type 3 (Kcc3) in Mouse Causes Multiple Cardiovascular Defects and Isosmotic Polyuria. PLoS One (2016) 0.75
SPAK-knockout mice manifest Gitelman syndrome and impaired vasoconstriction. J Am Soc Nephrol (2010) 2.73
Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1. Proc Natl Acad Sci U S A (2008) 2.62
High-resolution analysis of ethanol-induced locomotor stimulation in Drosophila. J Neurosci (2002) 2.58
Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms. Proc Natl Acad Sci U S A (2006) 1.93
DGKE variants cause a glomerular microangiopathy that mimics membranoproliferative GN. J Am Soc Nephrol (2012) 1.93
WNK1 activates SGK1 to regulate the epithelial sodium channel. Proc Natl Acad Sci U S A (2005) 1.76
Regulation of renal outer medullary potassium channel and renal K(+) excretion by Klotho. Mol Pharmacol (2009) 1.75
Intersectin links WNK kinases to endocytosis of ROMK1. J Clin Invest (2007) 1.67
Uromodulin upregulates TRPV5 by impairing caveolin-mediated endocytosis. Kidney Int (2013) 1.44
Evidence for endocytosis of ROMK potassium channel via clathrin-coated vesicles. Am J Physiol Renal Physiol (2002) 1.39
Insulin signaling in the nervous system regulates ethanol intoxication in Drosophila melanogaster. Nat Neurosci (2004) 1.38
WNK1 activates SGK1 by a phosphatidylinositol 3-kinase-dependent and non-catalytic mechanism. J Biol Chem (2005) 1.37
PIP2 activates TRPV5 and releases its inhibition by intracellular Mg2+. J Gen Physiol (2005) 1.35
Conformational changes of pore helix coupled to gating of TRPV5 by protons. EMBO J (2005) 1.31
Mechanism and molecular determinant for regulation of rabbit transient receptor potential type 5 (TRPV5) channel by extracellular pH. J Biol Chem (2003) 1.27
Protein kinase C inhibits caveolae-mediated endocytosis of TRPV5. Am J Physiol Renal Physiol (2008) 1.27
Cardioprotection by Klotho through downregulation of TRPC6 channels in the mouse heart. Nat Commun (2012) 1.25
IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway. J Clin Invest (2011) 1.18
Regulation of ROMK channel and K+ homeostasis by kidney-specific WNK1 kinase. J Biol Chem (2009) 1.17
Protein kinase C inhibits ROMK1 channel activity via a phosphatidylinositol 4,5-bisphosphate-dependent mechanism. J Biol Chem (2003) 1.14
Dietary potassium restriction stimulates endocytosis of ROMK channel in rat cortical collecting duct. Am J Physiol Renal Physiol (2003) 1.14
Endothelial-specific expression of WNK1 kinase is essential for angiogenesis and heart development in mice. Am J Pathol (2009) 1.12
Role of with-no-lysine [K] kinases in the pathogenesis of Gordon's syndrome. Pediatr Nephrol (2006) 1.11
Association of urinary sodium/potassium ratio with blood pressure: sex and racial differences. Clin J Am Soc Nephrol (2011) 1.06
Activation of PI3-kinase stimulates endocytosis of ROMK via Akt1/SGK1-dependent phosphorylation of WNK1. J Am Soc Nephrol (2011) 1.05
Structural determinants and specificities for ROMK1-phosphoinositide interaction. Am J Physiol Renal Physiol (2002) 1.02
Identification and functional characterization of Kir2.6 mutations associated with non-familial hypokalemic periodic paralysis. J Biol Chem (2011) 1.00
Calcium-sensing receptor decreases cell surface expression of the inwardly rectifying K+ channel Kir4.1. J Biol Chem (2010) 0.99
Serum and glucocorticoid-induced kinase (SGK) 1 and the epithelial sodium channel are regulated by multiple with no lysine (WNK) family members. J Biol Chem (2010) 0.99
Downregulation of NCC and NKCC2 cotransporters by kidney-specific WNK1 revealed by gene disruption and transgenic mouse models. Hum Mol Genet (2010) 0.98
The N-terminal extracellular domain is required for polycystin-1-dependent channel activity. J Biol Chem (2004) 0.93
Distal potassium handling based on flow modulation of maxi-K channel activity. Curr Opin Nephrol Hypertens (2009) 0.93
Domains of WNK1 kinase in the regulation of ROMK1. Am J Physiol Renal Physiol (2008) 0.92
Mechanism of thyrotoxic periodic paralysis. J Am Soc Nephrol (2012) 0.89
WNK1 promotes PIP₂ synthesis to coordinate growth factor and GPCR-Gq signaling. Curr Biol (2011) 0.88
Recent advances in distal tubular potassium handling. Am J Physiol Renal Physiol (2011) 0.87
WNK4 kinase stimulates caveola-mediated endocytosis of TRPV5 amplifying the dynamic range of regulation of the channel by protein kinase C. J Biol Chem (2010) 0.86
Kidney-specific WNK1 inhibits sodium reabsorption in the cortical thick ascending limb. Am J Physiol Renal Physiol (2012) 0.86
Adult neuronal Arf6 controls ethanol-induced behavior with Arfaptin downstream of Rac1 and RhoGAP18B. J Neurosci (2012) 0.86
WNK1 protein kinase regulates embryonic cardiovascular development through the OSR1 signaling cascade. J Biol Chem (2013) 0.85
The Drosophila NKCC Ncc69 is required for normal renal tubule function. Am J Physiol Cell Physiol (2012) 0.85
The mechanism of hypocalciuria with NaCl cotransporter inhibition. Nat Rev Nephrol (2011) 0.83
Long-lasting, experience-dependent alcohol preference in Drosophila. Addict Biol (2013) 0.83
Mechanism of urinary calcium regulation by urinary magnesium and pH. J Am Soc Nephrol (2008) 0.82
Extracellular potassium homeostasis: insights from hypokalemic periodic paralysis. Semin Nephrol (2013) 0.82
Hemodialysis catheter insertion: is increased PO2 a sign of arterial cannulation? A case report. BMC Nephrol (2014) 0.81
Kidney-specific WNK1 regulates sodium reabsorption and potassium secretion in mouse cortical collecting duct. Am J Physiol Renal Physiol (2012) 0.81
Flow-induced activation of TRPV5 and TRPV6 channels stimulates Ca(2+)-activated K(+) channel causing membrane hyperpolarization. Biochim Biophys Acta (2013) 0.80
Regulation of TRPV5 single-channel activity by intracellular pH. J Membr Biol (2007) 0.80
On the role of pore helix in regulation of TRPV5 by extracellular protons. J Membr Biol (2007) 0.80
Inhibition of ROMK potassium channel by syntaxin 1A. Am J Physiol Renal Physiol (2004) 0.79
Inward-rectifying potassium channelopathies: new insights into disorders of sodium and potassium homeostasis. Pediatr Nephrol (2014) 0.77
Novel KCNJ5 mutations in sporadic aldosterone-producing adenoma reduce Kir3.4 membrane abundance. J Clin Endocrinol Metab (2015) 0.75
Corrigendum: WNK1 kinase balances T cell adhesion versus migration in vivo. Nat Immunol (2017) 0.75
Acquired hypocalciuric hypercalcemia in a patient with CKD. Am J Kidney Dis (2013) 0.75