Published in J Clin Invest on March 22, 2007
A comprehensive guide to the ROMK potassium channel: form and function in health and disease. Am J Physiol Renal Physiol (2009) 2.51
The WNKs: atypical protein kinases with pleiotropic actions. Physiol Rev (2011) 1.88
Regulation of renal outer medullary potassium channel and renal K(+) excretion by Klotho. Mol Pharmacol (2009) 1.75
Molecular mechanism of pancreatic and salivary gland fluid and HCO3 secretion. Physiol Rev (2012) 1.71
The thiazide-sensitive Na+-Cl- cotransporter: molecular biology, functional properties, and regulation by WNKs. Am J Physiol Renal Physiol (2009) 1.58
WNK4 diverts the thiazide-sensitive NaCl cotransporter to the lysosome and stimulates AP-3 interaction. J Biol Chem (2009) 1.44
Regulation of potassium (K) handling in the renal collecting duct. Pflugers Arch (2008) 1.39
SLC26A9 is a Cl(-) channel regulated by the WNK kinases. J Physiol (2007) 1.33
Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia. Neuropsychopharmacology (2010) 1.19
IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway. J Clin Invest (2011) 1.18
Regulation of ROMK channel and K+ homeostasis by kidney-specific WNK1 kinase. J Biol Chem (2009) 1.17
Regulation of transport in the connecting tubule and cortical collecting duct. Compr Physiol (2012) 1.16
The ARH adaptor protein regulates endocytosis of the ROMK potassium secretory channel in mouse kidney. J Clin Invest (2009) 1.13
Endothelial-specific expression of WNK1 kinase is essential for angiogenesis and heart development in mice. Am J Pathol (2009) 1.12
Irbit mediates synergy between ca(2+) and cAMP signaling pathways during epithelial transport in mice. Gastroenterology (2013) 1.10
Activation of PI3-kinase stimulates endocytosis of ROMK via Akt1/SGK1-dependent phosphorylation of WNK1. J Am Soc Nephrol (2011) 1.05
Intersecting pathways in cell biology. Sci Signal (2010) 1.01
Calcium-sensing receptor decreases cell surface expression of the inwardly rectifying K+ channel Kir4.1. J Biol Chem (2010) 0.99
Src family protein tyrosine kinase (PTK) modulates the effect of SGK1 and WNK4 on ROMK channels. Proc Natl Acad Sci U S A (2009) 0.99
Downregulation of NCC and NKCC2 cotransporters by kidney-specific WNK1 revealed by gene disruption and transgenic mouse models. Hum Mol Genet (2010) 0.98
FGF23 promotes renal calcium reabsorption through the TRPV5 channel. EMBO J (2014) 0.97
WNK3 positively regulates epithelial calcium channels TRPV5 and TRPV6 via a kinase-dependent pathway. Am J Physiol Renal Physiol (2008) 0.95
MicroRNA 802 stimulates ROMK channels by suppressing caveolin-1. J Am Soc Nephrol (2011) 0.95
Caveolin-1 directly interacts with UT-A1 urea transporter: the role of caveolae/lipid rafts in UT-A1 regulation at the cell membrane. Am J Physiol Renal Physiol (2009) 0.94
The WNK/SPAK and IRBIT/PP1 pathways in epithelial fluid and electrolyte transport. Physiology (Bethesda) (2012) 0.94
Distal potassium handling based on flow modulation of maxi-K channel activity. Curr Opin Nephrol Hypertens (2009) 0.93
Protein phosphatase 1 modulates the inhibitory effect of With-no-Lysine kinase 4 on ROMK channels. Am J Physiol Renal Physiol (2012) 0.93
Domains of WNK1 kinase in the regulation of ROMK1. Am J Physiol Renal Physiol (2008) 0.92
WNK kinases, renal ion transport and hypertension. Am J Nephrol (2008) 0.91
POSH stimulates the ubiquitination and the clathrin-independent endocytosis of ROMK1 channels. J Biol Chem (2009) 0.91
Pathophysiological roles of WNK kinases in the kidney. Pflugers Arch (2010) 0.89
WNK1 promotes PIP₂ synthesis to coordinate growth factor and GPCR-Gq signaling. Curr Biol (2011) 0.88
Serine-threonine kinase with-no-lysine 4 (WNK4) controls blood pressure via transient receptor potential canonical 3 (TRPC3) in the vasculature. Proc Natl Acad Sci U S A (2011) 0.87
Recent advances in distal tubular potassium handling. Am J Physiol Renal Physiol (2011) 0.87
Kidney-specific WNK1 inhibits sodium reabsorption in the cortical thick ascending limb. Am J Physiol Renal Physiol (2012) 0.86
WNK4 kinase stimulates caveola-mediated endocytosis of TRPV5 amplifying the dynamic range of regulation of the channel by protein kinase C. J Biol Chem (2010) 0.86
Sorting it out in endosomes: an emerging concept in renal epithelial cell transport regulation. Physiology (Bethesda) (2010) 0.85
WNK1 protein kinase regulates embryonic cardiovascular development through the OSR1 signaling cascade. J Biol Chem (2013) 0.85
WNK4 inhibition of ENaC is independent of Nedd4-2-mediated ENaC ubiquitination. Am J Physiol Renal Physiol (2013) 0.84
Regulation and function of potassium channels in aldosterone-sensitive distal nephron. Curr Opin Nephrol Hypertens (2010) 0.83
Actions of the protein kinase WNK1 on endothelial cells are differentially mediated by its substrate kinases OSR1 and SPAK. Proc Natl Acad Sci U S A (2014) 0.82
A new dimension to Ras function: a novel role for nucleotide-free Ras in Class II phosphatidylinositol 3-kinase beta (PI3KC2β) regulation. PLoS One (2012) 0.82
Interactions with WNK (with no lysine) family members regulate oxidative stress response 1 and ion co-transporter activity. J Biol Chem (2012) 0.82
Src-family protein tyrosine kinase phosphorylates WNK4 and modulates its inhibitory effect on KCNJ1 (ROMK). Proc Natl Acad Sci U S A (2015) 0.81
Antagonistic regulation of cystic fibrosis transmembrane conductance regulator cell surface expression by protein kinases WNK4 and spleen tyrosine kinase. Mol Cell Biol (2011) 0.80
Flow-induced activation of TRPV5 and TRPV6 channels stimulates Ca(2+)-activated K(+) channel causing membrane hyperpolarization. Biochim Biophys Acta (2013) 0.80
An unexpected journey: conceptual evolution of mechanoregulated potassium transport in the distal nephron. Am J Physiol Cell Physiol (2015) 0.79
MicroRNA-194 (miR-194) regulates ROMK channel activity by targeting intersectin 1. Am J Physiol Renal Physiol (2013) 0.79
The Role of MicroRNAs in the Regulation of K(+) Channels in Epithelial Tissue. Front Physiol (2015) 0.77
Decrease in dietary K intake stimulates the generation of superoxide anions in the kidney and inhibits K secretory channels in the CCD. Am J Physiol Renal Physiol (2010) 0.77
Regulatory Crosstalk by Protein Kinases on CFTR Trafficking and Activity. Front Chem (2016) 0.77
Protein kinase WNK1 promotes cell surface expression of glucose transporter GLUT1 by regulating a Tre-2/USP6-BUB2-Cdc16 domain family member 4 (TBC1D4)-Rab8A complex. J Biol Chem (2010) 0.77
Regulators of Slc4 bicarbonate transporter activity. Front Physiol (2015) 0.77
Intersectin scaffold proteins and their role in cell signaling and endocytosis. Biochim Biophys Acta (2016) 0.76
Hypertension: the missing WNKs. Am J Physiol Renal Physiol (2016) 0.76
WNK signalling pathways in blood pressure regulation. Cell Mol Life Sci (2016) 0.75
With no lysine L-WNK1 isoforms are negative regulators of the K+-Cl- cotransporters. Am J Physiol Cell Physiol (2016) 0.75
Urinary Exosomes Contain MicroRNAs Capable of Paracrine Modulation of Tubular Transporters in Kidney. Sci Rep (2017) 0.75
ENaC and ROMK activity are inhibited in the DCT2/CNT of TgWnk4(PHAII) mice. Am J Physiol Renal Physiol (2016) 0.75
Cell-specific regulation of L-WNK1 by dietary K. Am J Physiol Renal Physiol (2015) 0.75
Multistep regulation of autophagy by WNK1. Proc Natl Acad Sci U S A (2016) 0.75
The role of renal transporters and novel regulatory interactions in the TAL that control blood pressure. Physiol Genomics (2017) 0.75
Human hypertension caused by mutations in WNK kinases. Science (2001) 8.71
Primary structure and functional expression of a mouse inward rectifier potassium channel. Nature (1993) 8.20
Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by Gbetagamma. Nature (1998) 6.32
The importance of being proline: the interaction of proline-rich motifs in signaling proteins with their cognate domains. FASEB J (2000) 6.26
Genome-wide analysis of human kinases in clathrin- and caveolae/raft-mediated endocytosis. Nature (2005) 5.30
Aquaporins in the kidney: from molecules to medicine. Physiol Rev (2002) 5.14
WNK4 regulates the balance between renal NaCl reabsorption and K+ secretion. Nat Genet (2003) 4.08
WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II. J Biol Chem (2000) 3.97
WNK kinases regulate thiazide-sensitive Na-Cl cotransport. J Clin Invest (2003) 3.67
The structural era of endocytosis. Science (1999) 3.53
The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases. Biochem J (2005) 3.52
Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4. Proc Natl Acad Sci U S A (2003) 3.48
WNK kinases, a novel protein kinase subfamily in multi-cellular organisms. Oncogene (2001) 2.48
SH3-domain-containing proteins function at distinct steps in clathrin-coated vesicle formation. Nat Cell Biol (1999) 2.48
Dap160/intersectin acts as a stabilizing scaffold required for synaptic development and vesicle endocytosis. Neuron (2004) 2.47
Dap160/intersectin scaffolds the periactive zone to achieve high-fidelity endocytosis and normal synaptic growth. Neuron (2004) 2.36
Regulation of WNK1 by an autoinhibitory domain and autophosphorylation. J Biol Chem (2002) 2.16
Intersectin, a novel adaptor protein with two Eps15 homology and five Src homology 3 domains. J Biol Chem (1998) 2.13
Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins. Proc Natl Acad Sci U S A (2004) 2.10
Dap160, a neural-specific Eps15 homology and multiple SH3 domain-containing protein that interacts with Drosophila dynamin. J Biol Chem (1998) 2.04
Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms. Proc Natl Acad Sci U S A (2006) 1.93
WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cells. Proc Natl Acad Sci U S A (2006) 1.90
Crystal structure of the kinase domain of WNK1, a kinase that causes a hereditary form of hypertension. Structure (2004) 1.82
The EH and SH3 domain Ese proteins regulate endocytosis by linking to dynamin and Eps15. EMBO J (1999) 1.82
WNK1 activates SGK1 to regulate the epithelial sodium channel. Proc Natl Acad Sci U S A (2005) 1.76
Multiple promoters in the WNK1 gene: one controls expression of a kidney-specific kinase-defective isoform. Mol Cell Biol (2003) 1.76
WNK1, a gene within a novel blood pressure control pathway, tissue-specifically generates radically different isoforms with and without a kinase domain. J Am Soc Nephrol (2003) 1.68
Paracellular Cl- permeability is regulated by WNK4 kinase: insight into normal physiology and hypertension. Proc Natl Acad Sci U S A (2004) 1.68
WNK1 kinase isoform switch regulates renal potassium excretion. Proc Natl Acad Sci U S A (2006) 1.65
Effect of dietary K intake on apical small-conductance K channel in CCD: role of protein tyrosine kinase. Am J Physiol Renal Physiol (2001) 1.64
EHSH1/intersectin, a protein that contains EH and SH3 domains and binds to dynamin and SNAP-25. A protein connection between exocytosis and endocytosis? J Biol Chem (1999) 1.53
Syndrome of hypertension and hyperkalemia with normal glomerular filtration rate. Hypertension (1986) 1.45
Evidence for endocytosis of ROMK potassium channel via clathrin-coated vesicles. Am J Physiol Renal Physiol (2002) 1.39
WNK1 activates SGK1 by a phosphatidylinositol 3-kinase-dependent and non-catalytic mechanism. J Biol Chem (2005) 1.37
WNK1 phosphorylates synaptotagmin 2 and modulates its membrane binding. Mol Cell (2004) 1.35
Sodium and calcium transport pathways along the mammalian distal nephron: from rabbit to human. Am J Physiol Renal Physiol (2003) 1.29
WNK1 affects surface expression of the ROMK potassium channel independent of WNK4. J Am Soc Nephrol (2006) 1.27
Dietary potassium restriction stimulates endocytosis of ROMK channel in rat cortical collecting duct. Am J Physiol Renal Physiol (2003) 1.14
Protein kinase C inhibits ROMK1 channel activity via a phosphatidylinositol 4,5-bisphosphate-dependent mechanism. J Biol Chem (2003) 1.14
Intersectin 2, a new multimodular protein involved in clathrin-mediated endocytosis. FEBS Lett (2000) 1.12
The human intersectin genes and their spliced variants are differentially expressed. Biochim Biophys Acta (2001) 1.06
Snap-shots of clathrin-mediated endocytosis. Trends Biochem Sci (2002) 0.94
Renal tubule potassium channels: function, regulation and structure. Acta Physiol Scand (2000) 0.88
Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1. Proc Natl Acad Sci U S A (2008) 2.62
Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms. Proc Natl Acad Sci U S A (2006) 1.93
DGKE variants cause a glomerular microangiopathy that mimics membranoproliferative GN. J Am Soc Nephrol (2012) 1.93
WNK1 activates SGK1 to regulate the epithelial sodium channel. Proc Natl Acad Sci U S A (2005) 1.76
Regulation of renal outer medullary potassium channel and renal K(+) excretion by Klotho. Mol Pharmacol (2009) 1.75
Uromodulin upregulates TRPV5 by impairing caveolin-mediated endocytosis. Kidney Int (2013) 1.44
Long noncoding RNA HOTAIR is a prognostic marker for esophageal squamous cell carcinoma progression and survival. PLoS One (2013) 1.44
Evidence for endocytosis of ROMK potassium channel via clathrin-coated vesicles. Am J Physiol Renal Physiol (2002) 1.39
WNK1 activates SGK1 by a phosphatidylinositol 3-kinase-dependent and non-catalytic mechanism. J Biol Chem (2005) 1.37
PIP2 activates TRPV5 and releases its inhibition by intracellular Mg2+. J Gen Physiol (2005) 1.35
Conformational changes of pore helix coupled to gating of TRPV5 by protons. EMBO J (2005) 1.31
Mechanism and molecular determinant for regulation of rabbit transient receptor potential type 5 (TRPV5) channel by extracellular pH. J Biol Chem (2003) 1.27
Protein kinase C inhibits caveolae-mediated endocytosis of TRPV5. Am J Physiol Renal Physiol (2008) 1.27
Cardioprotection by Klotho through downregulation of TRPC6 channels in the mouse heart. Nat Commun (2012) 1.25
IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway. J Clin Invest (2011) 1.18
Regulation of ROMK channel and K+ homeostasis by kidney-specific WNK1 kinase. J Biol Chem (2009) 1.17
Dietary potassium restriction stimulates endocytosis of ROMK channel in rat cortical collecting duct. Am J Physiol Renal Physiol (2003) 1.14
Protein kinase C inhibits ROMK1 channel activity via a phosphatidylinositol 4,5-bisphosphate-dependent mechanism. J Biol Chem (2003) 1.14
Endothelial-specific expression of WNK1 kinase is essential for angiogenesis and heart development in mice. Am J Pathol (2009) 1.12
Role of with-no-lysine [K] kinases in the pathogenesis of Gordon's syndrome. Pediatr Nephrol (2006) 1.11
Association of urinary sodium/potassium ratio with blood pressure: sex and racial differences. Clin J Am Soc Nephrol (2011) 1.06
Activation of PI3-kinase stimulates endocytosis of ROMK via Akt1/SGK1-dependent phosphorylation of WNK1. J Am Soc Nephrol (2011) 1.05
Structural determinants and specificities for ROMK1-phosphoinositide interaction. Am J Physiol Renal Physiol (2002) 1.02
Identification and functional characterization of Kir2.6 mutations associated with non-familial hypokalemic periodic paralysis. J Biol Chem (2011) 1.00
Calcium-sensing receptor decreases cell surface expression of the inwardly rectifying K+ channel Kir4.1. J Biol Chem (2010) 0.99
Serum and glucocorticoid-induced kinase (SGK) 1 and the epithelial sodium channel are regulated by multiple with no lysine (WNK) family members. J Biol Chem (2010) 0.99
phyllopod is a target gene of proneural proteins in Drosophila external sensory organ development. Proc Natl Acad Sci U S A (2004) 0.99
Downregulation of NCC and NKCC2 cotransporters by kidney-specific WNK1 revealed by gene disruption and transgenic mouse models. Hum Mol Genet (2010) 0.98
The N-terminal extracellular domain is required for polycystin-1-dependent channel activity. J Biol Chem (2004) 0.93
Distal potassium handling based on flow modulation of maxi-K channel activity. Curr Opin Nephrol Hypertens (2009) 0.93
Domains of WNK1 kinase in the regulation of ROMK1. Am J Physiol Renal Physiol (2008) 0.92
Mechanism of thyrotoxic periodic paralysis. J Am Soc Nephrol (2012) 0.89
WNK1 promotes PIP₂ synthesis to coordinate growth factor and GPCR-Gq signaling. Curr Biol (2011) 0.88
Recent advances in distal tubular potassium handling. Am J Physiol Renal Physiol (2011) 0.87
WNK4 kinase stimulates caveola-mediated endocytosis of TRPV5 amplifying the dynamic range of regulation of the channel by protein kinase C. J Biol Chem (2010) 0.86
Kidney-specific WNK1 inhibits sodium reabsorption in the cortical thick ascending limb. Am J Physiol Renal Physiol (2012) 0.86
The Drosophila NKCC Ncc69 is required for normal renal tubule function. Am J Physiol Cell Physiol (2012) 0.85
WNK1 protein kinase regulates embryonic cardiovascular development through the OSR1 signaling cascade. J Biol Chem (2013) 0.85
An emerging role for SPAK in NCC, NKCC, and blood pressure regulation. J Am Soc Nephrol (2010) 0.84
The mechanism of hypocalciuria with NaCl cotransporter inhibition. Nat Rev Nephrol (2011) 0.83
Human-induced pluripotent stem cell-derived cardiomyocytes for studies of cardiac ion transporters. Am J Physiol Cell Physiol (2013) 0.83
Extracellular potassium homeostasis: insights from hypokalemic periodic paralysis. Semin Nephrol (2013) 0.82
Mechanism of urinary calcium regulation by urinary magnesium and pH. J Am Soc Nephrol (2008) 0.82
Kidney-specific WNK1 regulates sodium reabsorption and potassium secretion in mouse cortical collecting duct. Am J Physiol Renal Physiol (2012) 0.81
Flow-induced activation of TRPV5 and TRPV6 channels stimulates Ca(2+)-activated K(+) channel causing membrane hyperpolarization. Biochim Biophys Acta (2013) 0.80
Regulation of TRPV5 single-channel activity by intracellular pH. J Membr Biol (2007) 0.80
On the role of pore helix in regulation of TRPV5 by extracellular protons. J Membr Biol (2007) 0.80
Inhibition of ROMK potassium channel by syntaxin 1A. Am J Physiol Renal Physiol (2004) 0.79
Inward-rectifying potassium channelopathies: new insights into disorders of sodium and potassium homeostasis. Pediatr Nephrol (2014) 0.77
Overexpression of MAC30 is associated with poor clinical outcome in human non-small-cell lung cancer. Tumour Biol (2012) 0.76
Corrigendum: WNK1 kinase balances T cell adhesion versus migration in vivo. Nat Immunol (2017) 0.75
Laparoscopic Heller myotomy is not superior to pneumatic dilation in the management of primary achalasia: Conclusions of a systematic review and meta-analysis of randomized controlled trials. Medicine (Baltimore) (2017) 0.75
Novel KCNJ5 mutations in sporadic aldosterone-producing adenoma reduce Kir3.4 membrane abundance. J Clin Endocrinol Metab (2015) 0.75
Implications of Dynamic Occupancy, Binding Kinetics, and Channel Gating Kinetics for hERG Blocker Safety Assessment and Mitigation. Curr Top Med Chem (2016) 0.75
Acquired hypocalciuric hypercalcemia in a patient with CKD. Am J Kidney Dis (2013) 0.75
Toward an understanding of the complete NCX1 lifetime in the cardiac sarcolemma. Adv Exp Med Biol (2013) 0.75
[Clinical features of coronavirus disease 2019 in children: a systemic review of severe acute respiratory syndrome, Middle East respiratory syndrome, and coronavirus disease 2019]. Zhongguo Dang Dai Er Ke Za Zhi (2020) 0.75