Published in Antimicrob Agents Chemother on October 11, 2010
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Quinolone-binding pocket of DNA gyrase: role of GyrB. Antimicrob Agents Chemother (2002) 1.38
The kinetic mechanism of AAC3-IV aminoglycoside acetyltransferase from Escherichia coli. Biochemistry (2005) 1.35
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Arabidopsis thaliana DNA gyrase is targeted to chloroplasts and mitochondria. Proc Natl Acad Sci U S A (2004) 1.32
A novel dimeric structure of the RimL Nalpha-acetyltransferase from Salmonella typhimurium. J Biol Chem (2005) 1.29
Mechanistic and structural analysis of aminoglycoside N-acetyltransferase AAC(6')-Ib and its bifunctional, fluoroquinolone-active AAC(6')-Ib-cr variant. Biochemistry (2008) 1.27
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Biochemical and structural characterization of Mycobacterium tuberculosis beta-lactamase with the carbapenems ertapenem and doripenem. Biochemistry (2010) 1.23
A crystal structure of the bifunctional antibiotic simocyclinone D8, bound to DNA gyrase. Science (2009) 1.23
Nucleotide binding to DNA gyrase causes loss of DNA wrap. J Mol Biol (2004) 1.20
The phytotoxin albicidin is a novel inhibitor of DNA gyrase. Antimicrob Agents Chemother (2006) 1.18
Functional annotation and kinetic characterization of PhnO from Salmonella enterica. Biochemistry (2006) 1.18
Homology models guide discovery of diverse enzyme specificities among dipeptide epimerases in the enolase superfamily. Proc Natl Acad Sci U S A (2012) 1.17
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The structure and mechanism of the Mycobacterium tuberculosis cyclodityrosine synthetase. Nat Chem Biol (2010) 1.17
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Simocyclinone D8, an inhibitor of DNA gyrase with a novel mode of action. Antimicrob Agents Chemother (2005) 1.16
Structural insights into stereochemical inversion by diaminopimelate epimerase: an antibacterial drug target. Proc Natl Acad Sci U S A (2006) 1.14
Structure of QnrB1, a plasmid-mediated fluoroquinolone resistance factor. J Biol Chem (2011) 1.13
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Small-angle X-ray scattering reveals the solution structure of the full-length DNA gyrase a subunit. Structure (2005) 1.05
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Slow-onset feedback inhibition: inhibition of Mycobacterium tuberculosis alpha-isopropylmalate synthase by L-leucine. J Am Chem Soc (2005) 1.03
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The key DNA-binding residues in the C-terminal domain of Mycobacterium tuberculosis DNA gyrase A subunit (GyrA). Nucleic Acids Res (2006) 1.03
Functional characterization of a novel ArgA from Mycobacterium tuberculosis. J Bacteriol (2005) 1.03
Hot-spot consensus of fluoroquinolone-mediated DNA cleavage by Gram-negative and Gram-positive type II DNA topoisomerases. Nucleic Acids Res (2007) 1.02
Aminoglycoside resistance resulting from tight drug binding to an altered aminoglycoside acetyltransferase. Antimicrob Agents Chemother (2003) 1.02
Steady-state and pre-steady-state kinetic analysis of Mycobacterium smegmatis cysteine ligase (MshC). Biochemistry (2007) 1.02
The three-dimensional structures of the Mycobacterium tuberculosis dihydrodipicolinate reductase-NADH-2,6-PDC and -NADPH-2,6-PDC complexes. Structural and mutagenic analysis of relaxed nucleotide specificity. Biochemistry (2003) 1.02
The active site of O-acetylserine sulfhydrylase is the anchor point for bienzyme complex formation with serine acetyltransferase. J Bacteriol (2005) 1.02
Kinetic and structural analysis of bisubstrate inhibition of the Salmonella enterica aminoglycoside 6'-N-acetyltransferase. Biochemistry (2007) 1.01
Mapping of the allosteric network in the regulation of alpha-isopropylmalate synthase from Mycobacterium tuberculosis by the feedback inhibitor L-leucine: solution-phase H/D exchange monitored by FT-ICR mass spectrometry. Biochemistry (2009) 1.00
Kinetic and inhibition studies of dihydroxybenzoate-AMP ligase from Escherichia coli. Biochemistry (2010) 1.00
Structure of the ternary complex of phosphomevalonate kinase: the enzyme and its family. Biochemistry (2009) 1.00
Kinetic and chemical mechanism of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate isomeroreductase. Biochemistry (2004) 0.99
Activity-based substrate profiling for Gcn5-related N-acetyltransferases: the use of chloroacetyl-coenzyme A to identify protein substrates. J Am Chem Soc (2006) 0.99
Evidence for the role of DNA strand passage in the mechanism of action of microcin B17 on DNA gyrase. Biochemistry (2005) 0.99
Coupling of the biosynthesis and export of the DNA gyrase inhibitor simocyclinone in Streptomyces antibioticus. Mol Microbiol (2009) 0.99
NXL104 irreversibly inhibits the β-lactamase from Mycobacterium tuberculosis. Biochemistry (2012) 0.98
How do type II topoisomerases use ATP hydrolysis to simplify DNA topology beyond equilibrium? Investigating the relaxation reaction of nonsupercoiling type II topoisomerases. J Mol Biol (2008) 0.98
Structures of the Michaelis complex (1.2 Å) and the covalent acyl intermediate (2.0 Å) of cefamandole bound in the active sites of the Mycobacterium tuberculosis β-lactamase K73A and E166A mutants. Biochemistry (2010) 0.97
Structures and mechanisms of the mycothiol biosynthetic enzymes. Curr Opin Chem Biol (2009) 0.97
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Inhibition of DNA gyrase and DNA topoisomerase IV of Staphylococcus aureus and Escherichia coli by aminocoumarin antibiotics. J Antimicrob Chemother (2011) 0.96
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Aminoglycoside microarrays to study antibiotic resistance. Angew Chem Int Ed Engl (2004) 0.95
The role of Ca²⁺ in the activity of Mycobacterium tuberculosis DNA gyrase. Nucleic Acids Res (2012) 0.95
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Discovery of function in the enolase superfamily: D-mannonate and d-gluconate dehydratases in the D-mannonate dehydratase subgroup. Biochemistry (2014) 0.94
Catalysis of diaphorase reactions by Mycobacterium tuberculosis lipoamide dehydrogenase occurs at the EH4 level. Biochemistry (2003) 0.94
A strand-passage conformation of DNA gyrase is required to allow the bacterial toxin, CcdB, to access its binding site. Nucleic Acids Res (2006) 0.93
Mechanistic and structural analysis of human spermidine/spermine N1-acetyltransferase. Biochemistry (2007) 0.93
A mutation in Escherichia coli DNA gyrase conferring quinolone resistance results in sensitivity to drugs targeting eukaryotic topoisomerase II. Antimicrob Agents Chemother (2004) 0.93
The action of the bacterial toxin, microcin B17, on DNA gyrase. Biochimie (2006) 0.93
Thioredoxin can influence gene expression by affecting gyrase activity. Nucleic Acids Res (2004) 0.92
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Vibrio cholerae ParE2 poisons DNA gyrase via a mechanism distinct from other gyrase inhibitors. J Biol Chem (2010) 0.92