PubRank

Richard J Kuhn

Author PubWeight™ 128.28‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 A structural perspective of the flavivirus life cycle. Nat Rev Microbiol 2005 5.02
2 Visualization of membrane protein domains by cryo-electron microscopy of dengue virus. Nat Struct Biol 2003 4.11
3 Structure of the immature dengue virus at low pH primes proteolytic maturation. Science 2008 3.86
4 Conformational changes of the flavivirus E glycoprotein. Structure 2004 3.66
5 Structures of immature flavivirus particles. EMBO J 2003 3.62
6 Structure of West Nile virus. Science 2003 3.48
7 Binding of a neutralizing antibody to dengue virus alters the arrangement of surface glycoproteins. Nat Struct Mol Biol 2008 3.27
8 The flavivirus precursor membrane-envelope protein complex: structure and maturation. Science 2008 3.26
9 Dengue virus nonstructural protein 3 redistributes fatty acid synthase to sites of viral replication and increases cellular fatty acid synthesis. Proc Natl Acad Sci U S A 2010 2.97
10 Placement of the structural proteins in Sindbis virus. J Virol 2002 2.81
11 Structural changes of envelope proteins during alphavirus fusion. Nature 2010 2.32
12 Picornavirus-receptor interactions. Trends Microbiol 2002 2.23
13 Flavivirus NS1 structures reveal surfaces for associations with membranes and the immune system. Science 2014 2.16
14 Structural insights into the mechanisms of antibody-mediated neutralization of flavivirus infection: implications for vaccine development. Cell Host Microbe 2008 2.16
15 Cryo-EM reconstruction of dengue virus in complex with the carbohydrate recognition domain of DC-SIGN. Cell 2006 2.08
16 The structure of the RNA-dependent RNA polymerase from bovine viral diarrhea virus establishes the role of GTP in de novo initiation. Proc Natl Acad Sci U S A 2004 2.05
17 Characterization of the early events in dengue virus cell entry by biochemical assays and single-virus tracking. J Virol 2007 2.03
18 Structural basis for the preferential recognition of immature flaviviruses by a fusion-loop antibody. EMBO J 2009 1.85
19 Solution structure of dengue virus capsid protein reveals another fold. Proc Natl Acad Sci U S A 2004 1.85
20 West Nile virus in complex with the Fab fragment of a neutralizing monoclonal antibody. Proc Natl Acad Sci U S A 2006 1.83
21 The crystal structure of coxsackievirus A21 and its interaction with ICAM-1. Structure 2005 1.82
22 Crystal structure of human enterovirus 71. Science 2012 1.79
23 Structure of immature West Nile virus. J Virol 2007 1.77
24 Dengue structure differs at the temperatures of its human and mosquito hosts. Proc Natl Acad Sci U S A 2013 1.75
25 A structural and functional perspective of alphavirus replication and assembly. Future Microbiol 2009 1.72
26 Mapping the structure and function of the E1 and E2 glycoproteins in alphaviruses. Structure 2006 1.68
27 Construction and applications of yellow fever virus replicons. Virology 2005 1.66
28 Structure of the Flavivirus helicase: implications for catalytic activity, protein interactions, and proteolytic processing. J Virol 2005 1.65
29 Yellow Fever virus NS3 plays an essential role in virus assembly independent of its known enzymatic functions. J Virol 2008 1.59
30 Structural proteomics of dengue virus. Curr Opin Microbiol 2008 1.57
31 Neutralization of West Nile virus by cross-linking of its surface proteins with Fab fragments of the human monoclonal antibody CR4354. Proc Natl Acad Sci U S A 2010 1.57
32 Structure-guided insights on the role of NS1 in flavivirus infection. Bioessays 2015 1.46
33 Dengue virus infection perturbs lipid homeostasis in infected mosquito cells. PLoS Pathog 2012 1.45
34 Flavivirus capsid is a dimeric alpha-helical protein. J Virol 2003 1.43
35 Influence of pr-M cleavage on the heterogeneity of extracellular dengue virus particles. J Virol 2010 1.41
36 Complexes of poliovirus serotypes with their common cellular receptor, CD155. J Virol 2003 1.31
37 Maturation of flaviviruses starts from one or more icosahedrally independent nucleation centres. EMBO Rep 2011 1.31
38 Ultrastructural analysis of hepatitis C virus particles. Proc Natl Acad Sci U S A 2013 1.29
39 Design, synthesis, and biological evaluation of antiviral agents targeting flavivirus envelope proteins. J Med Chem 2008 1.28
40 Functional characterization of cis and trans activity of the Flavivirus NS2B-NS3 protease. J Biol Chem 2007 1.25
41 Capturing a flavivirus pre-fusion intermediate. PLoS Pathog 2009 1.24
42 Heparin binding sites on Ross River virus revealed by electron cryo-microscopy. Virology 2005 1.18
43 Ultrastructural characterization and three-dimensional architecture of replication sites in dengue virus-infected mosquito cells. J Virol 2014 1.17
44 Structure of decay-accelerating factor bound to echovirus 7: a virus-receptor complex. Proc Natl Acad Sci U S A 2002 1.17
45 Catalytic core of alphavirus nonstructural protein nsP4 possesses terminal adenylyltransferase activity. J Virol 2006 1.13
46 Closing the door on flaviviruses: entry as a target for antiviral drug design. Antiviral Res 2008 1.09
47 Antiviral compounds discovered by virtual screening of small-molecule libraries against dengue virus E protein. ACS Chem Biol 2008 1.06
48 In vitro-assembled alphavirus core-like particles maintain a structure similar to that of nucleocapsid cores in mature virus. J Virol 2002 1.06
49 Characterization of purified Sindbis virus nsP4 RNA-dependent RNA polymerase activity in vitro. Virology 2008 1.05
50 The coiled-coil domain structure of the Sin Nombre virus nucleocapsid protein. J Mol Biol 2006 1.04
51 A physical interaction network of dengue virus and human proteins. Mol Cell Proteomics 2011 1.03
52 Alphavirus capsid protein helix I controls a checkpoint in nucleocapsid core assembly. J Virol 2006 1.01
53 Aura virus structure suggests that the T=4 organization is a fundamental property of viral structural proteins. J Virol 2002 1.00
54 Role of sindbis virus capsid protein region II in nucleocapsid core assembly and encapsidation of genomic RNA. J Virol 2008 0.98
55 Structure of human enterovirus 71 in complex with a capsid-binding inhibitor. Proc Natl Acad Sci U S A 2013 0.98
56 Molecular links between the E2 envelope glycoprotein and nucleocapsid core in Sindbis virus. J Mol Biol 2011 0.98
57 A heterologous coiled coil can substitute for helix I of the Sindbis virus capsid protein. J Virol 2003 0.98
58 Functional requirements of the yellow fever virus capsid protein. J Virol 2007 0.96
59 Role for conserved residues of sindbis virus nonstructural protein 2 methyltransferase-like domain in regulation of minus-strand synthesis and development of cytopathic infection. J Virol 2008 0.96
60 Sindbis virus nucleocapsid assembly: RNA folding promotes capsid protein dimerization. RNA 2004 0.95
61 Association of sindbis virus capsid protein with phospholipid membranes and the E2 glycoprotein: implications for alphavirus assembly. Biochemistry 2005 0.93
62 An investigation of phenylthiazole antiflaviviral agents. Bioorg Med Chem 2011 0.92
63 Cryo-electron tomography of rubella virus. J Virol 2012 0.92
64 Interactions of the cytoplasmic domain of Sindbis virus E2 with nucleocapsid cores promote alphavirus budding. J Virol 2011 0.90
65 Identification of inhibitors of yellow fever virus replication using a replicon-based high-throughput assay. Antimicrob Agents Chemother 2009 0.88
66 Rescue of infectious particles from preassembled alphavirus nucleocapsid cores. J Virol 2011 0.87
67 Design, synthesis, and biological evaluation of thiazoles targeting flavivirus envelope proteins. J Med Chem 2011 0.86
68 Functional characterization of the alphavirus TF protein. J Virol 2013 0.86
69 Structure determination of enterovirus 71. Acta Crystallogr D Biol Crystallogr 2012 0.86
70 Capturing a virus while it catches its breath. Structure 2012 0.85
71 Neutralizing antibodies can initiate genome release from human enterovirus 71. Proc Natl Acad Sci U S A 2014 0.85
72 Directed evolution of a virus exclusively utilizing human epidermal growth factor receptor as the entry receptor. J Virol 2013 0.84
73 Novel approaches to flavivirus drug discovery. Expert Opin Drug Discov 2012 0.83
74 Heterologous production, purification and characterization of enzymatically active Sindbis virus nonstructural protein nsP1. Protein Expr Purif 2011 0.83
75 Functional characterization of the Sindbis virus E2 glycoprotein by transposon linker-insertion mutagenesis. Virology 2007 0.83
76 Synthesis of dioxane-based antiviral agents and evaluation of their biological activities as inhibitors of Sindbis virus replication. Bioorg Med Chem 2007 0.82
77 Membrane curvature in flaviviruses. J Struct Biol 2013 0.82
78 Reactive oxygen species formation by UV-A irradiation of urocanic acid and the role of trace metals in this chemistry. Photochem Photobiol 2003 0.81
79 Design, expression, and purification of a Flaviviridae polymerase using a high-throughput approach to facilitate crystal structure determination. Protein Sci 2004 0.80
80 West Nile virus methyltransferase domain interacts with protein kinase G. Virol J 2013 0.79
81 Crystallization, high-resolution data collection and preliminary crystallographic analysis of Aura virus capsid protease and its complex with dioxane. Acta Crystallogr Sect F Struct Biol Cryst Commun 2011 0.79
82 Crystal structure of aura virus capsid protease and its complex with dioxane: new insights into capsid-glycoprotein molecular contacts. PLoS One 2012 0.78
83 Probing the early temporal and spatial interaction of the Sindbis virus capsid and E2 proteins with reverse genetics. J Virol 2012 0.78
84 Crystallization and preliminary X-ray diffraction analysis of West Nile virus. Acta Crystallogr Sect F Struct Biol Cryst Commun 2010 0.77
85 Rapid detection of dengue virus in serum using magnetic separation and fluorescence detection. Analyst 2007 0.77
86 Phototoxicity against tumor cells and Sindbis virus by an octahedral rhodium bisbipyridyl complex and evidence for the genome as a target in viral photoinactivation. Inorg Chem 2004 0.75
87 Development of novel antivirals against flaviviruses. Novartis Found Symp 2006 0.75