A dominant mutation in a neuronal acetylcholine receptor subunit leads to motor neuron degeneration in Caenorhabditis elegans.

PubWeight™: 0.94‹?› | Rank: Top 15%

🔗 View Article (PMC 2965043)

Published in J Neurosci on October 20, 2010

Authors

Belinda Barbagallo1, Hilary A Prescott, Patrick Boyle, Jason Climer, Michael M Francis

Author Affiliations

1: Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.

Articles cited by this

The genetics of Caenorhabditis elegans. Genetics (1974) 102.14

Green fluorescent protein as a marker for gene expression. Science (1994) 34.55

Cell death: critical control points. Cell (2004) 22.56

Post-embryonic cell lineages of the nematode, Caenorhabditis elegans. Dev Biol (1977) 19.51

Rapid gene mapping in Caenorhabditis elegans using a high density polymorphism map. Nat Genet (2001) 9.54

Genetic control of programmed cell death in the nematode C. elegans. Cell (1986) 6.04

Nicotinic acetylcholine receptors and nicotinic cholinergic mechanisms of the central nervous system. Annu Rev Pharmacol Toxicol (2007) 5.48

Cell death by necrosis: towards a molecular definition. Trends Biochem Sci (2006) 4.67

Coupling endoplasmic reticulum stress to the cell death program. Cell Death Differ (2004) 4.41

Caenorhabditis elegans gene ced-9 protects cells from programmed cell death. Nature (1992) 3.96

One GABA and two acetylcholine receptors function at the C. elegans neuromuscular junction. Nat Neurosci (1999) 3.88

Rapid single nucleotide polymorphism mapping in C. elegans. BMC Genomics (2005) 3.57

Mutations in the channel domain alter desensitization of a neuronal nicotinic receptor. Nature (1991) 3.52

Necrosis, a well-orchestrated form of cell demise: signalling cascades, important mediators and concomitant immune response. Biochim Biophys Acta (2006) 3.12

Neurodegeneration in Lurcher mice caused by mutation in delta2 glutamate receptor gene. Nature (1997) 3.10

Channel gating governed symmetrically by conserved leucine residues in the M2 domain of nicotinic receptors. Nature (1995) 3.06

Complete dissociation of motor neuron death from motor dysfunction by Bax deletion in a mouse model of ALS. J Neurosci (2006) 3.06

Calreticulin is essential for cardiac development. J Cell Biol (1999) 2.88

Mechanism of extrasynaptic dopamine signaling in Caenorhabditis elegans. Nat Neurosci (2004) 2.82

Calcium, ischemia and excitotoxicity. Cell Calcium (2010) 2.38

Caenorhabditis elegans levamisole resistance genes lev-1, unc-29, and unc-38 encode functional nicotinic acetylcholine receptor subunits. J Neurosci (1997) 2.31

The C. elegans glutamate receptor subunit NMR-1 is required for slow NMDA-activated currents that regulate reversal frequency during locomotion. Neuron (2001) 2.25

Specific aspartyl and calpain proteases are required for neurodegeneration in C. elegans. Nature (2002) 1.97

Axons break in animals lacking beta-spectrin. J Cell Biol (2007) 1.94

Calcium signaling in the ER: its role in neuronal plasticity and neurodegenerative disorders. Trends Neurosci (2000) 1.91

Necrotic cell death in C. elegans requires the function of calreticulin and regulators of Ca(2+) release from the endoplasmic reticulum. Neuron (2001) 1.90

acr-16 encodes an essential subunit of the levamisole-resistant nicotinic receptor at the Caenorhabditis elegans neuromuscular junction. J Biol Chem (2005) 1.87

The Ror receptor tyrosine kinase CAM-1 is required for ACR-16-mediated synaptic transmission at the C. elegans neuromuscular junction. Neuron (2005) 1.82

Molecular mechanisms of glutamate receptor-mediated excitotoxic neuronal cell death. Mol Neurobiol (2002) 1.74

Identification and characterization of novel nicotinic receptor-associated proteins in Caenorhabditis elegans. EMBO J (2005) 1.73

Calcium-permeable AMPA channels in neurodegenerative disease and ischemia. Curr Opin Neurobiol (2006) 1.72

Expression profiling of GABAergic motor neurons in Caenorhabditis elegans. Curr Biol (2005) 1.72

The Caenorhabditis elegans unc-63 gene encodes a levamisole-sensitive nicotinic acetylcholine receptor alpha subunit. J Biol Chem (2004) 1.70

Bcl-2 overexpression prevents motoneuron cell body loss but not axonal degeneration in a mouse model of a neurodegenerative disease. J Neurosci (1995) 1.61

A mutated acetylcholine receptor subunit causes neuronal degeneration in C. elegans. Neuron (1995) 1.60

Dying for a cause: invertebrate genetics takes on human neurodegeneration. Nat Rev Genet (2003) 1.51

The prototoxin lynx1 acts on nicotinic acetylcholine receptors to balance neuronal activity and survival in vivo. Neuron (2006) 1.46

The C. elegans NeuroD homolog cnd-1 functions in multiple aspects of motor neuron fate specification. Development (2000) 1.43

Calcium dysregulation in amyotrophic lateral sclerosis. Cell Calcium (2010) 1.43

Point mutant mice with hypersensitive alpha 4 nicotinic receptors show dopaminergic deficits and increased anxiety. Proc Natl Acad Sci U S A (2001) 1.39

Calnexin, calreticulin, and ERp57: teammates in glycoprotein folding. Cell Biochem Biophys (2003) 1.28

A neuronal acetylcholine receptor regulates the balance of muscle excitation and inhibition in Caenorhabditis elegans. PLoS Biol (2009) 1.27

Acetylcholine. WormBook (2007) 1.26

Regulation of nicotinic receptor trafficking by the transmembrane Golgi protein UNC-50. EMBO J (2007) 1.24

Early postnatal death and motor disorders in mice congenitally deficient in calnexin expression. Mol Cell Biol (2002) 1.22

Activation of nicotinic receptors uncouples a developmental timer from the molting timer in C. elegans. Development (2006) 1.12

Mice homozygous for the L250T mutation in the alpha7 nicotinic acetylcholine receptor show increased neuronal apoptosis and die within 1 day of birth. J Neurochem (2000) 1.12

The nicotinic acetylcholine receptor gene family of the nematode Caenorhabditis elegans: an update on nomenclature. Invert Neurosci (2007) 1.12

Prostate stem cell antigen is an endogenous lynx1-like prototoxin that antagonizes alpha7-containing nicotinic receptors and prevents programmed cell death of parasympathetic neurons. J Neurosci (2009) 1.08

UNC-119 suppresses axon branching in C. elegans. Development (2001) 1.06

Cell-autonomous inhibition of alpha 7-containing nicotinic acetylcholine receptors prevents death of parasympathetic neurons during development. J Neurosci (2007) 0.98

Insights from mouse models into the molecular basis of neurodegeneration. Annu Rev Physiol (2000) 0.91

Knockin mice with Leu9'Ser alpha4-nicotinic receptors: substantia nigra dopaminergic neurons are hypersensitive to agonist and lost postnatally. Physiol Genomics (2004) 0.80

Articles by these authors

Preparation of reduced representation bisulfite sequencing libraries for genome-scale DNA methylation profiling. Nat Protoc (2011) 4.18

Genomic distribution and inter-sample variation of non-CpG methylation across human cell types. PLoS Genet (2011) 2.98

DNA methylation dynamics during in vivo differentiation of blood and skin stem cells. Mol Cell (2012) 2.66

The Arabidopsis NPR1 protein is a receptor for the plant defense hormone salicylic acid. Cell Rep (2012) 2.13

A tyramine-gated chloride channel coordinates distinct motor programs of a Caenorhabditis elegans escape response. Neuron (2009) 2.01

Arrhythmogenic mechanisms of the Purkinje system during electric shocks: a modeling study. Heart Rhythm (2009) 1.83

Gel-free multiplexed reduced representation bisulfite sequencing for large-scale DNA methylation profiling. Genome Biol (2012) 1.76

Global DNA demethylation during mouse erythropoiesis in vivo. Science (2011) 1.73

Image-based models of cardiac structure with applications in arrhythmia and defibrillation studies. J Electrocardiol (2009) 1.71

Monoaminergic orchestration of motor programs in a complex C. elegans behavior. PLoS Biol (2013) 1.69

Enhancing evaluation in an undergraduate medical education program. Acad Med (2008) 1.49

The coactivator function of Arabidopsis NPR1 requires the core of its BTB/POZ domain and the oxidation of C-terminal cysteines. Plant Cell (2006) 1.48

Negative intratracheal pressure produced by esophageal detector devices causes tracheal wall collapse in a porcine cardiac arrest model. Anesth Analg (2010) 1.38

Evolutionary conserved role for TARPs in the gating of glutamate receptors and tuning of synaptic function. Neuron (2008) 1.27

Pitch comparisons between electrical stimulation of a cochlear implant and acoustic stimuli presented to a normal-hearing contralateral ear. J Assoc Res Otolaryngol (2010) 1.20

Reconstitution of invertebrate glutamate receptor function depends on stargazin-like proteins. Proc Natl Acad Sci U S A (2006) 1.20

SOL-1 is an auxiliary subunit that modulates the gating of GLR-1 glutamate receptors in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2006) 1.09

Development of a multiplexed microbioreactor system for high-throughput bioprocessing. Lab Chip (2005) 1.09

Wnt signaling regulates acetylcholine receptor translocation and synaptic plasticity in the adult nervous system. Cell (2012) 1.07

Use of telemedicine in the remote programming of cochlear implants. Acta Otolaryngol (2009) 1.06

Conserved SOL-1 proteins regulate ionotropic glutamate receptor desensitization. Proc Natl Acad Sci U S A (2006) 1.05

The transcriptional activator Pti4 is required for the recruitment of a repressosome nucleated by repressor SEBF at the potato PR-10a gene. Plant Cell (2008) 0.99

ACR-12 ionotropic acetylcholine receptor complexes regulate inhibitory motor neuron activity in Caenorhabditis elegans. J Neurosci (2013) 0.98

Genome-wide map of quantified epigenetic changes during in vitro chondrogenic differentiation of primary human mesenchymal stem cells. BMC Genomics (2013) 0.96

Identification of novel imprinted differentially methylated regions by global analysis of human-parthenogenetic-induced pluripotent stem cells. Stem Cell Reports (2013) 0.94

The effects of subunit composition on the inhibition of nicotinic receptors by the amphipathic blocker 2,2,6,6-tetramethylpiperidin-4-yl heptanoate. Mol Pharmacol (2005) 0.93

Transcranial ultrasound (TUS) effects on mental states: a pilot study. Brain Stimul (2012) 0.86

The effect of Gaussian noise on the threshold, dynamic range, and loudness of analogue cochlear implant stimuli. J Assoc Res Otolaryngol (2006) 0.86

Evidence of a tonotopic organization of the auditory cortex in cochlear implant users. J Neurosci (2007) 0.86

Arabidopsis clade I TGA transcription factors regulate plant defenses in an NPR1-independent fashion. Mol Plant Microbe Interact (2012) 0.83

Effects of auditory pathway anatomy and deafness characteristics? Part 2: On electrically evoked late auditory responses. Hear Res (2007) 0.82

A high rate n-of-m speech processing strategy for the first generation Clarion cochlear implant. Int J Audiol (2009) 0.81

Benefits of the HiRes 120 coding strategy combined with the Harmony processor in an adult European multicentre study. Acta Otolaryngol (2011) 0.80

European adult multi-centre HiRes® 120 study--an update on 65 subjects. Cochlear Implants Int (2010) 0.77

Use of telemedicine in the remote programming of cochlear implants. Cochlear Implants Int (2010) 0.77

Effects of auditory pathway anatomy and deafness characteristics? (1): On electrically evoked auditory brainstem responses. Hear Res (2006) 0.77

Role of Purkinje system in cardiac arrhythmias. Conf Proc IEEE Eng Med Biol Soc (2008) 0.77

Nonhost resistance of tomato to the bean pathogen Pseudomonas syringae pv. syringae B728a is due to a defective E3 ubiquitin ligase domain in avrptobb728a. Mol Plant Microbe Interact (2013) 0.76

Metacognitive capacity as a predictor of insight in first-episode psychosis. J Nerv Ment Dis (2015) 0.76

Predictors of referral to Supported Employment among consumers with co-occurring mental and substance use disorders. Community Ment Health J (2009) 0.76

Effects of median nerve block on radial artery diameter and peak velocity. Local Reg Anesth (2010) 0.75

One-year results of the banded neural response imaging study. Otol Neurotol (2008) 0.75

Links in the chain. A success story in Berwyn, Pa., demonstrates the value of bystander CPR, AEDs in public buildings & early ALS care. JEMS (2010) 0.75

Bilateral Changes of Spontaneous Activity Within the Central Auditory Pathway Upon Chronic Unilateral Intracochlear Electrical Stimulation. Otol Neurotol (2015) 0.75

Music benefits with HiRes Fidelity 120® sound processing. Cochlear Implants Int (2010) 0.75

SPAN: improved current steering on the advanced bionics CII and HiRes90K system. Cochlear Implants Int (2010) 0.75

Predicting Cochlear Implant Electrode Placement Using Monopolar, Three-Point and Four-Point Impedance Measurements. IEEE Trans Biomed Eng (2022) 0.75

Evaluation of music perception in adult users of HiRes® 120 and previous generations of Advanced Bionics® sound coding strategies. Cochlear Implants Int (2010) 0.75

Development of a paediatric audiovisual speech test in noise. Cochlear Implants Int (2010) 0.75

Confirmation of needle cricothyroidotomy using an esophageal detector device in a porcine model. Mil Med (2010) 0.75