Co-transcriptional RNA cleavage provides a failsafe termination mechanism for yeast RNA polymerase I.

PubWeight™: 0.86‹?›

🔗 View Article (PMC 3045592)

Published in Nucleic Acids Res on October 23, 2010

Authors

Priscilla Braglia1, Junya Kawauchi, Nick J Proudfoot

Author Affiliations

1: Sir William Dunn School of Pathology, University of Oxford, Oxford, OX1 3RE, UK.

Articles cited by this

The yeast Rat1 exonuclease promotes transcription termination by RNA polymerase II. Nature (2004) 4.65

RNase III cleaves eukaryotic preribosomal RNA at a U3 snoRNP-dependent site. Cell (1996) 3.54

Human 5' --> 3' exonuclease Xrn2 promotes transcription termination at co-transcriptional cleavage sites. Nature (2004) 3.52

Endonucleolytic RNA cleavage by a eukaryotic exosome. Nature (2008) 3.11

In exponentially growing Saccharomyces cerevisiae cells, rRNA synthesis is determined by the summed RNA polymerase I loading rate rather than by the number of active genes. Mol Cell Biol (2003) 2.88

Functional architecture of RNA polymerase I. Cell (2007) 2.86

A repeated 18 bp sequence motif in the mouse rDNA spacer mediates binding of a nuclear factor and transcription termination. Cell (1986) 2.46

Terminal exon definition occurs cotranscriptionally and promotes termination of RNA polymerase II. Mol Cell (1999) 2.29

Poly(A) site selection in the HIV-1 provirus: inhibition of promoter-proximal polyadenylation by the downstream major splice donor site. Genes Dev (1995) 2.13

Yeast Rnt1p is required for cleavage of the pre-ribosomal RNA in the 3' ETS but not the 5' ETS. RNA (1999) 2.11

A model for transcription termination by RNA polymerase I. Cell (1994) 2.00

The REB1 site is an essential component of a terminator for RNA polymerase I in Saccharomyces cerevisiae. Mol Cell Biol (1993) 1.87

5'-exonuclease-2 of Saccharomyces cerevisiae. Purification and features of ribonuclease activity with comparison to 5'-exonuclease-1. J Biol Chem (1995) 1.81

Adenylation and exosome-mediated degradation of cotranscriptionally cleaved pre-messenger RNA in human cells. Mol Cell (2006) 1.67

Budding yeast RNA polymerases I and II employ parallel mechanisms of transcriptional termination. Genes Dev (2008) 1.64

Efficient termination of transcription by RNA polymerase I requires the 5' exonuclease Rat1 in yeast. Genes Dev (2008) 1.50

The role of the 3' external transcribed spacer in yeast pre-rRNA processing. J Mol Biol (1998) 1.39

The exosome subunit Rrp43p is required for the efficient maturation of 5.8S, 18S and 25S rRNA. Nucleic Acids Res (1999) 1.35

A bipartite DNA-binding domain in yeast Reb1p. Mol Cell Biol (1993) 1.32

A small nucleolar RNA:ribozyme hybrid cleaves a nucleolar RNA target in vivo with near-perfect efficiency. Proc Natl Acad Sci U S A (1999) 1.20

Transcriptional termination by RNA polymerase I requires the small subunit Rpa12p. Proc Natl Acad Sci U S A (2004) 1.20

Yeast RNA polymerase I enhancer is dispensable for transcription of the chromosomal rRNA gene and cell growth, and its apparent transcription enhancement from ectopic promoters requires Fob1 protein. Mol Cell Biol (2001) 1.16

Mechanism of transcription termination: PTRF interacts with the largest subunit of RNA polymerase I and dissociates paused transcription complexes from yeast and mouse. Mol Gen Genet (1999) 1.13

The release element of the yeast polymerase I transcription terminator can function independently of Reb1p. Mol Cell Biol (1995) 1.07

Saccharomyces cerevisiae RNA polymerase I terminates transcription at the Reb1 terminator in vivo. Mol Cell Biol (1999) 1.05

A cotranscriptional model for 3'-end processing of the Saccharomyces cerevisiae pre-ribosomal RNA precursor. RNA (2004) 0.93

Terminating transcription in yeast: whether to be a 'nerd' or a 'rat'. Nat Struct Mol Biol (2008) 0.86

Articles by these authors

Pre-mRNA processing reaches back to transcription and ahead to translation. Cell (2009) 7.45

Cohesin complex promotes transcriptional termination between convergent genes in S. pombe. Cell (2008) 3.60

Human 5' --> 3' exonuclease Xrn2 promotes transcription termination at co-transcriptional cleavage sites. Nature (2004) 3.52

Gene loops juxtapose promoters and terminators in yeast. Nat Genet (2004) 3.33

U1 snRNA associates with TFIIH and regulates transcriptional initiation. Nat Struct Biol (2002) 3.25

Primary microRNA transcripts are processed co-transcriptionally. Nat Struct Mol Biol (2008) 3.21

Transcriptional collision between convergent genes in budding yeast. Proc Natl Acad Sci U S A (2002) 2.84

Yeast Sen1 helicase protects the genome from transcription-associated instability. Mol Cell (2011) 2.59

Pause sites promote transcriptional termination of mammalian RNA polymerase II. Mol Cell Biol (2006) 2.56

Gene loops enhance transcriptional directionality. Science (2012) 2.50

Exon tethering in transcription by RNA polymerase II. Mol Cell (2006) 2.47

Promoter proximal splice sites enhance transcription. Genes Dev (2002) 2.46

Gene loops function to maintain transcriptional memory through interaction with the nuclear pore complex. Genes Dev (2009) 2.24

Critical role of cyclin D1 nuclear import in cardiomyocyte proliferation. Circ Res (2003) 1.70

Autocatalytic RNA cleavage in the human beta-globin pre-mRNA promotes transcription termination. Nature (2004) 1.66

Budding yeast RNA polymerases I and II employ parallel mechanisms of transcriptional termination. Genes Dev (2008) 1.64

Fail-safe transcriptional termination for protein-coding genes in S. cerevisiae. Mol Cell (2009) 1.50

Transcription-dependent gene looping of the HIV-1 provirus is dictated by recognition of pre-mRNA processing signals. Mol Cell (2008) 1.50

Stress response gene ATF3 is a target of c-myc in serum-induced cell proliferation. EMBO J (2005) 1.41

RNA polymerase I in yeast transcribes dynamic nucleosomal rDNA. Nat Struct Mol Biol (2007) 1.29

Disengaging polymerase: terminating RNA polymerase II transcription in budding yeast. Biochim Biophys Acta (2012) 1.24

ATF3 inhibits doxorubicin-induced apoptosis in cardiac myocytes: a novel cardioprotective role of ATF3. J Mol Cell Cardiol (2002) 1.24

Transcriptional termination by RNA polymerase I requires the small subunit Rpa12p. Proc Natl Acad Sci U S A (2004) 1.20

Strong polyadenylation and weak pausing combine to cause efficient termination of transcription in the human Ggamma-globin gene. Mol Cell Biol (2005) 1.13

Transcriptional activation of the human stress-inducible transcriptional repressor ATF3 gene promoter by p53. Biochem Biophys Res Commun (2002) 1.12

Convergent transcription induces transcriptional gene silencing in fission yeast and mammalian cells. Nat Struct Mol Biol (2012) 1.08

The spanish connection: transcription and mRNA processing get even closer. Cell (2005) 1.08

Transcriptional termination sequences in the mouse serum albumin gene. RNA (2006) 1.06

An alternatively spliced isoform of transcriptional repressor ATF3 and its induction by stress stimuli. Nucleic Acids Res (2002) 1.00

Autoregulation of convergent RNAi genes in fission yeast. Genes Dev (2011) 0.99

Expression of cyclin D1 and CDK4 causes hypertrophic growth of cardiomyocytes in culture: a possible implication for cardiac hypertrophy. Biochem Biophys Res Commun (2002) 0.95

Role of the RNA/DNA kinase Grc3 in transcription termination by RNA polymerase I. EMBO Rep (2010) 0.91

Systems analysis of ATF3 in stress response and cancer reveals opposing effects on pro-apoptotic genes in p53 pathway. PLoS One (2011) 0.90

Dawdling polymerases allow introns time to splice. Nat Struct Biol (2003) 0.87

Terminating transcription in yeast: whether to be a 'nerd' or a 'rat'. Nat Struct Mol Biol (2008) 0.86

AT-rich sequence elements promote nascent transcript cleavage leading to RNA polymerase II termination. Nucleic Acids Res (2012) 0.83

Transcriptional elongation factor elongin A regulates retinoic acid-induced gene expression during neuronal differentiation. Cell Rep (2012) 0.78

Nuclear roadblocks for mRNA export. Cell (2008) 0.77

Feed backwards model for microRNA processing and splicing in plants. EMBO Rep (2013) 0.76

Rad51, friend or foe? Elife (2013) 0.75

Silencing in trans: position matters in fission yeast. EMBO Rep (2010) 0.75