PubRank

Joel K Elmquist

Author PubWeight™ 206.48‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. Cell Metab 2007 9.62
2 Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis. Neuron 2004 7.15
3 Divergence of melanocortin pathways in the control of food intake and energy expenditure. Cell 2005 7.04
4 Dentate gyrus NMDA receptors mediate rapid pattern separation in the hippocampal network. Science 2007 6.48
5 Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. Neuron 2006 5.27
6 The need to feed: homeostatic and hedonic control of eating. Neuron 2002 4.99
7 Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity. Nature 2007 4.20
8 Mice lacking ghrelin receptors resist the development of diet-induced obesity. J Clin Invest 2005 3.92
9 Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance. Nat Neurosci 2008 3.90
10 Melanocortin-4 receptors expressed by cholinergic neurons regulate energy balance and glucose homeostasis. Cell Metab 2011 3.68
11 PTP1B regulates leptin signal transduction in vivo. Dev Cell 2002 3.61
12 Expression of ghrelin receptor mRNA in the rat and the mouse brain. J Comp Neurol 2006 3.61
13 The hypothalamic arcuate nucleus: a key site for mediating leptin's effects on glucose homeostasis and locomotor activity. Cell Metab 2005 3.38
14 Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes. J Clin Invest 2005 3.29
15 Transgenic mice expressing green fluorescent protein under the control of the melanocortin-4 receptor promoter. J Neurosci 2003 3.08
16 Expression of melanocortin 4 receptor mRNA in the central nervous system of the rat. J Comp Neurol 2003 3.05
17 Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia. Cell Metab 2007 3.02
18 Leptin targets in the mouse brain. J Comp Neurol 2009 2.80
19 Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice. J Clin Invest 2008 2.77
20 Distinct narcolepsy syndromes in Orexin receptor-2 and Orexin null mice: molecular genetic dissection of Non-REM and REM sleep regulatory processes. Neuron 2003 2.73
21 Activation of central melanocortin pathways by fenfluramine. Science 2002 2.71
22 The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress. Nat Neurosci 2008 2.64
23 Distinct hypothalamic neurons mediate estrogenic effects on energy homeostasis and reproduction. Cell Metab 2011 2.61
24 Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility. Cell Metab 2010 2.58
25 Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons. J Clin Invest 2002 2.54
26 Segregation of acute leptin and insulin effects in distinct populations of arcuate proopiomelanocortin neurons. J Neurosci 2010 2.42
27 High-fat feeding promotes obesity via insulin receptor/PI3K-dependent inhibition of SF-1 VMH neurons. Nat Neurosci 2011 2.36
28 A cardiac microRNA governs systemic energy homeostasis by regulation of MED13. Cell 2012 2.29
29 Minireview: From anorexia to obesity--the yin and yang of body weight control. Endocrinology 2003 2.27
30 From neuroanatomy to behavior: central integration of peripheral signals regulating feeding behavior. Nat Neurosci 2012 2.26
31 Sixteen years and counting: an update on leptin in energy balance. J Clin Invest 2011 2.21
32 FGF21 regulates metabolism and circadian behavior by acting on the nervous system. Nat Med 2013 2.20
33 Serotonin reciprocally regulates melanocortin neurons to modulate food intake. Neuron 2006 2.16
34 Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in mice. J Clin Invest 2012 2.12
35 5-HT2CRs expressed by pro-opiomelanocortin neurons regulate energy homeostasis. Neuron 2008 2.04
36 Disruption of leptin receptor expression in the pancreas directly affects beta cell growth and function in mice. J Clin Invest 2007 1.99
37 Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells. Cell Metab 2006 1.96
38 Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice. J Clin Invest 2003 1.95
39 Brain SIRT1: anatomical distribution and regulation by energy availability. J Neurosci 2008 1.75
40 Hypothalamic pathways linking energy balance and reproduction. Am J Physiol Endocrinol Metab 2008 1.75
41 Glucagon-like peptide-1-responsive catecholamine neurons in the area postrema link peripheral glucagon-like peptide-1 with central autonomic control sites. J Neurosci 2003 1.74
42 Melanocortin 4 receptors reciprocally regulate sympathetic and parasympathetic preganglionic neurons. Cell 2013 1.71
43 Serotonin 2C receptor agonists improve type 2 diabetes via melanocortin-4 receptor signaling pathways. Cell Metab 2007 1.70
44 Leptin receptor expression in hindbrain Glp-1 neurons regulates food intake and energy balance in mice. J Clin Invest 2011 1.65
45 PI3K signaling in the ventromedial hypothalamic nucleus is required for normal energy homeostasis. Cell Metab 2010 1.57
46 Leptin's effect on puberty in mice is relayed by the ventral premammillary nucleus and does not require signaling in Kiss1 neurons. J Clin Invest 2010 1.49
47 Serotonin activates the hypothalamic-pituitary-adrenal axis via serotonin 2C receptor stimulation. J Neurosci 2007 1.49
48 Characterization of a novel binding partner of the melanocortin-4 receptor: attractin-like protein. Biochem J 2003 1.49
49 Monitoring FoxO1 localization in chemically identified neurons. J Neurosci 2008 1.39
50 Serotonin 2C receptor activates a distinct population of arcuate pro-opiomelanocortin neurons via TRPC channels. Neuron 2011 1.36
51 Postnatal Sim1 deficiency causes hyperphagic obesity and reduced Mc4r and oxytocin expression. J Neurosci 2010 1.32
52 Leptin engages a hypothalamic neurocircuitry to permit survival in the absence of insulin. Cell Metab 2013 1.32
53 PANIC-ATTAC: a mouse model for inducible and reversible beta-cell ablation. Diabetes 2008 1.31
54 Central administration of resveratrol improves diet-induced diabetes. Endocrinology 2009 1.30
55 Neuronal circuits that regulate feeding behavior and metabolism. Trends Neurosci 2013 1.26
56 A beta3-adrenergic-leptin-melanocortin circuit regulates behavioral and metabolic changes induced by chronic stress. Biol Psychiatry 2010 1.24
57 Central serotonin and melanocortin pathways regulating energy homeostasis. Ann N Y Acad Sci 2003 1.24
58 Phosphatidyl inositol 3-kinase signaling in hypothalamic proopiomelanocortin neurons contributes to the regulation of glucose homeostasis. Endocrinology 2009 1.23
59 From observation to experimentation: leptin action in the mediobasal hypothalamus. Am J Clin Nutr 2009 1.23
60 Central nervous control of energy and glucose balance: focus on the central melanocortin system. Ann N Y Acad Sci 2011 1.22
61 VGF is required for obesity induced by diet, gold thioglucose treatment, and agouti and is differentially regulated in pro-opiomelanocortin- and neuropeptide Y-containing arcuate neurons in response to fasting. J Neurosci 2002 1.22
62 Colocalization of ghrelin O-acyltransferase and ghrelin in gastric mucosal cells. Am J Physiol Endocrinol Metab 2009 1.21
63 Use of laser-capture microdissection for the identification of marker genes for the ventromedial hypothalamic nucleus. J Neurosci 2005 1.21
64 Identifying the efferent projections of leptin-responsive neurons in the dorsomedial hypothalamus using a novel conditional tracing approach. J Comp Neurol 2010 1.19
65 Neuropeptide Y deficiency attenuates responses to fasting and high-fat diet in obesity-prone mice. Diabetes 2006 1.19
66 A serotonin and melanocortin circuit mediates D-fenfluramine anorexia. J Neurosci 2010 1.18
67 Serotonin 2C receptors in pro-opiomelanocortin neurons regulate energy and glucose homeostasis. J Clin Invest 2013 1.17
68 Steroidogenic factor 1 directs programs regulating diet-induced thermogenesis and leptin action in the ventral medial hypothalamic nucleus. Proc Natl Acad Sci U S A 2011 1.17
69 Genetic tracing of Nav1.8-expressing vagal afferents in the mouse. J Comp Neurol 2011 1.16
70 5-HT2CRs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver. Nat Neurosci 2010 1.15
71 FOXO1 in the ventromedial hypothalamus regulates energy balance. J Clin Invest 2012 1.13
72 Orexin receptor 2 expression in the posterior hypothalamus rescues sleepiness in narcoleptic mice. Proc Natl Acad Sci U S A 2011 1.09
73 The role of central glucagon-like peptide-1 in mediating the effects of visceral illness: differential effects in rats and mice. Endocrinology 2004 1.09
74 Characterization of a novel ghrelin cell reporter mouse. Regul Pept 2009 1.08
75 Induction of leptin resistance by activation of cAMP-Epac signaling. Cell Metab 2011 1.08
76 Adipose tissue biology and cardiomyopathy: translational implications. Circ Res 2012 1.05
77 Neuroanatomy of melanocortin-4 receptor pathway in the lateral hypothalamic area. J Comp Neurol 2012 1.05
78 Chronic social defeat stress disrupts regulation of lipid synthesis. J Lipid Res 2010 1.04
79 The acute effects of leptin require PI3K signaling in the hypothalamic ventral premammillary nucleus. J Neurosci 2011 1.03
80 Specific roles of cyclooxygenase-1 and cyclooxygenase-2 in lipopolysaccharide-induced fever and Fos expression in rat brain. J Comp Neurol 2003 1.02
81 Hcrtr1 and 2 signaling differentially regulates depression-like behaviors. Behav Brain Res 2011 1.01
82 Modulation of the central melanocortin system by leptin, insulin, and serotonin: co-ordinated actions in a dispersed neuronal network. Eur J Pharmacol 2011 1.00
83 Melanocortin 4 receptor signaling in dopamine 1 receptor neurons is required for procedural memory learning. Physiol Behav 2012 0.99
84 Shift in Kiss1 cell activity requires estrogen receptor α. J Neurosci 2013 0.98
85 Neuronal and nonneuronal cholinergic structures in the mouse gastrointestinal tract and spleen. J Comp Neurol 2013 0.98
86 Functional implications of limited leptin receptor and ghrelin receptor coexpression in the brain. J Comp Neurol 2012 0.97
87 Neuropeptide Y Y1 receptor mRNA in rodent brain: distribution and colocalization with melanocortin-4 receptor. J Comp Neurol 2005 0.97
88 Laser-capture microdissection and transcriptional profiling of the dorsomedial nucleus of the hypothalamus. J Comp Neurol 2012 0.95
89 Rethinking the central causes of diabetes. Nat Med 2003 0.94
90 The role of transcriptional regulators in central control of appetite and body weight. Nat Clin Pract Endocrinol Metab 2009 0.94
91 Ciliary neurotrophic factor and leptin induce distinct patterns of immediate early gene expression in the brain. Diabetes 2004 0.93
92 SF-1 in the ventral medial hypothalamic nucleus: a key regulator of homeostasis. Mol Cell Endocrinol 2010 0.93
93 CNS-specific ablation of steroidogenic factor 1 results in impaired female reproductive function. Mol Endocrinol 2010 0.92
94 Hindbrain ghrelin receptor signaling is sufficient to maintain fasting glucose. PLoS One 2012 0.90
95 In search of an effective obesity treatment: a shot in the dark or a shot in the arm? Proc Natl Acad Sci U S A 2006 0.89
96 A role for ΔFosB in calorie restriction-induced metabolic changes. Biol Psychiatry 2011 0.88
97 Expression of the diabetes-associated gene TCF7L2 in adult mouse brain. J Comp Neurol 2009 0.86
98 Physiology: do neural signals remodel bone? Nature 2005 0.85
99 A good night's sleep: future antidote to the obesity epidemic? Ann Intern Med 2004 0.84
100 Cannabinoid receptor 1 in the vagus nerve is dispensable for body weight homeostasis but required for normal gastrointestinal motility. J Neurosci 2012 0.83
101 Elevated resistin levels induce central leptin resistance and increased atherosclerotic progression in mice. Diabetologia 2014 0.83
102 Melanocortin-4 receptor expression in different classes of spinal and vagal primary afferent neurons in the mouse. J Comp Neurol 2012 0.82
103 Lighting up the hypothalamus: coordinated control of feeding behavior. Nat Neurosci 2011 0.81
104 "AMPing up" our understanding of the hypothalamic control of energy balance. J Clin Invest 2007 0.81
105 Loss of Goosecoid-like and DiGeorge syndrome critical region 14 in interpeduncular nucleus results in altered regulation of rapid eye movement sleep. Proc Natl Acad Sci U S A 2010 0.80
106 Tipping the scales early: probing the long-term effects of obesity. J Clin Invest 2012 0.79
107 Nuclear receptor LRH-1 induces the reproductive neuropeptide kisspeptin in the hypothalamus. Mol Endocrinol 2013 0.78
108 Mrap2: an accessory protein linked to obesity. Cell Metab 2013 0.77
109 Orexin neurons and the TASK of glucosensing. Neuron 2006 0.75
110 Movin' on up: adipocytes become regulators of nutrient homeostasis. Cell Metab 2006 0.75
111 Brain nuclear receptors and body weight regulation. J Clin Invest 2017 0.75
112 Expression of Leptin Receptor Isoforms in Rat Brain Microvessels. Endocrinology 1998 0.75
113 Activation of SOCS-3 Messenger Ribonucleic Acid in the Hypothalamus by Ciliary Neurotrophic Factor. Endocrinology 1999 0.75
114 Characterization of Expression of Hypothalamic Appetite-Regulating Peptides in Obese Hyperleptinemic Brown Adipose Tissue-Deficient (Uncoupling Protein-Promoter-Driven Diphtheria Toxin A) Mice* *This work was supported by a grant from Eli Lilly & Co. (to E.M.F.), NIH Grant DK-R37-28082 (to J.S.F.), and NIH Grant MH-56537 (to J.K.E.). Endocrinology 1998 0.75