Published in Neuron on June 05, 2003
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Almorexant promotes sleep and exacerbates cataplexy in a murine model of narcolepsy. Sleep (2013) 0.96
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H1N1 influenza virus induces narcolepsy-like sleep disruption and targets sleep-wake regulatory neurons in mice. Proc Natl Acad Sci U S A (2015) 0.89
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Activity of pontine neurons during sleep and cataplexy in hypocretin knock-out mice. J Neurosci (2009) 0.89
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Narcoleptic orexin receptor knockout mice express enhanced cholinergic properties in laterodorsal tegmental neurons. Eur J Neurosci (2010) 0.88
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Tumor necrosis factor-alpha regulates the Hypocretin system via mRNA degradation and ubiquitination. Biochim Biophys Acta (2010) 0.85
Sites of action of sleep and wake drugs: insights from model organisms. Curr Opin Neurobiol (2013) 0.85
Controlled cortical impact traumatic brain injury acutely disrupts wakefulness and extracellular orexin dynamics as determined by intracerebral microdialysis in mice. J Neurotrauma (2012) 0.85
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Mechanistic insights into influenza vaccine-associated narcolepsy. Hum Vaccin Immunother (2016) 0.85
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Developmental changes in CSF hypocretin-1 (orexin-A) levels in normal and genetically narcoleptic Doberman pinschers. J Physiol (2004) 0.83
A mathematical model towards understanding the mechanism of neuronal regulation of wake-NREMS-REMS states. PLoS One (2012) 0.83
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Differential actions of orexin receptors in brainstem cholinergic and monoaminergic neurons revealed by receptor knockouts: implications for orexinergic signaling in arousal and narcolepsy. Front Neurosci (2013) 0.82
Influence of inhibitory serotonergic inputs to orexin/hypocretin neurons on the diurnal rhythm of sleep and wakefulness. Sleep (2013) 0.82
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Norepinephrine is required to promote wakefulness and for hypocretin-induced arousal in zebrafish. Elife (2015) 0.81
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Control of stress-dependent cardiac growth and gene expression by a microRNA. Science (2007) 12.08
A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure. Proc Natl Acad Sci U S A (2006) 10.09
Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. Cell Metab (2007) 9.62
Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. Cell Metab (2005) 9.14
Transient regenerative potential of the neonatal mouse heart. Science (2011) 9.02
The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis. Dev Cell (2008) 7.26
Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis. Neuron (2004) 7.15
Divergence of melanocortin pathways in the control of food intake and energy expenditure. Cell (2005) 7.04
A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice. Science (2007) 6.64
White fat progenitor cells reside in the adipose vasculature. Science (2008) 6.49
Dentate gyrus NMDA receptors mediate rapid pattern separation in the hippocampal network. Science (2007) 6.48
Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c. J Biol Chem (2002) 5.89
Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis. Cell (2004) 5.80
microRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart. Genes Dev (2008) 5.39
A family of microRNAs encoded by myosin genes governs myosin expression and muscle performance. Dev Cell (2009) 5.28
Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. Neuron (2006) 5.27
Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis. Nature (2003) 5.19
Cardiac autophagy is a maladaptive response to hemodynamic stress. J Clin Invest (2007) 5.17
The need to feed: homeostatic and hedonic control of eating. Neuron (2002) 4.99
MicroRNAs miR-143 and miR-145 modulate cytoskeletal dynamics and responsiveness of smooth muscle cells to injury. Genes Dev (2009) 4.62
Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9. Proc Natl Acad Sci U S A (2005) 4.56
Histone deacetylases 1 and 2 redundantly regulate cardiac morphogenesis, growth, and contractility. Genes Dev (2007) 4.50
Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41. Proc Natl Acad Sci U S A (2008) 4.45
Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart development. Mol Cell Biol (2004) 4.24
Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity. Nature (2007) 4.20
Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome. Proc Natl Acad Sci U S A (2003) 4.03
Mice lacking ghrelin receptors resist the development of diet-induced obesity. J Clin Invest (2005) 3.92
Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance. Nat Neurosci (2008) 3.90
Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol. J Clin Invest (2002) 3.85
Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1-/- mice. Nat Genet (2003) 3.78
Potentiation of serum response factor activity by a family of myocardin-related transcription factors. Proc Natl Acad Sci U S A (2002) 3.74
Modulation of K-Ras-dependent lung tumorigenesis by MicroRNA-21. Cancer Cell (2010) 3.72
Melanocortin-4 receptors expressed by cholinergic neurons regulate energy balance and glucose homeostasis. Cell Metab (2011) 3.68
An intragenic MEF2-dependent enhancer directs muscle-specific expression of microRNAs 1 and 133. Proc Natl Acad Sci U S A (2007) 3.62
PTP1B regulates leptin signal transduction in vivo. Dev Cell (2002) 3.61
Expression of ghrelin receptor mRNA in the rat and the mouse brain. J Comp Neurol (2006) 3.61
Hypothalamic orexin neurons regulate arousal according to energy balance in mice. Neuron (2003) 3.61
Fibulin-5 is an elastin-binding protein essential for elastic fibre development in vivo. Nature (2002) 3.60
Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice. J Clin Invest (2006) 3.54
Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta. J Biol Chem (2002) 3.52
Twist regulates cytokine gene expression through a negative feedback loop that represses NF-kappaB activity. Cell (2003) 3.40
The serum response factor coactivator myocardin is required for vascular smooth muscle development. Proc Natl Acad Sci U S A (2003) 3.40
The hypothalamic arcuate nucleus: a key site for mediating leptin's effects on glucose homeostasis and locomotor activity. Cell Metab (2005) 3.38
Mitochondrial deficiency and cardiac sudden death in mice lacking the MEF2A transcription factor. Nat Med (2002) 3.31
Requirement for serum response factor for skeletal muscle growth and maturation revealed by tissue-specific gene deletion in mice. Proc Natl Acad Sci U S A (2005) 3.30
Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes. J Clin Invest (2005) 3.29
Activated glycogen synthase-3 beta suppresses cardiac hypertrophy in vivo. Proc Natl Acad Sci U S A (2002) 3.27
Modulation of synaptic plasticity and memory by Reelin involves differential splicing of the lipoprotein receptor Apoer2. Neuron (2005) 3.25
Histone deacetylase degradation and MEF2 activation promote the formation of slow-twitch myofibers. J Clin Invest (2007) 3.19
Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion. Proc Natl Acad Sci U S A (2002) 3.09
Transgenic mice expressing green fluorescent protein under the control of the melanocortin-4 receptor promoter. J Neurosci (2003) 3.08
Histone deacetylase 7 maintains vascular integrity by repressing matrix metalloproteinase 10. Cell (2006) 3.07
Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor. Proc Natl Acad Sci U S A (2006) 3.05
Expression of melanocortin 4 receptor mRNA in the central nervous system of the rat. J Comp Neurol (2003) 3.05
Smooth muscle-selective deletion of guanylyl cyclase-A prevents the acute but not chronic effects of ANP on blood pressure. Proc Natl Acad Sci U S A (2002) 3.03
Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia. Cell Metab (2007) 3.02
MEF2C transcription factor controls chondrocyte hypertrophy and bone development. Dev Cell (2007) 2.96
Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion. Proc Natl Acad Sci U S A (2002) 2.93
Persistent expression of the ATP-binding cassette transporter, Abcg2, identifies cardiac SP cells in the developing and adult heart. Dev Biol (2004) 2.89
Direct involvement of orexinergic systems in the activation of the mesolimbic dopamine pathway and related behaviors induced by morphine. J Neurosci (2006) 2.84
Leptin targets in the mouse brain. J Comp Neurol (2009) 2.80
Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice. J Clin Invest (2008) 2.77
Hippo pathway effector Yap promotes cardiac regeneration. Proc Natl Acad Sci U S A (2013) 2.76
TRPC6 fulfills a calcineurin signaling circuit during pathologic cardiac remodeling. J Clin Invest (2006) 2.74
Activation of central melanocortin pathways by fenfluramine. Science (2002) 2.71
Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis. J Clin Invest (2004) 2.66
Collecting duct-specific knockout of endothelin-1 causes hypertension and sodium retention. J Clin Invest (2004) 2.66
The delta isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overload. Proc Natl Acad Sci U S A (2009) 2.66
The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress. Nat Neurosci (2008) 2.64
Double-knockout mice for alpha- and beta-synucleins: effect on synaptic functions. Proc Natl Acad Sci U S A (2004) 2.62
Distinct hypothalamic neurons mediate estrogenic effects on energy homeostasis and reproduction. Cell Metab (2011) 2.61
The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner. Development (2004) 2.61
Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility. Cell Metab (2010) 2.58
Behavioral state instability in orexin knock-out mice. J Neurosci (2004) 2.56
Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons. J Clin Invest (2002) 2.54
Modulation of cardiac growth and development by HOP, an unusual homeodomain protein. Cell (2002) 2.53
Regulation of PI3-kinase/Akt signaling by muscle-enriched microRNA-486. Proc Natl Acad Sci U S A (2010) 2.47
Attenuated defense response and low basal blood pressure in orexin knockout mice. Am J Physiol Regul Integr Comp Physiol (2003) 2.45
Conformational switch of syntaxin-1 controls synaptic vesicle fusion. Science (2008) 2.44
Segregation of acute leptin and insulin effects in distinct populations of arcuate proopiomelanocortin neurons. J Neurosci (2010) 2.42
Regulation of insulin-like growth factor signaling by Yap governs cardiomyocyte proliferation and embryonic heart size. Sci Signal (2011) 2.38
High-fat feeding promotes obesity via insulin receptor/PI3K-dependent inhibition of SF-1 VMH neurons. Nat Neurosci (2011) 2.36
Orexin/hypocretin and histamine: distinct roles in the control of wakefulness demonstrated using knock-out mouse models. J Neurosci (2009) 2.35
A threshold of GATA4 and GATA6 expression is required for cardiovascular development. Proc Natl Acad Sci U S A (2006) 2.32
Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice. J Clin Invest (2008) 2.31
Modulation of smooth muscle gene expression by association of histone acetyltransferases and deacetylases with myocardin. Mol Cell Biol (2005) 2.30
A cardiac microRNA governs systemic energy homeostasis by regulation of MED13. Cell (2012) 2.29
An essential role for orexins in emergence from general anesthesia. Proc Natl Acad Sci U S A (2008) 2.27
Minireview: From anorexia to obesity--the yin and yang of body weight control. Endocrinology (2003) 2.27
Histone deacetylases 1 and 2 control the progression of neural precursors to neurons during brain development. Proc Natl Acad Sci U S A (2009) 2.27