Published in Endocrinology on September 01, 2003
Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index. PLoS Med (2004) 11.17
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Leptin action in the forebrain regulates the hindbrain response to satiety signals. J Clin Invest (2005) 2.14
Homeostatic and hedonic signals interact in the regulation of food intake. J Nutr (2009) 1.95
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Cumulative dietary energy intake determines the onset of puberty in female rats. Environ Health Perspect (2004) 0.83
Melanin concentrating hormone and estrogen receptor-alpha are coexstensive but not coexpressed in cells of male rat hypothalamus. Neurosci Lett (2007) 0.82
Activating mu-opioid receptors in the lateral parabrachial nucleus increases c-Fos expression in forebrain areas associated with caloric regulation, reward and cognition. Neuroscience (2009) 0.81
Intermittent fasting dietary restriction regimen negatively influences reproduction in young rats: a study of hypothalamo-hypophysial-gonadal axis. PLoS One (2013) 0.81
Regulation of AMP-activated protein kinase signaling by AFF4 protein, member of AF4 (ALL1-fused gene from chromosome 4) family of transcription factors, in hypothalamic neurons. J Biol Chem (2012) 0.81
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Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis. Neuron (2004) 7.15
Divergence of melanocortin pathways in the control of food intake and energy expenditure. Cell (2005) 7.04
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Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. Neuron (2006) 5.27
The need to feed: homeostatic and hedonic control of eating. Neuron (2002) 4.99
Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity. Nature (2007) 4.20
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The hypothalamic arcuate nucleus: a key site for mediating leptin's effects on glucose homeostasis and locomotor activity. Cell Metab (2005) 3.38
Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes. J Clin Invest (2005) 3.29
Transgenic mice expressing green fluorescent protein under the control of the melanocortin-4 receptor promoter. J Neurosci (2003) 3.08
Expression of melanocortin 4 receptor mRNA in the central nervous system of the rat. J Comp Neurol (2003) 3.05
Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia. Cell Metab (2007) 3.02
Leptin targets in the mouse brain. J Comp Neurol (2009) 2.80
Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice. J Clin Invest (2008) 2.77
Distinct narcolepsy syndromes in Orexin receptor-2 and Orexin null mice: molecular genetic dissection of Non-REM and REM sleep regulatory processes. Neuron (2003) 2.73
Activation of central melanocortin pathways by fenfluramine. Science (2002) 2.71
The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress. Nat Neurosci (2008) 2.64
Distinct hypothalamic neurons mediate estrogenic effects on energy homeostasis and reproduction. Cell Metab (2011) 2.61
Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility. Cell Metab (2010) 2.58
Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons. J Clin Invest (2002) 2.54
Segregation of acute leptin and insulin effects in distinct populations of arcuate proopiomelanocortin neurons. J Neurosci (2010) 2.42
High-fat feeding promotes obesity via insulin receptor/PI3K-dependent inhibition of SF-1 VMH neurons. Nat Neurosci (2011) 2.36
A cardiac microRNA governs systemic energy homeostasis by regulation of MED13. Cell (2012) 2.29
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Sixteen years and counting: an update on leptin in energy balance. J Clin Invest (2011) 2.21
FGF21 regulates metabolism and circadian behavior by acting on the nervous system. Nat Med (2013) 2.20
Serotonin reciprocally regulates melanocortin neurons to modulate food intake. Neuron (2006) 2.16
Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in mice. J Clin Invest (2012) 2.12
5-HT2CRs expressed by pro-opiomelanocortin neurons regulate energy homeostasis. Neuron (2008) 2.04
Disruption of leptin receptor expression in the pancreas directly affects beta cell growth and function in mice. J Clin Invest (2007) 1.99
Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells. Cell Metab (2006) 1.96
Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice. J Clin Invest (2003) 1.95
Brain SIRT1: anatomical distribution and regulation by energy availability. J Neurosci (2008) 1.75
Hypothalamic pathways linking energy balance and reproduction. Am J Physiol Endocrinol Metab (2008) 1.75
Glucagon-like peptide-1-responsive catecholamine neurons in the area postrema link peripheral glucagon-like peptide-1 with central autonomic control sites. J Neurosci (2003) 1.74
Melanocortin 4 receptors reciprocally regulate sympathetic and parasympathetic preganglionic neurons. Cell (2013) 1.71
Serotonin 2C receptor agonists improve type 2 diabetes via melanocortin-4 receptor signaling pathways. Cell Metab (2007) 1.70
Leptin receptor expression in hindbrain Glp-1 neurons regulates food intake and energy balance in mice. J Clin Invest (2011) 1.65
PI3K signaling in the ventromedial hypothalamic nucleus is required for normal energy homeostasis. Cell Metab (2010) 1.57
Leptin's effect on puberty in mice is relayed by the ventral premammillary nucleus and does not require signaling in Kiss1 neurons. J Clin Invest (2010) 1.49
Serotonin activates the hypothalamic-pituitary-adrenal axis via serotonin 2C receptor stimulation. J Neurosci (2007) 1.49
Characterization of a novel binding partner of the melanocortin-4 receptor: attractin-like protein. Biochem J (2003) 1.49
Monitoring FoxO1 localization in chemically identified neurons. J Neurosci (2008) 1.39
Serotonin 2C receptor activates a distinct population of arcuate pro-opiomelanocortin neurons via TRPC channels. Neuron (2011) 1.36
Postnatal Sim1 deficiency causes hyperphagic obesity and reduced Mc4r and oxytocin expression. J Neurosci (2010) 1.32
Leptin engages a hypothalamic neurocircuitry to permit survival in the absence of insulin. Cell Metab (2013) 1.32
PANIC-ATTAC: a mouse model for inducible and reversible beta-cell ablation. Diabetes (2008) 1.31
Central administration of resveratrol improves diet-induced diabetes. Endocrinology (2009) 1.30
Neuronal circuits that regulate feeding behavior and metabolism. Trends Neurosci (2013) 1.26
A beta3-adrenergic-leptin-melanocortin circuit regulates behavioral and metabolic changes induced by chronic stress. Biol Psychiatry (2010) 1.24
Central serotonin and melanocortin pathways regulating energy homeostasis. Ann N Y Acad Sci (2003) 1.24
Phosphatidyl inositol 3-kinase signaling in hypothalamic proopiomelanocortin neurons contributes to the regulation of glucose homeostasis. Endocrinology (2009) 1.23
From observation to experimentation: leptin action in the mediobasal hypothalamus. Am J Clin Nutr (2009) 1.23
Central nervous control of energy and glucose balance: focus on the central melanocortin system. Ann N Y Acad Sci (2011) 1.22
Colocalization of ghrelin O-acyltransferase and ghrelin in gastric mucosal cells. Am J Physiol Endocrinol Metab (2009) 1.21
Use of laser-capture microdissection for the identification of marker genes for the ventromedial hypothalamic nucleus. J Neurosci (2005) 1.21
Identifying the efferent projections of leptin-responsive neurons in the dorsomedial hypothalamus using a novel conditional tracing approach. J Comp Neurol (2010) 1.19
Neuropeptide Y deficiency attenuates responses to fasting and high-fat diet in obesity-prone mice. Diabetes (2006) 1.19
A serotonin and melanocortin circuit mediates D-fenfluramine anorexia. J Neurosci (2010) 1.18
Serotonin 2C receptors in pro-opiomelanocortin neurons regulate energy and glucose homeostasis. J Clin Invest (2013) 1.17
Steroidogenic factor 1 directs programs regulating diet-induced thermogenesis and leptin action in the ventral medial hypothalamic nucleus. Proc Natl Acad Sci U S A (2011) 1.17
Genetic tracing of Nav1.8-expressing vagal afferents in the mouse. J Comp Neurol (2011) 1.16
5-HT2CRs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver. Nat Neurosci (2010) 1.15
FOXO1 in the ventromedial hypothalamus regulates energy balance. J Clin Invest (2012) 1.13
Orexin receptor 2 expression in the posterior hypothalamus rescues sleepiness in narcoleptic mice. Proc Natl Acad Sci U S A (2011) 1.09
The role of central glucagon-like peptide-1 in mediating the effects of visceral illness: differential effects in rats and mice. Endocrinology (2004) 1.09
Characterization of a novel ghrelin cell reporter mouse. Regul Pept (2009) 1.08
Induction of leptin resistance by activation of cAMP-Epac signaling. Cell Metab (2011) 1.08
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Neuroanatomy of melanocortin-4 receptor pathway in the lateral hypothalamic area. J Comp Neurol (2012) 1.05
Chronic social defeat stress disrupts regulation of lipid synthesis. J Lipid Res (2010) 1.04
The acute effects of leptin require PI3K signaling in the hypothalamic ventral premammillary nucleus. J Neurosci (2011) 1.03
Specific roles of cyclooxygenase-1 and cyclooxygenase-2 in lipopolysaccharide-induced fever and Fos expression in rat brain. J Comp Neurol (2003) 1.02
Hcrtr1 and 2 signaling differentially regulates depression-like behaviors. Behav Brain Res (2011) 1.01
Modulation of the central melanocortin system by leptin, insulin, and serotonin: co-ordinated actions in a dispersed neuronal network. Eur J Pharmacol (2011) 1.00
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Shift in Kiss1 cell activity requires estrogen receptor α. J Neurosci (2013) 0.98
Neuronal and nonneuronal cholinergic structures in the mouse gastrointestinal tract and spleen. J Comp Neurol (2013) 0.98
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Neuropeptide Y Y1 receptor mRNA in rodent brain: distribution and colocalization with melanocortin-4 receptor. J Comp Neurol (2005) 0.97
Laser-capture microdissection and transcriptional profiling of the dorsomedial nucleus of the hypothalamus. J Comp Neurol (2012) 0.95
Rethinking the central causes of diabetes. Nat Med (2003) 0.94
The role of transcriptional regulators in central control of appetite and body weight. Nat Clin Pract Endocrinol Metab (2009) 0.94
Ciliary neurotrophic factor and leptin induce distinct patterns of immediate early gene expression in the brain. Diabetes (2004) 0.93
SF-1 in the ventral medial hypothalamic nucleus: a key regulator of homeostasis. Mol Cell Endocrinol (2010) 0.93
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