Published in Nat Methods on October 31, 2010
Optical control of mammalian endogenous transcription and epigenetic states. Nature (2013) 6.09
Spatiotemporal control of gene expression by a light-switchable transgene system. Nat Methods (2012) 2.79
TULIPs: tunable, light-controlled interacting protein tags for cell biology. Nat Methods (2012) 2.59
Remote control of therapeutic T cells through a small molecule-gated chimeric receptor. Science (2015) 2.50
Using optogenetics to interrogate the dynamic control of signal transmission by the Ras/Erk module. Cell (2013) 2.22
Optogenetic protein clustering and signaling activation in mammalian cells. Nat Methods (2013) 2.22
Optogenetic tools for analyzing the neural circuits of behavior. Trends Cogn Sci (2011) 2.15
Optical control of protein activity by fluorescent protein domains. Science (2012) 2.10
Optogenetic control of organelle transport and positioning. Nature (2015) 1.99
Designing photoswitchable peptides using the AsLOV2 domain. Chem Biol (2012) 1.99
Optogenetic control of phosphoinositide metabolism. Proc Natl Acad Sci U S A (2012) 1.92
The promise of optogenetics in cell biology: interrogating molecular circuits in space and time. Nat Methods (2010) 1.87
Channelrhodopsin engineering and exploration of new optogenetic tools. Nat Methods (2010) 1.70
Light-inducible spatiotemporal control of gene activation by customizable zinc finger transcription factors. J Am Chem Soc (2012) 1.69
An Optogenetic Method to Modulate Cell Contractility during Tissue Morphogenesis. Dev Cell (2015) 1.59
Growth cone travel in space and time: the cellular ensemble of cytoskeleton, adhesion, and membrane. Neuron (2012) 1.58
Strategies to achieve conditional gene mutation in mice. Cold Spring Harb Protoc (2014) 1.54
Optogenetic control of molecular motors and organelle distributions in cells. Chem Biol (2015) 1.51
A light-inducible CRISPR-Cas9 system for control of endogenous gene activation. Nat Chem Biol (2015) 1.48
Illuminating cell signalling with optogenetic tools. Nat Rev Mol Cell Biol (2014) 1.46
From cudgel to scalpel: toward precise neural control with optogenetics. Nat Methods (2010) 1.45
Spatiotemporal Control of Intracellular Phase Transitions Using Light-Activated optoDroplets. Cell (2016) 1.44
Optical control of cell signaling by single-chain photoswitchable kinases. Science (2017) 1.41
Optogenetic control of cells and circuits. Annu Rev Cell Dev Biol (2011) 1.40
Engineering an improved light-induced dimer (iLID) for controlling the localization and activity of signaling proteins. Proc Natl Acad Sci U S A (2014) 1.34
An optimized optogenetic clustering tool for probing protein interaction and function. Nat Commun (2014) 1.33
Postsynaptic signaling during plasticity of dendritic spines. Trends Neurosci (2012) 1.32
Engineering of bacterial phytochromes for near-infrared imaging, sensing, and light-control in mammals. Chem Soc Rev (2013) 1.31
Rational design of a split-Cas9 enzyme complex. Proc Natl Acad Sci U S A (2015) 1.30
An optogenetic gene expression system with rapid activation and deactivation kinetics. Nat Chem Biol (2014) 1.30
Photoactivatable CRISPR-Cas9 for optogenetic genome editing. Nat Biotechnol (2015) 1.28
Editing the epigenome: technologies for programmable transcription and epigenetic modulation. Nat Methods (2016) 1.24
A light-inducible organelle-targeting system for dynamically activating and inactivating signaling in budding yeast. Mol Biol Cell (2013) 1.19
Multi-chromatic control of mammalian gene expression and signaling. Nucleic Acids Res (2013) 1.17
Ultraviolet-B-mediated induction of protein-protein interactions in mammalian cells. Nat Commun (2013) 1.17
Very long-term memories may be stored in the pattern of holes in the perineuronal net. Proc Natl Acad Sci U S A (2013) 1.17
A light-triggered protein secretion system. J Cell Biol (2013) 1.15
Live imaging of multicolor-labeled cells in Drosophila. Development (2013) 1.12
Optogenetic control of cell function using engineered photoreceptors. Biol Cell (2012) 1.09
Light-mediated control of DNA transcription in yeast. Methods (2012) 1.09
Optogenetic control of transcription in zebrafish. PLoS One (2012) 1.07
Light-mediated kinetic control reveals the temporal effect of the Raf/MEK/ERK pathway in PC12 cell neurite outgrowth. PLoS One (2014) 1.07
Multiple bHLH proteins form heterodimers to mediate CRY2-dependent regulation of flowering-time in Arabidopsis. PLoS Genet (2013) 1.07
Chemical biology strategies for posttranslational control of protein function. Chem Biol (2014) 1.07
Optogenetic approaches to cell migration and beyond. Curr Opin Cell Biol (2014) 1.06
Mouse genome engineering via CRISPR-Cas9 for study of immune function. Immunity (2015) 1.02
Tuning response curves for synthetic biology. ACS Synth Biol (2013) 1.01
Triggered Ca2+ influx is required for extended synaptotagmin 1-induced ER-plasma membrane tethering. EMBO J (2015) 1.01
Optogenetic control of intracellular signaling pathways. Trends Biotechnol (2014) 1.01
Localized light-induced protein dimerization in living cells using a photocaged dimerizer. Nat Commun (2014) 1.01
Photochemistry of flavoprotein light sensors. Nat Chem Biol (2014) 1.00
Benchmarking of optical dimerizer systems. ACS Synth Biol (2014) 0.99
Genetically encoded molecular probes to visualize and perturb signaling dynamics in living biological systems. J Cell Sci (2014) 0.99
Genetically encoded light-activated transcription for spatiotemporal control of gene expression and gene silencing in mammalian cells. J Am Chem Soc (2013) 0.98
Optobiology: optical control of biological processes via protein engineering. Biochem Soc Trans (2013) 0.97
Genetic encoding of photocaged cysteine allows photoactivation of TEV protease in live mammalian cells. J Am Chem Soc (2014) 0.96
Blue light-dependent interaction between cryptochrome2 and CIB1 regulates transcription and leaf senescence in soybean. Plant Cell (2013) 0.96
Reversible Optogenetic Control of Subcellular Protein Localization in a Live Vertebrate Embryo. Dev Cell (2016) 0.95
Optogenetic control of PIP3: PIP3 is sufficient to induce the actin-based active part of growth cones and is regulated via endocytosis. PLoS One (2013) 0.95
Correlating in Vitro and in Vivo Activities of Light-Inducible Dimers: A Cellular Optogenetics Guide. ACS Synth Biol (2015) 0.95
Self-organization of protrusions and polarity during eukaryotic chemotaxis. Curr Opin Cell Biol (2014) 0.94
Biomedically relevant circuit-design strategies in mammalian synthetic biology. Mol Syst Biol (2013) 0.93
Biochemical Computation for Spine Structural Plasticity. Neuron (2015) 0.93
Natural photoreceptors as a source of fluorescent proteins, biosensors, and optogenetic tools. Annu Rev Biochem (2015) 0.92
Ultradian oscillations and pulses: coordinating cellular responses and cell fate decisions. Development (2014) 0.92
Arabidopsis CRY2 and ZTL mediate blue-light regulation of the transcription factor CIB1 by distinct mechanisms. Proc Natl Acad Sci U S A (2013) 0.91
Optochemogenetics (OCG) allows more precise control of genetic engineering in mice with CreER regulators. Bioconjug Chem (2012) 0.90
Bio-inspired voltage-dependent calcium channel blockers. Nat Commun (2013) 0.90
Subcellular optogenetic inhibition of G proteins generates signaling gradients and cell migration. Mol Biol Cell (2014) 0.89
Molecular tools and approaches for optogenetics. Biol Psychiatry (2012) 0.88
General method for regulating protein stability with light. ACS Chem Biol (2013) 0.88
In Situ Formation of an Azo Bridge on Proteins Controllable by Visible Light. J Am Chem Soc (2015) 0.88
Apocalmodulin itself promotes ion channel opening and Ca(2+) regulation. Cell (2014) 0.87
Plant flavoprotein photoreceptors. Plant Cell Physiol (2014) 0.87
Degradation of Arabidopsis CRY2 is regulated by SPA proteins and phytochrome A. Plant Cell (2012) 0.86
Mammalian synthetic biology: emerging medical applications. J R Soc Interface (2015) 0.86
Guiding lights: recent developments in optogenetic control of biochemical signals. Pflugers Arch (2013) 0.86
Optimized second-generation CRY2-CIB dimerizers and photoactivatable Cre recombinase. Nat Chem Biol (2016) 0.86
Synthetic physiology strategies for adapting tools from nature for genetically targeted control of fast biological processes. Methods Enzymol (2011) 0.85
Algal photoreceptors: in vivo functions and potential applications. Planta (2013) 0.85
Regulation of endogenous transmembrane receptors through optogenetic Cry2 clustering. Nat Commun (2015) 0.84
Near-infrared light responsive synthetic c-di-GMP module for optogenetic applications. ACS Synth Biol (2014) 0.84
Formation of Arabidopsis Cryptochrome 2 photobodies in mammalian nuclei: application as an optogenetic DNA damage checkpoint switch. J Biol Chem (2013) 0.84
Light-dependent, dark-promoted interaction between Arabidopsis cryptochrome 1 and phytochrome B proteins. J Biol Chem (2012) 0.84
A modular open platform for systematic functional studies under physiological conditions. Nucleic Acids Res (2015) 0.83
Integrating optogenetic and pharmacological approaches to study neural circuit function: current applications and future directions. Pharmacol Rev (2013) 0.83
Photo-activatable Cre recombinase regulates gene expression in vivo. Sci Rep (2015) 0.83
Photoreceptor engineering. Front Mol Biosci (2015) 0.83
Light-inducible gene regulation with engineered zinc finger proteins. Methods Mol Biol (2014) 0.83
Spatio-temporal manipulation of small GTPase activity at subcellular level and on timescale of seconds in living cells. J Vis Exp (2012) 0.82
Optogenetic engineering: light-directed cell motility. Angew Chem Int Ed Engl (2014) 0.82
Epigenome editing. Nat Biotechnol (2013) 0.82
Cell-permeant and photocleavable chemical inducer of dimerization. Angew Chem Int Ed Engl (2014) 0.82
An open-hardware platform for optogenetics and photobiology. Sci Rep (2016) 0.82
How to understand and outwit adaptation. Dev Cell (2014) 0.82
Subcellular optogenetics - controlling signaling and single-cell behavior. J Cell Sci (2014) 0.82
Optogenetic control of nuclear protein export. Nat Commun (2016) 0.82
Optogenetic Control of Gene Expression in Drosophila. PLoS One (2015) 0.81
Near-infrared optogenetic pair for protein regulation and spectral multiplexing. Nat Chem Biol (2017) 0.81
Synthetic dual-input mammalian genetic circuits enable tunable and stringent transcription control by chemical and light. Nucleic Acids Res (2015) 0.81
Spatiotemporal control of cell signalling using a light-switchable protein interaction. Nature (2009) 6.74
Controlling signal transduction with synthetic ligands. Science (1993) 6.70
Biochemical and genetic analysis of the yeast proteome with a movable ORF collection. Genes Dev (2005) 6.14
A light-switchable gene promoter system. Nat Biotechnol (2002) 5.28
Photoexcited CRY2 interacts with CIB1 to regulate transcription and floral initiation in Arabidopsis. Science (2008) 3.44
Induction of protein-protein interactions in live cells using light. Nat Biotechnol (2009) 3.16
A novel molecular recognition motif necessary for targeting photoactivated phytochrome signaling to specific basic helix-loop-helix transcription factors. Plant Cell (2004) 3.10
Syntaxin-4 defines a domain for activity-dependent exocytosis in dendritic spines. Cell (2010) 2.88
Cryptochrome blue light photoreceptors are activated through interconversion of flavin redox states. J Biol Chem (2007) 2.56
The signaling state of Arabidopsis cryptochrome 2 contains flavin semiquinone. J Biol Chem (2007) 2.23
Genetically encoded photoswitching of actin assembly through the Cdc42-WASP-Arp2/3 complex pathway. Proc Natl Acad Sci U S A (2008) 2.06
Activation of protein splicing with light in yeast. Nat Methods (2008) 2.02
Unnatural ligands for engineered proteins: new tools for chemical genetics. Annu Rev Biophys Biomol Struct (2000) 1.99
N-terminal domain-mediated homodimerization is required for photoreceptor activity of Arabidopsis CRYPTOCHROME 1. Plant Cell (2005) 1.60
Regulation of Cre recombinase by ligand-induced complementation of inactive fragments. Nucleic Acids Res (2003) 1.57
Preparation of organotypic hippocampal slice cultures for long-term live imaging. Nat Protoc (2006) 1.52
Action spectrum for cryptochrome-dependent hypocotyl growth inhibition in Arabidopsis. Plant Physiol (2002) 1.41
Chemically induced and light-independent cryptochrome photoreceptor activation. Mol Plant (2007) 1.09
In vivo light-induced activation of neural circuitry in transgenic mice expressing channelrhodopsin-2. Neuron (2007) 7.59
Recycling endosomes supply AMPA receptors for LTP. Science (2004) 5.51
Plasticity-induced growth of dendritic spines by exocytic trafficking from recycling endosomes. Neuron (2006) 4.27
Myosin Vb mobilizes recycling endosomes and AMPA receptors for postsynaptic plasticity. Cell (2008) 3.73
Glutamate receptor dynamics in dendritic microdomains. Neuron (2008) 3.28
Syntaxin-4 defines a domain for activity-dependent exocytosis in dendritic spines. Cell (2010) 2.88
Organelles and trafficking machinery for postsynaptic plasticity. Annu Rev Neurosci (2006) 2.82
Polarized secretory trafficking directs cargo for asymmetric dendrite growth and morphogenesis. Neuron (2005) 2.77
Dynamics and regulation of clathrin coats at specialized endocytic zones of dendrites and spines. Neuron (2002) 2.73
TGF-beta signaling specifies axons during brain development. Cell (2010) 2.59
Development of a bird integrity index: using bird assemblages as indicators of riparian condition. Environ Manage (2002) 2.57
Postsynaptic positioning of endocytic zones and AMPA receptor cycling by physical coupling of dynamin-3 to Homer. Neuron (2007) 2.50
Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3. Hum Mol Genet (2011) 2.38
Endocytosis and synaptic removal of NR3A-containing NMDA receptors by PACSIN1/syndapin1. Nat Neurosci (2006) 2.37
Development and evaluation of a Macroinvertebrate Biotic Integrity Index (MBII) for regionally assessing Mid-Atlantic Highlands Streams. Environ Manage (2003) 2.29
Ube3a is required for experience-dependent maturation of the neocortex. Nat Neurosci (2009) 2.28
Endocytic trafficking and recycling maintain a pool of mobile surface AMPA receptors required for synaptic potentiation. Neuron (2009) 2.27
Dual modes of endoplasmic reticulum-to-Golgi transport in dendrites revealed by live-cell imaging. J Neurosci (2003) 2.15
Homeostatic plasticity and NMDA receptor trafficking. Trends Neurosci (2005) 2.11
Emerging roles for ubiquitin and protein degradation in neuronal function. Pharmacol Rev (2007) 2.11
A ferroportin transcript that lacks an iron-responsive element enables duodenal and erythroid precursor cells to evade translational repression. Cell Metab (2009) 2.10
Neuronal polarity and trafficking. Neuron (2003) 2.10
Activity-dependent mRNA splicing controls ER export and synaptic delivery of NMDA receptors. Neuron (2003) 2.09
Mapping dynamic protein interactions in MAP kinase signaling using live-cell fluorescence fluctuation spectroscopy and imaging. Proc Natl Acad Sci U S A (2007) 2.06
Neural circuit mechanisms for pattern detection and feature combination in olfactory cortex. Neuron (2011) 2.05
Lateral organization of endocytic machinery in dendritic spines. Nat Neurosci (2004) 2.04
Ubiquitination in postsynaptic function and plasticity. Annu Rev Cell Dev Biol (2010) 1.94
Optimizing promoters for recombinant adeno-associated virus-mediated gene expression in the peripheral and central nervous system using self-complementary vectors. Hum Gene Ther (2011) 1.90
Transsynaptic signaling by activity-dependent cleavage of neuroligin-1. Neuron (2012) 1.79
Ubiquitin and protein turnover in synapse function. Neuron (2005) 1.78
Mercury concentration in fish from streams and rivers throughout the western United States. Environ Sci Technol (2007) 1.76
Local zones of endoplasmic reticulum complexity confine cargo in neuronal dendrites. Cell (2012) 1.75
Metaplasticity at single glutamatergic synapses. Neuron (2010) 1.74
Dual modes of cdc42 recycling fine-tune polarized morphogenesis. Dev Cell (2009) 1.73
Genetic control of neuronal activity in mice conditionally expressing TRPV1. Nat Methods (2008) 1.70
Phosphatidylinositol-4,5-bisphosphate regulates NMDA receptor activity through alpha-actinin. J Neurosci (2007) 1.67
Modeling autism by SHANK gene mutations in mice. Neuron (2013) 1.64
Coordinated PKA and PKC phosphorylation suppresses RXR-mediated ER retention and regulates the surface delivery of NMDA receptors. Neuropharmacology (2003) 1.62
Structural plasticity with preserved topology in the postsynaptic protein network. Proc Natl Acad Sci U S A (2008) 1.53
Molecular genetics and imaging technologies for circuit-based neuroanatomy. Nature (2009) 1.51
A social and ecological assessment of tropical land uses at multiple scales: the Sustainable Amazon Network. Philos Trans R Soc Lond B Biol Sci (2013) 1.48
Microanatomy of dendritic spines: emerging principles of synaptic pathology in psychiatric and neurological disease. Biol Psychiatry (2004) 1.45
Endocytosis and degradative sorting of NMDA receptors by conserved membrane-proximal signals. J Neurosci (2004) 1.44
The inhibition of polo kinase by matrimony maintains G2 arrest in the meiotic cell cycle. PLoS Biol (2007) 1.42
The HSF-like transcription factor TBF1 is a major molecular switch for plant growth-to-defense transition. Curr Biol (2012) 1.38
Spine microdomains for postsynaptic signaling and plasticity. Trends Cell Biol (2009) 1.36
Neurabin/protein phosphatase-1 complex regulates dendritic spine morphogenesis and maturation. Mol Biol Cell (2005) 1.34
Light stimulates a transducin-independent increase of cytoplasmic Ca2+ and suppression of current in cones from the zebrafish mutant nof. J Neurosci (2003) 1.33
Secretory trafficking in neuronal dendrites. Nat Cell Biol (2004) 1.32
Lethal combinations. Nat Genet (2003) 1.28
Mechanisms and function of dendritic exocytosis. Neuron (2011) 1.28
The effects of amyloid precursor protein on postsynaptic composition and activity. J Biol Chem (2009) 1.25
New modules are added to vibrissal premotor circuitry with the emergence of exploratory whisking. Neuron (2013) 1.24
Pruning and loss of excitatory synapses by the parkin ubiquitin ligase. Proc Natl Acad Sci U S A (2008) 1.23
A dysregulated endocannabinoid-eicosanoid network supports pathogenesis in a mouse model of Alzheimer's disease. Cell Rep (2012) 1.22
Secretory outposts for the local processing of membrane cargo in neuronal dendrites. Traffic (2008) 1.21
Rapid profiling of disease alleles using a tunable reporter of protein misfolding. Genetics (2012) 1.20
Activity-induced remodeling of olfactory bulb microcircuits revealed by monosynaptic tracing. PLoS One (2011) 1.19
The folliculin-FNIP1 pathway deleted in human Birt-Hogg-Dubé syndrome is required for murine B-cell development. Blood (2012) 1.17
Regulation of mitochondrial oxidative metabolism by tumor suppressor FLCN. J Natl Cancer Inst (2012) 1.16
Quantitative proteomics approach for identifying protein-drug interactions in complex mixtures using protein stability measurements. Proc Natl Acad Sci U S A (2010) 1.14
Learning from NMDA receptor trafficking: clues to the development and maturation of glutamatergic synapses. Neurosignals (2004) 1.12
Stream biomonitoring using macroinvertebrates around the globe: a comparison of large-scale programs. Environ Monit Assess (2014) 1.11
Apolipoprotein E receptor 2 interactions with the N-methyl-D-aspartate receptor. J Biol Chem (2005) 1.11
Transient activation of specific neurons in mice by selective expression of the capsaicin receptor. Nat Commun (2012) 1.10
Roles of the mammalian cytosolic cysteine desulfurase, ISCS, and scaffold protein, ISCU, in iron-sulfur cluster assembly. J Biol Chem (2006) 1.10
Optogenetic control of cell function using engineered photoreceptors. Biol Cell (2012) 1.09
Light-mediated control of DNA transcription in yeast. Methods (2012) 1.09
SAM domain-based protein oligomerization observed by live-cell fluorescence fluctuation spectroscopy. PLoS One (2008) 1.08
In vivo and in vitro examination of stability of primary hyperoxaluria-associated human alanine:glyoxylate aminotransferase. J Biol Chem (2008) 1.06
Activity-dependent expression of RNA binding protein HuD and its association with mRNAs in neurons. RNA Biol (2008) 1.03
Benchmarking of optical dimerizer systems. ACS Synth Biol (2014) 0.99
Age-related regulation of dendritic endocytosis associated with altered clathrin dynamics. Neurobiol Aging (2003) 0.97
A genetic test for yeast two-hybrid bait competency using RanBPM. Genetics (2009) 0.93
Parallel on-axis holographic phase microscopy of biological cells and unicellular microorganism dynamics. Appl Opt (2010) 0.90
The Angelman syndrome protein Ube3a/E6AP is required for Golgi acidification and surface protein sialylation. J Neurosci (2013) 0.89
Subcellular localization of spastin: implications for the pathogenesis of hereditary spastic paraplegia. Neurogenetics (2005) 0.89
Towards a protocol for stream macroinvertebrate sampling in China. Environ Monit Assess (2013) 0.88
Cell type-specific dendritic polarity in the absence of spatially organized external cues. Brain Cell Biol (2007) 0.86
Cell-mediated assembly of phototherapeutics. Angew Chem Int Ed Engl (2014) 0.85
Light-dependent, dark-promoted interaction between Arabidopsis cryptochrome 1 and phytochrome B proteins. J Biol Chem (2012) 0.84
The problem of using fixed-area subsampling methods to estimate macroinvertebrate richness: a case study with Neotropical stream data. Environ Monit Assess (2012) 0.84
Orientation and alkylation effects on cation-pi interactions in aqueous solution. J Am Chem Soc (2004) 0.81
Visually determined stream mesohabitats influence benthic macroinvertebrate assessments in headwater streams. Environ Monit Assess (2014) 0.80
B(12)-mediated, long wavelength photopolymerization of hydrogels. J Am Chem Soc (2015) 0.78
Mining and modeling human genetics for autism therapeutics. Curr Opin Neurobiol (2012) 0.78
Permanganate oxidation of 1,5,9-trienes: stereoselective synthesis of tetrahydrofuran-containing fragments. J Org Chem (2002) 0.77
Membrane trafficking and cytoskeletal dynamics in neuronal function. Mol Cell Neurosci (2011) 0.77
Level and extent of mercury contamination in Oregon, USA, lotic fish. Environ Toxicol Chem (2002) 0.76
Hydrogen/deuterium exchange- and protease digestion-based screening assay for protein-ligand binding detection. Anal Chem (2009) 0.75
Combining and aggregating environmental data for status and trend assessments: challenges and approaches. Environ Monit Assess (2015) 0.75
Neuronal and glial cell biology. Curr Opin Neurobiol (2010) 0.75
Mercury concentration in frozen whole-fish homogenates is insensitive to holding time. Arch Environ Contam Toxicol (2007) 0.75
Signalling mechanisms. Curr Opin Neurobiol (2009) 0.75
Induced-fit binding of a polyproline helix by a β-hairpin peptide. Angew Chem Int Ed Engl (2011) 0.75
Quantitative tolerance values for common stream benthic macroinvertebrates in the Yangtze River Delta, Eastern China. Environ Monit Assess (2014) 0.75