Published in Science on February 24, 2017
Optogenetics: Lighting up kinases. Nat Chem Biol (2017) 0.75
Understanding CRY2 interactions for optical control of intracellular signaling. Nat Commun (2017) 0.75
A Split-Abl Kinase for Direct Activation in Cells. Cell Chem Biol (2017) 0.75
The protein kinase complement of the human genome. Science (2002) 35.36
A genetically encoded photoactivatable Rac controls the motility of living cells. Nature (2009) 7.25
Spatiotemporal control of cell signalling using a light-switchable protein interaction. Nature (2009) 6.74
A light-switchable gene promoter system. Nat Biotechnol (2002) 5.28
A decade of CDK5. Nat Rev Mol Cell Biol (2001) 5.24
Rapid blue-light-mediated induction of protein interactions in living cells. Nat Methods (2010) 4.70
Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition. Nat Struct Mol Biol (2004) 4.40
Induction of protein-protein interactions in live cells using light. Nat Biotechnol (2009) 3.16
Encoding and decoding cellular information through signaling dynamics. Cell (2013) 2.96
Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention. Leukemia (2003) 2.89
Surface sites for engineering allosteric control in proteins. Science (2008) 2.82
Spatiotemporal control of gene expression by a light-switchable transgene system. Nat Methods (2012) 2.79
Light-activated DNA binding in a designed allosteric protein. Proc Natl Acad Sci U S A (2008) 2.67
TULIPs: tunable, light-controlled interacting protein tags for cell biology. Nat Methods (2012) 2.59
Targeting RAS-ERK signalling in cancer: promises and challenges. Nat Rev Drug Discov (2014) 2.44
Dynamics and variability of ERK2 response to EGF in individual living cells. Mol Cell (2009) 2.42
Two cyclin-dependent kinase pathways are essential for polarized trafficking of presynaptic components. Cell (2010) 2.32
Using optogenetics to interrogate the dynamic control of signal transmission by the Ras/Erk module. Cell (2013) 2.22
Optogenetic protein clustering and signaling activation in mammalian cells. Nat Methods (2013) 2.22
The structural basis for control of eukaryotic protein kinases. Annu Rev Biochem (2012) 2.21
Frequency-modulated pulses of ERK activity transmit quantitative proliferation signals. Mol Cell (2012) 2.11
Optical control of protein activity by fluorescent protein domains. Science (2012) 2.10
Designing photoswitchable peptides using the AsLOV2 domain. Chem Biol (2012) 1.99
A conserved docking site in MEKs mediates high-affinity binding to MAP kinases and cooperates with a scaffold protein to enhance signal transmission. J Biol Chem (2000) 1.96
Quantitative understanding of the energy transfer between fluorescent proteins connected via flexible peptide linkers. Biochemistry (2006) 1.83
The ERK MAP kinase cascade mediates tail swelling and a protective response to rectal infection in C. elegans. Curr Biol (2004) 1.77
High-sensitivity measurements of multiple kinase activities in live single cells. Cell (2014) 1.76
Strong negative feedback from Erk to Raf confers robustness to MAPK signalling. Mol Syst Biol (2011) 1.65
Allosteric activation of functionally asymmetric RAF kinase dimers. Cell (2013) 1.60
Endocytosis of receptor tyrosine kinases. Cold Spring Harb Perspect Biol (2013) 1.57
A Mek1-Mek2 heterodimer determines the strength and duration of the Erk signal. Nat Struct Mol Biol (2009) 1.48
Cytoplasmic localization of the mitogen-activated protein kinase activator MEK. J Biol Chem (1994) 1.47
Positive- and negative-feedback regulations coordinate the dynamic behavior of the Ras-Raf-MEK-ERK signal transduction pathway. J Cell Sci (2009) 1.41
Reversible protein inactivation by optogenetic trapping in cells. Nat Methods (2014) 1.38
An optogenetic gene expression system with rapid activation and deactivation kinetics. Nat Chem Biol (2014) 1.30
Photoactivatable CRISPR-Cas9 for optogenetic genome editing. Nat Biotechnol (2015) 1.28
Ultraviolet-B-mediated induction of protein-protein interactions in mammalian cells. Nat Commun (2013) 1.17
Multi-chromatic control of mammalian gene expression and signaling. Nucleic Acids Res (2013) 1.17
Spatiotemporal control of fibroblast growth factor receptor signals by blue light. Chem Biol (2014) 1.15
A light-triggered protein secretion system. J Cell Biol (2013) 1.15
Optogenetic control of protein kinase activity in mammalian cells. ACS Synth Biol (2013) 1.11
Light-mediated kinetic control reveals the temporal effect of the Raf/MEK/ERK pathway in PC12 cell neurite outgrowth. PLoS One (2014) 1.07
Spatio-temporally precise activation of engineered receptor tyrosine kinases by light. EMBO J (2014) 1.05
Engineering of a red-light-activated human cAMP/cGMP-specific phosphodiesterase. Proc Natl Acad Sci U S A (2014) 1.03
Engineered pairs of distinct photoswitches for optogenetic control of cellular proteins. Nat Commun (2015) 0.98
Raf-independent, PP2A-dependent MEK activation in response to ERK silencing. Biochem Biophys Res Commun (2009) 0.96
Light-inducible receptor tyrosine kinases that regulate neurotrophin signalling. Nat Commun (2014) 0.95
"RAF" neighborhood: protein-protein interaction in the Raf/Mek/Erk pathway. FEBS Lett (2014) 0.91
Engineering extrinsic disorder to control protein activity in living cells. Science (2016) 0.80
Spatial and Temporal Regulation of Receptor Tyrosine Kinase Activation and Intracellular Signal Transduction. Annu Rev Biochem (2016) 0.78
Optical control of biological processes by light-switchable proteins. Wiley Interdiscip Rev Dev Biol (2015) 0.75
Fast two-photon imaging of subcellular voltage dynamics in neuronal tissue with genetically encoded indicators. Elife (2017) 0.75
Understanding CRY2 interactions for optical control of intracellular signaling. Nat Commun (2017) 0.75
A Single-Chain Photoswitchable CRISPR-Cas9 Architecture for Light-Inducible Gene Editing and Transcription. ACS Chem Biol (2017) 0.75