Small G protein signaling in neuronal plasticity and memory formation: the specific role of ras family proteins.

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Published in Neuron on November 04, 2010

Authors

Xiaojing Ye1, Thomas J Carew

Author Affiliations

1: Department of Neurobiology and Behavior, Center for the Neurobiology of Learning and Memory, University of California, Irvine, CA 92697, USA.

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ras genes. Annu Rev Biochem (1987) 22.59

The molecular biology of memory storage: a dialogue between genes and synapses. Science (2001) 11.85

Phosphatidylinositol-3-OH kinase as a direct target of Ras. Nature (1994) 10.34

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP. Nature (1998) 9.30

Synaptic plasticity and memory: an evaluation of the hypothesis. Annu Rev Neurosci (2000) 8.20

Protein prenylation: molecular mechanisms and functional consequences. Annu Rev Biochem (1996) 8.08

The RAF proteins take centre stage. Nat Rev Mol Cell Biol (2004) 8.04

Von Recklinghausen neurofibromatosis. N Engl J Med (1981) 7.69

GEFs and GAPs: critical elements in the control of small G proteins. Cell (2007) 7.32

The emerging mechanisms of isoform-specific PI3K signalling. Nat Rev Mol Cell Biol (2010) 6.28

A family of cAMP-binding proteins that directly activate Rap1. Science (1998) 6.12

A ras-related gene with transformation suppressor activity. Cell (1989) 5.81

ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK. Cell (1992) 5.77

Synaptic AMPA receptor plasticity and behavior. Neuron (2009) 5.58

Reversal of learning deficits in a Tsc2+/- mouse model of tuberous sclerosis. Nat Med (2008) 5.15

mTOR signaling: at the crossroads of plasticity, memory and disease. Trends Neurosci (2009) 5.04

Ras signalling on the endoplasmic reticulum and the Golgi. Nat Cell Biol (2002) 4.91

Inactivation of hippocampus or caudate nucleus with lidocaine differentially affects expression of place and response learning. Neurobiol Learn Mem (1996) 4.90

Rap1 mediates sustained MAP kinase activation induced by nerve growth factor. Nature (1998) 4.62

Ras and Rap control AMPA receptor trafficking during synaptic plasticity. Cell (2002) 4.50

Balancing structure and function at hippocampal dendritic spines. Annu Rev Neurosci (2008) 4.38

Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation. EMBO J (1996) 3.99

Tumour predisposition in mice heterozygous for a targeted mutation in Nf1. Nat Genet (1994) 3.97

The autistic neuron: troubled translation? Cell (2008) 3.81

Phospholipase Cgamma activates Ras on the Golgi apparatus by means of RasGRP1. Nature (2003) 3.66

Molecular cloning of cDNAs encoding a guanine-nucleotide-releasing factor for Ras p21. Nature (1992) 3.48

Regulation of dendritic spine morphology by SPAR, a PSD-95-associated RapGAP. Neuron (2001) 3.30

Behavioral phenotyping of transgenic and knockout mice: experimental design and evaluation of general health, sensory functions, motor abilities, and specific behavioral tests. Brain Res (1999) 3.27

Synaptic plasticity, memory and the hippocampus: a neural network approach to causality. Nat Rev Neurosci (2008) 3.24

Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration. Nature (2008) 3.19

Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1. Nature (2002) 3.05

Activation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway is required for metabotropic glutamate receptor-dependent long-term depression. J Neurosci (2004) 3.04

Circadian oscillation of hippocampal MAPK activity and cAmp: implications for memory persistence. Nat Neurosci (2008) 3.03

Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice. Nat Med (1995) 2.99

Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3 encode proteins closely related to ras in the 'effector' region. Oncogene (1988) 2.94

Spred is a Sprouty-related suppressor of Ras signalling. Nature (2001) 2.87

The spread of Ras activity triggered by activation of a single dendritic spine. Science (2008) 2.87

Dendritic spines and long-term plasticity. Nat Rev Neurosci (2005) 2.83

An analysis of variation in expression of neurofibromatosis (NF) type 1 (NF1): evidence for modifying genes. Am J Hum Genet (1993) 2.79

Spine architecture and synaptic plasticity. Trends Neurosci (2005) 2.79

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Neurofibromin regulation of ERK signaling modulates GABA release and learning. Cell (2008) 2.65

SynGAP: a synaptic RasGAP that associates with the PSD-95/SAP90 protein family. Neuron (1998) 2.63

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The HMG-CoA reductase inhibitor lovastatin reverses the learning and attention deficits in a mouse model of neurofibromatosis type 1. Curr Biol (2005) 2.62

Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor. Science (1993) 2.60

Molecular psychology: roles for the ERK MAP kinase cascade in memory. Annu Rev Pharmacol Toxicol (2002) 2.55

Structural and metabolic brain changes in the striatum associated with methamphetamine abuse. Addiction (2007) 2.49

A role for the PI-3 kinase signaling pathway in fear conditioning and synaptic plasticity in the amygdala. Neuron (2001) 2.48

A proposed test battery and constellations of specific behavioral paradigms to investigate the behavioral phenotypes of transgenic and knockout mice. Horm Behav (1997) 2.47

Calcium activation of Ras mediated by neuronal exchange factor Ras-GRF. Nature (1995) 2.47

SynGAP regulates ERK/MAPK signaling, synaptic plasticity, and learning in the complex with postsynaptic density 95 and NMDA receptor. J Neurosci (2002) 2.46

Ras-activated endocytosis is mediated by the Rab5 guanine nucleotide exchange activity of RIN1. Dev Cell (2001) 2.46

Ral-GTPases mediate a distinct downstream signaling pathway from Ras that facilitates cellular transformation. EMBO J (1996) 2.44

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RapV12 antagonizes Ras-dependent activation of ERK1 and ERK2 by LPA and EGF in Rat-1 fibroblasts. EMBO J (1993) 2.38

Ral-GTPases: approaching their 15 minutes of fame. Trends Cell Biol (2003) 2.36

Membrane depolarization and calcium influx stimulate MEK and MAP kinase via activation of Ras. Neuron (1994) 2.34

A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM kinase II. Neuron (1998) 2.33

Synapsins as regulators of neurotransmitter release. Philos Trans R Soc Lond B Biol Sci (1999) 2.32

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Rho GTPases, dendritic structure, and mental retardation. J Neurobiol (2005) 2.19

Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation in animal cells. Science (1993) 2.17

A role for the Ras signalling pathway in synaptic transmission and long-term memory. Nature (1997) 2.16

NMDA receptor-dependent activation of the small GTPase Rab5 drives the removal of synaptic AMPA receptors during hippocampal LTD. Neuron (2005) 2.15

Proteolytic degradation of SCOP in the hippocampus contributes to activation of MAP kinase and memory. Cell (2007) 2.12

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A role for the Ral guanine nucleotide dissociation stimulator in mediating Ras-induced transformation. J Biol Chem (1996) 2.06

Regulation of eukaryotic initiation factor 4E by converging signaling pathways during metabotropic glutamate receptor-dependent long-term depression. J Neurosci (2006) 2.04

SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation. Neuron (2004) 1.97

Amygdala depotentiation and fear extinction. Proc Natl Acad Sci U S A (2007) 1.91

Rap2-JNK removes synaptic AMPA receptors during depotentiation. Neuron (2005) 1.90

Ras-dependent growth factor regulation of MEK kinase in PC12 cells. Science (1994) 1.89

State-dependent Ras signaling and AMPA receptor trafficking. Genes Dev (2005) 1.86

Phosphatidylinositol 3-kinase is required for the expression but not for the induction or the maintenance of long-term potentiation in the hippocampal CA1 region. J Neurosci (2002) 1.85

Rap1-induced p38 mitogen-activated protein kinase activation facilitates AMPA receptor trafficking via the GDI.Rab5 complex. Potential role in (S)-3,5-dihydroxyphenylglycene-induced long term depression. J Biol Chem (2004) 1.79

PI3 kinase signaling is required for retrieval and extinction of contextual memory. Nat Neurosci (2005) 1.76

The role of synaptic GTPase-activating protein in neuronal development and synaptic plasticity. J Neurosci (2003) 1.71

Rap1 couples cAMP signaling to a distinct pool of p42/44MAPK regulating excitability, synaptic plasticity, learning, and memory. Neuron (2003) 1.71

A mouse model for the learning and memory deficits associated with neurofibromatosis type I. Nat Genet (1997) 1.71

Phosphatidylinositol 3-kinase regulates the induction of long-term potentiation through extracellular signal-related kinase-independent mechanisms. J Neurosci (2003) 1.70

Modulation of presynaptic plasticity and learning by the H-ras/extracellular signal-regulated kinase/synapsin I signaling pathway. J Neurosci (2005) 1.68

Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic. Cell (1994) 1.67

Serotonin-mediated endocytosis of apCAM: an early step of learning-related synaptic growth in Aplysia. Science (1992) 1.62

Altered synaptic plasticity in Drosophila memory mutants with a defective cyclic AMP cascade. Science (1991) 1.62

Increased transmitter release at excitatory synapses produced by direct activation of adenylate cyclase in rat hippocampal slices. J Neurosci (1994) 1.61

Neurofibromin regulates G protein-stimulated adenylyl cyclase activity. Nat Neurosci (2002) 1.58

Epac2 induces synapse remodeling and depression and its disease-associated forms alter spines. Nat Neurosci (2009) 1.58

Dual MAP kinase pathways mediate opposing forms of long-term plasticity at CA3-CA1 synapses. Nat Neurosci (2000) 1.57

H-Ras signaling and K-Ras signaling are differentially dependent on endocytosis. Mol Cell Biol (2002) 1.55

Identification of the neurofibromatosis type 1 gene product. Proc Natl Acad Sci U S A (1991) 1.55

Differential induction of long-term synaptic facilitation by spaced and massed applications of serotonin at sensory neuron synapses of Aplysia californica. Learn Mem (1999) 1.54

Cognitive function and academic performance in neurofibromatosis. 1: consensus statement from the NF1 Cognitive Disorders Task Force. Neurology (1997) 1.52

Nitric oxide mediates N-methyl-D-aspartate receptor-induced activation of p21ras. Proc Natl Acad Sci U S A (1998) 1.51

Activity-dependent dendritic spine structural plasticity is regulated by small GTPase Rap1 and its target AF-6. Neuron (2005) 1.50

Presynaptic enhancement of inhibitory synaptic transmission by protein kinases A and C in the rat hippocampus in vitro. J Neurosci (1995) 1.50

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