Published in Cell on June 01, 2007
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Random versus directionally persistent cell migration. Nat Rev Mol Cell Biol (2009) 4.99
Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1. Cell (2012) 3.77
Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy? Nat Rev Cancer (2010) 3.59
The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1. Mol Cell (2013) 2.79
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Breaching multiple barriers: leukocyte motility through venular walls and the interstitium. Nat Rev Mol Cell Biol (2010) 2.72
Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome. Cell (2014) 2.68
Regulation of mTORC1 by amino acids. Trends Cell Biol (2014) 2.64
The structural basis for activation of the Rab Ypt1p by the TRAPP membrane-tethering complexes. Cell (2008) 2.61
The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins. Nat Cell Biol (2011) 2.45
Conformational changes in the G protein Gs induced by the β2 adrenergic receptor. Nature (2011) 2.43
It takes two to tango: regulation of G proteins by dimerization. Nat Rev Mol Cell Biol (2009) 2.34
PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility. J Cell Biol (2008) 2.31
Centralspindlin and α-catenin regulate Rho signalling at the epithelial zonula adherens. Nat Cell Biol (2012) 2.23
Rho protein crosstalk: another social network? Trends Cell Biol (2011) 2.19
DLC-1:a Rho GTPase-activating protein and tumour suppressor. J Cell Mol Med (2007) 2.09
Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo. Nat Chem Biol (2011) 2.00
Rho GTPases: functions and association with cancer. Clin Exp Metastasis (2007) 1.98
A bacterial Ras-like small GTP-binding protein and its cognate GAP establish a dynamic spatial polarity axis to control directed motility. PLoS Biol (2010) 1.90
The Rho exchange factor Arhgef1 mediates the effects of angiotensin II on vascular tone and blood pressure. Nat Med (2010) 1.84
Forcing form and function: biomechanical regulation of tumor evolution. Trends Cell Biol (2010) 1.77
Structural basis and mechanism of autoregulation in 3-phosphoinositide-dependent Grp1 family Arf GTPase exchange factors. Mol Cell (2007) 1.76
Allele-specific inhibitors inactivate mutant KRAS G12C by a trapping mechanism. Science (2016) 1.73
AtNOS/AtNOA1 is a functional Arabidopsis thaliana cGTPase and not a nitric-oxide synthase. J Biol Chem (2008) 1.71
Targeting of the GTPase Irgm1 to the phagosomal membrane via PtdIns(3,4)P(2) and PtdIns(3,4,5)P(3) promotes immunity to mycobacteria. Nat Immunol (2009) 1.70
SH3BP1, an exocyst-associated RhoGAP, inactivates Rac1 at the front to drive cell motility. Mol Cell (2011) 1.70
Myosin-IXA regulates collective epithelial cell migration by targeting RhoGAP activity to cell-cell junctions. Curr Biol (2012) 1.70
Abl kinase inhibits the engulfment of apoptotic [corrected] cells in Caenorhabditis elegans. PLoS Biol (2009) 1.69
Nutrient signaling to mTOR and cell growth. Trends Biochem Sci (2013) 1.68
Oncogenic Kras initiates leukemia in hematopoietic stem cells. PLoS Biol (2009) 1.67
Efficient termination of vacuolar Rab GTPase signaling requires coordinated action by a GAP and a protein kinase. J Cell Biol (2008) 1.66
Mechanical regulation of signaling pathways in bone. Gene (2012) 1.65
A dual binding mode for RhoGTPases in plexin signalling. PLoS Biol (2011) 1.63
Specificity in Ras and Rap signaling. J Biol Chem (2008) 1.62
Feedback regulation through myosin II confers robustness on RhoA signalling at E-cadherin junctions. Nat Cell Biol (2015) 1.62
Rac signaling in breast cancer: a tale of GEFs and GAPs. Cell Signal (2011) 1.61
Hematopoiesis and leukemogenesis in mice expressing oncogenic NrasG12D from the endogenous locus. Blood (2010) 1.60
The guanine nucleotide exchange factors trio, Ect2, and Vav3 mediate the invasive behavior of glioblastoma. Am J Pathol (2008) 1.57
ROP/RAC GTPase signaling. Curr Opin Plant Biol (2007) 1.57
Structural insights into eRF3 and stop codon recognition by eRF1. Genes Dev (2009) 1.57
A novel function for Cyclin A2: control of cell invasion via RhoA signaling. J Cell Biol (2012) 1.54
Visualization of small GTPase activity with fluorescence resonance energy transfer-based biosensors. Nat Protoc (2009) 1.53
Illuminating the functional and structural repertoire of human TBC/RABGAPs. Nat Rev Mol Cell Biol (2012) 1.51
Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to proliferative Ras/RAF and nutrient-dependent mTOR signaling. Blood (2014) 1.50
The Rho exchange factors Vav2 and Vav3 favor skin tumor initiation and promotion by engaging extracellular signaling loops. PLoS Biol (2013) 1.50
Substrate binding disrupts dimerization and induces nucleotide exchange of the chloroplast GTPase Toc33. Biochem J (2011) 1.49
Evolution of the Ras-like small GTPases and their regulators. Small GTPases (2011) 1.48
Ras trafficking, localization and compartmentalized signalling. Semin Cell Dev Biol (2011) 1.48
The universally conserved prokaryotic GTPases. Microbiol Mol Biol Rev (2011) 1.47
Vibrio cholerae T3SS effector VopE modulates mitochondrial dynamics and innate immune signaling by targeting Miro GTPases. Cell Host Microbe (2014) 1.47
The role of Epac proteins, novel cAMP mediators, in the regulation of immune, lung and neuronal function. Br J Pharmacol (2009) 1.46
uPAR promotes formation of the p130Cas-Crk complex to activate Rac through DOCK180. J Cell Biol (2008) 1.43
Arf1-GTP-induced tubule formation suggests a function of Arf family proteins in curvature acquisition at sites of vesicle budding. J Biol Chem (2008) 1.40
The TRAPP complex: insights into its architecture and function. Traffic (2008) 1.40
A RASopathy gene commonly mutated in cancer: the neurofibromatosis type 1 tumour suppressor. Nat Rev Cancer (2015) 1.40
A kinome RNAi screen identified AMPK as promoting poxvirus entry through the control of actin dynamics. PLoS Pathog (2010) 1.39
Regulation of autophagy by the Rab GTPase network. Cell Death Differ (2014) 1.37
Epac: effectors and biological functions. Naunyn Schmiedebergs Arch Pharmacol (2008) 1.37
Role of DLC-1, a tumor suppressor protein with RhoGAP activity, in regulation of the cytoskeleton and cell motility. Cancer Metastasis Rev (2009) 1.36
DLC1: a significant GAP in the cancer genome. Genes Dev (2008) 1.36
Regulation of dynamic polarity switching in bacteria by a Ras-like G-protein and its cognate GAP. EMBO J (2010) 1.35
RASA1 maintains the lymphatic vasculature in a quiescent functional state in mice. J Clin Invest (2012) 1.31
Wild-type H- and N-Ras promote mutant K-Ras-driven tumorigenesis by modulating the DNA damage response. Cancer Cell (2014) 1.30
The GAP arginine finger movement into the catalytic site of Ras increases the activation entropy. Proc Natl Acad Sci U S A (2008) 1.30
Kinetic studies of the Arf activator Arno on model membranes in the presence of Arf effectors suggest control by a positive feedback loop. J Biol Chem (2010) 1.28
The Rap-RapGAP complex: GTP hydrolysis without catalytic glutamine and arginine residues. EMBO J (2008) 1.28
New insights into how the Rho guanine nucleotide dissociation inhibitor regulates the interaction of Cdc42 with membranes. J Biol Chem (2009) 1.27
Vps41 phosphorylation and the Rab Ypt7 control the targeting of the HOPS complex to endosome-vacuole fusion sites. Mol Biol Cell (2009) 1.26
Sos-mediated cross-activation of wild-type Ras by oncogenic Ras is essential for tumorigenesis. Nat Commun (2012) 1.26
Structural mechanisms for regulation of membrane traffic by rab GTPases. Traffic (2009) 1.25
Regulation of TOR by small GTPases. EMBO Rep (2012) 1.24
Characterization of a Cdc42 protein inhibitor and its use as a molecular probe. J Biol Chem (2013) 1.24
Structure and function of the intracellular region of the plexin-b1 transmembrane receptor. J Biol Chem (2009) 1.24
Germline KRAS mutations cause aberrant biochemical and physical properties leading to developmental disorders. Hum Mutat (2010) 1.24
From mechanical force to RhoA activation. Biochemistry (2012) 1.23
The primate-specific protein TBC1D3 is required for optimal macropinocytosis in a novel ARF6-dependent pathway. Mol Biol Cell (2008) 1.23
Plexins are GTPase-activating proteins for Rap and are activated by induced dimerization. Sci Signal (2012) 1.23
Contribution of guanine nucleotide exchange factor Vav2 to hyperhomocysteinemic glomerulosclerosis in rats. Hypertension (2008) 1.23
Mutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt signalling pathways. Hum Mol Genet (2009) 1.22
Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1. Elife (2013) 1.22
Molecular kinetics. Ras activation by SOS: allosteric regulation by altered fluctuation dynamics. Science (2014) 1.21
Crystal structure of the plexin A3 intracellular region reveals an autoinhibited conformation through active site sequestration. Proc Natl Acad Sci U S A (2009) 1.21
The on-off relationship of Rho and Rac during integrin-mediated adhesion and cell migration. Small GTPases (2014) 1.21
Coronin 1A promotes a cytoskeletal-based feedback loop that facilitates Rac1 translocation and activation. EMBO J (2011) 1.19
The RhoA activator GEF-H1/Lfc is a transforming growth factor-beta target gene and effector that regulates alpha-smooth muscle actin expression and cell migration. Mol Biol Cell (2010) 1.18
Rap1a is a key regulator of fibroblast growth factor 2-induced angiogenesis and together with Rap1b controls human endothelial cell functions. Mol Cell Biol (2008) 1.18
Coordination of intracellular transport steps by GTPases. Semin Cell Dev Biol (2010) 1.17
Direct spatial control of Epac1 by cyclic AMP. Mol Cell Biol (2009) 1.17
Structural analysis of the Ras-like G protein MglA and its cognate GAP MglB and implications for bacterial polarity. EMBO J (2011) 1.16
Rho GTPases: masters of cell migration. Small GTPases (2014) 1.14
Transcriptome analysis on Chinese shrimp Fenneropenaeus chinensis during WSSV acute infection. PLoS One (2013) 1.14
A Ral GAP complex links PI 3-kinase/Akt signaling to RalA activation in insulin action. Mol Biol Cell (2010) 1.13
PYK2/PDZ-RhoGEF links Ca2+ signaling to RhoA. Arterioscler Thromb Vasc Biol (2009) 1.12
Small G protein signaling in neuronal plasticity and memory formation: the specific role of ras family proteins. Neuron (2010) 1.12
A RAS renaissance: emerging targeted therapies for KRAS-mutated non-small cell lung cancer. Clin Cancer Res (2014) 1.11
Intramolecular activation mechanism of the Dictyostelium LRRK2 homolog Roco protein GbpC. J Biol Chem (2008) 1.11
Prostaglandins in cancer cell adhesion, migration, and invasion. Int J Cell Biol (2012) 1.09
Genome-wide identification of miR-200 targets reveals a regulatory network controlling cell invasion. EMBO J (2014) 1.09
Structural basis for small G protein effector interaction of Ras-related protein 1 (Rap1) and adaptor protein Krev interaction trapped 1 (KRIT1). J Biol Chem (2012) 1.09
An acylation cycle regulates localization and activity of palmitoylated Ras isoforms. Science (2005) 5.99
Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. Cell (2012) 5.71
Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling. Nature (2013) 5.04
Structural insight into filament formation by mammalian septins. Nature (2007) 2.90
It takes two to tango: regulation of G proteins by dimerization. Nat Rev Mol Cell Biol (2009) 2.34
The complex of Arl2-GTP and PDE delta: from structure to function. EMBO J (2002) 2.24
Vinculin associates with endothelial VE-cadherin junctions to control force-dependent remodeling. J Cell Biol (2012) 2.12
Structure and regulation of the cAMP-binding domains of Epac2. Nat Struct Biol (2003) 2.11
The regulation of mDia1 by autoinhibition and its release by Rho*GTP. EMBO J (2005) 2.10
Capturing cyclic nucleotides in action: snapshots from crystallographic studies. Nat Rev Mol Cell Biol (2007) 2.07
The GTPase-activating protein Rap1GAP uses a catalytic asparagine. Nature (2004) 2.06
Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo. Nat Chem Biol (2011) 2.00
How guanylate-binding proteins achieve assembly-stimulated processive cleavage of GTP to GMP. Nature (2006) 1.92
Structure of the cyclic-AMP-responsive exchange factor Epac2 in its auto-inhibited state. Nature (2006) 1.88
The GDI-like solubilizing factor PDEδ sustains the spatial organization and signalling of Ras family proteins. Nat Cell Biol (2011) 1.87
Cyclic nucleotide analogs as probes of signaling pathways. Nat Methods (2008) 1.84
Dimerisation-dependent GTPase reaction of MnmE: how potassium acts as GTPase-activating element. EMBO J (2006) 1.75
The core FH2 domain of diaphanous-related formins is an elongated actin binding protein that inhibits polymerization. Mol Cell (2004) 1.74
Structural insight into the recognition of the H3K4me3 mark by the TFIID subunit TAF3. Structure (2008) 1.72
A restricted spectrum of NRAS mutations causes Noonan syndrome. Nat Genet (2009) 1.71
Structure of a 14-3-3 coordinated hexamer of the plant plasma membrane H+ -ATPase by combining X-ray crystallography and electron cryomicroscopy. Mol Cell (2007) 1.67
Structural view of a fungal toxin acting on a 14-3-3 regulatory complex. EMBO J (2003) 1.67
The retinitis pigmentosa 2 gene product is a GTPase-activating protein for Arf-like 3. Nat Struct Mol Biol (2008) 1.64
Structural basis for the reversible activation of a Rho protein by the bacterial toxin SopE. EMBO J (2002) 1.64
A new family of RhoGEFs activates the Rop molecular switch in plants. Nature (2005) 1.64
Structure of the Roc-COR domain tandem of C. tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase. EMBO J (2008) 1.62
The VASP tetramerization domain is a right-handed coiled coil based on a 15-residue repeat. Proc Natl Acad Sci U S A (2004) 1.57
Ligand-mediated activation of the cAMP-responsive guanine nucleotide exchange factor Epac. J Biol Chem (2003) 1.53
RanGAP mediates GTP hydrolysis without an arginine finger. Nature (2002) 1.50
Structural insights into HypB, a GTP-binding protein that regulates metal binding. J Biol Chem (2006) 1.47
A novel cyclic AMP-dependent Epac-Rit signaling pathway contributes to PACAP38-mediated neuronal differentiation. Mol Cell Biol (2006) 1.45
Phosphorylation-independent interaction between 14-3-3 and exoenzyme S: from structure to pathogenesis. EMBO J (2007) 1.38
cAMP sensor Epac as a determinant of ATP-sensitive potassium channel activity in human pancreatic beta cells and rat INS-1 cells. J Physiol (2006) 1.36
GTP-induced conformational changes in septins and implications for function. Proc Natl Acad Sci U S A (2009) 1.35
Regulation of dynamic polarity switching in bacteria by a Ras-like G-protein and its cognate GAP. EMBO J (2010) 1.35
Nucleotide binding and filament assembly of recombinant yeast septin complexes. Biol Chem (2005) 1.34
The structure of the TrmE GTP-binding protein and its implications for tRNA modification. EMBO J (2004) 1.34
8-pCPT-2'-O-Me-cAMP-AM: an improved Epac-selective cAMP analogue. Chembiochem (2008) 1.32
The GAP arginine finger movement into the catalytic site of Ras increases the activation entropy. Proc Natl Acad Sci U S A (2008) 1.30
Rap-specific GTPase activating protein follows an alternative mechanism. J Biol Chem (2002) 1.28
Human OLA1 defines an ATPase subfamily in the Obg family of GTP-binding proteins. J Biol Chem (2007) 1.28
The Rap-RapGAP complex: GTP hydrolysis without catalytic glutamine and arginine residues. EMBO J (2008) 1.28
Specificity of interactions between mDia isoforms and Rho proteins. J Biol Chem (2008) 1.27
Stabilizing a weak binding state for effectors in the human ras protein by cyclen complexes. Angew Chem Int Ed Engl (2010) 1.25
AF6 negatively regulates Rap1-induced cell adhesion. J Biol Chem (2005) 1.24
Germline KRAS mutations cause aberrant biochemical and physical properties leading to developmental disorders. Hum Mutat (2010) 1.24
GAP1 family members constitute bifunctional Ras and Rap GTPase-activating proteins. J Biol Chem (2006) 1.22
Structural evidence for a common intermediate in small G protein-GEF reactions. Mol Cell (2007) 1.20
Neuron specific Rab4 effector GRASP-1 coordinates membrane specialization and maturation of recycling endosomes. PLoS Biol (2010) 1.18
Noonan syndrome gain-of-function mutations in NRAS cause zebrafish gastrulation defects. Dis Model Mech (2011) 1.18
Communication between the regulatory and the catalytic region of the cAMP-responsive guanine nucleotide exchange factor Epac. J Biol Chem (2003) 1.18
Direct spatial control of Epac1 by cyclic AMP. Mol Cell Biol (2009) 1.17
Specificity of Arl2/Arl3 signaling is mediated by a ternary Arl3-effector-GAP complex. FEBS Lett (2008) 1.17
Structural analysis of the Ras-like G protein MglA and its cognate GAP MglB and implications for bacterial polarity. EMBO J (2011) 1.16
Crystal structure of the human retinitis pigmentosa 2 protein and its interaction with Arl3. Structure (2006) 1.15
Characterization of the GbpD-activated Rap1 pathway regulating adhesion and cell polarity in Dictyostelium discoideum. J Biol Chem (2006) 1.14
Dominant-negative ALK2 allele associates with congenital heart defects. Circulation (2009) 1.14
Reassessment of the role of FKBP38 in the Rheb/mTORC1 pathway. FEBS Lett (2009) 1.13
Structural basis for Arl3-specific release of myristoylated ciliary cargo from UNC119. EMBO J (2012) 1.12
The RapGEF PDZ-GEF2 is required for maturation of cell-cell junctions. Cell Signal (2008) 1.11
Vinculin-dependent Cadherin mechanosensing regulates efficient epithelial barrier formation. Biol Open (2012) 1.10
Perturbation of the conformational equilibria in Ras by selective mutations as studied by 31P NMR spectroscopy. FEBS Lett (2004) 1.08
Synthesis of the Rheb and K-Ras4B GTPases. Angew Chem Int Ed Engl (2010) 1.07
A phosphoryl transfer intermediate in the GTPase reaction of Ras in complex with its GTPase-activating protein. Proc Natl Acad Sci U S A (2006) 1.06
Epac activates the small G proteins Rap1 and Rab3A to achieve exocytosis. J Biol Chem (2009) 1.06
Fluorescence methods in the study of small GTP-binding proteins. Methods Mol Biol (2002) 1.05
Epac1 and PDZ-GEF cooperate in Rap1 mediated endothelial junction control. Cell Signal (2011) 1.03
Characterisation of PDZ-GEFs, a family of guanine nucleotide exchange factors specific for Rap1 and Rap2. Biochim Biophys Acta (2003) 1.02
Fourier transform infrared spectroscopy on the Rap.RapGAP reaction, GTPase activation without an arginine finger. J Biol Chem (2004) 1.02
The structure of an Arf-ArfGAP complex reveals a Ca2+ regulatory mechanism. Cell (2010) 1.02
Biochemical characterization of the Ran-RanBP1-RanGAP system: are RanBP proteins and the acidic tail of RanGAP required for the Ran-RanGAP GTPase reaction? Mol Cell Biol (2003) 1.02
Cyclic AMP signalling in Dictyostelium: G-proteins activate separate Ras pathways using specific RasGEFs. EMBO Rep (2007) 1.01
Kissing G domains of MnmE monitored by X-ray crystallography and pulse electron paramagnetic resonance spectroscopy. PLoS Biol (2009) 1.01
Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations. Proc Natl Acad Sci U S A (2012) 0.99
Lipidated ras and rab peptides and proteins--synthesis, structure, and function. Angew Chem Int Ed Engl (2006) 0.99
The interplay between RPGR, PDEδ and Arl2/3 regulate the ciliary targeting of farnesylated cargo. EMBO Rep (2013) 0.98
Spatial regulation of cyclic AMP-Epac1 signaling in cell adhesion by ERM proteins. Mol Cell Biol (2010) 0.98
Rho proteins of plants--functional cycle and regulation of cytoskeletal dynamics. Eur J Cell Biol (2011) 0.98
G-domain dimerization orchestrates the tRNA wobble modification reaction in the MnmE/GidA complex. J Mol Biol (2009) 0.97
A Rap/phosphatidylinositol 3-kinase pathway controls pseudopod formation [corrected]. Mol Biol Cell (2010) 0.96
Structural dynamics in the activation of Epac. J Biol Chem (2007) 0.96
Unravelling the mechanism of dual-specificity GAPs. EMBO J (2010) 0.96
Structure and function of Rho-type molecular switches in plants. Plant Physiol Biochem (2007) 0.95
The nucleoporin RanBP2 tethers the cAMP effector Epac1 and inhibits its catalytic activity. J Cell Biol (2011) 0.94
Properties of the interaction of Arf-like protein 2 with PDEdelta. J Mol Biol (2005) 0.94
Conformational states of Ras complexed with the GTP analogue GppNHp or GppCH2p: implications for the interaction with effector proteins. Biochemistry (2005) 0.93
The PI3K effector Arap3 interacts with the PI(3,4,5)P3 phosphatase SHIP2 in a SAM domain-dependent manner. Cell Signal (2007) 0.92
Structural and biochemical properties of Sept7, a unique septin required for filament formation. Biol Chem (2011) 0.92
RPGR and RP2: targets for the treatment of X-linked retinitis pigmentosa? Expert Opin Ther Targets (2009) 0.91
Amino acids of the bacterial toxin SopE involved in G nucleotide exchange on Cdc42. J Biol Chem (2003) 0.91
Insight into catalysis of a unique GTPase reaction by a combined biochemical and FTIR approach. J Mol Biol (2006) 0.89
Fluoride complexes of oncogenic Ras mutants to study the Ras-RasGap interaction. Biol Chem (2008) 0.89
The crystal structure of the Ran-Nup153ZnF2 complex: a general Ran docking site at the nuclear pore complex. Structure (2008) 0.87
A structural rationale for selective stabilization of anti-tumor interactions of 14-3-3 proteins by cotylenin A. J Mol Biol (2009) 0.87
Differences between the interaction of beta-catenin with non-phosphorylated and single-mimicked phosphorylated 20-amino acid residue repeats of the APC protein. J Mol Biol (2003) 0.86
Bmp and nodal independently regulate lefty1 expression to maintain unilateral nodal activity during left-right axis specification in zebrafish. PLoS Genet (2011) 0.86
Human septin isoforms and the GDP-GTP cycle. Biol Chem (2014) 0.85