Published in PLoS Biol on October 19, 2010
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia. Nature (2011) 7.94
Reductive carboxylation supports growth in tumour cells with defective mitochondria. Nature (2011) 6.57
Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability. Proc Natl Acad Sci U S A (2011) 5.24
A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence. Nature (2013) 3.46
Quantitative flux analysis reveals folate-dependent NADPH production. Nature (2014) 2.93
What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer. Genes Dev (2013) 2.31
Comparative metabolic flux profiling of melanoma cell lines: beyond the Warburg effect. J Biol Chem (2011) 2.24
Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation. Genes Dev (2011) 2.20
Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation. Proc Natl Acad Sci U S A (2012) 2.10
Fibroblast heterogeneity in the cancer wound. J Exp Med (2014) 2.09
Identification of additional IDH mutations associated with oncometabolite R(-)-2-hydroxyglutarate production. Oncogene (2011) 1.87
Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells. Dev Cell (2016) 1.65
Glutamine-driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia. Mol Syst Biol (2013) 1.56
Serine catabolism regulates mitochondrial redox control during hypoxia. Cancer Discov (2014) 1.53
Metabolism of stromal and immune cells in health and disease. Nature (2014) 1.49
Transcription factor NRF2 regulates miR-1 and miR-206 to drive tumorigenesis. J Clin Invest (2013) 1.42
Famine versus feast: understanding the metabolism of tumors in vivo. Trends Biochem Sci (2015) 1.42
Multifunctional essentiality of succinate metabolism in adaptation to hypoxia in Mycobacterium tuberculosis. Proc Natl Acad Sci U S A (2013) 1.41
Asparagine plays a critical role in regulating cellular adaptation to glutamine depletion. Mol Cell (2014) 1.36
Staying alive: metabolic adaptations to quiescence. Cell Cycle (2012) 1.28
Mitochondrial metabolism of glucose and glutamine is required for intracellular growth of Toxoplasma gondii. Cell Host Microbe (2012) 1.22
The proteomics of quiescent and nonquiescent cell differentiation in yeast stationary-phase cultures. Mol Biol Cell (2011) 1.21
Quantitative dynamics of the link between cellular metabolism and histone acetylation. J Biol Chem (2013) 1.19
Human phosphoglycerate dehydrogenase produces the oncometabolite D-2-hydroxyglutarate. ACS Chem Biol (2014) 1.15
Fatty acid labeling from glutamine in hypoxia can be explained by isotope exchange without net reductive isocitrate dehydrogenase (IDH) flux. J Biol Chem (2013) 1.13
Cell biology. The essence of quiescence. Science (2011) 1.12
Targeting unique metabolic properties of breast tumor initiating cells. Stem Cells (2014) 1.10
Endothelial cell metabolism in normal and diseased vasculature. Circ Res (2015) 1.09
NADPH oxidase-derived reactive oxygen species increases expression of monocyte chemotactic factor genes in cultured adipocytes. J Biol Chem (2012) 1.08
Serine biosynthesis with one carbon catabolism and the glycine cleavage system represents a novel pathway for ATP generation. PLoS One (2011) 1.08
Dysregulated metabolism contributes to oncogenesis. Semin Cancer Biol (2015) 1.03
Proliferation and tissue remodeling in cancer: the hallmarks revisited. Cell Death Dis (2012) 1.03
Glutamine-fueled mitochondrial metabolism is decoupled from glycolysis in melanoma. Pigment Cell Melanoma Res (2012) 1.00
Changing appetites: the adaptive advantages of fuel choice. Trends Cell Biol (2013) 1.00
H4K20 methylation regulates quiescence and chromatin compaction. Mol Biol Cell (2013) 0.99
Is cancer a metabolic disease? Am J Pathol (2013) 0.99
Separation of metabolic supply and demand: aerobic glycolysis as a normal physiological response to fluctuating energetic demands in the membrane. Cancer Metab (2014) 0.99
Constant growth rate can be supported by decreasing energy flux and increasing aerobic glycolysis. Cell Rep (2014) 0.98
A conserved cell growth cycle can account for the environmental stress responses of divergent eukaryotes. Mol Biol Cell (2012) 0.96
DNA methylation directs functional maturation of pancreatic β cells. J Clin Invest (2015) 0.96
Glucose controls morphodynamics of LPS-stimulated macrophages. PLoS One (2014) 0.94
Autophagy: resetting glutamine-dependent metabolism and oxygen consumption. Autophagy (2012) 0.94
The portal fibroblast: not just a poor man's stellate cell. Gastroenterology (2014) 0.93
A microRNA network regulates proliferative timing and extracellular matrix synthesis during cellular quiescence in fibroblasts. Genome Biol (2012) 0.93
Metabolic reprogramming during purine stress in the protozoan pathogen Leishmania donovani. PLoS Pathog (2014) 0.91
Microenvironmental acidosis in carcinogenesis and metastases: new strategies in prevention and therapy. Cancer Metastasis Rev (2014) 0.91
Metabolomics and diabetes: analytical and computational approaches. Diabetes (2015) 0.90
A novel cell-cycle-indicator, mVenus-p27K-, identifies quiescent cells and visualizes G0-G1 transition. Sci Rep (2014) 0.89
Detection of metabolic fluxes of O and H atoms into intracellular water in mammalian cells. PLoS One (2012) 0.89
A role for RNA post-transcriptional regulation in satellite cell activation. Skelet Muscle (2012) 0.88
Quantitation of cellular metabolic fluxes of methionine. Anal Chem (2014) 0.87
Metabolic regulation of histone post-translational modifications. ACS Chem Biol (2015) 0.87
Resistance to Dasatinib in primary chronic lymphocytic leukemia lymphocytes involves AMPK-mediated energetic re-programming. Oncotarget (2013) 0.86
The Role of Mitochondrial NADPH-Dependent Isocitrate Dehydrogenase in Cancer Cells. Int J Cell Biol (2012) 0.85
Exogenous Fatty Acids Are the Preferred Source of Membrane Lipids in Proliferating Fibroblasts. Cell Chem Biol (2016) 0.84
Quiescent fibroblasts are protected from proteasome inhibition-mediated toxicity. Mol Biol Cell (2012) 0.83
Histone deacetylase inhibitor-induced cancer stem cells exhibit high pentose phosphate pathway metabolism. Oncotarget (2016) 0.82
Quiescent fibroblasts are more active in mounting robust inflammatory responses than proliferative fibroblasts. PLoS One (2012) 0.82
Modelling mammalian cellular quiescence. Interface Focus (2014) 0.82
Cancer cell growth and survival as a system-level property sustained by enhanced glycolysis and mitochondrial metabolic remodeling. Front Physiol (2012) 0.80
Bone marrow microenvironment modulation of acute lymphoblastic leukemia phenotype. Exp Hematol (2015) 0.80
Aerobic glycolysis: beyond proliferation. Front Immunol (2015) 0.80
Human fibroblast switches to anaerobic metabolic pathway in response to serum starvation: a mimic of warburg effect. Int J Mol Cell Med (2014) 0.80
Investigating mitochondrial redox state using NADH and NADPH autofluorescence. Free Radic Biol Med (2016) 0.80
Low-glucose enhances keratocyte-characteristic phenotype from corneal stromal cells in serum-free conditions. Sci Rep (2015) 0.79
AMPK negatively regulates tensin-dependent integrin activity. J Cell Biol (2017) 0.79
Starved epithelial cells uptake extracellular matrix for survival. Nat Commun (2017) 0.79
A novel regulation of PD-1 ligands on mesenchymal stromal cells through MMP-mediated proteolytic cleavage. Oncoimmunology (2015) 0.79
Quiescent and proliferative fibroblasts exhibit differential p300 HAT activation through control of 5-methoxytryptophan production. PLoS One (2014) 0.78
Metabolic plasticity in CLL: adaptation to the hypoxic niche. Leukemia (2015) 0.78
Reductive carboxylation is a major metabolic pathway in the retinal pigment epithelium. Proc Natl Acad Sci U S A (2016) 0.77
Cross-talk between signaling and metabolism in the vasculature. Vascul Pharmacol (2016) 0.77
Heterogeneity in Cancer Metabolism: New Concepts in an Old Field. Antioxid Redox Signal (2016) 0.77
The importance of controlling mRNA turnover during cell proliferation. Curr Genet (2016) 0.77
Long-term quiescent fibroblast cells transit into senescence. PLoS One (2014) 0.77
Evaluation of royal jelly as an alternative to fetal bovine serum in cell culture using cell proliferation assays and live cell imaging. Afr J Tradit Complement Altern Med (2013) 0.77
L-Lactate Protects Skin Fibroblasts against Aging-Associated Mitochondrial Dysfunction via Mitohormesis. Oxid Med Cell Longev (2015) 0.77
The quantified cell. Mol Biol Cell (2014) 0.75
A high ratio of G1 to G0 phase cells and an accumulation of G1 phase cells before S phase progression after injurious stimuli in the proximal tubule. Physiol Rep (2014) 0.75
Reciprocal regulation of acetyl-CoA carboxylase 1 and senescence in human fibroblasts involves oxidant mediated p38 MAPK activation. Arch Biochem Biophys (2016) 0.75
Mutations in SLC25A22: hyperprolinaemia, vacuolated fibroblasts and presentation with developmental delay. J Inherit Metab Dis (2017) 0.75
RAC2-P38 MAPK-dependent NADPH oxidase activity is associated with the resistance of quiescent cells to ionizing radiation. Cell Cycle (2016) 0.75
Distinct Cell Stress Responses Induced by ATP Restriction in Quiescent Human Fibroblasts. Front Genet (2016) 0.75
Metabolic control of the cell cycle. Cell Cycle (2015) 0.75
Human dermal fibroblasts in psychiatry research. Neuroscience (2016) 0.75
Imaging Sensitivity of Quiescent Cancer Cells to Metabolic Perturbations in Bone Marrow Spheroids. Tomography (2016) 0.75
An In Vitro Model of Cellular Quiescence in Primary Human Dermal Fibroblasts. Methods Mol Biol (2018) 0.75
Isocitrate dehydrogenases in physiology and cancer: biochemical and molecular insight. Cell Biosci (2017) 0.75
The Stromal Microenvironment Modulates Mitochondrial Oxidative Phosphorylation in Chronic Lymphocytic Leukemia Cells. Neoplasia (2017) 0.75
Proteomic and Metabolomic Characterization of a Mammalian Cellular Transition from Quiescence to Proliferation. Cell Rep (2017) 0.75
A map of protein dynamics during cell-cycle progression and cell-cycle exit. PLoS Biol (2017) 0.75
CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev (1999) 24.83
The transcriptional program in the response of human fibroblasts to serum. Science (1999) 19.19
The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab (2008) 18.87
Wound healing--aiming for perfect skin regeneration. Science (1997) 16.08
The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate. Cancer Cell (2010) 13.13
Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction. Proc Natl Acad Sci U S A (2008) 11.71
Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast. J Biol Chem (1998) 10.77
The CD28 signaling pathway regulates glucose metabolism. Immunity (2002) 6.65
Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells. J Cell Biol (2007) 6.54
Evidence that glutamine, not sugar, is the major energy source for cultured HeLa cells. J Biol Chem (1979) 6.53
Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapy. Nat Biotechnol (2008) 5.77
Fuel feeds function: energy metabolism and the T-cell response. Nat Rev Immunol (2005) 5.29
Simultaneous determination of multiple intracellular metabolites in glycolysis, pentose phosphate pathway and tricarboxylic acid cycle by liquid chromatography-mass spectrometry. J Chromatogr A (2007) 4.68
Separation and quantitation of water soluble cellular metabolites by hydrophilic interaction chromatography-tandem mass spectrometry. J Chromatogr A (2006) 4.62
Stationary phase in the yeast Saccharomyces cerevisiae. Microbiol Rev (1993) 4.54
"Sleeping beauty": quiescence in Saccharomyces cerevisiae. Microbiol Mol Biol Rev (2004) 4.23
Tissue repair, contraction, and the myofibroblast. Wound Repair Regen (2005) 3.70
A new description of cellular quiescence. PLoS Biol (2006) 3.56
Postprandial blood glucose. American Diabetes Association. Diabetes Care (2001) 3.38
Isolation of a highly quiescent subpopulation of primitive leukemic cells in chronic myeloid leukemia. Blood (1999) 3.33
Analytical strategies for LC-MS-based targeted metabolomics. J Chromatogr B Analyt Technol Biomed Life Sci (2008) 3.05
Mitochondrial metabolism of glutamine and glutamate and its physiological significance. Physiol Rev (1983) 2.92
Dynamics of the cellular metabolome during human cytomegalovirus infection. PLoS Pathog (2006) 2.88
Quantifying reductive carboxylation flux of glutamine to lipid in a brown adipocyte cell line. J Biol Chem (2008) 2.76
A high-performance liquid chromatography-tandem mass spectrometry method for quantitation of nitrogen-containing intracellular metabolites. J Am Soc Mass Spectrom (2005) 2.46
Oxythiamine and dehydroepiandrosterone inhibit the nonoxidative synthesis of ribose and tumor cell proliferation. Cancer Res (1997) 2.35
Control of the reversibility of cellular quiescence by the transcriptional repressor HES1. Science (2008) 2.29
Kinetic flux profiling of nitrogen assimilation in Escherichia coli. Nat Chem Biol (2006) 2.19
A general topoisomerase I-dependent transcriptional repression in the stationary phase in yeast. Genes Dev (1991) 2.18
Early effects of phytohaemagglutinin on glucose metabolism of normal human lymphocytes. Biochem J (1968) 1.94
Glutamine and glucose metabolism during thymocyte proliferation. Pathways of glutamine and glutamate metabolism. Biochem J (1985) 1.92
Protein synthesis in long-term stationary-phase cultures of Saccharomyces cerevisiae. J Bacteriol (1994) 1.85
Cytokine stimulation of aerobic glycolysis in hematopoietic cells exceeds proliferative demand. FASEB J (2004) 1.79
let-7 Overexpression leads to an increased fraction of cells in G2/M, direct down-regulation of Cdc34, and stabilization of Wee1 kinase in primary fibroblasts. J Biol Chem (2009) 1.65
Optimal identification of biochemical reaction networks. Biophys J (2004) 1.56
Primitive, quiescent and difficult to kill: the role of non-proliferating stem cells in chronic myeloid leukemia. Cell Cycle (2006) 1.43
Glutamine: a major energy source for cultured mammalian cells. Fed Proc (1984) 1.42
Reverse flux through cardiac NADP(+)-isocitrate dehydrogenase under normoxia and ischemia. Am J Physiol Heart Circ Physiol (2002) 1.41
Glucose and glutamine metabolism in C6 glioma cells studied by carbon 13 NMR. Biochimie (1996) 1.30
Glutamine and glutamate as vital metabolites. Braz J Med Biol Res (2003) 1.26
Correlated measurements of DNA, RNA, and protein in individual cells by flow cytometry. Science (1985) 1.18
Keloids and hypertrophic scars: are they two different sides of the same coin? Dermatol Surg (2007) 1.14
Regulating the angiogenic balance in tissues. Cell Cycle (2008) 1.13
The cancer stem cell paradigm: a new understanding of tumor development and treatment. Expert Opin Ther Targets (2010) 1.09
Alterations in hexose monophosphate shunt during lymphoblastic transformation. Cell Immunol (1974) 1.08
Differential destruction of stem cells: implications for targeted cancer stem cell therapy. Cancer Res (2009) 1.01
Oxidative stress-induced apoptosis in dividing fibroblasts involves activation of p38 MAP kinase and over-expression of Bax: resistance of quiescent cells to oxidative stress. Apoptosis (2003) 1.01
Normal and perturbed Chinese hamster ovary cells: correlation of DNA, RNA, and protein content by flow cytometry. J Cell Biol (1985) 0.99
Modulation of pentose phosphate pathway during cell cycle progression in human colon adenocarcinoma cell line HT29. Int J Cancer (2009) 0.98
Autophagy is activated, but is not required for the G0 function of BCL-2 or BCL-xL. Cell Cycle (2008) 0.96
Mechanism of inhibition of growth of 3T3-L1 fibroblasts and their differentiation to adipocytes by dehydroepiandrosterone and related steroids: role of glucose-6-phosphate dehydrogenase. Proc Natl Acad Sci U S A (1989) 0.94
Targeting cancer stem cells for more effective therapies: Taking out cancer's locomotive engine. Biochem Pharmacol (2009) 0.88
Eradication of leukemia stem cells as a new goal of therapy in leukemia. Clin Cancer Res (2006) 0.87
Complex regulation of fibronectin synthesis by cells in culture. Am J Physiol (1983) 0.85
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature (2009) 19.65
The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate. Cancer Cell (2010) 13.13
Absolute metabolite concentrations and implied enzyme active site occupancy in Escherichia coli. Nat Chem Biol (2009) 8.36
Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. Genes Dev (2011) 7.43
Telomerase modulates expression of growth-controlling genes and enhances cell proliferation. Nat Cell Biol (2003) 7.02
Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapy. Nat Biotechnol (2008) 5.77
Evidence for an alternative glycolytic pathway in rapidly proliferating cells. Science (2010) 5.44
A search for conserved sequences in coding regions reveals that the let-7 microRNA targets Dicer within its coding sequence. Proc Natl Acad Sci U S A (2008) 5.11
Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells. Nature (2013) 4.71
Separation and quantitation of water soluble cellular metabolites by hydrophilic interaction chromatography-tandem mass spectrometry. J Chromatogr A (2006) 4.62
Mechanisms of polarized growth and organelle segregation in yeast. Annu Rev Cell Dev Biol (2004) 3.41
The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism. Genes Dev (2010) 3.40
Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1. Cancer Res (2010) 3.30
Absolute quantitation of intracellular metabolite concentrations by an isotope ratio-based approach. Nat Protoc (2008) 3.24
Metabolomic analysis via reversed-phase ion-pairing liquid chromatography coupled to a stand alone orbitrap mass spectrometer. Anal Chem (2010) 3.22
Analytical strategies for LC-MS-based targeted metabolomics. J Chromatogr B Analyt Technol Biomed Life Sci (2008) 3.05
Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis. Genes Dev (2013) 2.90
Dynamics of the cellular metabolome during human cytomegalovirus infection. PLoS Pathog (2006) 2.88
Metabolomic analysis and visualization engine for LC-MS data. Anal Chem (2010) 2.77
Exploring the human genome with functional maps. Genome Res (2009) 2.69
Conservation of the metabolomic response to starvation across two divergent microbes. Proc Natl Acad Sci U S A (2006) 2.68
Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids. Proc Natl Acad Sci U S A (2013) 2.57
A high-performance liquid chromatography-tandem mass spectrometry method for quantitation of nitrogen-containing intracellular metabolites. J Am Soc Mass Spectrom (2005) 2.46
Quorum sensing controls biofilm formation in Vibrio cholerae through modulation of cyclic di-GMP levels and repression of vpsT. J Bacteriol (2008) 2.45
Ammonium toxicity and potassium limitation in yeast. PLoS Biol (2006) 2.39
Kinetic flux profiling for quantitation of cellular metabolic fluxes. Nat Protoc (2008) 2.35
Control of the reversibility of cellular quiescence by the transcriptional repressor HES1. Science (2008) 2.29
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature (2010) 2.21
Kinetic flux profiling of nitrogen assimilation in Escherichia coli. Nat Chem Biol (2006) 2.19
Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation. Proc Natl Acad Sci U S A (2012) 2.10
Absence of detectable arsenate in DNA from arsenate-grown GFAJ-1 cells. Science (2012) 2.03
Host-parasite interactions revealed by Plasmodium falciparum metabolomics. Cell Host Microbe (2009) 2.00
Growth-limiting intracellular metabolites in yeast growing under diverse nutrient limitations. Mol Biol Cell (2009) 1.92
Retracted Branched tricarboxylic acid metabolism in Plasmodium falciparum. Nature (2010) 1.92
Robust control of nitrogen assimilation by a bifunctional enzyme in E. coli. Mol Cell (2011) 1.70
Divergent effects of human cytomegalovirus and herpes simplex virus-1 on cellular metabolism. PLoS Pathog (2011) 1.66
let-7 Overexpression leads to an increased fraction of cells in G2/M, direct down-regulation of Cdc34, and stabilization of Wee1 kinase in primary fibroblasts. J Biol Chem (2009) 1.65
Identifying decomposition products in extracts of cellular metabolites. Anal Biochem (2006) 1.62
Yeast cells can access distinct quiescent states. Genes Dev (2011) 1.59
Metabolomics-driven quantitative analysis of ammonia assimilation in E. coli. Mol Syst Biol (2009) 1.57
Glutamine-driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia. Mol Syst Biol (2013) 1.56
Synaptojanin 1-linked phosphoinositide dyshomeostasis and cognitive deficits in mouse models of Down's syndrome. Proc Natl Acad Sci U S A (2008) 1.54
LC-MS data processing with MAVEN: a metabolomic analysis and visualization engine. Curr Protoc Bioinformatics (2012) 1.52
Regulatory and metabolic rewiring during laboratory evolution of ethanol tolerance in E. coli. Mol Syst Biol (2010) 1.47
Coordinated concentration changes of transcripts and metabolites in Saccharomyces cerevisiae. PLoS Comput Biol (2009) 1.47
FOXO3 shares common targets with ASCL1 genome-wide and inhibits ASCL1-dependent neurogenesis. Cell Rep (2013) 1.45
"Myc'ed messages": myc induces transcription of E2F1 while inhibiting its translation via a microRNA polycistron. PLoS Genet (2007) 1.45
Systems-level metabolic flux profiling elucidates a complete, bifurcated tricarboxylic acid cycle in Clostridium acetobutylicum. J Bacteriol (2010) 1.44
Riboneogenesis in yeast. Cell (2011) 1.43
α-Ketoglutarate coordinates carbon and nitrogen utilization via enzyme I inhibition. Nat Chem Biol (2011) 1.41
Metabolomics in systems microbiology. Curr Opin Biotechnol (2010) 1.40
Detailing regulatory networks through large scale data integration. Bioinformatics (2009) 1.38
Autophagy suppresses RIP kinase-dependent necrosis enabling survival to mTOR inhibition. PLoS One (2012) 1.37
The code within the code: microRNAs target coding regions. Cell Cycle (2010) 1.35
PI4P and Rab inputs collaborate in myosin-V-dependent transport of secretory compartments in yeast. Dev Cell (2011) 1.28
Staying alive: metabolic adaptations to quiescence. Cell Cycle (2012) 1.28
A domino effect in antifolate drug action in Escherichia coli. Nat Chem Biol (2008) 1.26
The Vibrio cholerae quorum-sensing autoinducer CAI-1: analysis of the biosynthetic enzyme CqsA. Nat Chem Biol (2009) 1.26
Antifolate-induced depletion of intracellular glycine and purines inhibits thymineless death in E. coli. ACS Chem Biol (2010) 1.23
Isotope ratio-based profiling of microbial folates. J Am Soc Mass Spectrom (2007) 1.23
Calcium blocks formation of apoptosome by preventing nucleotide exchange in Apaf-1. Mol Cell (2007) 1.21
Quantitative dynamics of the link between cellular metabolism and histone acetylation. J Biol Chem (2013) 1.19
Origins of human mitochondrial point mutations as DNA polymerase gamma-mediated errors. Mutat Res (2006) 1.18
Human phosphoglycerate dehydrogenase produces the oncometabolite D-2-hydroxyglutarate. ACS Chem Biol (2014) 1.15
Nearest Neighbor Networks: clustering expression data based on gene neighborhoods. BMC Bioinformatics (2007) 1.15
Robustness in glyoxylate bypass regulation. PLoS Comput Biol (2009) 1.15
Fatty acid labeling from glutamine in hypoxia can be explained by isotope exchange without net reductive isocitrate dehydrogenase (IDH) flux. J Biol Chem (2013) 1.13
Regulating the angiogenic balance in tissues. Cell Cycle (2008) 1.13
Liquid chromatography-high resolution mass spectrometry analysis of fatty acid metabolism. Anal Chem (2011) 1.13
Remodeling of the metabolome during early frog development. PLoS One (2011) 1.12
Synaptic vesicle-like lipidome of human cytomegalovirus virions reveals a role for SNARE machinery in virion egress. Proc Natl Acad Sci U S A (2011) 1.10
Achieving optimal growth through product feedback inhibition in metabolism. PLoS Comput Biol (2010) 1.10
Tumoral lymphocytic infiltration and expression of the chemokine CXCL10 in breast cancers from the Ontario Familial Breast Cancer Registry. Clin Cancer Res (2012) 1.09
Pyrimidine homeostasis is accomplished by directed overflow metabolism. Nature (2013) 1.09
An immunohistochemical method for identifying fibroblasts in formalin-fixed, paraffin-embedded tissue. J Histochem Cytochem (2007) 1.08
Biclustering via optimal re-ordering of data matrices in systems biology: rigorous methods and comparative studies. BMC Bioinformatics (2008) 1.07
Adenovirus type 5 exerts genome-wide control over cellular programs governing proliferation, quiescence, and survival. Genome Biol (2007) 1.07