Branched tricarboxylic acid metabolism in Plasmodium falciparum.

Reductive carboxylation supports growth in tumour cells with defective mitochondria. Nature (2011) 6.57

Expanding coverage of the metabolome for global metabolite profiling. Anal Chem (2011) 2.28

A research agenda for malaria eradication: basic science and enabling technologies. PLoS Med (2011) 1.89

Sequencing of the smallest Apicomplexan genome from the human pathogen Babesia microti. Nucleic Acids Res (2012) 1.49

Mitochondrial metabolism of sexual and asexual blood stages of the malaria parasite Plasmodium falciparum. BMC Biol (2013) 1.46

Harnessing genomics and genome biology to understand malaria biology. Nat Rev Genet (2012) 1.41

Metabolomics in systems microbiology. Curr Opin Biotechnol (2010) 1.40

Reconstruction and flux-balance analysis of the Plasmodium falciparum metabolic network. Mol Syst Biol (2010) 1.37

Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier. Trends Microbiol (2011) 1.36

Meta-analysis of untargeted metabolomic data from multiple profiling experiments. Nat Protoc (2012) 1.29

Mitochondrial metabolism of glucose and glutamine is required for intracellular growth of Toxoplasma gondii. Cell Host Microbe (2012) 1.22

Metabolic reprogramming and metabolic dependency in T cells. Immunol Rev (2012) 1.18

Impaired skeletal muscle microvascular function and increased skeletal muscle oxygen consumption in severe falciparum malaria. J Infect Dis (2012) 1.15

Arrested oocyst maturation in Plasmodium parasites lacking type II NADH:ubiquinone dehydrogenase. J Biol Chem (2011) 1.09

Isotopomer profiling of Leishmania mexicana promastigotes reveals important roles for succinate fermentation and aspartate uptake in tricarboxylic acid cycle (TCA) anaplerosis, glutamate synthesis, and growth. J Biol Chem (2011) 1.09

Metabolomics in drug target discovery. Cold Spring Harb Symp Quant Biol (2011) 1.05

Global mass spectrometry based metabolomics profiling of erythrocytes infected with Plasmodium falciparum. PLoS One (2013) 1.03

Central carbon metabolism of Plasmodium parasites. Mol Biochem Parasitol (2010) 1.02

Mitochondrial electron transport inhibition and viability of intraerythrocytic Plasmodium falciparum. Antimicrob Agents Chemother (2010) 1.00

Systems biological approaches to measure and understand vaccine immunity in humans. Semin Immunol (2013) 0.98

Metabolic fate of fumarate, a side product of the purine salvage pathway in the intraerythrocytic stages of Plasmodium falciparum. J Biol Chem (2011) 0.98

Application of genomics to field investigations of malaria by the international centers of excellence for malaria research. Acta Trop (2011) 0.95

Metabolomics and malaria biology. Mol Biochem Parasitol (2010) 0.95

ATP synthase complex of Plasmodium falciparum: dimeric assembly in mitochondrial membranes and resistance to genetic disruption. J Biol Chem (2011) 0.95

A constitutive pan-hexose permease for the Plasmodium life cycle and transgenic models for screening of antimalarial sugar analogs. FASEB J (2010) 0.91

The metabolic roles of the endosymbiotic organelles of Toxoplasma and Plasmodium spp. Curr Opin Microbiol (2013) 0.91

Intermediary metabolism in protists: a sequence-based view of facultative anaerobic metabolism in evolutionarily diverse eukaryotes. Protist (2010) 0.91

Use of a selective inhibitor to define the chemotherapeutic potential of the plasmodial hexose transporter in different stages of the parasite's life cycle. Antimicrob Agents Chemother (2011) 0.91

Interrogating a hexokinase-selected small-molecule library for inhibitors of Plasmodium falciparum hexokinase. Antimicrob Agents Chemother (2013) 0.90

Recent advances in mapping environmental microbial metabolisms through 13C isotopic fingerprints. J R Soc Interface (2012) 0.89

A host GPCR signaling network required for the cytolysis of infected cells facilitates release of apicomplexan parasites. Cell Host Microbe (2013) 0.89

A key role for lipoic acid synthesis during Plasmodium liver stage development. Cell Microbiol (2013) 0.87

Proteomic analysis of Plasmodium in the mosquito: progress and pitfalls. Parasitology (2012) 0.87

Stable isotope-labeled tracers for metabolic pathway elucidation by GC-MS and FT-MS. Methods Mol Biol (2014) 0.87

Systems immunology of human malaria. Trends Parasitol (2012) 0.86

Metabolomic analysis of patient plasma yields evidence of plant-like α-linolenic acid metabolism in Plasmodium falciparum. J Infect Dis (2012) 0.86

Phosphoenolpyruvate carboxylase identified as a key enzyme in erythrocytic Plasmodium falciparum carbon metabolism. PLoS Pathog (2014) 0.85

Plasmodial sugar transporters as anti-malarial drug targets and comparisons with other protozoa. Malar J (2011) 0.85

Effects of Neospora caninum infection on brain microvascular endothelial cells bioenergetics. Parasit Vectors (2013) 0.85

Sirtuins of parasitic protozoa: in search of function(s). Mol Biochem Parasitol (2012) 0.82

Lipoic acid metabolism of Plasmodium--a suitable drug target. Curr Pharm Des (2012) 0.82

Plasmodium falciparum glutamate dehydrogenase a is dispensable and not a drug target during erythrocytic development. Malar J (2011) 0.81

Transcript level responses of Plasmodium falciparum to antimycin A. Protist (2012) 0.79

Extraction of hydrophilic metabolites from Plasmodium falciparum-infected erythrocytes for metabolomic analysis. Methods Mol Biol (2013) 0.77

No need for labels: the autofluorescence of Leishmania tarentolae mitochondria and the necessity of negative controls. PLoS One (2012) 0.76

Metabolism: Malaria parasite stands out. Nature (2010) 0.76

Beyond blueprints. Nat Chem Biol (2012) 0.75

Identification of Novel Plasmodium falciparum Hexokinase Inhibitors with Antiparasitic Activity. Antimicrob Agents Chemother (2016) 0.75

The use of functional genomics in conjunction with metabolomics for Mycobacterium tuberculosis research. Dis Markers (2014) 0.75

Crystallization and preliminary X-ray diffraction of malate dehydrogenase from Plasmodium falciparum. Acta Crystallogr Sect F Struct Biol Cryst Commun (2012) 0.75

Human malaria parasites in continuous culture. Science (1976) 59.70

Genome sequence of the human malaria parasite Plasmodium falciparum. Nature (2002) 37.89

Synchronization of Plasmodium falciparum erythrocytic stages in culture. J Parasitol (1979) 23.90

The transcriptome of the intraerythrocytic developmental cycle of Plasmodium falciparum. PLoS Biol (2003) 11.86

Regulation of cellular metabolism by protein lysine acetylation. Science (2010) 10.55

A uniform proteomics MS/MS analysis platform utilizing open XML file formats. Mol Syst Biol (2005) 9.81

ATP-citrate lyase links cellular metabolism to histone acetylation. Science (2009) 8.82

Extraction, purification and analysis of histones. Nat Protoc (2007) 6.25

Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux. Science (2010) 6.04

Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapy. Nat Biotechnol (2008) 5.77

Transformation with human dihydrofolate reductase renders malaria parasites insensitive to WR99210 but does not affect the intrinsic activity of proguanil. Proc Natl Acad Sci U S A (1997) 5.75

Culture of normal human leukocytes. JAMA (1967) 4.50

Chemical derivatization of histones for facilitated analysis by mass spectrometry. Nat Protoc (2007) 3.78

Di- and triphosphopyridine nucleotide isocitric dehydrogenases in yeast. J Biol Chem (1951) 3.73

Distinct physiological states of Plasmodium falciparum in malaria-infected patients. Nature (2007) 3.69

Localization of organellar proteins in Plasmodium falciparum using a novel set of transfection vectors and a new immunofluorescence fixation method. Mol Biochem Parasitol (2004) 3.13

Specific role of mitochondrial electron transport in blood-stage Plasmodium falciparum. Nature (2007) 3.08

Analytical strategies for LC-MS-based targeted metabolomics. J Chromatogr B Analyt Technol Biomed Life Sci (2008) 3.05

The fatty acid biosynthesis enzyme FabI plays a key role in the development of liver-stage malarial parasites. Cell Host Microbe (2008) 2.98

Quantifying reductive carboxylation flux of glutamine to lipid in a brown adipocyte cell line. J Biol Chem (2008) 2.76

Type II fatty acid synthesis is essential only for malaria parasite late liver stage development. Cell Microbiol (2008) 2.49

Plasmodium falciparum ensures its amino acid supply with multiple acquisition pathways and redundant proteolytic enzyme systems. Proc Natl Acad Sci U S A (2006) 2.43

Host-parasite interactions revealed by Plasmodium falciparum metabolomics. Cell Host Microbe (2009) 2.00

The malaria parasite Plasmodium falciparum has only one pyruvate dehydrogenase complex, which is located in the apicoplast. Mol Microbiol (2005) 1.98

Proteomic profiling of Plasmodium sporozoite maturation identifies new proteins essential for parasite development and infectivity. PLoS Pathog (2008) 1.98

Protein glycosylation in the malaria parasite. Parasitol Today (1999) 1.90

Mitochondrial evolution and functions in malaria parasites. Annu Rev Microbiol (2009) 1.74

A genetic screen for improved plasmid segregation reveals a role for Rep20 in the interaction of Plasmodium falciparum chromosomes. EMBO J (2002) 1.69

Metabolic maps and functions of the Plasmodium mitochondrion. FEMS Microbiol Rev (2006) 1.57

The malaria parasite Plasmodium falciparum histones: organization, expression, and acetylation. Gene (2006) 1.56

Stable expression of a new chimeric fluorescent reporter in the human malaria parasite Plasmodium falciparum. Infect Immun (2000) 1.55

Mitochondria of mammalian Plasmodium spp. Parasitology (1991) 1.37

Mitochondrial drug targets in apicomplexan parasites. Curr Drug Targets (2007) 1.19

Selective stage-specific changes in the permeability to small hydrophilic solutes of human erythrocytes infected with Plasmodium falciparum. Mol Biochem Parasitol (1985) 1.16

Purine salvage pathways in the intraerythrocytic malaria parasite Plasmodium falciparum. Eukaryot Cell (2008) 1.13

Intraerythrocytic Plasmodium falciparum utilize a broad range of serum-derived fatty acids with limited modification for their growth. Parasitology (2006) 1.11

Absence of alpha-ketoglutarate dehydrogenase activity and presence of CO2-fixing activity in Plasmodium falciparum grown in vitro in human erythrocytes. J Protozool (1984) 1.10

Targeting histone deacetylase inhibitors for anti-malarial therapy. Curr Top Med Chem (2009) 1.06

Purification and characterization of Plasmodium falciparum succinate dehydrogenase. Mol Biochem Parasitol (2000) 1.04

Cytochalasin D and latrunculin affect chromosome behaviour during meiosis in crane-fly spermatocytes. Chromosome Res (1998) 0.90

Isolation of mitochondria from Plasmodium falciparum showing dihydroorotate dependent respiration. Parasitol Int (2001) 0.89

An iron regulatory-like protein expressed in Plasmodium falciparum displays aconitase activity. Mol Biochem Parasitol (2005) 0.89

Isocitrate dehydrogenase of Plasmodium falciparum. Eur J Biochem (2003) 0.86

A novel direct homogeneous assay for ATP citrate lyase. J Lipid Res (2009) 0.83

Genome sequence of the human malaria parasite Plasmodium falciparum. Nature (2002) 37.89

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature (2009) 19.65

The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate. Cancer Cell (2010) 13.13

The transcriptome of the intraerythrocytic developmental cycle of Plasmodium falciparum. PLoS Biol (2003) 11.86

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat Med (2012) 11.14

Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii. Nature (2002) 8.92

Absolute metabolite concentrations and implied enzyme active site occupancy in Escherichia coli. Nat Chem Biol (2009) 8.36

Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. Genes Dev (2011) 7.43

Regulation of HP1-chromatin binding by histone H3 methylation and phosphorylation. Nature (2005) 6.40

Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma. Science (2013) 6.29

Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapy. Nat Biotechnol (2008) 5.77

Evidence for an alternative glycolytic pathway in rapidly proliferating cells. Science (2010) 5.44

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells. Nature (2013) 4.71

Separation and quantitation of water soluble cellular metabolites by hydrophilic interaction chromatography-tandem mass spectrometry. J Chromatogr A (2006) 4.62

Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization. Nat Med (2011) 3.82

A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells. Nat Chem Biol (2011) 3.60

The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism. Genes Dev (2010) 3.40

Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1. Cancer Res (2010) 3.30

Absolute quantitation of intracellular metabolite concentrations by an isotope ratio-based approach. Nat Protoc (2008) 3.24

Metabolomic analysis via reversed-phase ion-pairing liquid chromatography coupled to a stand alone orbitrap mass spectrometer. Anal Chem (2010) 3.22

Specific DNA-binding by apicomplexan AP2 transcription factors. Proc Natl Acad Sci U S A (2008) 3.10

Cathepsin L proteolytically processes histone H3 during mouse embryonic stem cell differentiation. Cell (2008) 3.09

Specific role of mitochondrial electron transport in blood-stage Plasmodium falciparum. Nature (2007) 3.08

Analytical strategies for LC-MS-based targeted metabolomics. J Chromatogr B Analyt Technol Biomed Life Sci (2008) 3.05

Expression patterns and post-translational modifications associated with mammalian histone H3 variants. J Biol Chem (2005) 3.00

SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. Nature (2012) 2.96

Quiescent fibroblasts exhibit high metabolic activity. PLoS Biol (2010) 2.94

Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis. Genes Dev (2013) 2.90

Dynamics of the cellular metabolome during human cytomegalovirus infection. PLoS Pathog (2006) 2.88

Asymmetrically modified nucleosomes. Cell (2012) 2.79

Metabolomic analysis and visualization engine for LC-MS data. Anal Chem (2010) 2.77

New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. Mol Microbiol (2010) 2.76

Conservation of the metabolomic response to starvation across two divergent microbes. Proc Natl Acad Sci U S A (2006) 2.68

Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids. Proc Natl Acad Sci U S A (2013) 2.57

High throughput characterization of combinatorial histone codes. Mol Cell Proteomics (2009) 2.52

The histone variant macroH2A suppresses melanoma progression through regulation of CDK8. Nature (2010) 2.49

A high-performance liquid chromatography-tandem mass spectrometry method for quantitation of nitrogen-containing intracellular metabolites. J Am Soc Mass Spectrom (2005) 2.46

Quorum sensing controls biofilm formation in Vibrio cholerae through modulation of cyclic di-GMP levels and repression of vpsT. J Bacteriol (2008) 2.45

Ammonium toxicity and potassium limitation in yeast. PLoS Biol (2006) 2.39

Kinetic flux profiling for quantitation of cellular metabolic fluxes. Nat Protoc (2008) 2.35

In vivo residue-specific histone methylation dynamics. J Biol Chem (2009) 2.33

Mass spectrometry analysis of Arabidopsis histone H3 reveals distinct combinations of post-translational modifications. Nucleic Acids Res (2004) 2.28

NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming. Mol Cell (2011) 2.27

Histone h3 lysine 56 acetylation is linked to the core transcriptional network in human embryonic stem cells. Mol Cell (2009) 2.27

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature (2010) 2.21

Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and craniofacial development. Nature (2010) 2.20

Kinetic flux profiling of nitrogen assimilation in Escherichia coli. Nat Chem Biol (2006) 2.19

One-pot shotgun quantitative mass spectrometry characterization of histones. J Proteome Res (2009) 2.13

Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation. Proc Natl Acad Sci U S A (2012) 2.10

Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling. Nat Immunol (2010) 2.07

Absence of detectable arsenate in DNA from arsenate-grown GFAJ-1 cells. Science (2012) 2.03

Host-parasite interactions revealed by Plasmodium falciparum metabolomics. Cell Host Microbe (2009) 2.00

Identification and genome-wide prediction of DNA binding specificities for the ApiAP2 family of regulators from the malaria parasite. PLoS Pathog (2010) 2.00

The RING finger protein MSL2 in the MOF complex is an E3 ubiquitin ligase for H2B K34 and is involved in crosstalk with H3 K4 and K79 methylation. Mol Cell (2011) 1.96

Growth-limiting intracellular metabolites in yeast growing under diverse nutrient limitations. Mol Biol Cell (2009) 1.92

Serine 31 phosphorylation of histone variant H3.3 is specific to regions bordering centromeres in metaphase chromosomes. Proc Natl Acad Sci U S A (2005) 1.91

Examining histone posttranslational modification patterns by high-resolution mass spectrometry. Methods Enzymol (2012) 1.83

Proteome-wide prediction of acetylation substrates. Proc Natl Acad Sci U S A (2009) 1.81

Site-specific genome editing in Plasmodium falciparum using engineered zinc-finger nucleases. Nat Methods (2012) 1.79

Histone H3 lysine 56 methylation regulates DNA replication through its interaction with PCNA. Mol Cell (2012) 1.79

The Apicomplexan AP2 family: integral factors regulating Plasmodium development. Mol Biochem Parasitol (2010) 1.74

Mitochondrial evolution and functions in malaria parasites. Annu Rev Microbiol (2009) 1.74

A novel histone deacetylase pathway regulates mitosis by modulating Aurora B kinase activity. Genes Dev (2006) 1.70

Robust control of nitrogen assimilation by a bifunctional enzyme in E. coli. Mol Cell (2011) 1.70

The validity of mitochondrial dehydrogenases as antimalarial drug targets. Trends Parasitol (2007) 1.68

Divergent effects of human cytomegalovirus and herpes simplex virus-1 on cellular metabolism. PLoS Pathog (2011) 1.66

Identifying decomposition products in extracts of cellular metabolites. Anal Biochem (2006) 1.62

Yeast cells can access distinct quiescent states. Genes Dev (2011) 1.59

Metabolomics-driven quantitative analysis of ammonia assimilation in E. coli. Mol Syst Biol (2009) 1.57

Glutamine-driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia. Mol Syst Biol (2013) 1.56

Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex. EMBO J (2007) 1.55

Genomic dissection of the cell-type-specification circuit in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (2004) 1.52

LC-MS data processing with MAVEN: a metabolomic analysis and visualization engine. Curr Protoc Bioinformatics (2012) 1.52

A mixed integer linear optimization framework for the identification and quantification of targeted post-translational modifications of highly modified proteins using multiplexed electron transfer dissociation tandem mass spectrometry. Mol Cell Proteomics (2009) 1.51

The significance, development and progress of high-throughput combinatorial histone code analysis. Cell Mol Life Sci (2010) 1.51

Identification of histone H3 lysine 36 acetylation as a highly conserved histone modification. J Biol Chem (2006) 1.50

Chromatin-specific remodeling by HMGB1 and linker histone H1 silences proinflammatory genes during endotoxin tolerance. Mol Cell Biol (2009) 1.49

Regulatory and metabolic rewiring during laboratory evolution of ethanol tolerance in E. coli. Mol Syst Biol (2010) 1.47

Coordinated concentration changes of transcripts and metabolites in Saccharomyces cerevisiae. PLoS Comput Biol (2009) 1.47

Selection of long oligonucleotides for gene expression microarrays using weighted rank-sum strategy. BMC Bioinformatics (2007) 1.45

Systems-level metabolic flux profiling elucidates a complete, bifurcated tricarboxylic acid cycle in Clostridium acetobutylicum. J Bacteriol (2010) 1.44

Riboneogenesis in yeast. Cell (2011) 1.43

α-Ketoglutarate coordinates carbon and nitrogen utilization via enzyme I inhibition. Nat Chem Biol (2011) 1.41

Metabolomics in systems microbiology. Curr Opin Biotechnol (2010) 1.40

Breaking the histone code with quantitative mass spectrometry. Expert Rev Proteomics (2011) 1.39

Heterochromatin protein 1 is extensively decorated with histone code-like post-translational modifications. Mol Cell Proteomics (2009) 1.39

Combinatorial profiling of chromatin binding modules reveals multisite discrimination. Nat Chem Biol (2010) 1.39

A member of a conserved Plasmodium protein family with membrane-attack complex/perforin (MACPF)-like domains localizes to the micronemes of sporozoites. Mol Biochem Parasitol (2004) 1.38

Reconstruction and flux-balance analysis of the Plasmodium falciparum metabolic network. Mol Syst Biol (2010) 1.37

Autophagy suppresses RIP kinase-dependent necrosis enabling survival to mTOR inhibition. PLoS One (2012) 1.37

Proteomic and genomic approaches reveal critical functions of H3K9 methylation and heterochromatin protein-1γ in reprogramming to pluripotency. Nat Cell Biol (2013) 1.33