Published in Proc Natl Acad Sci U S A on April 16, 2012
How cancer metabolism is tuned for proliferation and vulnerable to disruption. Nature (2012) 3.77
Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells. Nature (2012) 3.77
Serine, glycine and one-carbon units: cancer metabolism in full circle. Nat Rev Cancer (2013) 3.23
Serine is a natural ligand and allosteric activator of pyruvate kinase M2. Nature (2012) 3.01
Quantitative flux analysis reveals folate-dependent NADPH production. Nature (2014) 2.93
The Emerging Hallmarks of Cancer Metabolism. Cell Metab (2016) 2.32
Metabolic targets for cancer therapy. Nat Rev Drug Discov (2013) 2.32
Therapeutic targets in cancer cell metabolism and autophagy. Nat Biotechnol (2012) 2.27
TIGAR is required for efficient intestinal regeneration and tumorigenesis. Dev Cell (2013) 2.03
Emerging roles of PKM2 in cell metabolism and cancer progression. Trends Endocrinol Metab (2012) 1.87
Serine and glycine metabolism in cancer. Trends Biochem Sci (2014) 1.70
NRF2 regulates serine biosynthesis in non-small cell lung cancer. Nat Genet (2015) 1.60
Serine catabolism regulates mitochondrial redox control during hypoxia. Cancer Discov (2014) 1.53
PKM2, a Central Point of Regulation in Cancer Metabolism. Int J Cell Biol (2013) 1.41
Transfer RNA and human disease. Front Genet (2014) 1.35
Regulation of substrate utilization by the mitochondrial pyruvate carrier. Mol Cell (2014) 1.30
mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle. Science (2016) 1.24
Targeting cancer metabolism. Clin Cancer Res (2012) 1.21
Breast cancer stem cells rely on fermentative glycolysis and are sensitive to 2-deoxyglucose treatment. Cell Death Dis (2014) 1.20
The histone H3 methyltransferase G9A epigenetically activates the serine-glycine synthesis pathway to sustain cancer cell survival and proliferation. Cell Metab (2013) 1.09
cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions. Cell Res (2015) 1.06
Serine and one-carbon metabolism in cancer. Nat Rev Cancer (2016) 1.06
Pyruvate kinase: Function, regulation and role in cancer. Semin Cell Dev Biol (2015) 1.02
GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2. Genes Dev (2015) 1.00
Changing appetites: the adaptive advantages of fuel choice. Trends Cell Biol (2013) 1.00
Glycolysis, tumor metabolism, cancer growth and dissemination. A new pH-based etiopathogenic perspective and therapeutic approach to an old cancer question. Oncoscience (2014) 0.96
Pyruvate kinase and aspartate-glutamate carrier distributions reveal key metabolic links between neurons and glia in retina. Proc Natl Acad Sci U S A (2014) 0.95
Modeling cancer metabolism on a genome scale. Mol Syst Biol (2015) 0.92
GRP78 enhances the glutamine metabolism to support cell survival from glucose deficiency by modulating the β-catenin signaling. Oncotarget (2014) 0.92
Phosphorylation of the translation initiation factor eIF2α at serine 51 determines the cell fate decisions of Akt in response to oxidative stress. Cell Death Dis (2015) 0.91
Rapid analysis of glycolytic and oxidative substrate flux of cancer cells in a microplate. PLoS One (2014) 0.91
Extensive decoupling of metabolic genes in cancer. PLoS Comput Biol (2015) 0.91
Pyruvate kinase is a dosage-dependent regulator of cellular amino acid homeostasis. Oncotarget (2012) 0.90
Warburg effect and translocation-induced genomic instability: two yeast models for cancer cells. Front Oncol (2013) 0.90
The importance of serine metabolism in cancer. J Cell Biol (2016) 0.89
Mapping cancer cell metabolism with(13)C flux analysis: Recent progress and future challenges. J Carcinog (2013) 0.88
KDM4C and ATF4 Cooperate in Transcriptional Control of Amino Acid Metabolism. Cell Rep (2016) 0.87
Cancer metabolism meets systems biology: Pyruvate kinase isoform PKM2 is a metabolic master regulator. J Carcinog (2013) 0.86
Rapid uptake of glucose and lactate, and not hypoxia, induces apoptosis in three-dimensional tumor tissue culture. Integr Biol (Camb) (2014) 0.84
Rapamycin regulates biochemical metabolites. Cell Cycle (2013) 0.84
Mitochondrial dysfunction remodels one-carbon metabolism in human cells. Elife (2016) 0.84
Nutrient acquisition strategies of mammalian cells. Nature (2017) 0.84
In scarcity and abundance: metabolic signals regulating cell growth. Physiology (Bethesda) (2013) 0.83
Targeting Cancer Metabolism: Dietary and Pharmacologic Interventions. Cancer Discov (2016) 0.82
Stress eating and tuning out: cancer cells re-wire metabolism to counter stress. Crit Rev Biochem Mol Biol (2013) 0.82
Reducing the serine availability complements the inhibition of the glutamine metabolism to block leukemia cell growth. Oncotarget (2016) 0.81
Altered metabolite levels in cancer: implications for tumour biology and cancer therapy. Nat Rev Cancer (2016) 0.80
Regulation of Metabolic Activity by p53. Metabolites (2017) 0.79
Emerging metabolic targets in the therapy of hematological malignancies. Biomed Res Int (2013) 0.79
Metabolomic Analysis Reveals Increased Aerobic Glycolysis and Amino Acid Deficit in a Cellular Model of Amyotrophic Lateral Sclerosis. Mol Neurobiol (2015) 0.79
Amino acid management in cancer. Semin Cell Dev Biol (2015) 0.78
Metformin prevents DMH-induced colorectal cancer in diabetic rats by reversing the warburg effect. Cancer Med (2015) 0.78
Diabetes promotes DMH-induced colorectal cancer by increasing the activity of glycolytic enzymes in rats. PLoS One (2014) 0.78
Metabolic control of tumour progression and antitumour immunity. Curr Opin Oncol (2014) 0.77
Heterogeneity in Cancer Metabolism: New Concepts in an Old Field. Antioxid Redox Signal (2016) 0.77
De novo transcriptome sequencing and analysis of male, pseudo-male and female yellow perch, Perca flavescens. PLoS One (2017) 0.77
High serine:glyoxylate aminotransferase activity lowers leaf daytime serine levels, inducing the phosphoserine pathway in Arabidopsis. J Exp Bot (2016) 0.76
Metabolic rewiring in melanoma. Oncogene (2016) 0.76
Amino Acids Regulate mTORC1 by an Obligate Two-step Mechanism. J Biol Chem (2016) 0.76
One-carbon metabolism and nucleotide biosynthesis as attractive targets for anticancer therapy. Oncotarget (2017) 0.75
Undercover: gene control by metabolites and metabolic enzymes. Genes Dev (2016) 0.75
Nutrient stress revamps cancer cell metabolism. Cell Res (2015) 0.75
Regulation of SESAME-mediated H3T11 phosphorylation by glycolytic enzymes and metabolites. PLoS One (2017) 0.75
Transcriptional Profiling Reveals a Common Metabolic Program in High-Risk Human Neuroblastoma and Mouse Neuroblastoma Sphere-Forming Cells. Cell Rep (2016) 0.75
The Pasteur's Dictum: Nitrogen Promotes Growth and Oxygen Reduces the Need for Sugar. Front Oncol (2014) 0.75
Spheroid cancer stem cells display reprogrammed metabolism and obtain energy by actively running the tricarboxylic acid (TCA) cycle. Oncotarget (2016) 0.75
Adaptive response to l-serine deficiency is mediated by p38 MAPK activation via 1-deoxysphinganine in normal fibroblasts. FEBS Open Bio (2016) 0.75
Systems biology analysis of drivers underlying hallmarks of cancer cell metabolism. Sci Rep (2017) 0.75
Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) and serine biosynthetic pathway genes are co-ordinately increased during anabolic agent-induced skeletal muscle growth. Sci Rep (2016) 0.75
Combining structure-based pharmacophore modeling, virtual screening, and in silico ADMET analysis to discover novel tetrahydro-quinoline based pyruvate kinase isozyme M2 activators with antitumor activity. Drug Des Devel Ther (2014) 0.75
Synergistic Inhibitory Effects of Hypoxia and Iron Deficiency on Hepatic Glucose Response in Mouse Liver. Diabetes (2016) 0.75
Glucose catabolism in liver tumors induced by c-MYC can be sustained by various PKM1/PKM2 ratios and pyruvate kinase activities. Cancer Res (2017) 0.75
Exploiting tumour addiction with a serine and glycine-free diet. Cell Death Differ (2017) 0.75
Alteration of cellular metabolism in cancer cells and its therapeutic prospects. J Oral Maxillofac Pathol (2017) 0.75
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature (2008) 18.20
Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol Cell (2000) 17.44
An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Mol Cell (2003) 15.12
Pyruvate kinase M2 is a phosphotyrosine-binding protein. Nature (2008) 9.77
Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism. J Biol Chem (1998) 9.37
Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. Nature (2011) 8.03
Bidirectional transport of amino acids regulates mTOR and autophagy. Cell (2009) 7.88
Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1. Cell (2011) 7.33
Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. Nat Genet (2011) 6.89
Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapy. Nat Biotechnol (2008) 5.77
Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth. Sci Signal (2009) 5.57
HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer. Nature (2009) 5.48
Evidence for an alternative glycolytic pathway in rapidly proliferating cells. Science (2010) 5.44
The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation. EMBO J (2010) 3.76
Pyruvate kinase type M2: a key regulator of the metabolic budget system in tumor cells. Int J Biochem Cell Biol (2010) 3.72
The M1- and M2-type isozymes of rat pyruvate kinase are produced from the same gene by alternative RNA splicing. J Biol Chem (1986) 3.64
Metabolomic analysis via reversed-phase ion-pairing liquid chromatography coupled to a stand alone orbitrap mass spectrometer. Anal Chem (2010) 3.22
The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism. Proc Natl Acad Sci U S A (2010) 3.08
Quiescent fibroblasts exhibit high metabolic activity. PLoS Biol (2010) 2.94
Metabolomic analysis and visualization engine for LC-MS data. Anal Chem (2010) 2.77
Enhanced serine production by bone metastatic breast cancer cells stimulates osteoclastogenesis. Breast Cancer Res Treat (2010) 2.40
Double role for pyruvate kinase type M2 in the expansion of phosphometabolite pools found in tumor cells. Crit Rev Oncog (1992) 1.82
Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase. J Med Chem (2010) 1.61
Enzymic imbalance in serine metabolism in human colon carcinoma and rat sarcoma. Br J Cancer (1988) 1.52
Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase. Bioorg Med Chem Lett (2010) 1.37
Metabolic cooperation between different oncogenes during cell transformation: interaction between activated ras and HPV-16 E7. Oncogene (2001) 1.36
Role of the transcription factor ATF4 in the anabolic actions of insulin and the anti-anabolic actions of glucocorticoids. J Biol Chem (2007) 1.36
Atf4 regulates obesity, glucose homeostasis, and energy expenditure. Diabetes (2009) 1.34
Tumor M2-pyruvate kinase in lung cancer patients: immunohistochemical detection and disease monitoring. Anticancer Res (2002) 1.25
Quantification of tumor type M2 pyruvate kinase (Tu M2-PK) in human carcinomas. Anticancer Res (1997) 1.15
Pyruvate kinase. Classes of regulatory isoenzymes in mammalian tissues. Eur J Biochem (1973) 1.14
Immunohistological demonstration of the same type of pyruvate kinase isoenzyme (M2-Pk) in tumors of chicken and rat. Virchows Arch B Cell Pathol Incl Mol Pathol (1981) 1.06
Structural and kinetic differences between the M2 type pyruvate kinases from lung and various tumors. Biomed Biochim Acta (1983) 0.95
mRNA differential display of gene expression in colonic carcinoma. Electrophoresis (2002) 0.88
Human colon tumors: enzymic and histological characteristics. Cancer (1978) 0.87
Differentiation in vivo and in vitro of pyruvate kinase isozymes in rat muscle. Biochimie (1977) 0.84
Kinetic evidence for the presence of two forms of M2-type pyruvate kinase in rat small intestine. Biochem Biophys Res Commun (1974) 0.83
Genetic and epigenetic control of the pyruvate kinase isozymes in mammals. Isozymes Curr Top Biol Med Res (1983) 0.83
Pyruvate kinase isozymes in man. II. L type and erythrocyte-type isozymes. Electrofocusing and immunologic studies. Hum Genet (1976) 0.82
Modification of interconversion of pyruvate kinase type M2 from chicken liver by fructose 1,6-bisphosphate and l-alanine. Hoppe Seylers Z Physiol Chem (1977) 0.82
Pyruvate kinase isozymes in man. I. M type isozymes in adult and foetal tissues, electrofocusing and immunological studies. Hum Genet (1976) 0.81
Comparative kinetic behaviour and regulation by fructose-1,6-bisphosphate and ATP of pyruvate kinase from erythrocytes, reticulocytes and bone marrow cells. Comp Biochem Physiol B (1987) 0.81
Pyruvate kinase isozymes in various tissues of rat, and increase of spleen-type pyruvate kinase in liver by injecting chromatins from spleen and tumor. J Biochem (1976) 0.78
Pattern of pyruvate kinase isozymes in erythroleukemia cell lines and in normal human erythroblasts. Blood (1984) 0.78
Ontogenesis of pyruvate kinase in the brain and liver tissues of the rat. Biochimie (1978) 0.78
Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science (2009) 49.82
An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature (2005) 22.40
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature (2009) 19.65
The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab (2008) 18.87
Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell (2005) 17.81
Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc Natl Acad Sci U S A (2007) 15.88
Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell (2010) 15.20
The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate. Cancer Cell (2010) 13.13
Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction. Proc Natl Acad Sci U S A (2008) 11.71
AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. Mol Cell (2005) 11.19
Metabolic reprogramming: a cancer hallmark even warburg did not anticipate. Cancer Cell (2012) 9.88
Akt stimulates aerobic glycolysis in cancer cells. Cancer Res (2004) 9.35
Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase. Cancer Cell (2005) 9.33
Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma. J Clin Invest (2007) 9.33
Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes. Nat Cell Biol (2004) 8.85
ATP-citrate lyase links cellular metabolism to histone acetylation. Science (2009) 8.82
IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype. Nature (2012) 8.66
Absolute metabolite concentrations and implied enzyme active site occupancy in Escherichia coli. Nat Chem Biol (2009) 8.36
IDH mutation impairs histone demethylation and results in a block to cell differentiation. Nature (2012) 7.95
Brick by brick: metabolism and tumor cell growth. Curr Opin Genet Dev (2008) 7.87
ATP citrate lyase inhibition can suppress tumor cell growth. Cancer Cell (2005) 7.65
Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. Genes Dev (2011) 7.43
Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth. Cancer Res (2007) 7.42
Autophagy in metazoans: cell survival in the land of plenty. Nat Rev Mol Cell Biol (2005) 7.11
The CD28 signaling pathway regulates glucose metabolism. Immunity (2002) 6.65
Tumor suppressors and cell metabolism: a recipe for cancer growth. Genes Dev (2009) 6.46
Glutamine addiction: a new therapeutic target in cancer. Trends Biochem Sci (2010) 6.30
CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms. Mol Cell Biol (2005) 6.18
Alkylating DNA damage stimulates a regulated form of necrotic cell death. Genes Dev (2004) 6.08
Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapy. Nat Biotechnol (2008) 5.77
Evidence for an alternative glycolytic pathway in rapidly proliferating cells. Science (2010) 5.44
Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation. Blood (2008) 5.43
Death by design: apoptosis, necrosis and autophagy. Curr Opin Cell Biol (2004) 5.31
Fuel feeds function: energy metabolism and the T-cell response. Nat Rev Immunol (2005) 5.29
Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability. Proc Natl Acad Sci U S A (2011) 5.24
Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake. Mol Biol Cell (2002) 5.06
Necrotic death as a cell fate. Genes Dev (2006) 4.93
The proapoptotic factors Bax and Bak regulate T Cell proliferation through control of endoplasmic reticulum Ca(2+) homeostasis. Immunity (2007) 4.74
AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation. Science (2009) 4.72
Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells. Nature (2013) 4.71
Separation and quantitation of water soluble cellular metabolites by hydrophilic interaction chromatography-tandem mass spectrometry. J Chromatogr A (2006) 4.62
Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria. Cell (2010) 4.62
The glucose dependence of Akt-transformed cells can be reversed by pharmacologic activation of fatty acid beta-oxidation. Oncogene (2005) 4.28
Vegetarian dietary patterns and mortality in Adventist Health Study 2. JAMA Intern Med (2013) 4.27
Hypoxia-induced energy stress regulates mRNA translation and cell growth. Mol Cell (2006) 4.20
The transcription factor HIF-1alpha plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis. Genes Dev (2007) 4.13
HIF and c-Myc: sibling rivals for control of cancer cell metabolism and proliferation. Cancer Cell (2007) 4.10
Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis. N Engl J Med (2004) 4.06
Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation. Blood (2010) 3.98
Akt-dependent transformation: there is more to growth than just surviving. Oncogene (2005) 3.91
Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival. Mol Cell Biol (2003) 3.84
The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor. Genes Dev (2003) 3.79
p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase. Nat Cell Biol (2011) 3.70
PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis. Mol Cell (2006) 3.66
Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak. Mol Cell (2004) 3.62
Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis. Nat Immunol (2002) 3.58
Revving the engine: signal transduction fuels T cell activation. Immunity (2007) 3.57
Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis. J Cell Biol (2003) 3.52
Autophagy: basic principles and relevance to disease. Annu Rev Pathol (2008) 3.52
ATP citrate lyase is an important component of cell growth and transformation. Oncogene (2005) 3.48
Phosphatidylinositol 3-kinase-dependent modulation of carnitine palmitoyltransferase 1A expression regulates lipid metabolism during hematopoietic cell growth. J Biol Chem (2006) 3.45
The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism. Genes Dev (2010) 3.40
The roles of therapy-induced autophagy and necrosis in cancer treatment. Clin Cancer Res (2007) 3.35
Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1. Cancer Res (2010) 3.30
Absolute quantitation of intracellular metabolite concentrations by an isotope ratio-based approach. Nat Protoc (2008) 3.24
Metabolic enzymes as oncogenes or tumor suppressors. N Engl J Med (2009) 3.24
Metabolomic analysis via reversed-phase ion-pairing liquid chromatography coupled to a stand alone orbitrap mass spectrometer. Anal Chem (2010) 3.22
The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase. Mol Cell Biol (2002) 3.08
Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation. Science (2010) 3.05
Analytical strategies for LC-MS-based targeted metabolomics. J Chromatogr B Analyt Technol Biomed Life Sci (2008) 3.05
Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress. Genes Dev (2011) 2.97
The endoplasmic reticulum gateway to apoptosis by Bcl-X(L) modulation of the InsP3R. Nat Cell Biol (2005) 2.94
Quiescent fibroblasts exhibit high metabolic activity. PLoS Biol (2010) 2.94
Ammonia-induced autophagy is independent of ULK1/ULK2 kinases. Proc Natl Acad Sci U S A (2011) 2.91
Cellular metabolism and disease: what do metabolic outliers teach us? Cell (2012) 2.90
Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis. Genes Dev (2013) 2.90
Dynamics of the cellular metabolome during human cytomegalovirus infection. PLoS Pathog (2006) 2.88
Akt activation promotes degradation of tuberin and FOXO3a via the proteasome. J Biol Chem (2003) 2.80
Metabolomic analysis and visualization engine for LC-MS data. Anal Chem (2010) 2.77
Conservation of the metabolomic response to starvation across two divergent microbes. Proc Natl Acad Sci U S A (2006) 2.68
The survival kinases Akt and Pim as potential pharmacological targets. J Clin Invest (2005) 2.62
Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids. Proc Natl Acad Sci U S A (2013) 2.57
Regulation of T lymphocyte metabolism. J Immunol (2004) 2.55