Published in Development on December 01, 2010
Origins and functional evolution of Y chromosomes across mammals. Nature (2014) 1.89
The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength. Genes Dev (2014) 1.68
The R-spondin protein family. Genome Biol (2012) 1.62
The evolutionary causes and consequences of sex-biased gene expression. Nat Rev Genet (2013) 1.50
Do you know the sex of your cells? Am J Physiol Cell Physiol (2013) 1.49
The end of gonad-centric sex determination in mammals. Trends Genet (2011) 1.39
Six novel Y chromosome genes in Anopheles mosquitoes discovered by independently sequencing males and females. BMC Genomics (2013) 1.04
Global genome analysis of the downstream binding targets of testis determining factor SRY and SOX9. PLoS One (2012) 0.98
Steroid signaling within Drosophila ovarian epithelial cells sex-specifically modulates early germ cell development and meiotic entry. PLoS One (2012) 0.92
The molecular and cellular basis of gonadal sex reversal in mice and humans. Wiley Interdiscip Rev Dev Biol (2012) 0.91
Male sex determination: insights into molecular mechanisms. Asian J Androl (2011) 0.89
The influence of sex-linked genetic mechanisms on attention and impulsivity. Biol Psychol (2011) 0.88
SRY protein function in sex determination: thinking outside the box. Chromosome Res (2012) 0.88
SRY directly regulates the neurotrophin 3 promoter during male sex determination and testis development in rats. Biol Reprod (2011) 0.87
Plasticity of gene-regulatory networks controlling sex determination: of masters, slaves, usual suspects, newcomers, and usurpators. EMBO Rep (2015) 0.86
Hypospadias and genes related to genital tubercle and early urethral development. J Urol (2013) 0.85
Synergistic effect of SRY and its direct target, WDR5, on Sox9 expression. PLoS One (2012) 0.85
Role of the prion protein family in the gonads. Front Cell Dev Biol (2014) 0.84
Unveiling combinatorial regulation through the combination of ChIP information and in silico cis-regulatory module detection. Nucleic Acids Res (2012) 0.84
Characterization of sex determination and sex differentiation genes in Latimeria. PLoS One (2013) 0.83
SOX9 inhibits β-TrCP-mediated protein degradation to promote nuclear GLI1 expression and cancer stem cell properties. J Cell Sci (2015) 0.83
Selective accumulation of germ-line associated gene products in early development of the sea star and distinct differences from germ-line development in the sea urchin. Dev Dyn (2013) 0.82
Chromosome y regulates survival following murine coxsackievirus b3 infection. G3 (Bethesda) (2012) 0.82
Mammalian testis-determining factor SRY and the enigma of inherited human sex reversal: frustrated induced fit in a bent protein-DNA complex. J Biol Chem (2011) 0.82
Sox9 duplications are a relevant cause of Sry-negative XX sex reversal dogs. PLoS One (2014) 0.82
Structure-function analysis of mouse Sry reveals dual essential roles of the C-terminal polyglutamine tract in sex determination. Proc Natl Acad Sci U S A (2014) 0.82
Long non-coding RNA regulation of reproduction and development. Mol Reprod Dev (2015) 0.82
Genomic analysis of the Pacific oyster (Crassostrea gigas) reveals possible conservation of vertebrate sex determination in a mollusc. G3 (Bethesda) (2014) 0.80
Complex mechanisms regulate developmental expression of the matA (HMG) mating type gene in homothallic Aspergillus nidulans. Genetics (2011) 0.80
Evidence for avian cell autonomous sex identity (CASI) and implications for the sex-determination process? Chromosome Res (2012) 0.80
Genomic imprinting, action, and interaction of maternal and fetal genomes. Proc Natl Acad Sci U S A (2014) 0.79
Gonad differentiation in the rabbit: evidence of species-specific features. PLoS One (2013) 0.79
Cellular and molecular mechanisms of sexual differentiation in the mammalian nervous system. Front Neuroendocrinol (2016) 0.79
Transcriptome Sequencing and Comparative Analysis of Ovary and Testis Identifies Potential Key Sex-Related Genes and Pathways in Scallop Patinopecten yessoensis. Mar Biotechnol (NY) (2016) 0.78
Comparative Transcriptome Analysis Reveals Sex-Biased Gene Expression in Juvenile Chinese Mitten Crab Eriocheir sinensis. PLoS One (2015) 0.78
Gadd45g is essential for primary sex determination, male fertility and testis development. PLoS One (2013) 0.78
Mammalian viviparity: a complex niche in the evolution of genomic imprinting. Heredity (Edinb) (2014) 0.78
UPF2, a nonsense-mediated mRNA decay factor, is required for prepubertal Sertoli cell development and male fertility by ensuring fidelity of the transcriptome. Development (2014) 0.78
Transgenic expression of Map3k4 rescues T-associated sex reversal (Tas) in mice. Hum Mol Genet (2014) 0.78
Environmentally Induced Epigenetic Transgenerational Inheritance of Altered SRY Genomic Binding During Gonadal Sex Determination. Environ Epigenet (2015) 0.77
Sexual differences in cell proliferation in the ventricular zone, cell migration and differentiation in the HVC of juvenile Bengalese finch. PLoS One (2014) 0.77
SGF29 and Sry pathway in hepatocarcinogenesis. World J Biol Chem (2015) 0.77
Long exposure to mature ooplasm can alter DNA methylation at imprinted loci in non-growing oocytes but not in prospermatogonia. Reproduction (2013) 0.77
Computational biophysical, biochemical, and evolutionary signature of human R-spondin family proteins, the member of canonical Wnt/β-catenin signaling pathway. Biomed Res Int (2014) 0.76
A Boolean network model of human gonadal sex determination. Theor Biol Med Model (2015) 0.76
RevSex duplication-induced and sex-related differences in the SOX9 regulatory region chromatin landscape in human fibroblasts. Epigenetics (2013) 0.76
Regulation of sex determination in mice by a non-coding genomic region. Genetics (2014) 0.76
Stochastic anomaly of methylome but persistent SRY hypermethylation in disorder of sex development in canine somatic cell nuclear transfer. Sci Rep (2016) 0.75
Genome-Wide Identification and Transcriptome-Based Expression Profiling of the Sox Gene Family in the Nile Tilapia (Oreochromis niloticus). Int J Mol Sci (2016) 0.75
Hepatocyte-ductal transdifferentiation is mediated by reciprocal repression of SOX9 and C/EBPα. Cell Reprogram (2014) 0.75
Identification of the key stages for sex determination in the silkworm, Bombyx mori. Dev Genes Evol (2013) 0.75
Transgenic Expression of the piRNA-Resistant Masculinizer Gene Induces Female-Specific Lethality and Partial Female-to-Male Sex Reversal in the Silkworm, Bombyx mori. PLoS Genet (2016) 0.75
Insights into female germ cell biology: from in vivo development to in vitro derivations. Asian J Androl (2015) 0.75
The role of sex chromosomes in mammalian germ cell differentiation: can the germ cells carrying X and Y chromosomes differentiate into fertile oocytes? Asian J Androl (2015) 0.75
Primary sex determination of placental mammals: a modelling study uncovers dynamical developmental constraints in the formation of Sertoli and granulosa cells. BMC Syst Biol (2016) 0.75
A site-specific, single-copy transgenesis strategy to identify 5' regulatory sequences of the mouse testis-determining gene Sry. PLoS One (2014) 0.75
Differential lactate and cholesterol synthetic activities in XY and XX Sertoli cells. Sci Rep (2017) 0.75
Zebrafish: A Versatile Animal Model for Fertility Research. Biomed Res Int (2016) 0.75
Painful ovulation in a 46,XX SRY -ve adult male with SOX9 duplication. Endocrinol Diabetes Metab Case Rep (2017) 0.75
Retinoid signaling determines germ cell fate in mice. Science (2006) 4.17
Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families. Dev Cell (2002) 3.39
Sox18 induces development of the lymphatic vasculature in mice. Nature (2008) 2.91
Sex determination and gonadal development in mammals. Physiol Rev (2007) 2.60
Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators. Curr Opin Genet Dev (2002) 2.24
Expression of distinct RNAs from 3' untranslated regions. Nucleic Acids Res (2010) 2.08
Redundant roles of Sox17 and Sox18 in postnatal angiogenesis in mice. J Cell Sci (2006) 2.05
Genesis and expansion of metazoan transcription factor gene classes. Mol Biol Evol (2008) 2.01
Retinoic acid, meiosis and germ cell fate in mammals. Development (2007) 1.91
Hypoxia induces chondrocyte-specific gene expression in mesenchymal cells in association with transcriptional activation of Sox9. Bone (2005) 1.68
Redundant roles of Sox17 and Sox18 in early cardiovascular development of mouse embryos. Biochem Biophys Res Commun (2007) 1.68
FGF9 suppresses meiosis and promotes male germ cell fate in mice. Dev Cell (2010) 1.64
Sox18 and Sox7 play redundant roles in vascular development. Blood (2007) 1.60
Seeds of concern. Nature (2004) 1.57
Sertoli cell differentiation is induced both cell-autonomously and through prostaglandin signaling during mammalian sex determination. Dev Biol (2005) 1.55
SOX9 regulates prostaglandin D synthase gene transcription in vivo to ensure testis development. J Biol Chem (2007) 1.42
SoxF genes: Key players in the development of the cardio-vascular system. Int J Biochem Cell Biol (2009) 1.41
Germ cells enter meiosis in a rostro-caudal wave during development of the mouse ovary. Mol Reprod Dev (2004) 1.38
Endothelial cell migration directs testis cord formation. Dev Biol (2008) 1.35
The makings of maleness: towards an integrated view of male sexual development. Nat Rev Genet (2006) 1.35
Expression profiling of purified mouse gonadal somatic cells during the critical time window of sex determination reveals novel candidate genes for human sexual dysgenesis syndromes. Hum Mol Genet (2006) 1.33
Copy number variation in patients with disorders of sex development due to 46,XY gonadal dysgenesis. PLoS One (2011) 1.32
Etiology of ovarian failure in blepharophimosis ptosis epicanthus inversus syndrome: FOXL2 is a conserved, early-acting gene in vertebrate ovarian development. Endocrinology (2003) 1.28
SOX8 is expressed during testis differentiation in mice and synergizes with SF1 to activate the Amh promoter in vitro. J Biol Chem (2003) 1.28
Mouse germ cell development: from specification to sex determination. Mol Cell Endocrinol (2009) 1.24
Delayed Sry and Sox9 expression in developing mouse gonads underlies B6-Y(DOM) sex reversal. Dev Biol (2005) 1.24
Sry and the hesitant beginnings of male development. Dev Biol (2006) 1.22
Initiating meiosis: the case for retinoic acid. Biol Reprod (2012) 1.17
A critical time window of Sry action in gonadal sex determination in mice. Development (2008) 1.14
Sox8 is a critical regulator of adult Sertoli cell function and male fertility. Dev Biol (2008) 1.13
In situ hybridization of whole-mount embryos. Methods Mol Biol (2006) 1.13
Building the mammalian testis: origins, differentiation, and assembly of the component cell populations. Genes Dev (2013) 1.13
Sox7 and Sox17 are strain-specific modifiers of the lymphangiogenic defects caused by Sox18 dysfunction in mice. Development (2009) 1.13
Sox18 mutations in the ragged mouse alleles ragged-like and opossum. Genesis (2003) 1.11
Epigenetic regulation of mouse sex determination by the histone demethylase Jmjd1a. Science (2013) 1.11
Sox10 gain-of-function causes XX sex reversal in mice: implications for human 22q-linked disorders of sex development. Hum Mol Genet (2009) 1.11
Loss of mitogen-activated protein kinase kinase kinase 4 (MAP3K4) reveals a requirement for MAPK signalling in mouse sex determination. PLoS Biol (2009) 1.10
Sex determination in mammalian germ cells: extrinsic versus intrinsic factors. Reproduction (2010) 1.10
Coordinated expression of scleraxis and Sox9 genes during embryonic development of tendons and cartilage. J Orthop Res (2002) 1.09
Segmental territories along the cardinal veins generate lymph sacs via a ballooning mechanism during embryonic lymphangiogenesis in mice. Dev Biol (2011) 1.08
Antagonism of the testis- and ovary-determining pathways during ovotestis development in mice. Mech Dev (2009) 1.05
Identification of novel markers of mouse fetal ovary development. PLoS One (2012) 1.03
The transcription factors steroidogenic factor-1 and SOX9 regulate expression of Vanin-1 during mouse testis development. J Biol Chem (2004) 1.02
SOX9 regulates microRNA miR-202-5p/3p expression during mouse testis differentiation. Biol Reprod (2013) 1.02
Onset of meiosis in the chicken embryo; evidence of a role for retinoic acid. BMC Dev Biol (2008) 1.02
Control of mammalian germ cell entry into meiosis. Mol Cell Endocrinol (2013) 1.01
Three-dimensional visualization of testis cord morphogenesis, a novel tubulogenic mechanism in development. Dev Dyn (2009) 1.01
Effect of disrupted SOX18 transcription factor function on tumor growth, vascularization, and endothelial development. J Natl Cancer Inst (2006) 1.00
Conserved regulatory modules in the Sox9 testis-specific enhancer predict roles for SOX, TCF/LEF, Forkhead, DMRT, and GATA proteins in vertebrate sex determination. Int J Biochem Cell Biol (2009) 0.98
Genomic screen for genes involved in mammalian craniofacial development. Genesis (2003) 0.97
Tumor lymphangiogenesis as a potential therapeutic target. J Oncol (2012) 0.97
A multi-exon deletion within WWOX is associated with a 46,XY disorder of sex development. Eur J Hum Genet (2011) 0.97
Retinoblastoma 1 protein modulates XY germ cell entry into G1/G0 arrest during fetal development in mice. Biol Reprod (2009) 0.95
Expression of the tudor-related gene Tdrd5 during development of the male germline in mice. Gene Expr Patterns (2004) 0.95
FOXL2 and BMP2 act cooperatively to regulate follistatin gene expression during ovarian development. Endocrinology (2010) 0.95
Loss of Wnt5a disrupts primordial germ cell migration and male sexual development in mice. Biol Reprod (2012) 0.94
Endogenous Nodal signaling regulates germ cell potency during mammalian testis development. Development (2012) 0.94
The rhox homeobox gene family shows sexually dimorphic and dynamic expression during mouse embryonic gonad development. Biol Reprod (2008) 0.93
Evaluation of candidate markers for the peritubular myoid cell lineage in the developing mouse testis. Reproduction (2005) 0.93
Defective survival of proliferating Sertoli cells and androgen receptor function in a mouse model of the ATR-X syndrome. Hum Mol Genet (2011) 0.92
CXCR4/SDF1 interaction inhibits the primordial to primary follicle transition in the neonatal mouse ovary. Dev Biol (2006) 0.92
The VCAM-1 gene that encodes the vascular cell adhesion molecule is a target of the Sry-related high mobility group box gene, Sox18. J Biol Chem (2003) 0.92
Up-regulation of SOX9 in human sex-determining region on the Y chromosome (SRY)-negative XX males. Clin Endocrinol (Oxf) (2007) 0.91
The cerebellin 4 precursor gene is a direct target of SRY and SOX9 in mice. Biol Reprod (2009) 0.90
Genetic ablation of SOX18 function suppresses tumor lymphangiogenesis and metastasis of melanoma in mice. Cancer Res (2012) 0.90
Male sex determination: insights into molecular mechanisms. Asian J Androl (2011) 0.89
Antagonistic regulation of Cyp26b1 by transcription factors SOX9/SF1 and FOXL2 during gonadal development in mice. FASEB J (2011) 0.89
SRY protein function in sex determination: thinking outside the box. Chromosome Res (2012) 0.88
Cbx2, a polycomb group gene, is required for Sry gene expression in mice. Endocrinology (2011) 0.87
Male-specific expression of Aldh1a1 in mouse and chicken fetal testes: implications for retinoid balance in gonad development. Dev Dyn (2009) 0.87
HMG box transcription factor gene Hbp1 is expressed in germ cells of the developing mouse testis. Dev Dyn (2004) 0.87
The molecular genetics of sex determination and sex reversal in mammals. Semin Reprod Med (2012) 0.87
Uncovering gene regulatory networks during mouse fetal germ cell development. Biol Reprod (2010) 0.86
Wnt signaling in ovarian development inhibits Sf1 activation of Sox9 via the Tesco enhancer. Endocrinology (2011) 0.86
VEGFD regulates blood vascular development by modulating SOX18 activity. Blood (2013) 0.86
Regulation of germ cell meiosis in the fetal ovary. Int J Dev Biol (2012) 0.86
A cell-autonomous role for WT1 in regulating Sry in vivo. Hum Mol Genet (2009) 0.85
Sex-specific expression of a novel gene Tmem184a during mouse testis differentiation. Reproduction (2007) 0.85
Three-dimensional imaging of Prox1-EGFP transgenic mouse gonads reveals divergent modes of lymphangiogenesis in the testis and ovary. PLoS One (2012) 0.84
Charting the course of ovarian development in vertebrates. Int J Dev Biol (2002) 0.84
Extensive vascularization of developing mouse ovaries revealed by caveolin-1 expression. Dev Dyn (2002) 0.84
Sox factors transcriptionally regulate ROBO4 gene expression in developing vasculature in zebrafish. J Biol Chem (2011) 0.84
Osteopontin and related SIBLING glycoprotein genes are expressed by Sertoli cells during mouse testis development. Dev Dyn (2005) 0.84
Functional analysis of the SRY-KRAB interaction in mouse sex determination. Biol Cell (2009) 0.83
Sox8 is expressed at similar levels in gonads of both sexes during the sex determining period in turtles. Dev Dyn (2004) 0.83
Global survey of protein expression during gonadal sex determination in mice. Mol Cell Proteomics (2009) 0.83
Transcription factors ER71/ETV2 and SOX9 participate in a positive feedback loop in fetal and adult mouse testis. J Biol Chem (2012) 0.83
Gonadal defects in Cited2-mutant mice indicate a role for SF1 in both testis and ovary differentiation. Int J Dev Biol (2010) 0.83
FOXL2 transcriptionally represses Sf1 expression by antagonizing WT1 during ovarian development in mice. FASEB J (2014) 0.82
A male-specific role for p38 mitogen-activated protein kinase in germ cell sex differentiation in mice. Biol Reprod (2010) 0.81
Nodal/Cripto signaling in fetal male germ cell development: implications for testicular germ cell tumors. Int J Dev Biol (2013) 0.81
Sox8 and Sertoli-cell function. Ann N Y Acad Sci (2007) 0.80
Cell cycle analysis of fetal germ cells during sex differentiation in mice. Biol Cell (2009) 0.80
Vascular defects in a mouse model of hypotrichosis-lymphedema-telangiectasia syndrome indicate a role for SOX18 in blood vessel maturation. Hum Mol Genet (2009) 0.80
Tmem26 is dynamically expressed during palate and limb development but is not required for embryonic survival. PLoS One (2011) 0.80
Ex vivo magnetofection: a novel strategy for the study of gene function in mouse organogenesis. Dev Dyn (2009) 0.80
Cytoplasmic plaque formation in hemidesmosome development is dependent on SoxF transcription factor function. PLoS One (2012) 0.79
Comparative proteomic analysis to study molecular events during gonad development in mice. Genesis (2006) 0.79
New insights into SRY regulation through identification of 5' conserved sequences. BMC Mol Biol (2008) 0.79
Developmental expression of Musashi-1 and Musashi-2 RNA-binding proteins during spermatogenesis: analysis of the deleterious effects of dysregulated expression. Biol Reprod (2014) 0.79