Published in Biochim Biophys Acta on November 11, 2010
NADPH oxidase 4 limits bone mass by promoting osteoclastogenesis. J Clin Invest (2013) 2.48
Orai1-mediated calcium entry plays a critical role in osteoclast differentiation and function by regulating activation of the transcription factor NFATc1. FASEB J (2011) 0.96
Autocrine signaling is a key regulatory element during osteoclastogenesis. Biol Open (2014) 0.86
Deletion of Orai1 alters expression of multiple genes during osteoclast and osteoblast maturation. Cell Calcium (2012) 0.85
Resolvin E1 regulates osteoclast fusion via DC-STAMP and NFATc1. FASEB J (2013) 0.83
Involvement of the Ca²⁺ signaling pathway in osteoprotegerin inhibition of osteoclast differentiation and maturation. J Vet Sci (2014) 0.78
Xanthotoxin prevents bone loss in ovariectomized mice through the inhibition of RANKL-induced osteoclastogenesis. Osteoporos Int (2016) 0.77
Selective induction of P2Y14 receptor by RANKL promotes osteoclast formation. Mol Cells (2013) 0.76
NADPH oxidase 4 represents a potential target for the treatment of osteoporosis. Cell Mol Immunol (2014) 0.75
Cordycepin Prevents Bone Loss through Inhibiting Osteoclastogenesis by Scavenging ROS Generation. Nutrients (2016) 0.75
TRPV1 deletion impaired fracture healing and inhibited osteoclast and osteoblast differentiation. Sci Rep (2017) 0.75
Dendritic Cell-Specific Transmembrane Protein (DC-STAMP) Regulates Osteoclast Differentiation via the Ca2+ /NFATc1 Axis. J Cell Physiol (2016) 0.75
Methyl Gallate Inhibits Osteoclast Formation and Function by Suppressing Akt and Btk-PLCγ2-Ca(2+) Signaling and Prevents Lipopolysaccharide-Induced Bone Loss. Int J Mol Sci (2017) 0.75
Sitagliptin, An Anti-diabetic Drug, Suppresses Estrogen Deficiency-Induced OsteoporosisIn Vivo and Inhibits RANKL-Induced Osteoclast Formation and Bone Resorption In Vitro. Front Pharmacol (2017) 0.75
Tusc2/Fus1 regulates osteoclast differentiation through NF-κB and NFATc1. BMB Rep (2017) 0.75
Nardosinone Suppresses RANKL-Induced Osteoclastogenesis and Attenuates Lipopolysaccharide-Induced Alveolar Bone Resorption. Front Pharmacol (2017) 0.75
Calcium signalling: dynamics, homeostasis and remodelling. Nat Rev Mol Cell Biol (2003) 18.97
Osteoclast differentiation and activation. Nature (2003) 18.59
Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell (1998) 17.76
A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Nature (2006) 14.78
Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proc Natl Acad Sci U S A (1998) 12.61
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature (1999) 12.32
Store-operated calcium channels. Physiol Rev (2005) 11.95
CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry. Science (2006) 9.61
Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts. Dev Cell (2002) 9.10
The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene. Nature (1990) 8.94
Genome-wide RNAi screen of Ca(2+) influx identifies genes that regulate Ca(2+) release-activated Ca(2+) channel activity. Proc Natl Acad Sci U S A (2006) 7.26
Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems. Nat Rev Immunol (2007) 5.86
Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand. Proc Natl Acad Sci U S A (1999) 5.78
Therapeutic approaches to bone diseases. Science (2000) 5.60
Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis. Nature (2004) 4.92
Skeletal remodeling in health and disease. Nat Med (2007) 4.31
Defective mast cell effector functions in mice lacking the CRACM1 pore subunit of store-operated calcium release-activated calcium channels. Nat Immunol (2007) 3.57
Cytosolic calcium oscillators. FASEB J (1988) 3.37
Spatial and temporal aspects of cellular calcium signaling. FASEB J (1996) 2.87
A peptidomimetic antagonist of the alpha(v)beta3 integrin inhibits bone resorption in vitro and prevents osteoporosis in vivo. J Clin Invest (1997) 2.37
The osteoclast functional antigen, implicated in the regulation of bone resorption, is biochemically related to the vitronectin receptor. J Cell Biol (1989) 2.27
Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals. Cell (2008) 2.13
Renal Ca2+ wasting, hyperabsorption, and reduced bone thickness in mice lacking TRPV5. J Clin Invest (2003) 2.09
Osteoimmunology and the effects of the immune system on bone. Nat Rev Rheumatol (2009) 2.01
Capacitative calcium entry supports calcium oscillations in human embryonic kidney cells. J Physiol (2004) 1.92
TRPV4-mediated calcium influx regulates terminal differentiation of osteoclasts. Cell Metab (2008) 1.79
Decoding of cytoplasmic Ca(2+) oscillations through the spatial signature drives gene expression. Curr Biol (2009) 1.66
RANKL-mediated reactive oxygen species pathway that induces long lasting Ca2+ oscillations essential for osteoclastogenesis. J Biol Chem (2010) 1.58
Arg-Gly-Asp (RGD) peptides and the anti-vitronectin receptor antibody 23C6 inhibit dentine resorption and cell spreading by osteoclasts. Exp Cell Res (1991) 1.57
Methods for studying store-operated calcium entry. Methods (2008) 1.57
Calcium signaling in the development and function of T-lineage cells. Immunol Rev (2009) 1.45
Ca2+/calcineurin signalling in cells of the immune system. Biochem Biophys Res Commun (2003) 1.44
RGS10-null mutation impairs osteoclast differentiation resulting from the loss of [Ca2+]i oscillation regulation. Genes Dev (2007) 1.42
Osteoblasts induce Ca2+ oscillation-independent NFATc1 activation during osteoclastogenesis. Proc Natl Acad Sci U S A (2008) 1.35
The epithelial Ca2+ channel TRPV5 is essential for proper osteoclastic bone resorption. Proc Natl Acad Sci U S A (2005) 1.23
Control of cytosolic free calcium in rat and chicken osteoclasts. The role of extracellular calcium and calcitonin. J Biol Chem (1989) 1.19
The calcium sensing receptor is directly involved in both osteoclast differentiation and apoptosis. FASEB J (2006) 1.17
Perspectives: adhesion receptors in bone. J Bone Miner Res (1989) 1.14
'Calcium-activated' intracellular calcium elevation: a novel mechanism of osteoclast regulation. Biochem Biophys Res Commun (1989) 1.10
Anti-resorptive therapies for osteoporosis. Semin Cell Dev Biol (2008) 1.01
Integrin receptor-mediated mobilisation of intranuclear calcium in rat osteoclasts. J Cell Sci (1993) 0.99
The role of calcium release activated calcium channels in osteoclast differentiation. J Cell Physiol (2011) 0.98
RANK ligand-induced elevation of cytosolic Ca2+ accelerates nuclear translocation of nuclear factor kappa B in osteoclasts. J Biol Chem (2002) 0.97
TRPV-5 mediates a receptor activator of NF-kappaB (RANK) ligand-induced increase in cytosolic Ca2+ in human osteoclasts and down-regulates bone resorption. J Biol Chem (2010) 0.96
A ryanodine receptor-like molecule expressed in the osteoclast plasma membrane functions in extracellular Ca2+ sensing. J Clin Invest (1995) 0.95
Involvement of capacitive calcium entry and calcium store refilling in osteoclastic survival and bone resorption process. Cell Calcium (2003) 0.94
Linkage of extracellular and intracellular control of cytosolic Ca2+ in rat osteoclasts in the presence of thapsigargin. J Bone Miner Res (1993) 0.92
Necessity of inositol (1,4,5)-trisphosphate receptor 1 and mu-calpain in NO-induced osteoclast motility. J Cell Sci (2007) 0.91
Ca(2+) influx through the osteoclastic plasma membrane ryanodine receptor. Am J Physiol Renal Physiol (2002) 0.88
Extracellular protons acidify osteoclasts, reduce cytosolic calcium, and promote expression of cell-matrix attachment structures. J Clin Invest (1989) 0.88
ATP induces an intracellular calcium pulse in osteoclasts. Biochem Biophys Res Commun (1993) 0.86
Anti-resorptives in the management of osteoporosis. Best Pract Res Clin Endocrinol Metab (2008) 0.85
Lyn inhibits osteoclast differentiation by interfering with PLCgamma1-mediated Ca2+ signaling. FEBS Lett (2009) 0.83
Calcium-sensing receptors in bone cells. J Musculoskelet Neuronal Interact (2004) 0.83
Identification and characterization of a sodium/calcium exchanger, NCX-1, in osteoclasts and its role in bone resorption. Biochem Biophys Res Commun (2001) 0.83
Intracellular calcium puffs in osteoclasts. Exp Cell Res (1999) 0.82
Caffeine modulates Ca2+ receptor activation in isolated rat osteoclasts and induces intracellular Ca2+ release. Am J Physiol (1995) 0.82
Evidence that a ryanodine receptor triggers signal transduction in the osteoclast. Biochem Biophys Res Commun (1992) 0.80
Effects of inositol trisphosphate on calcium mobilization in bone cells. Calcif Tissue Int (1991) 0.80
Distribution of inositol 1,4,5-trisphosphate receptors in rat osteoclasts. Acta Histochem Cytochem (2008) 0.79
Calcium influx and release in isolated rat osteoclasts. Exp Physiol (1994) 0.79
Calcium signal induced by mechanical perturbation of osteoclasts. J Cell Physiol (1995) 0.77
A novel calcium sensor stimulating inositol phosphate formation and [Ca2+]i signaling expressed by GCT23 osteoclast-like cells. Proc Assoc Am Physicians (1999) 0.77
Store-operated calcium channels. Physiol Rev (2005) 11.95
Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor, Stim1. J Biol Chem (2006) 5.32
Defective mast cell effector functions in mice lacking the CRACM1 pore subunit of store-operated calcium release-activated calcium channels. Nat Immunol (2007) 3.57
STIM1 is a MT-plus-end-tracking protein involved in remodeling of the ER. Curr Biol (2008) 2.79
Calcium inhibition and calcium potentiation of Orai1, Orai2, and Orai3 calcium release-activated calcium channels. J Biol Chem (2007) 2.58
Complex actions of 2-aminoethyldiphenyl borate on store-operated calcium entry. J Biol Chem (2008) 2.32
Comparison of human TRPC3 channels in receptor-activated and store-operated modes. Differential sensitivity to channel blockers suggests fundamental differences in channel composition. J Biol Chem (2002) 2.18
Emerging perspectives in store-operated Ca2+ entry: roles of Orai, Stim and TRP. Biochim Biophys Acta (2006) 2.00
Capacitative calcium entry supports calcium oscillations in human embryonic kidney cells. J Physiol (2004) 1.92
TRPC channels function independently of STIM1 and Orai1. J Physiol (2009) 1.83
Ca2+-store-dependent and -independent reversal of Stim1 localization and function. J Cell Sci (2008) 1.80
Signaling mechanism for receptor-activated canonical transient receptor potential 3 (TRPC3) channels. J Biol Chem (2003) 1.70
Activation and regulation of store-operated calcium entry. J Cell Mol Med (2010) 1.70
The mammalian TRPC cation channels. Biochim Biophys Acta (2004) 1.62
Methods for studying store-operated calcium entry. Methods (2008) 1.57
Calcium oscillations. Cold Spring Harb Perspect Biol (2011) 1.56
Role of the microtubule cytoskeleton in the function of the store-operated Ca2+ channel activator STIM1. J Cell Sci (2007) 1.55
Role of the store-operated calcium entry proteins Stim1 and Orai1 in muscarinic cholinergic receptor-stimulated calcium oscillations in human embryonic kidney cells. J Physiol (2007) 1.53
The TRPC3/6/7 subfamily of cation channels. Cell Calcium (2003) 1.52
Phosphorylation of STIM1 underlies suppression of store-operated calcium entry during mitosis. Nat Cell Biol (2009) 1.51
Expression level of the canonical transient receptor potential 3 (TRPC3) channel determines its mechanism of activation. J Biol Chem (2003) 1.46
Negative regulation of TRPC3 channels by protein kinase C-mediated phosphorylation of serine 712. Mol Pharmacol (2004) 1.42
Dissociation of regulated trafficking of TRPC3 channels to the plasma membrane from their activation by phospholipase C. J Biol Chem (2006) 1.39
STIM1 is a calcium sensor specialized for digital signaling. Curr Biol (2009) 1.31
Mechanisms of phospholipase C-regulated calcium entry. Curr Mol Med (2004) 1.31
Complex functions of phosphatidylinositol 4,5-bisphosphate in regulation of TRPC5 cation channels. Pflugers Arch (2008) 1.26
Complex regulation of the TRPC3, 6 and 7 channel subfamily by diacylglycerol and phosphatidylinositol-4,5-bisphosphate. Cell Calcium (2007) 1.25
Obligatory role of Src kinase in the signaling mechanism for TRPC3 cation channels. J Biol Chem (2004) 1.22
Canonical transient receptor potential TRPC7 can function as both a receptor- and store-operated channel in HEK-293 cells. Am J Physiol Cell Physiol (2004) 1.19
Mechanism of inhibition of TRPC cation channels by 2-aminoethoxydiphenylborane. Mol Pharmacol (2005) 1.19
Phosphoregulation of STIM1 leads to exclusion of the endoplasmic reticulum from the mitotic spindle. Curr Biol (2012) 1.16
An inositol 1,4,5-trisphosphate receptor-dependent cation entry pathway in DT40 B lymphocytes. EMBO J (2002) 1.03
The role of canonical transient receptor potential 7 in B-cell receptor-activated channels. J Biol Chem (2005) 1.02
Calcium influx mechanisms underlying calcium oscillations in rat hepatocytes. Hepatology (2008) 1.00
Ca2+-calmodulin-dependent facilitation and Ca2+ inactivation of Ca2+ release-activated Ca2+ channels. J Biol Chem (2004) 1.00
Native TRPC7 channel activation by an inositol trisphosphate receptor-dependent mechanism. J Biol Chem (2006) 0.99
A calmodulin/inositol 1,4,5-trisphosphate (IP3) receptor-binding region targets TRPC3 to the plasma membrane in a calmodulin/IP3 receptor-independent process. J Biol Chem (2003) 0.98
Ca2+ influx and protein scaffolding via TRPC3 sustain PKCbeta and ERK activation in B cells. J Cell Sci (2010) 0.98
Orai1-mediated calcium entry plays a critical role in osteoclast differentiation and function by regulating activation of the transcription factor NFATc1. FASEB J (2011) 0.96
Alternative translation initiation gives rise to two isoforms of Orai1 with distinct plasma membrane mobilities. J Cell Sci (2012) 0.93
2-aminoethoxydiphenyl borane activates a novel calcium-permeable cation channel. Mol Pharmacol (2003) 0.91
Role of STIM1- and Orai1-mediated Ca2+ entry in Ca2+-induced epidermal keratinocyte differentiation. J Cell Sci (2012) 0.89
Protection of TRPC7 cation channels from calcium inhibition by closely associated SERCA pumps. FASEB J (2006) 0.88
Ca(2+) mobilization through dorsal root ganglion Ca(2+)-sensing receptor stably expressed in HEK293 cells. Am J Physiol Cell Physiol (2007) 0.85
Deletion of Orai1 alters expression of multiple genes during osteoclast and osteoblast maturation. Cell Calcium (2012) 0.85
Role of Orai1 and store-operated calcium entry in mouse lacrimal gland signalling and function. J Physiol (2013) 0.84
PLC-gamma: an old player has a new role. Nat Cell Biol (2002) 0.83
Regulation of store-operated calcium entry during cell division. Biochem Soc Trans (2012) 0.83
SOC: now also store-operated cyclase. Nat Cell Biol (2009) 0.82
Store operated calcium entry in NIH-3T3 cells. J Med Invest (2009) 0.75