Published in J Ocul Pharmacol Ther on November 20, 2010
Retinal endothelial cell apoptosis. Apoptosis (2012) 0.88
Polyol effects on growth factors and MAPK signaling in rat retinal capillary cells. J Ocul Pharmacol Ther (2013) 0.81
Protective Effects of Panax notoginseng Saponins against High Glucose-Induced Oxidative Injury in Rat Retinal Capillary Endothelial Cells. Evid Based Complement Alternat Med (2016) 0.79
Novel transgenic mouse models develop retinal changes associated with early diabetic retinopathy similar to those observed in rats with diabetes mellitus. Exp Eye Res (2013) 0.78
The unfolded protein response to endoplasmic reticulum stress in cultured astrocytes and rat brain during experimental diabetes. Neurochem Int (2013) 0.78
Hydrogen-rich saline reduces cell death through inhibition of DNA oxidative stress and overactivation of poly (ADP-ribose) polymerase-1 in retinal ischemia-reperfusion injury. Mol Med Rep (2015) 0.77
Immune response in the eye following epileptic seizures. J Neuroinflammation (2016) 0.76
Cell matrix contact modifies endothelial major histocompatibility complex class II expression in high-glucose environment. Am J Physiol Heart Circ Physiol (2013) 0.75
The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group. N Engl J Med (1993) 102.56
Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38. UK Prospective Diabetes Study Group. BMJ (1998) 32.73
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science (2004) 19.08
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science (2006) 13.91
Endoplasmic reticulum stress: cell life and death decisions. J Clin Invest (2005) 8.45
Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities. Nat Rev Drug Discov (2008) 7.64
The glucose-regulated proteins: stress induction and clinical applications. Trends Biochem Sci (2001) 5.18
ER chaperones in mammalian development and human diseases. FEBS Lett (2007) 4.40
Pericytes in the microvasculature. Cardiovasc Res (1996) 3.95
Early worsening of diabetic retinopathy in the Diabetes Control and Complications Trial. Arch Ophthalmol (1998) 3.83
The ER chaperone and signaling regulator GRP78/BiP as a monitor of endoplasmic reticulum stress. Methods (2005) 3.40
Progression of incipient diabetic retinopathy during good glycemic control. Diabetes (1987) 3.30
Glucose depletion accounts for the induction of two transformation-sensitive membrane proteinsin Rous sarcoma virus-transformed chick embryo fibroblasts. Proc Natl Acad Sci U S A (1977) 3.26
The endoplasmic reticulum chaperone improves insulin resistance in type 2 diabetes. Diabetes (2005) 3.00
Mechanisms initiating cataract formation. Proctor Lecture. Invest Ophthalmol (1974) 2.77
Pathways for protein disulphide bond formation. Trends Cell Biol (2000) 2.51
Pancreatic beta-cell failure and diabetes in mice with a deletion mutation of the endoplasmic reticulum molecular chaperone gene P58IPK. Diabetes (2005) 2.46
Proteinuria and hyperglycemia induce endoplasmic reticulum stress. J Am Soc Nephrol (2008) 2.41
Progression of retinopathy with intensive versus conventional treatment in the Diabetes Control and Complications Trial. Diabetes Control and Complications Trial Research Group. Ophthalmology (1995) 2.40
Contribution of polyol pathway to diabetes-induced oxidative stress. J Am Soc Nephrol (2003) 1.79
Pericytes and the pathogenesis of diabetic retinopathy. Horm Metab Res (2005) 1.74
Grp78 heterozygosity promotes adaptive unfolded protein response and attenuates diet-induced obesity and insulin resistance. Diabetes (2009) 1.67
Endoplasmic reticulum stress is implicated in retinal inflammation and diabetic retinopathy. FEBS Lett (2009) 1.65
Protein folding in the endoplasmic reticulum and the unfolded protein response. Handb Exp Pharmacol (2006) 1.51
The mural cell in perspective. Arch Ophthalmol (1967) 1.39
The unfolded protein response in lens epithelial cells from galactosemic rat lenses. Invest Ophthalmol Vis Sci (2006) 1.37
Apoptosis induced by endoplasmic reticulum stress involved in diabetic kidney disease. Biochem Biophys Res Commun (2008) 1.37
Hypoglycemia as a barrier to glycemic control. J Diabetes Complications (2004) 1.37
Studies of rat and human retinas predict a role for the polyol pathway in human diabetic retinopathy. Diabetes (2004) 1.35
The polyol pathway as a mechanism for diabetic retinopathy: attractive, elusive, and resilient. Exp Diabetes Res (2007) 1.35
Involvement of ER stress in retinal cell death. Mol Vis (2007) 1.32
NIH conference. Aldose reductase and complications of diabetes. Ann Intern Med (1984) 1.27
Role of the unfolded protein response (UPR) in cataract formation. Exp Eye Res (2006) 1.21
Response of VEGF expression to amino acid deprivation and inducers of endoplasmic reticulum stress. Invest Ophthalmol Vis Sci (2002) 1.17
Retinal ganglion cell death induced by endoplasmic reticulum stress in a chronic glaucoma model. Brain Res (2009) 1.15
Diabetes alters sphingolipid metabolism in the retina: a potential mechanism of cell death in diabetic retinopathy. Diabetes (2006) 1.13
Induction of endoplasmic reticulum stress in retinal pericytes by glucose deprivation. Curr Eye Res (2006) 1.12
Effect of an inducer of BiP, a molecular chaperone, on endoplasmic reticulum (ER) stress-induced retinal cell death. Invest Ophthalmol Vis Sci (2008) 1.11
Pyridine nucleotide redox abnormalities in diabetes. Antioxid Redox Signal (2007) 1.10
Diabetic and galactosaemic cataracts. Ciba Found Symp (1984) 1.08
How does glucose generate oxidative stress in peripheral nerve? Int Rev Neurobiol (2002) 1.03
Retinal capillary pericyte apoptosis in early human diabetic retinopathy. Chin Med J (Engl) (1997) 1.02
Stress, the endoplasmic reticulum, and insulin resistance. Ann N Y Acad Sci (2006) 1.01
Endoplasmic reticulum stress is activated in light-induced retinal degeneration. J Neurosci Res (2008) 1.01
High glucose-induced downregulation of connexin 43 expression promotes apoptosis in microvascular endothelial cells. Invest Ophthalmol Vis Sci (2008) 1.01
The role of polyol pathway in glucose-induced apoptosis of cultured retinal pericytes. Diabetes Res Clin Pract (2003) 1.00
Astrocyte-derived glutathione attenuates hemin-induced apoptosis in cerebral microvascular cells. Glia (2010) 0.99
P58(IPK) inhibition of endoplasmic reticulum stress in human retinal capillary endothelial cells in vitro. Mol Vis (2008) 0.98
The role of endoplasmic reticulum stress in the early stage of diabetic retinopathy. Acta Diabetol (2009) 0.96
Serum-withdrawal-dependent apoptosis of hippocampal neuroblasts involves Ca++ release by endoplasmic reticulum and caspase-12 activation. Brain Res (2007) 0.95
Role of the polyol pathway in high glucose-induced apoptosis of retinal pericytes and proliferation of endothelial cells. Invest Ophthalmol Vis Sci (2008) 0.93
Impact of mitochondrial ROS production in the pathogenesis of insulin resistance. Diabetes Res Clin Pract (2007) 0.93
Neuroprotective effects of minocycline against in vitro and in vivo retinal ganglion cell damage. Brain Res (2005) 0.92
Hyperglycemia-induced endoplasmic reticulum stress in endothelial cells. Nutrition (2010) 0.91
High glucose and oxidative/nitrosative stress conditions induce apoptosis in retinal endothelial cells by a caspase-independent pathway. Exp Eye Res (2009) 0.90
Lig-8, a bioactive lignophenol derivative from bamboo lignin, protects against neuronal damage in vitro and in vivo. J Pharmacol Sci (2006) 0.87
Selective pericyte degeneration in the retinal capillaries of galactose-fed dogs results from apoptosis linked to aldose reductase-catalyzed galactitol accumulation. J Diabetes Complications (2002) 0.87
The BB Wistar rat: an experimental model for the study of diabetic retinopathy. Metabolism (1983) 0.86
Dose-dependent reduction of retinal vessel changes associated with diabetic retinopathy in galactose-fed dogs by the aldose reductase inhibitor M79175. J Ocul Pharmacol Ther (1997) 0.85
Effects of aldose reductase inhibitors and galactose withdrawal on fluorescein angiographic lesions in galactose-fed dogs. Arch Ophthalmol (2003) 0.85
Increased expression of IRE1alpha and stress-related signal transduction proteins in ischemia-reperfusion injured retina. Clin Ophthalmol (2008) 0.84
Polyol formation in cell lines of rat retinal capillary pericytes and endothelial cells (TR-rPCT and TR-iBRB). J Ocul Pharmacol Ther (2009) 0.84
Aldose reductase and pericyte-endothelial cell contacts in retina and optic nerve. Invest Ophthalmol Vis Sci (1989) 0.84
Confirmation of lens hydration by Raman spectroscopy. Exp Eye Res (1990) 0.82
Prevention of pericyte loss by trolox in diabetic rat retina. J Toxicol Environ Health A (1998) 0.82
The role of lens epithelium in sugar cataract formation. Exp Eye Res (1990) 0.82
Endoplasmic reticulum Ca2+ signaling and mitochondrial Cyt c release in astrocytes following oxygen and glucose deprivation. J Neurochem (2010) 0.81
Effect of galactose diet removal on the progression of retinal vessel changes in galactose-fed dogs. Invest Ophthalmol Vis Sci (2002) 0.81
Nerve conduction velocity, laser Doppler flow, and axonal caliber in galactose and streptozotocin diabetes. Brain Res (1998) 0.81
Endoplasmic reticulum stress inhibits collagen synthesis independent of collagen-modifying enzymes in different chondrocyte populations and dermal fibroblasts. Biochem Cell Biol (2010) 0.80
Autoimmune destruction of pericytes as the cause of diabetic retinopathy. Clin Ophthalmol (2008) 0.77
A risk-benefit assessment of conventional versus intensive insulin therapy. Drug Saf (1994) 0.76
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet (2013) 8.02
TGM6 identified as a novel causative gene of spinocerebellar ataxias using exome sequencing. Brain (2010) 3.66
Intracellular MHC class II molecules promote TLR-triggered innate immune responses by maintaining activation of the kinase Btk. Nat Immunol (2011) 3.12
Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res (2011) 3.05
Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54. Nat Genet (2010) 2.95
Identification of PRRT2 as the causative gene of paroxysmal kinesigenic dyskinesias. Brain (2011) 2.80
Pathway analysis of coronary atherosclerosis. Physiol Genomics (2005) 2.59
Transforming growth factor-beta-regulated miR-24 promotes skeletal muscle differentiation. Nucleic Acids Res (2008) 2.44
Association analyses identify six new psoriasis susceptibility loci in the Chinese population. Nat Genet (2010) 2.41
In vitro derivation of functional insulin-producing cells from human embryonic stem cells. Cell Res (2007) 2.28
Molecular characterization of geminivirus-derived small RNAs in different plant species. Nucleic Acids Res (2006) 2.26
Association between vitamin D and risk of colorectal cancer: a systematic review of prospective studies. J Clin Oncol (2011) 2.24
Expression of mutant p53 proteins implicates a lineage relationship between neural stem cells and malignant astrocytic glioma in a murine model. Cancer Cell (2009) 2.14
No significant association between the TP53 codon 72 polymorphism and breast cancer risk: a meta-analysis of 21 studies involving 24,063 subjects. Breast Cancer Res Treat (2010) 2.12
MRI-based finite-element analysis of left ventricular aneurysm. Am J Physiol Heart Circ Physiol (2005) 2.06
Helical myofiber orientation after myocardial infarction and left ventricular surgical restoration in sheep. J Thorac Cardiovasc Surg (2005) 2.06
Obesity and risk of colorectal cancer: a systematic review of prospective studies. PLoS One (2013) 2.02
Exome sequencing reveals mutations in TRPV3 as a cause of Olmsted syndrome. Am J Hum Genet (2012) 1.91
Aspirin for primary prevention of cardiovascular events in patients with diabetes: A meta-analysis. Diabetes Res Clin Pract (2009) 1.90
MicroRNA-99a inhibits hepatocellular carcinoma growth and correlates with prognosis of patients with hepatocellular carcinoma. J Biol Chem (2011) 1.88
SP1 mediates the link between methylation of the tumour suppressor miR-149 and outcome in colorectal cancer. J Pathol (2013) 1.87
Tumor-associated microglia/macrophages enhance the invasion of glioma stem-like cells via TGF-β1 signaling pathway. J Immunol (2012) 1.86
New approaches to in vitro models of blood-brain barrier drug transport. Drug Discov Today (2003) 1.86
Sequence composition, organization, and evolution of the core Triticeae genome. Plant J (2004) 1.79
Homoeologous recombination, chromosome engineering and crop improvement. Chromosome Res (2007) 1.73
Space-time crystals of trapped ions. Phys Rev Lett (2012) 1.71
Role of the CaMKII/NMDA receptor complex in the maintenance of synaptic strength. J Neurosci (2011) 1.70
A pericyte-derived angiopoietin-1 multimeric complex induces occludin gene expression in brain capillary endothelial cells through Tie-2 activation in vitro. J Neurochem (2004) 1.69
A sodalite-like framework based on octacyanomolybdate and neodymium with guest methanol molecules and neodymium octahydrate ions. Angew Chem Int Ed Engl (2006) 1.67
miR-150 as a potential biomarker associated with prognosis and therapeutic outcome in colorectal cancer. Gut (2011) 1.66
MicroRNA patterns associated with clinical prognostic parameters and CNS relapse prediction in pediatric acute leukemia. PLoS One (2009) 1.62
Shear stress regulation of Krüppel-like factor 2 expression is flow pattern-specific. Biochem Biophys Res Commun (2006) 1.57
The return periods and risk assessment of severe dust storms in Inner Mongolia with consideration of the main contributing factors. Environ Monit Assess (2011) 1.56
Exome sequencing and unrelated findings in the context of complex disease research: ethical and clinical implications. Discov Med (2011) 1.52
Kielin/chordin-like protein attenuates both acute and chronic renal injury. J Am Soc Nephrol (2013) 1.51
Candidate microRNA biomarkers in human colorectal cancer: systematic review profiling studies and experimental validation. Int J Cancer (2011) 1.46
Development and application of transgenic technologies in cassava. Plant Mol Biol (2004) 1.46
High nuclear grade, frequent mitotic activity, cyclin D1 and p53 overexpression are associated with stromal invasion in mammary intracystic papillary carcinoma. Breast J (2005) 1.44
Extremely low genetic diversity indicating the endangered status of Ranodon sibiricus (Amphibia: Caudata) and implications for phylogeography. PLoS One (2012) 1.44
Transcriptome profiling of low temperature-treated cassava apical shoots showed dynamic responses of tropical plant to cold stress. BMC Genomics (2012) 1.43
Lack of association between HER2 codon 655 polymorphism and breast cancer susceptibility: meta-analysis of 22 studies involving 19,341 subjects. Breast Cancer Res Treat (2010) 1.43
The proteomics of lipid droplets: structure, dynamics, and functions of the organelle conserved from bacteria to humans. J Lipid Res (2012) 1.40
The BioCassava plus program: biofortification of cassava for sub-Saharan Africa. Annu Rev Plant Biol (2011) 1.40
The role of mechanical bowel preparation before ileal urinary diversion: a systematic review and meta-analysis. Urol Int (2014) 1.39
Thioredoxin interacting protein (TXNIP) induces inflammation through chromatin modification in retinal capillary endothelial cells under diabetic conditions. J Cell Physiol (2009) 1.38
The unfolded protein response in lens epithelial cells from galactosemic rat lenses. Invest Ophthalmol Vis Sci (2006) 1.37
Robot-assisted versus conventional laparoscopic surgery for colorectal disease, focusing on rectal cancer: a meta-analysis. Ann Surg Oncol (2012) 1.35
Glycomic analyses of mouse models of congenital muscular dystrophy. J Biol Chem (2011) 1.32
Therapeutic target database update 2014: a resource for targeted therapeutics. Nucleic Acids Res (2013) 1.31
Effect of ventricular size and patch stiffness in surgical anterior ventricular restoration: a finite element model study. Ann Thorac Surg (2005) 1.30
Multiple genome alignments facilitate development of NPCL markers: a case study of tetrapod phylogeny focusing on the position of turtles. Mol Biol Evol (2011) 1.30
Genotypic variants at 2q33 and risk of esophageal squamous cell carcinoma in China: a meta-analysis of genome-wide association studies. Hum Mol Genet (2012) 1.28
An LRRTM4-HSPG complex mediates excitatory synapse development on dentate gyrus granule cells. Neuron (2013) 1.26
Distribution and progression of chondrocyte damage in a whole-organ model of human ankle intra-articular fracture. J Bone Joint Surg Am (2011) 1.26
Molecular basis of the interaction of Saccharomyces cerevisiae Eaf3 chromo domain with methylated H3K36. J Biol Chem (2008) 1.26
Acetylated STAT3 is crucial for methylation of tumor-suppressor gene promoters and inhibition by resveratrol results in demethylation. Proc Natl Acad Sci U S A (2012) 1.26
Black silicon with self-cleaning surface prepared by wetting processes. Nanoscale Res Lett (2013) 1.25
IL28B genetic variation is associated with spontaneous clearance of hepatitis C virus, treatment response, serum IL-28B levels in Chinese population. PLoS One (2012) 1.25
CD4 +CD25 + regulatory T cells decreased the antitumor activity of cytokine-induced killer (CIK) cells of lung cancer patients. J Clin Immunol (2007) 1.24
Role of positive selection in the retention of duplicate genes in mammalian genomes. Proc Natl Acad Sci U S A (2006) 1.24
Genome-wide association of bipolar disorder suggests an enrichment of replicable associations in regions near genes. PLoS Genet (2011) 1.23
Confirmation by exome sequencing of the pathogenic role of NCSTN mutations in acne inversa (hidradenitis suppurativa). J Invest Dermatol (2011) 1.23
Magnetic resonance imaging-based finite element stress analysis after linear repair of left ventricular aneurysm. J Thorac Cardiovasc Surg (2008) 1.22
Diabetic cataracts: mechanisms and management. Diabetes Metab Res Rev (2010) 1.22
Molecular mechanisms underlying the analgesic property of intrathecal dexmedetomidine and its neurotoxicity evaluation: an in vivo and in vitro experimental study. PLoS One (2013) 1.21
Elevated oncofoetal miR-17-5p expression regulates colorectal cancer progression by repressing its target gene P130. Nat Commun (2012) 1.21
Role of hepatitis B virus genotype mixture, subgenotypes C2 and B2 on hepatocellular carcinoma: compared with chronic hepatitis B and asymptomatic carrier state in the same area. Carcinogenesis (2008) 1.20
Proteomics identification of desmin as a potential oncofetal diagnostic and prognostic biomarker in colorectal cancer. Mol Cell Proteomics (2009) 1.20
Cohort Profile: the Dongfeng-Tongji cohort study of retired workers. Int J Epidemiol (2012) 1.19
Weak anti-localization and quantum oscillations of surface states in topological insulator Bi₂Se₂Te. Sci Rep (2012) 1.19
Constitutive MHC class I molecules negatively regulate TLR-triggered inflammatory responses via the Fps-SHP-2 pathway. Nat Immunol (2012) 1.18
Intranasal administration with NAD+ profoundly decreases brain injury in a rat model of transient focal ischemia. Front Biosci (2007) 1.18
Layer-specific fMRI reflects different neuronal computations at different depths in human V1. PLoS One (2012) 1.18
Ring expanded nucleoside analogues inhibit RNA helicase and intracellular human immunodeficiency virus type 1 replication. J Med Chem (2008) 1.17
Comparison of 2-microm continuous wave laser vaporesection of the prostate and transurethral resection of the prostate: a prospective nonrandomized trial with 1-year follow-up. Urology (2009) 1.16
Akinetic myocardial infarcts must contain contracting myocytes: finite-element model study. Am J Physiol Heart Circ Physiol (2004) 1.16
Decreased microRNA-142-3p/5p expression causes CD4+ T cell activation and B cell hyperstimulation in systemic lupus erythematosus. Arthritis Rheum (2012) 1.15
The effect of anteroapical aneurysm plication on end-systolic three-dimensional strain in the sheep: a magnetic resonance imaging tagging study. J Thorac Cardiovasc Surg (2006) 1.15
Passivation mechanism of thermal atomic layer-deposited Al2O3 films on silicon at different annealing temperatures. Nanoscale Res Lett (2013) 1.15
miRNA-29c suppresses lung cancer cell adhesion to extracellular matrix and metastasis by targeting integrin β1 and matrix metalloproteinase2 (MMP2). PLoS One (2013) 1.14
Enhanced reactive oxygen species scavenging by overproduction of superoxide dismutase and catalase delays postharvest physiological deterioration of cassava storage roots. Plant Physiol (2013) 1.14
Engineering resistance to geminiviruses--review and perspectives. Plant Biotechnol J (2007) 1.14
Vasopressin receptor-mediated functional signaling pathway in primary cilia of renal epithelial cells. Am J Physiol Renal Physiol (2008) 1.14
Nano-CeO2 exhibits adverse effects at environmental relevant concentrations. Environ Sci Technol (2011) 1.14
Human embryonic stem cells and metastatic colorectal cancer cells shared the common endogenous human microRNA-26b. J Cell Mol Med (2011) 1.14
Palmitoyl-protein thioesterase-1 deficiency mediates the activation of the unfolded protein response and neuronal apoptosis in INCL. Hum Mol Genet (2005) 1.13
Down-regulated miR-331-5p and miR-27a are associated with chemotherapy resistance and relapse in leukaemia. J Cell Mol Med (2011) 1.13
High resolution digital holographic microscopy with a wide field of view based on a synthetic aperture technique and use of linear CCD scanning. Appl Opt (2008) 1.13
Cassava genetic transformation and its application in breeding. J Integr Plant Biol (2011) 1.13
Induction of endoplasmic reticulum stress in retinal pericytes by glucose deprivation. Curr Eye Res (2006) 1.12
The relationship between early embryo development and tumourigenesis. J Cell Mol Med (2010) 1.12
Tumor-derived extracellular mutations of PTPRT /PTPrho are defective in cell adhesion. Mol Cancer Res (2008) 1.11
Crystal structure of a folate energy-coupling factor transporter from Lactobacillus brevis. Nature (2013) 1.11
UHRF1 promotes cell growth and metastasis through repression of p16(ink⁴a) in colorectal cancer. Ann Surg Oncol (2012) 1.10
MethylPurify: tumor purity deconvolution and differential methylation detection from single tumor DNA methylomes. Genome Biol (2014) 1.09
Decreased risk of liver cancer with thiazolidinediones therapy in patients with type 2 diabetes: Results from a meta-analysis. Hepatology (2013) 1.09
Dose-dependent RNAi-mediated geminivirus resistance in the tropical root crop cassava. Plant Mol Biol (2009) 1.09
Laparoscopy or not: a meta-analysis of the surgical effects of laparoscopic versus open appendicectomy. Surg Laparosc Endosc Percutan Tech (2010) 1.08
A set of miRNAs that involve in the pathways of drug resistance and leukemic stem-cell differentiation is associated with the risk of relapse and glucocorticoid response in childhood ALL. Hum Mol Genet (2011) 1.07
Development of a chemically stable 10-hydroxycamptothecin nanosuspensions. Int J Pharm (2009) 1.07