The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group.

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Published in N Engl J Med on September 30, 1993

Authors

Diabetes Control and Complications Trial Research Group, D M Nathan, S Genuth, J Lachin, P Cleary, O Crofford, M Davis, L Rand, C Siebert

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Sustaining safe sex: a longitudinal study of a sample of homosexual men. AIDS (1993) 2.35

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Interaction of the regulatory gene product with the operator site in the L-arabinose operon of Escherichia coli. J Mol Biol (1974) 1.97

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In vitro activation of the transcription of araBAD operon by araC activator. Proc Natl Acad Sci U S A (1974) 1.91

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Psychobiologic mechanisms of posttraumatic stress disorder. Arch Gen Psychiatry (1993) 1.88

Temporal and spatial association of histone H2A variant hv1 with transcriptionally competent chromatin during nuclear development in Tetrahymena thermophila. Genes Dev (1993) 1.87

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Effects of interstimulus interval length and variability on startle-response habituation in the rat. J Comp Physiol Psychol (1970) 1.67

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Cortical afferents to the extended amygdala. Ann N Y Acad Sci (1999) 1.62

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Standards of care for diabetes. Diabetes Care (1994) 1.59

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Surface protein-CAT reporter fusions demonstrate differential gene expression in the vir regulon of Streptococcus pyogenes. Mol Microbiol (1992) 1.59

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Mitogen-activated protein kinase cascade in the basolateral nucleus of amygdala is involved in extinction of fear-potentiated startle. J Neurosci (2001) 1.58

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A prospective study of cigarette smoking and the incidence of diabetes mellitus among US male physicians. Am J Med (2000) 1.57

Lesions of the amygdala, but not of the cerebellum or red nucleus, block conditioned fear as measured with the potentiated startle paradigm. Behav Neurosci (1986) 1.57

Normal conditioned inhibition and extinction of freezing and fear-potentiated startle following electrolytic lesions of medical prefrontal cortex in rats. Behav Neurosci (1997) 1.55

The control of VTEC in the animal reservoir. Int J Food Microbiol (2001) 1.54

Single-void urine samples can be used to estimate quantitative microalbuminuria. Diabetes Care (1987) 1.54

Agreement between ambulance paramedic- and physician-recorded neurological signs with Face Arm Speech Test (FAST) in acute stroke patients. Stroke (2004) 1.52

Utilization and cost analysis of bedside capillary glucose testing in a large teaching hospital: implications for managing point of care testing. Am J Med (1994) 1.52