Published in Cell on July 01, 1978
Carboxy terminus of polyoma middle-sized tumor antigen is required for attachment to membranes, associated protein kinase activities, and cell transformation. Proc Natl Acad Sci U S A (1982) 3.12
Comparison of phosphorylation of two polyoma virus middle T antigens in vivo and in vitro. J Virol (1981) 2.85
Variations in polyoma virus genotype in relation to tumor induction in mice. Characterization of wild type strains with widely differing tumor profiles. Am J Pathol (1987) 2.84
Genetic and biochemical definition of the bovine papillomavirus E5 transforming protein. EMBO J (1987) 2.23
Middle T antigen as primary inducer of full expression of the phenotype of transformation by polyoma virus. J Virol (1980) 1.96
Regulation of cellular phenotype and expression of polyomavirus middle T antigen in rat fibroblasts. Mol Cell Biol (1985) 1.94
Polyoma virus middle T antigen: relationship to cell membranes and apparent lack of ATP-binding activity. Mol Cell Biol (1982) 1.87
Simian virus 40 small-t protein is required for loss of actin cable networks in rat cells. J Virol (1980) 1.68
Association of cellular 56,000- and 32,000-molecular-weight protein with BK virus and polyoma virus t-antigens. J Virol (1981) 1.63
Regulation of c-myc and c-fos mRNA levels by polyomavirus: distinct roles for the capsid protein VP1 and the viral early proteins. Proc Natl Acad Sci U S A (1987) 1.58
Characterization of polyoma mutants with altered middle and large T-antigens. J Virol (1981) 1.58
Induction and utilization of an ATM signaling pathway by polyomavirus. J Virol (2005) 1.53
A polyoma mutant that encodes small T antigen but not middle T antigen demonstrates uncoupling of cell surface and cytoskeletal changes associated with cell transformation. Mol Cell Biol (1984) 1.52
Polyoma viral middle T-antigen is required for transformation. J Virol (1982) 1.43
Simian virus 40 t antigen affects the sensitivity of cellular DNA synthesis to theophylline. J Virol (1979) 1.43
The DnaJ domain of polyomavirus large T antigen is required to regulate Rb family tumor suppressor function. J Virol (1997) 1.21
Failure of simian virus 40 small t antigen to disorganize actin cables in nonpermissive cell lines. J Virol (1988) 1.20
Isolation and characterization of NIH 3T3 cells expressing polyomavirus small T antigen. J Virol (1986) 1.18
Phosphorylation of polyomavirus large T antigen: effects of viral mutations and cell growth state. J Virol (1987) 1.05
Small and middle T antigens contribute to lytic and abortive polyomavirus infection. J Virol (1985) 1.05
Protein domains connect cell cycle stimulation directly to initiation of DNA replication. Proc Natl Acad Sci U S A (1994) 1.02
Induction of p53-independent apoptosis by simian virus 40 small t antigen. J Virol (2001) 1.01
Mutational analysis of polyomavirus small-T-antigen functions in productive infection and in transformation. J Virol (1989) 1.00
Antibodies against a nonapeptide of polyomavirus middle T antigen: cross-reaction with a cellular protein(s). J Virol (1983) 0.95
J domain-independent regulation of the Rb family by polyomavirus large T antigen. J Virol (2000) 0.94
Signaling from polyomavirus middle T and small T defines different roles for protein phosphatase 2A. Mol Cell Biol (1998) 0.94
Host range and cell cycle activation properties of polyomavirus large T-antigen mutants defective in pRB binding. J Virol (1994) 0.93
Polyoma virus middle t antigen: a tumor progression factor. J Virol (1980) 0.90
Inositol trisphosphate levels in cells expressing wild-type and mutant polyomavirus middle T antigens: evidence for activation of phospholipase C via activation of pp60c-src. J Virol (1990) 0.90
Zinc-binding and protein-protein interactions mediated by the polyomavirus large T antigen zinc finger. J Virol (1995) 0.89
Factors which disorganize microtubules or microfilaments increase the frequency of cell transformation by polyoma virus. J Virol (1980) 0.88
Effects of large and small T antigens on DNA synthesis and cell division in simian virus 40-transformed BALB/c 3T3 cells. J Virol (1982) 0.88
Stimulation of host centriolar antigen in TC7 cells by simian virus 40: requirement for RNA and protein syntheses and an intact simian virus 40 small-t gene function. J Virol (1982) 0.88
Phosphorylation sites in polyomavirus large T antigen that regulate its function in viral, but not cellular, DNA synthesis. J Virol (1997) 0.86
DNA synthesis in temperature-sensitive mutants of the cell cycle infected by polyoma virus and adenovirus. Proc Natl Acad Sci U S A (1979) 0.85
Phosphatidylinositol 3-kinase binding to polyoma virus middle tumor antigen mediates elevation of glucose transport by increasing translocation of the GLUT1 transporter. Proc Natl Acad Sci U S A (1995) 0.85
Loss of DNA-binding and new transcriptional trans-activation function in polyomavirus large T-antigen with mutation of zinc finger motif. Nucleic Acids Res (1990) 0.85
Genetic analysis of polyomavirus large T nuclear localization: nuclear localization is required for productive association with pRb family members. J Virol (1996) 0.84
Activation of CREB/ATF sites by polyomavirus large T antigen. J Virol (2005) 0.84
Necdin, a p53-target gene, is an inhibitor of p53-mediated growth arrest. PLoS One (2012) 0.81
Rat cells transformed by simian virus 40 give rise to tumor cells which contain no viral proteins and often no viral DNA. Mol Cell Biol (1983) 0.80
Polyomavirus middle T antigen induces ribosomal protein S6 phosphorylation through pp60c-src-dependent and -independent pathways. Mol Cell Biol (1988) 0.80
The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes. J Virol (1989) 8.68
Presence and expression of human papillomavirus sequences in human cervical carcinoma cell lines. Am J Pathol (1985) 6.18
Structure of simian virus 40 at 3.8-A resolution. Nature (1991) 5.96
Host range mutants of polyoma virus. Proc Natl Acad Sci U S A (1970) 5.68
Tumor antigen(s) in cell productively infected by wild-type polyoma virus and mutant NG-18. Proc Natl Acad Sci U S A (1978) 4.64
Systemic immunization with papillomavirus L1 protein completely prevents the development of viral mucosal papillomas. Proc Natl Acad Sci U S A (1995) 4.15
Phosphorylation of polyoma T antigens. Cell (1979) 3.94
Virus-specific RNA in cells productively infected or transformed by polyoma virus. J Mol Biol (1966) 3.92
TGF-beta 1 inhibition of c-myc transcription and growth in keratinocytes is abrogated by viral transforming proteins with pRB binding domains. Cell (1990) 3.55
The E5 transforming gene of bovine papillomavirus encodes a small, hydrophobic polypeptide. Science (1986) 3.37
Structure of murine polyomavirus complexed with an oligosaccharide receptor fragment. Nature (1994) 3.35
The carboxy-terminal domain shared by the bovine papillomavirus E2 transactivator and repressor proteins contains a specific DNA binding activity. EMBO J (1988) 3.20
Two calcium-binding proteins in infiltrate macrophages of rheumatoid arthritis. Nature (1987) 3.12
Carboxy terminus of polyoma middle-sized tumor antigen is required for attachment to membranes, associated protein kinase activities, and cell transformation. Proc Natl Acad Sci U S A (1982) 3.12
Caffeine-induced uncoupling of mitosis from the completion of DNA replication in mammalian cells. Science (1986) 2.89
Comparison of phosphorylation of two polyoma virus middle T antigens in vivo and in vitro. J Virol (1981) 2.85
Variations in polyoma virus genotype in relation to tumor induction in mice. Characterization of wild type strains with widely differing tumor profiles. Am J Pathol (1987) 2.84
Phosphorylation of middle T by pp60c-src: a switch for binding of phosphatidylinositol 3-kinase and optimal tumorigenesis. Cell (1989) 2.71
Host range selection of transformation-defective hr-t mutants of polyoma virus. Virology (1977) 2.68
Comparisons of two early gene functions essential for transformation in polyoma virus and SV-40. Virology (1979) 2.64
44-amino-acid E5 transforming protein of bovine papillomavirus requires a hydrophobic core and specific carboxyl-terminal amino acids. Mol Cell Biol (1988) 2.50
Deficiency in histone acetylation in nontransforming host range mutants of polyoma virus. Proc Natl Acad Sci U S A (1976) 2.37
Relative target sizes for the inactivation of the transforming and reproductive abilities of polyoma virus. Proc Natl Acad Sci U S A (1965) 2.32
Activation of cyclin A-dependent protein kinases during apoptosis. Proc Natl Acad Sci U S A (1994) 2.29
Hr-t and ts-a: two early gene functions of polyoma virus. Virology (1977) 2.28
Immunohistochemical localization of keratin in normal human tissues. Lab Invest (1980) 2.28
Genetic and biochemical definition of the bovine papillomavirus E5 transforming protein. EMBO J (1987) 2.23
Effect of streptolysin O on erythrocyte membranes, liposomes, and lipid dispersions. A protein-cholesterol interaction. J Cell Biol (1975) 2.22
Analysis of host range of nontransforming polyoma virus mutants. Virology (1975) 2.18
Inhibition of VSV binding and infectivity by phosphatidylserine: is phosphatidylserine a VSV-binding site? Cell (1983) 2.11
Regulation of cellular phenotype and expression of polyomavirus middle T antigen in rat fibroblasts. Mol Cell Biol (1985) 1.94
The E6 and E7 genes of HPV-18 are sufficient for inducing two-stage in vitro transformation of human keratinocytes. Oncogene (1989) 1.94
The E5 oncoprotein of bovine papillomavirus is oriented asymmetrically in Golgi and plasma membranes. Virology (1989) 1.93
Identification of DNA sequence changes leading to loss of transforming ability in polyoma virus. J Biol Chem (1980) 1.89
Bovine papillomavirus E5 oncoprotein binds to the 16K component of vacuolar H(+)-ATPases. Nature (1991) 1.88
Polyoma virus middle T antigen: relationship to cell membranes and apparent lack of ATP-binding activity. Mol Cell Biol (1982) 1.87
The BPV-1 E5 protein, the 16 kDa membrane pore-forming protein and the PDGF receptor exist in a complex that is dependent on hydrophobic transmembrane interactions. EMBO J (1992) 1.85
A monoclonal antibody to a subset of human monocytes found only in the peripheral blood and inflammatory tissues. J Immunol (1986) 1.84
Antiphospholipid antibodies, proteins C and S, and coagulation changes in sickle cell disease. J Lab Clin Med (1999) 1.82
Polyomavirus replication in mice: influences of VP1 type and route of inoculation. J Virol (1991) 1.79
A single-amino-acid substitution in polyomavirus VP1 correlates with plaque size and hemagglutination behavior. J Virol (1991) 1.77
Immunoperoxidase localization of keratin in human neoplasms: a preliminary survey. Am J Pathol (1980) 1.76
Amantadine and dansylcadaverine inhibit vesicular stomatitis virus uptake and receptor-mediated endocytosis of alpha 2-macroglobulin. Proc Natl Acad Sci U S A (1982) 1.76
The E5 oncoprotein of bovine papillomavirus binds to a 16 kd cellular protein. EMBO J (1990) 1.72
Transformation by polyoma virus is drastically reduced by substitution of phenylalanine for tyrosine at residue 315 of middle-sized tumor antigen. Proc Natl Acad Sci U S A (1984) 1.71
Host range transforming gene of polyoma virus plays a role in virus assembly. Proc Natl Acad Sci U S A (1983) 1.69
Transcriptional activation of the telomerase hTERT gene by human papillomavirus type 16 E6 oncoprotein. J Virol (2001) 1.68
Phosphatidylinositol 3-phosphate is present in normal and transformed fibroblasts and is resistant to hydrolysis by bovine brain phospholipase C II. J Biol Chem (1989) 1.67
The human papillomavirus type 6 and 16 E5 proteins are membrane-associated proteins which associate with the 16-kilodalton pore-forming protein. J Virol (1993) 1.67
Polyomavirus tumor induction in mice: effects of polymorphisms of VP1 and large T antigen. J Virol (1991) 1.66
Promotion of vascular smooth muscle cell growth by homocysteine: a link to atherosclerosis. Proc Natl Acad Sci U S A (1994) 1.66
Papilloma virus immortalized tracheal epithelial cells retain a well-differentiated phenotype. Am J Physiol (1993) 1.66
Polyomavirus tumor induction in mice: influences of viral coding and noncoding sequences on tumor profiles. J Virol (1987) 1.65
Human papillomavirus types 6 and 11 have antigenically distinct strongly immunogenic conformationally dependent neutralizing epitopes. Virology (1994) 1.64
Two calcium-binding proteins associated with specific stages of myeloid cell differentiation are expressed by subsets of macrophages in inflammatory tissues. Clin Exp Immunol (1988) 1.64
Early steps of polyomavirus entry into cells. J Virol (2000) 1.64
Apoptosis and the cell cycle. J Cell Biochem (1995) 1.60
Role of conformational epitopes expressed by human papillomavirus major capsid proteins in the serologic detection of infection and prophylactic vaccination. Gynecol Oncol (1994) 1.58
The human papillomavirus-16 E6 oncoprotein decreases the vigilance of mitotic checkpoints. Oncogene (1997) 1.58
DNA sequence alterations in Hr-t deletion mutants of polyoma virus. Cell (1979) 1.56
Immunization with a pentameric L1 fusion protein protects against papillomavirus infection. J Virol (2001) 1.55
Genetic and structural analysis of a virulence determinant in polyomavirus VP1. J Virol (1995) 1.52
A polyoma mutant that encodes small T antigen but not middle T antigen demonstrates uncoupling of cell surface and cytoskeletal changes associated with cell transformation. Mol Cell Biol (1984) 1.52
Virion assembly defect of polyomavirus hr-t mutants: underphosphorylation of major capsid protein VP1 before viral DNA encapsidation. J Virol (1985) 1.50
Discrimination between sialic acid-containing receptors and pseudoreceptors regulates polyomavirus spread in the mouse. J Virol (1999) 1.47
Absence of a cell membrane alteration function in non-transforming mutants of polyoma virus. Proc Natl Acad Sci U S A (1970) 1.47
pH-dependent fusion induced by vesicular stomatitis virus glycoprotein reconstituted into phospholipid vesicles. J Biol Chem (1984) 1.44
Bacteriocin production by transformable group H streptococci. J Bacteriol (1972) 1.43
Properties of a Streptococcus sanguis (group H) bacteriocin and its separation from the competence factor of transformation. J Bacteriol (1973) 1.41
Delayed traumatic intracerebral hematomas: "Spät-Apoplexie". Report of two cases. J Neurosurg (1990) 1.40
Suppression of apoptosis by dominant negative mutants of cyclin-dependent protein kinases. J Biol Chem (1996) 1.40
The human papillomavirus type 16 E6 and E7 oncoproteins dissociate cellular telomerase activity from the maintenance of telomere length. J Biol Chem (1997) 1.38
Antibody to the nonapeptide Glu-Glu-Glu-Glu-Tyr-Met-Pro-Met-Glu is specific for polyoma middle T antigen and inhibits in vitro kinase activity. J Biol Chem (1982) 1.37
Receptor-mediated endocytosis in cultured fibroblasts: cryptic coated pits and the formation of receptosomes. J Histochem Cytochem (1981) 1.35
Saturable binding sites for vesicular stomatitis virus on the surface of Vero cells. J Virol (1982) 1.34
Susceptibility to tumors induced by polyoma virus is conferred by an endogenous mouse mammary tumor virus superantigen. J Exp Med (1995) 1.33
DNA sequence of the HPV-16 E5 ORF and the structural conservation of its encoded protein. Virology (1988) 1.33
Induction of cyclin A gene expression by homocysteine in vascular smooth muscle cells. J Clin Invest (1996) 1.33
Expression of polyoma early gene products in E. coli. Nucleic Acids Res (1985) 1.29
The hr-t gene of polyoma virus. Biochim Biophys Acta (1982) 1.28
Duplication of noncoding sequences in polyomavirus specifically augments the development of thymic tumors in mice. J Virol (1988) 1.27
Ventriculoatrial shunt infection due to Cryptococcus neoformans: an ultrastructural and quantitative microbiological study. Neurosurgery (1986) 1.24
Natural variants of the human papillomavirus type 16 E6 protein differ in their abilities to alter keratinocyte differentiation and to induce p53 degradation. J Virol (1996) 1.21
HPV-1 L1 protein expressed in cos cells displays conformational epitopes found on intact virions. Virology (1992) 1.21
Spontaneously regressing oral papillomas induce systemic antibodies that neutralize canine oral papillomavirus. Exp Mol Pathol (2000) 1.20
Serum- and calcium-induced differentiation of human keratinocytes is inhibited by the E6 oncoprotein of human papillomavirus type 16. J Virol (1996) 1.20
Keratin protein domains within the human epidermis. Exp Cell Res (1981) 1.19
Evidence of a role for phosphatidylinositol 3-kinase activation in the blocking of apoptosis by polyomavirus middle T antigen. J Virol (1998) 1.18
Selective isolation of newly synthesized mammalian mRNA after in vivo labeling with 4-thiouridine or 6-thioguanosine. Anal Biochem (1988) 1.18
Representative cDNA libraries and their utility in gene expression profiling. Biotechniques (1999) 1.17
Coagulation changes in individuals with sickle cell trait. Am J Hematol (2002) 1.16
Disappearance of cyclin A correlates with permanent withdrawal of cardiomyocytes from the cell cycle in human and rat hearts. J Clin Invest (1995) 1.16
The E5 gene of HPV-16 enhances keratinocyte immortalization by full-length DNA. Virology (1996) 1.15
Changes in frequency, morphology, and behavior of tumors induced in mice by a polyoma virus mutant with a specifically altered oncogene. Am J Pathol (1992) 1.15
Separation of immortalization from tumor induction with polyoma large T mutants that fail to bind the retinoblastoma gene product. Oncogene (1992) 1.15