Published in Science on November 23, 1990
c-Myc target genes involved in cell growth, apoptosis, and metabolism. Mol Cell Biol (1999) 8.17
A global transcriptional regulatory role for c-Myc in Burkitt's lymphoma cells. Proc Natl Acad Sci U S A (2003) 7.30
Compilation of vertebrate-encoded transcription factors. Nucleic Acids Res (1992) 5.35
Genomic binding by the Drosophila Myc, Max, Mad/Mnt transcription factor network. Genes Dev (2003) 4.68
The ornithine decarboxylase gene is a transcriptional target of c-Myc. Proc Natl Acad Sci U S A (1993) 4.66
Id proteins Id1 and Id2 selectively inhibit DNA binding by one class of helix-loop-helix proteins. Mol Cell Biol (1991) 4.42
MYC-induced cancer cell energy metabolism and therapeutic opportunities. Clin Cancer Res (2009) 4.32
Binding of myc proteins to canonical and noncanonical DNA sequences. Mol Cell Biol (1993) 4.08
CCAAT/enhancer binding protein gene promoter: binding of nuclear factors during differentiation of 3T3-L1 preadipocytes. Proc Natl Acad Sci U S A (1991) 3.98
DNA-binding specificities of the GATA transcription factor family. Mol Cell Biol (1993) 3.91
MYC as a regulator of ribosome biogenesis and protein synthesis. Nat Rev Cancer (2010) 3.64
c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines. EMBO J (1994) 3.58
New core promoter element in RNA polymerase II-dependent transcription: sequence-specific DNA binding by transcription factor IIB. Genes Dev (1998) 3.45
Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma. Cell (2008) 3.43
Discrimination between related DNA sites by a single amino acid residue of Myc-related basic-helix-loop-helix proteins. Proc Natl Acad Sci U S A (1992) 3.25
Dual DNA binding specificity of ADD1/SREBP1 controlled by a single amino acid in the basic helix-loop-helix domain. Mol Cell Biol (1995) 3.10
c-Myc represses transcription in vivo by a novel mechanism dependent on the initiator element and Myc box II. EMBO J (1994) 3.01
Myc-Max heterodimers activate a DEAD box gene and interact with multiple E box-related sites in vivo. EMBO J (1996) 2.86
Repression of cyclin D1: a novel function of MYC. Mol Cell Biol (1994) 2.67
The orphan nuclear receptor estrogen-related receptor alpha is a transcriptional regulator of the human medium-chain acyl coenzyme A dehydrogenase gene. Mol Cell Biol (1997) 2.64
Myc versus USF: discrimination at the cad gene is determined by core promoter elements. Mol Cell Biol (1997) 2.62
c-Myc regulates cyclin D-Cdk4 and -Cdk6 activity but affects cell cycle progression at multiple independent points. Mol Cell Biol (1999) 2.50
An alternative pathway for gene regulation by Myc. EMBO J (1997) 2.43
MAZ, a zinc finger protein, binds to c-MYC and C2 gene sequences regulating transcriptional initiation and termination. Proc Natl Acad Sci U S A (1992) 2.40
Evolutionary conservation and adaptation in the mechanism that regulates SREBP action: what a long, strange tRIP it's been. Genes Dev (2009) 2.37
Regulation of the pancreatic islet-specific gene BETA2 (neuroD) by neurogenin 3. Mol Cell Biol (2000) 2.34
Single amino acid substitutions alter helix-loop-helix protein specificity for bases flanking the core CANNTG motif. EMBO J (1992) 2.34
Differential modulation of cyclin gene expression by MYC. Proc Natl Acad Sci U S A (1993) 2.31
Increased expression of eukaryotic translation initiation factors eIF-4E and eIF-2 alpha in response to growth induction by c-myc. Proc Natl Acad Sci U S A (1993) 2.29
Ubiquitous expression of the 43- and 44-kDa forms of transcription factor USF in mammalian cells. Nucleic Acids Res (1994) 2.27
Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain family. Proc Natl Acad Sci U S A (1993) 2.27
Enhancer-binding activity of the tal-1 oncoprotein in association with the E47/E12 helix-loop-helix proteins. Mol Cell Biol (1991) 2.25
PCF1 and PCF2 specifically bind to cis elements in the rice proliferating cell nuclear antigen gene. Plant Cell (1997) 2.23
An essential E box in the promoter of the gene encoding the mRNA cap-binding protein (eukaryotic initiation factor 4E) is a target for activation by c-myc. Mol Cell Biol (1996) 2.22
Determination of the c-MYC DNA-binding site. Proc Natl Acad Sci U S A (1991) 2.19
The c-MYC oncoprotein is a substrate of the acetyltransferases hGCN5/PCAF and TIP60. Mol Cell Biol (2004) 2.13
c-Myc is a critical target for c/EBPalpha in granulopoiesis. Mol Cell Biol (2001) 2.10
Coexamination of site-specific transcription factor binding and promoter activity in living cells. Mol Cell Biol (1999) 2.09
Mutagenesis of the myogenin basic region identifies an ancient protein motif critical for activation of myogenesis. Proc Natl Acad Sci U S A (1991) 2.08
c-Myc protein synthesis is initiated from the internal ribosome entry segment during apoptosis. Mol Cell Biol (2000) 2.03
Statistical analysis of the genomic distribution and correlation of regulatory elements in the ENCODE regions. Genome Res (2007) 2.03
Hierarchical phosphorylation at N-terminal transformation-sensitive sites in c-Myc protein is regulated by mitogens and in mitosis. Mol Cell Biol (1994) 2.01
Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation. EMBO J (1995) 1.93
Induction of ribosomal genes and hepatocyte hypertrophy by adenovirus-mediated expression of c-Myc in vivo. Proc Natl Acad Sci U S A (2000) 1.89
A consensus sequence for binding of Lrp to DNA. J Bacteriol (1995) 1.88
Myc proteins as therapeutic targets. Oncogene (2010) 1.88
Myc-enhanced expression of Cul1 promotes ubiquitin-dependent proteolysis and cell cycle progression. Genes Dev (2000) 1.87
Transcriptional activation by Myc is under negative control by the transcription factor AP-2. EMBO J (1995) 1.82
Pbx1 is converted into a transcriptional activator upon acquiring the N-terminal region of E2A in pre-B-cell acute lymphoblastoid leukemia. Proc Natl Acad Sci U S A (1993) 1.81
Evi-1, a murine zinc finger proto-oncogene, encodes a sequence-specific DNA-binding protein. Mol Cell Biol (1991) 1.77
Sequence-specific transcriptional activation by Myc and repression by Max. Mol Cell Biol (1993) 1.77
myc boxes, which are conserved in myc family proteins, are signals for protein degradation via the proteasome. Mol Cell Biol (1998) 1.77
Systematic identification of cis-regulatory sequences active in mouse and human embryonic stem cells. PLoS Genet (2007) 1.77
The monomer-binding orphan receptor Rev-Erb represses transcription as a dimer on a novel direct repeat. Mol Cell Biol (1995) 1.76
The Myc transactivation domain promotes global phosphorylation of the RNA polymerase II carboxy-terminal domain independently of direct DNA binding. Mol Cell Biol (2007) 1.75
A genomewide survey of basic helix-loop-helix factors in Drosophila. Proc Natl Acad Sci U S A (2000) 1.72
HMG-I/Y, a new c-Myc target gene and potential oncogene. Mol Cell Biol (2000) 1.71
Opposite regulation of gene transcription and cell proliferation by c-Myc and Max. Proc Natl Acad Sci U S A (1993) 1.70
Identification of downstream-initiated c-Myc proteins which are dominant-negative inhibitors of transactivation by full-length c-Myc proteins. Mol Cell Biol (1997) 1.69
Transactivation of gene expression by Myc is inhibited by mutation at the phosphorylation sites Thr-58 and Ser-62. Proc Natl Acad Sci U S A (1993) 1.65
Assembly of a bZIP-bHLH transcription activation complex: formation of the yeast Cbf1-Met4-Met28 complex is regulated through Met28 stimulation of Cbf1 DNA binding. EMBO J (1997) 1.63
Base preferences for DNA binding by the bHLH-Zip protein USF: effects of MgCl2 on specificity and comparison with binding of Myc family members. Nucleic Acids Res (1994) 1.61
Analysis of Myc-induced histone modifications on target chromatin. PLoS One (2008) 1.59
A link between increased transforming activity of lymphoma-derived MYC mutant alleles, their defective regulation by p107, and altered phosphorylation of the c-Myc transactivation domain. Mol Cell Biol (1995) 1.59
The orphan receptor Rev-ErbA alpha activates transcription via a novel response element. Mol Cell Biol (1993) 1.58
Characterization of the DNA-binding site repertoire for the Epstein-Barr virus transcription factor R. Nucleic Acids Res (1994) 1.58
Autoregulation of the human C/EBP alpha gene by stimulation of upstream stimulatory factor binding. Mol Cell Biol (1995) 1.57
Sequence-specific DNA binding by Myc proteins. Proc Natl Acad Sci U S A (1991) 1.55
Distinct DNA binding preferences for the c-Myc/Max and Max/Max dimers. Nucleic Acids Res (1993) 1.53
A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell (2009) 1.53
MyoD and the regulation of myogenesis by helix-loop-helix proteins. J Clin Invest (1991) 1.52
N-Myc regulates a widespread euchromatic program in the human genome partially independent of its role as a classical transcription factor. Cancer Res (2008) 1.52
High affinity YY1 binding motifs: identification of two core types (ACAT and CCAT) and distribution of potential binding sites within the human beta globin cluster. Nucleic Acids Res (1995) 1.52
Determination of the minimal essential nucleotide sequence for diphtheria tox repressor binding by in vitro affinity selection. Proc Natl Acad Sci U S A (1994) 1.49
mTFE3, an X-linked transcriptional activator containing basic helix-loop-helix and zipper domains, utilizes the zipper to stabilize both DNA binding and multimerization. Mol Cell Biol (1992) 1.49
Overlapping roles and asymmetrical cross-regulation of the USF proteins in mice. Proc Natl Acad Sci U S A (1998) 1.47
Cloning, genetic mapping, and expression analysis of an Arabidopsis thaliana gene that encodes 1-aminocyclopropane-1-carboxylate synthase. Proc Natl Acad Sci U S A (1992) 1.45
Wild-type circadian rhythmicity is dependent on closely spaced E boxes in the Drosophila timeless promoter. Mol Cell Biol (2001) 1.41
Cell-type-dependent activity of the ubiquitous transcription factor USF in cellular proliferation and transcriptional activation. Mol Cell Biol (1999) 1.40
Darwinian molecular imaging. Eur J Nucl Med Mol Imaging (2009) 1.40
DNA-binding specificity of the cut repeats from the human cut-like protein. Mol Cell Biol (1995) 1.39
Intracellular association of the protein product of the c-myc oncogene with the TATA-binding protein. Mol Cell Biol (1994) 1.39
RB and c-Myc activate expression of the E-cadherin gene in epithelial cells through interaction with transcription factor AP-2. Mol Cell Biol (1998) 1.39
Activation domains of L-Myc and c-Myc determine their transforming potencies in rat embryo cells. Mol Cell Biol (1992) 1.39
Antisense SCL suppresses self-renewal and enhances spontaneous erythroid differentiation of the human leukaemic cell line K562. EMBO J (1991) 1.38
An E-box element localized in the first intron mediates regulation of the prothymosin alpha gene by c-myc. Mol Cell Biol (1994) 1.38
Interleukin-6- and leukemia inhibitory factor-induced terminal differentiation of myeloid leukemia cells is blocked at an intermediate stage by constitutive c-myc. Mol Cell Biol (1991) 1.37
Mxi2, a mitogen-activated protein kinase that recognizes and phosphorylates Max protein. Proc Natl Acad Sci U S A (1995) 1.37
Sequence-specific DNA binding of individual cut repeats of the human CCAAT displacement/cut homeodomain protein. Proc Natl Acad Sci U S A (1994) 1.37
Activation of cyclin-dependent kinases by Myc mediates induction of cyclin A, but not apoptosis. EMBO J (1996) 1.37
Expression and activity of L-Myc in normal mouse development. Mol Cell Biol (1996) 1.36
Inhibitory effects of antisense oligodeoxynucleotides targeting c-myc mRNA on smooth muscle cell proliferation and migration. Proc Natl Acad Sci U S A (1993) 1.35
Expression of the mad gene during cell differentiation in vivo and its inhibition of cell growth in vitro. J Cell Biol (1995) 1.35
The proneural proteins Atonal and Scute regulate neural target genes through different E-box binding sites. Mol Cell Biol (2004) 1.35
The Myc negative autoregulation mechanism requires Myc-Max association and involves the c-myc P2 minimal promoter. Mol Cell Biol (1997) 1.33
Neuroendocrine differentiation factor, IA-1, is a transcriptional repressor and contains a specific DNA-binding domain: identification of consensus IA-1 binding sequence. Nucleic Acids Res (2002) 1.33
A point mutation in the MyoD basic domain imparts c-Myc-like properties. Proc Natl Acad Sci U S A (1992) 1.32
Transforming growth factor beta 1-responsive element: closely associated binding sites for USF and CCAAT-binding transcription factor-nuclear factor I in the type 1 plasminogen activator inhibitor gene. Mol Cell Biol (1992) 1.32
DNA-binding properties of the E1A-associated 300-kilodalton protein. Mol Cell Biol (1992) 1.31
Expression of a single transfected cDNA converts fibroblasts to myoblasts. Cell (1987) 22.17
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Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression. Cell (1997) 7.64
MyoD is a sequence-specific DNA binding protein requiring a region of myc homology to bind to the muscle creatine kinase enhancer. Cell (1989) 6.94
MyoD1: a nuclear phosphoprotein requiring a Myc homology region to convert fibroblasts to myoblasts. Science (1988) 6.78
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Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate. Genes Dev (1994) 6.42
Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion. Proc Natl Acad Sci U S A (2000) 6.30
Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix protein. Science (1995) 6.25
An unwinding activity that covalently modifies its double-stranded RNA substrate. Cell (1988) 5.93
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Mad: a heterodimeric partner for Max that antagonizes Myc transcriptional activity. Cell (1993) 5.28
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Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3. Cell (1995) 4.98
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Xenopus embryos regulate the nuclear localization of XMyoD. Genes Dev (1994) 4.77
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Transfection of a DNA locus that mediates the conversion of 10T1/2 fibroblasts to myoblasts. Cell (1986) 3.34
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