Stress hypERactivation in the β-cell.

The delicate balance between secreted protein folding and endoplasmic reticulum-associated degradation in human physiology. Physiol Rev (2012) 1.95

Higher maternal gestational glucose concentration is associated with lower offspring insulin sensitivity and altered beta-cell function. J Clin Endocrinol Metab (2011) 1.14

Autosomal dominant diabetes arising from a Wolfram syndrome 1 mutation. Diabetes (2013) 0.99

Interaction between mitochondria and the endoplasmic reticulum: implications for the pathogenesis of type 2 diabetes mellitus. Exp Diabetes Res (2011) 0.96

Acute hypoxia induces apoptosis of pancreatic β-cell by activation of the unfolded protein response and upregulation of CHOP. Cell Death Dis (2012) 0.88

Proinsulin misfolding and endoplasmic reticulum stress during the development and progression of diabetes. Mol Aspects Med (2015) 0.88

Valproate pretreatment protects pancreatic β-cells from palmitate-induced ER stress and apoptosis by inhibiting glycogen synthase kinase-3β. J Biomed Sci (2014) 0.83

Altered metabolic signature in pre-diabetic NOD mice. PLoS One (2012) 0.83

High glucose exposure promotes activation of protein phosphatase 2A in rodent islets and INS-1 832/13 β-cells by increasing the posttranslational carboxylmethylation of its catalytic subunit. Endocrinology (2013) 0.80

Cdc37/Hsp90 protein-mediated regulation of IRE1α protein activity in endoplasmic reticulum stress response and insulin synthesis in INS-1 cells. J Biol Chem (2011) 0.79

Deletion of the fission yeast homologue of human insulinase reveals a TORC1-dependent pathway mediating resistance to proteotoxic stress. PLoS One (2013) 0.77

Impaired oxidative endoplasmic reticulum stress response caused by deficiency of thyroid hormone receptor α. J Biol Chem (2014) 0.77

Congenital central diabetes insipidus and optic atrophy in a Wolfram newborn: is there a role for WFS1 gene in neurodevelopment? Ital J Pediatr (2014) 0.76

Fetal hyperglycemia and a high-fat diet contribute to aberrant glucose tolerance and hematopoiesis in adult rats. Pediatr Res (2014) 0.76

Role of IRE1α/XBP-1 in Cystic Fibrosis Airway Inflammation. Int J Mol Sci (2017) 0.75

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature (2002) 16.52

FGF-21 as a novel metabolic regulator. J Clin Invest (2005) 10.69

Autophagy is activated for cell survival after endoplasmic reticulum stress. Mol Cell Biol (2006) 8.89

Transcriptional and translational control in the Mammalian unfolded protein response. Annu Rev Cell Dev Biol (2002) 6.48

Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1. Cell Metab (2006) 4.11

Pnpla3I148M knockin mice accumulate PNPLA3 on lipid droplets and develop hepatic steatosis. Hepatology (2014) 4.01

Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells. Nat Med (2011) 3.31

Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones. J Cell Sci (2004) 3.31

Fibroblast growth factor-21 improves pancreatic beta-cell function and survival by activation of extracellular signal-regulated kinase 1/2 and Akt signaling pathways. Diabetes (2006) 3.02

Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasome. Cell Metab (2012) 2.39

Requirement of inositol pyrophosphates for full exocytotic capacity in pancreatic beta cells. Science (2007) 2.36

Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK-SIRT1-PGC-1alpha pathway. Proc Natl Acad Sci U S A (2010) 2.27

WFS1 is a novel component of the unfolded protein response and maintains homeostasis of the endoplasmic reticulum in pancreatic beta-cells. J Biol Chem (2005) 2.25

Role of incretin hormones in the regulation of insulin secretion in diabetic and nondiabetic humans. Am J Physiol Endocrinol Metab (2004) 2.23

Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells. J Clin Invest (2010) 2.22

Beta-cell secretory products activate alpha-cell ATP-dependent potassium channels to inhibit glucagon release. Diabetes (2005) 2.04

Endoplasmic reticulum stress and pancreatic β-cell death. Trends Endocrinol Metab (2011) 2.01

Mice lacking ANGPTL8 (Betatrophin) manifest disrupted triglyceride metabolism without impaired glucose homeostasis. Proc Natl Acad Sci U S A (2013) 1.96

The role of IRE1alpha in the degradation of insulin mRNA in pancreatic beta-cells. PLoS One (2008) 1.95

Hepatic and glucagon-like peptide-1-mediated reversal of diabetes by glucagon receptor antisense oligonucleotide inhibitors. J Clin Invest (2004) 1.93

Sulfonylurea receptor type 1 knock-out mice have intact feeding-stimulated insulin secretion despite marked impairment in their response to glucose. J Biol Chem (2002) 1.85

The Cell Physiology of Biphasic Insulin Secretion. News Physiol Sci (2000) 1.83

Measuring ER stress and the unfolded protein response using mammalian tissue culture system. Methods Enzymol (2011) 1.80

A novel glucokinase activator modulates pancreatic islet and hepatocyte function. Endocrinology (2005) 1.75

Glucose inhibition of glucagon secretion from rat alpha-cells is mediated by GABA released from neighboring beta-cells. Diabetes (2004) 1.73

SUR1 regulates PKA-independent cAMP-induced granule priming in mouse pancreatic B-cells. J Gen Physiol (2003) 1.68

Position-dependent FUS-RNA interactions regulate alternative splicing events and transcriptions. Sci Rep (2012) 1.58

Transcriptional regulation of VEGF-A by the unfolded protein response pathway. PLoS One (2010) 1.52

Wnt3a-induced mesoderm formation and cardiomyogenesis in human embryonic stem cells. Stem Cells (2009) 1.48

Fluoride induces endoplasmic reticulum stress in ameloblasts responsible for dental enamel formation. J Biol Chem (2005) 1.42

Endoplasmic reticulum stress in beta-cells and development of diabetes. Curr Opin Pharmacol (2009) 1.41

The binary switch that controls the life and death decisions of ER stressed β cells. Curr Opin Cell Biol (2010) 1.41

Glucose stimulates glucagon release in single rat alpha-cells by mechanisms that mirror the stimulus-secretion coupling in beta-cells. Endocrinology (2005) 1.35

Regulated exocytosis of GABA-containing synaptic-like microvesicles in pancreatic beta-cells. J Gen Physiol (2004) 1.31

The role of nitric oxide and the unfolded protein response in cytokine-induced beta-cell death. Diabetes (2007) 1.28

AIP1 is critical in transducing IRE1-mediated endoplasmic reticulum stress response. J Biol Chem (2008) 1.27

Liver X receptor activation stimulates insulin secretion via modulation of glucose and lipid metabolism in pancreatic beta-cells. Diabetes (2004) 1.25

Removal of Ca2+ channel beta3 subunit enhances Ca2+ oscillation frequency and insulin exocytosis. Cell (2004) 1.22

The IRE1α-XBP1 pathway is essential for osteoblast differentiation through promoting transcription of Osterix. EMBO Rep (2011) 1.21

Phosphatidylinositol 4-kinase serves as a metabolic sensor and regulates priming of secretory granules in pancreatic beta cells. Proc Natl Acad Sci U S A (2003) 1.20

Retracted Wolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion. Nat Cell Biol (2012) 1.20

ER stress as a trigger for β-cell dysfunction and autoimmunity in type 1 diabetes. Diabetes (2012) 1.19

Tomosyn is expressed in beta-cells and negatively regulates insulin exocytosis. Diabetes (2006) 1.17

Cdc42 and Rac1 are major contributors to the saturated fatty acid-stimulated JNK pathway in hepatocytes. J Hepatol (2011) 1.16

Inositol hexakisphosphate promotes dynamin I- mediated endocytosis. Proc Natl Acad Sci U S A (2002) 1.14

XBP1 activates the transcription of its target genes via an ACGT core sequence under ER stress. Biochem Biophys Res Commun (2005) 1.10

High ER stress in beta-cells stimulates intracellular degradation of misfolded insulin. Biochem Biophys Res Commun (2004) 1.09

Glucagon stimulates exocytosis in mouse and rat pancreatic alpha-cells by binding to glucagon receptors. Mol Endocrinol (2004) 1.06

Endoplasmic reticulum stress-induced apoptosis and auto-immunity in diabetes. Curr Mol Med (2006) 1.05

Cytoplasmic polyadenylation element binding protein deficiency stimulates PTEN and Stat3 mRNA translation and induces hepatic insulin resistance. PLoS Genet (2012) 1.03

Cyclin-dependent kinase 5 associated with p39 promotes Munc18-1 phosphorylation and Ca(2+)-dependent exocytosis. J Biol Chem (2004) 1.02

IRE1-dependent activation of AMPK in response to nitric oxide. Mol Cell Biol (2011) 1.00

The binary switch between life and death of endoplasmic reticulum-stressed beta cells. Curr Opin Endocrinol Diabetes Obes (2010) 0.99

Increase in cellular glutamate levels stimulates exocytosis in pancreatic beta-cells. FEBS Lett (2002) 0.99

GABAB receptor activation inhibits exocytosis in rat pancreatic beta-cells by G-protein-dependent activation of calcineurin. J Physiol (2004) 0.99

Autosomal dominant diabetes arising from a Wolfram syndrome 1 mutation. Diabetes (2013) 0.99

Activation of liver X receptors and retinoid X receptors induces growth arrest and apoptosis in insulin-secreting cells. Endocrinology (2006) 0.97

Calcium efflux from the endoplasmic reticulum leads to β-cell death. Endocrinology (2013) 0.97

FUS/TLS assembles into stress granules and is a prosurvival factor during hyperosmolar stress. J Cell Physiol (2013) 0.96

Sterol regulatory element-binding protein 1 mediates liver X receptor-beta-induced increases in insulin secretion and insulin messenger ribonucleic acid levels. Endocrinology (2006) 0.95

Rapid association of protein kinase C-epsilon with insulin granules is essential for insulin exocytosis. J Biol Chem (2003) 0.95

Endoplasmic reticulum stress signaling in pancreatic beta-cells. Antioxid Redox Signal (2007) 0.95

A novel role for the centrosomal protein, pericentrin, in regulation of insulin secretory vesicle docking in mouse pancreatic beta-cells. PLoS One (2010) 0.89

Pathological endoplasmic reticulum stress mediated by the IRE1 pathway contributes to pre-insulitic beta cell apoptosis in a virus-induced rat model of type 1 diabetes. Diabetologia (2013) 0.89

Valproate, a mood stabilizer, induces WFS1 expression and modulates its interaction with ER stress protein GRP94. PLoS One (2009) 0.88

cPLA2alpha-evoked formation of arachidonic acid and lysophospholipids is required for exocytosis in mouse pancreatic beta-cells. Am J Physiol Endocrinol Metab (2003) 0.86

Imidazoline NNC77-0074 stimulates Ca2+-evoked exocytosis in INS-1E cells by a phospholipase A2-dependent mechanism. Biochem Biophys Res Commun (2003) 0.85

Atrial natriuretic peptide regulates lipid mobilization and oxygen consumption in human adipocytes by activating AMPK. Biochem Biophys Res Commun (2011) 0.85

Sulfatide controls insulin secretion by modulation of ATP-sensitive K(+)-channel activity and Ca(2+)-dependent exocytosis in rat pancreatic beta-cells. Diabetes (2002) 0.85

C16:0 sulfatide inhibits insulin secretion in rat beta-cells by reducing the sensitivity of KATP channels to ATP inhibition. Diabetes (2006) 0.85

Dorfin-CHIP chimeric proteins potently ubiquitylate and degrade familial ALS-related mutant SOD1 proteins and reduce their cellular toxicity. Neurobiol Dis (2006) 0.83

Imidazoline NNC77-0074 stimulates insulin secretion and inhibits glucagon release by control of Ca(2+)-dependent exocytosis in pancreatic alpha- and beta-cells. Eur J Pharmacol (2003) 0.82

A case of intra-abdominal desmoplastic small-round-cell tumor with elevated serum CA125. Pediatr Surg Int (2002) 0.82

The PDZ/coiled-coil domain containing protein PIST modulates insulin secretion in MIN6 insulinoma cells by interacting with somatostatin receptor subtype 5. FEBS Lett (2005) 0.81

Involvement of protein kinase C-epsilon in inositol hexakisphosphate-induced exocytosis in mouse pancreatic beta-cells. J Biol Chem (2003) 0.81

KLF15 is a molecular link between endoplasmic reticulum stress and insulin resistance. PLoS One (2013) 0.81

Protein kinase C signaling during T cell activation induces the endoplasmic reticulum stress response. Cell Stress Chaperones (2008) 0.80

Islet cell hyperplasia in transgenic mice overexpressing EAT/mcl-1, a bcl-2 related gene. Mol Cell Endocrinol (2003) 0.80

Cevoglitazar, a novel peroxisome proliferator-activated receptor-alpha/gamma dual agonist, potently reduces food intake and body weight in obese mice and cynomolgus monkeys. Endocrinology (2010) 0.80

Squamous metaplasia in the cyst epithelium of type 1 congenital pulmonary airway malformation after thoracoamniotic shunt placement. Hum Pathol (2012) 0.80

Secretory phospholipase A2 is released from pancreatic beta-cells and stimulates insulin secretion via inhibition of ATP-dependent K+ channels. Biochem Biophys Res Commun (2003) 0.79

Establishment of a system for monitoring endoplasmic reticulum redox state in mammalian cells. Lab Invest (2013) 0.79

c-Abl inhibition delays motor neuron degeneration in the G93A mouse, an animal model of amyotrophic lateral sclerosis. PLoS One (2012) 0.79

Lack of matrix metalloproteinase (MMP)-1 and -3 expression in Ewing sarcoma may be due to loss of accessibility of the MMP regulatory element to the specific fusion protein in vivo. Biochem Biophys Res Commun (2002) 0.79

The IRE1α-XBP1 pathway positively regulates parathyroid hormone (PTH)/PTH-related peptide receptor expression and is involved in pth-induced osteoclastogenesis. J Biol Chem (2012) 0.78

Transmission of proteotoxicity across cellular compartments. Genes Dev (2002) 0.78

Characterization of a novel, brain-penetrating CB1 receptor inverse agonist: metabolic profile in diet-induced obese models and aspects of central activity. Naunyn Schmiedebergs Arch Pharmacol (2011) 0.78

Heat shock protein 90 (HSP90) inhibitors activate the heat shock factor 1 (HSF1) stress response pathway and improve glucose regulation in diabetic mice. Biochem Biophys Res Commun (2012) 0.77

Establishment and characterization of a clonal human extraskeletal Ewing's sarcoma cell line, EES1. Tohoku J Exp Med (2006) 0.77

Endoplasmic reticulum: an interface between the immune system and metabolism. Diabetes (2014) 0.75

Rpl13a small nucleolar RNAs regulate systemic glucose metabolism. J Clin Invest (2016) 0.75

Research resource: Monitoring endoplasmic reticulum membrane integrity in β-cells at the single-cell level. Mol Endocrinol (2015) 0.75

[ER stress and β cell death - therapeutic approach to combat ER stress]. Nihon Yakurigaku Zasshi (2014) 0.75

The imidazoline NNC77-0020 affects glucose-dependent insulin, glucagon and somatostatin secretion in mouse pancreatic islets. Naunyn Schmiedebergs Arch Pharmacol (2003) 0.75