Published in Lab Invest on September 16, 2013
The ATF6 pathway of the ER stress response contributes to enhanced viability in glioblastoma. Oncotarget (2016) 0.87
IRE1 prevents endoplasmic reticulum membrane permeabilization and cell death under pathological conditions. Sci Signal (2015) 0.79
Research resource: Monitoring endoplasmic reticulum membrane integrity in β-cells at the single-cell level. Mol Endocrinol (2015) 0.75
Mutation in GNE Downregulates Peroxiredoxin IV Altering ER Redox Homeostasis. Neuromolecular Med (2017) 0.75
The unfolded protein response: from stress pathway to homeostatic regulation. Science (2011) 15.71
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science (2006) 13.91
Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell (2010) 10.96
Investigating mitochondrial redox potential with redox-sensitive green fluorescent protein indicators. J Biol Chem (2004) 5.26
Oxidative protein folding in eukaryotes: mechanisms and consequences. J Cell Biol (2004) 4.96
Imaging dynamic redox changes in mammalian cells with green fluorescent protein indicators. J Biol Chem (2004) 4.75
The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes. Endocr Rev (2008) 3.56
Real-time redox measurements during endoplasmic reticulum stress reveal interlinked protein folding functions. Cell (2008) 2.53
Oxidative protein folding by an endoplasmic reticulum-localized peroxiredoxin. Mol Cell (2010) 2.51
WFS1 is a novel component of the unfolded protein response and maintains homeostasis of the endoplasmic reticulum in pancreatic beta-cells. J Biol Chem (2005) 2.25
ERO1-L, a human protein that favors disulfide bond formation in the endoplasmic reticulum. J Biol Chem (2000) 2.24
Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells. J Clin Invest (2010) 2.22
Role of endoplasmic reticulum stress in metabolic disease and other disorders. Annu Rev Med (2012) 1.98
Endoplasmic reticulum stress and atherosclerosis. Nat Med (2010) 1.78
The binary switch that controls the life and death decisions of ER stressed β cells. Curr Opin Cell Biol (2010) 1.41
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature (2002) 16.52
Autophagy is activated for cell survival after endoplasmic reticulum stress. Mol Cell Biol (2006) 8.89
Transcriptional and translational control in the Mammalian unfolded protein response. Annu Rev Cell Dev Biol (2002) 6.48
IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates. Cell (2009) 4.65
Intracellular signaling by the unfolded protein response. Annu Rev Cell Dev Biol (2006) 4.55
On the mechanism of sensing unfolded protein in the endoplasmic reticulum. Proc Natl Acad Sci U S A (2005) 4.25
Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1. Cell Metab (2006) 4.11
Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones. J Cell Sci (2004) 3.31
IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress. Cell Metab (2012) 2.80
Real-time redox measurements during endoplasmic reticulum stress reveal interlinked protein folding functions. Cell (2008) 2.53
Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasome. Cell Metab (2012) 2.39
IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2. Science (2012) 2.25
WFS1 is a novel component of the unfolded protein response and maintains homeostasis of the endoplasmic reticulum in pancreatic beta-cells. J Biol Chem (2005) 2.25
Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells. J Clin Invest (2010) 2.22
Endoplasmic reticulum stress and pancreatic β-cell death. Trends Endocrinol Metab (2011) 2.01
The role of IRE1alpha in the degradation of insulin mRNA in pancreatic beta-cells. PLoS One (2008) 1.95
Signaling cell death from the endoplasmic reticulum stress response. Curr Opin Cell Biol (2010) 1.81
Measuring ER stress and the unfolded protein response using mammalian tissue culture system. Methods Enzymol (2011) 1.80
Caspase-2 cleavage of BID is a critical apoptotic signal downstream of endoplasmic reticulum stress. Mol Cell Biol (2008) 1.75
Differential expression of inflammation- and apoptosis-related genes in spinal cords of a mutant SOD1 transgenic mouse model of familial amyotrophic lateral sclerosis. J Neurochem (2002) 1.63
Gene expression profile of spinal motor neurons in sporadic amyotrophic lateral sclerosis. Ann Neurol (2005) 1.59
Position-dependent FUS-RNA interactions regulate alternative splicing events and transcriptions. Sci Rep (2012) 1.58
Disulfide bond mediates aggregation, toxicity, and ubiquitylation of familial amyotrophic lateral sclerosis-linked mutant SOD1. J Biol Chem (2007) 1.57
Transcriptional regulation of VEGF-A by the unfolded protein response pathway. PLoS One (2010) 1.52
X-box binding protein 1 (XBP1s) is a critical determinant of Pseudomonas aeruginosa homoserine lactone-mediated apoptosis. PLoS Pathog (2013) 1.50
A kinase inhibitor activates the IRE1alpha RNase to confer cytoprotection against ER stress. Biochem Biophys Res Commun (2007) 1.50
Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors. Nat Chem Biol (2012) 1.46
Fluoride induces endoplasmic reticulum stress in ameloblasts responsible for dental enamel formation. J Biol Chem (2005) 1.42
Endoplasmic reticulum stress in beta-cells and development of diabetes. Curr Opin Pharmacol (2009) 1.41
The binary switch that controls the life and death decisions of ER stressed β cells. Curr Opin Cell Biol (2010) 1.41
The UPR and cell fate at a glance. J Cell Sci (2010) 1.30
The role of endoplasmic reticulum stress in human pathology. Annu Rev Pathol (2014) 1.29
The role of nitric oxide and the unfolded protein response in cytokine-induced beta-cell death. Diabetes (2007) 1.28
AIP1 is critical in transducing IRE1-mediated endoplasmic reticulum stress response. J Biol Chem (2008) 1.27
The IRE1α-XBP1 pathway is essential for osteoblast differentiation through promoting transcription of Osterix. EMBO Rep (2011) 1.21
Retracted Wolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion. Nat Cell Biol (2012) 1.20
Dorfin ubiquitylates mutant SOD1 and prevents mutant SOD1-mediated neurotoxicity. J Biol Chem (2002) 1.19
ER stress as a trigger for β-cell dysfunction and autoimmunity in type 1 diabetes. Diabetes (2012) 1.19
Cdc42 and Rac1 are major contributors to the saturated fatty acid-stimulated JNK pathway in hepatocytes. J Hepatol (2011) 1.16
XBP1 activates the transcription of its target genes via an ACGT core sequence under ER stress. Biochem Biophys Res Commun (2005) 1.10
High ER stress in beta-cells stimulates intracellular degradation of misfolded insulin. Biochem Biophys Res Commun (2004) 1.09
Endoplasmic reticulum stress-induced apoptosis and auto-immunity in diabetes. Curr Mol Med (2006) 1.05
Loss of TDP-43 causes age-dependent progressive motor neuron degeneration. Brain (2013) 1.05
Spontaneous development of endoplasmic reticulum stress that can lead to diabetes mellitus is associated with higher calcium-independent phospholipase A2 expression: a role for regulation by SREBP-1. J Biol Chem (2009) 1.05
Cytoplasmic polyadenylation element binding protein deficiency stimulates PTEN and Stat3 mRNA translation and induces hepatic insulin resistance. PLoS Genet (2012) 1.03
Mitochondrial localization of mutant superoxide dismutase 1 triggers caspase-dependent cell death in a cellular model of familial amyotrophic lateral sclerosis. J Biol Chem (2002) 1.03
Rationalizing translation attenuation in the network architecture of the unfolded protein response. Proc Natl Acad Sci U S A (2008) 1.02
Stress hypERactivation in the β-cell. Islets (2010) 1.01
IRE1-dependent activation of AMPK in response to nitric oxide. Mol Cell Biol (2011) 1.00
The binary switch between life and death of endoplasmic reticulum-stressed beta cells. Curr Opin Endocrinol Diabetes Obes (2010) 0.99
Oxidative stress induced by glutathione depletion reproduces pathological modifications of TDP-43 linked to TDP-43 proteinopathies. Neurobiol Dis (2011) 0.99
Autosomal dominant diabetes arising from a Wolfram syndrome 1 mutation. Diabetes (2013) 0.99
Calcium efflux from the endoplasmic reticulum leads to β-cell death. Endocrinology (2013) 0.97
FUS/TLS assembles into stress granules and is a prosurvival factor during hyperosmolar stress. J Cell Physiol (2013) 0.96
Dorfin localizes to Lewy bodies and ubiquitylates synphilin-1. J Biol Chem (2003) 0.95
Endoplasmic reticulum stress signaling in pancreatic beta-cells. Antioxid Redox Signal (2007) 0.95
Naratriptan mitigates CGRP1-associated motor neuron degeneration caused by an expanded polyglutamine repeat tract. Nat Med (2012) 0.91
Disruption of axonal transport in motor neuron diseases. Int J Mol Sci (2012) 0.89
Amyotrophic lateral sclerosis: an update on recent genetic insights. J Neurol (2013) 0.89
A novel role for the centrosomal protein, pericentrin, in regulation of insulin secretory vesicle docking in mouse pancreatic beta-cells. PLoS One (2010) 0.89
Pathological endoplasmic reticulum stress mediated by the IRE1 pathway contributes to pre-insulitic beta cell apoptosis in a virus-induced rat model of type 1 diabetes. Diabetologia (2013) 0.89
Heat shock factor-1 influences pathological lesion distribution of polyglutamine-induced neurodegeneration. Nat Commun (2013) 0.88
Valproate, a mood stabilizer, induces WFS1 expression and modulates its interaction with ER stress protein GRP94. PLoS One (2009) 0.88
Dorfin prevents cell death by reducing mitochondrial localizing mutant superoxide dismutase 1 in a neuronal cell model of familial amyotrophic lateral sclerosis. J Neurochem (2004) 0.86
FUS-regulated region- and cell-type-specific transcriptome is associated with cell selectivity in ALS/FTLD. Sci Rep (2013) 0.85
Gene expressions specifically detected in motor neurons (dynactin 1, early growth response 3, acetyl-CoA transporter, death receptor 5, and cyclin C) differentially correlate to pathologic markers in sporadic amyotrophic lateral sclerosis. J Neuropathol Exp Neurol (2007) 0.84
The ALS/FTLD-related RNA-binding proteins TDP-43 and FUS have common downstream RNA targets in cortical neurons. FEBS Open Bio (2013) 0.83
Dorfin-CHIP chimeric proteins potently ubiquitylate and degrade familial ALS-related mutant SOD1 proteins and reduce their cellular toxicity. Neurobiol Dis (2006) 0.83
A case of intra-abdominal desmoplastic small-round-cell tumor with elevated serum CA125. Pediatr Surg Int (2002) 0.82
Dorfin ameliorates phenotypes in a transgenic mouse model of amyotrophic lateral sclerosis. J Neurosci Res (2010) 0.82
Cleaved cytokeratin-18 is a mechanistically informative biomarker in idiopathic pulmonary fibrosis. Respir Res (2012) 0.81
KLF15 is a molecular link between endoplasmic reticulum stress and insulin resistance. PLoS One (2013) 0.81
Dorfin localizes to the ubiquitylated inclusions in Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, and amyotrophic lateral sclerosis. Am J Pathol (2003) 0.81
Gene expression profiling toward understanding of ALS pathogenesis. Ann N Y Acad Sci (2006) 0.81
Islet cell hyperplasia in transgenic mice overexpressing EAT/mcl-1, a bcl-2 related gene. Mol Cell Endocrinol (2003) 0.80
Squamous metaplasia in the cyst epithelium of type 1 congenital pulmonary airway malformation after thoracoamniotic shunt placement. Hum Pathol (2012) 0.80
The principal PINK1 and Parkin cellular events triggered in response to dissipation of mitochondrial membrane potential occur in primary neurons. Genes Cells (2013) 0.80
Protein kinase C signaling during T cell activation induces the endoplasmic reticulum stress response. Cell Stress Chaperones (2008) 0.80
RNP2 of RNA recognition motif 1 plays a central role in the aberrant modification of TDP-43. PLoS One (2013) 0.79
Lack of matrix metalloproteinase (MMP)-1 and -3 expression in Ewing sarcoma may be due to loss of accessibility of the MMP regulatory element to the specific fusion protein in vivo. Biochem Biophys Res Commun (2002) 0.79
c-Abl inhibition delays motor neuron degeneration in the G93A mouse, an animal model of amyotrophic lateral sclerosis. PLoS One (2012) 0.79
Transmission of proteotoxicity across cellular compartments. Genes Dev (2002) 0.78
The IRE1α-XBP1 pathway positively regulates parathyroid hormone (PTH)/PTH-related peptide receptor expression and is involved in pth-induced osteoclastogenesis. J Biol Chem (2012) 0.78
Establishment and characterization of a clonal human extraskeletal Ewing's sarcoma cell line, EES1. Tohoku J Exp Med (2006) 0.77
Caspase-1 and -3 mRNAs are differentially upregulated in motor neurons and glial cells in mutant SOD1 transgenic mouse spinal cord: a study using laser microdissection and real-time RT-PCR. Neurochem Res (2003) 0.77
Targeting ABL-IRE1α Signaling Spares ER-Stressed Pancreatic β Cells to Reverse Autoimmune Diabetes. Cell Metab (2017) 0.75
Correction: X-Box Binding Protein 1 (XBP1s) Is a Critical Determinant of Pseudomonas aeruginosa Homoserine Lactone-Mediated Apoptosis. PLoS Pathog (2016) 0.75
Rpl13a small nucleolar RNAs regulate systemic glucose metabolism. J Clin Invest (2016) 0.75
Research resource: Monitoring endoplasmic reticulum membrane integrity in β-cells at the single-cell level. Mol Endocrinol (2015) 0.75
Archaeal proteasomes effectively degrade aggregation-prone proteins and reduce cellular toxicities in mammalian cells. J Biol Chem (2006) 0.75
Endoplasmic reticulum: an interface between the immune system and metabolism. Diabetes (2014) 0.75
Mitochondrial localization of mutant superoxide dismutase 1 triggers caspase-dependent cell death in a cellular model of familial amyotrophic lateral sclerosis. J Biol Chem (2016) 0.75
Gene Expression Profile of Inflammatory Myopathy with Malignancy is Similar to that of Dermatomyositis rather than Polymyositis. Intern Med (2016) 0.75