Published in J Hum Genet on December 02, 2010
Polymorphism of ABCB1/MDR1 C3435T in children and adolescents with partial epilepsy is due to different criteria for drug resistance - preliminary results. Med Sci Monit (2014) 0.80
Benzodiazepine-associated hepatic encephalopathy significantly increased healthcare utilization and medical costs of Chinese cirrhotic patients: 7-year experience. Dig Dis Sci (2014) 0.75
Missing heritability and strategies for finding the underlying causes of complex disease. Nat Rev Genet (2010) 14.81
A high-density admixture map for disease gene discovery in african americans. Am J Hum Genet (2004) 10.87
The genetic structure and history of Africans and African Americans. Science (2009) 10.65
Multifactor dimensionality reduction software for detecting gene-gene and gene-environment interactions. Bioinformatics (2003) 9.91
Characterization of microRNA expression levels and their biological correlates in human cancer cell lines. Cancer Res (2007) 6.57
Power of multifactor dimensionality reduction for detecting gene-gene interactions in the presence of genotyping error, missing data, phenocopy, and genetic heterogeneity. Genet Epidemiol (2003) 6.31
A balanced accuracy function for epistasis modeling in imbalanced datasets using multifactor dimensionality reduction. Genet Epidemiol (2007) 4.15
Proteomic patterns of tumour subsets in non-small-cell lung cancer. Lancet (2003) 4.01
Genetics, statistics and human disease: analytical retooling for complexity. Trends Genet (2004) 3.35
Whole genome association study of brain-wide imaging phenotypes for identifying quantitative trait loci in MCI and AD: A study of the ADNI cohort. Neuroimage (2010) 3.27
Renin-angiotensin system gene polymorphisms and atrial fibrillation. Circulation (2004) 3.02
Breast cancer risk-associated SNPs modulate the affinity of chromatin for FOXA1 and alter gene expression. Nat Genet (2012) 2.86
Alzheimer's Disease Neuroimaging Initiative biomarkers as quantitative phenotypes: Genetics core aims, progress, and plans. Alzheimers Dement (2010) 2.79
Failure to replicate a genetic association may provide important clues about genetic architecture. PLoS One (2009) 2.72
A global view of epistasis. Nat Genet (2005) 2.71
Machine learning for detecting gene-gene interactions: a review. Appl Bioinformatics (2006) 2.56
Optimization of neural network architecture using genetic programming improves detection and modeling of gene-gene interactions in studies of human diseases. BMC Bioinformatics (2003) 2.47
Chapter 11: Genome-wide association studies. PLoS Comput Biol (2012) 2.46
Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia. Nat Genet (2012) 2.26
Sudden deafness and anterior inferior cerebellar artery infarction. Stroke (2002) 2.18
Epigenomic enhancer profiling defines a signature of colon cancer. Science (2012) 2.15
Genetic basis for adverse events after smallpox vaccination. J Infect Dis (2008) 2.09
Concordance of multiple analytical approaches demonstrates a complex relationship between DNA repair gene SNPs, smoking and bladder cancer susceptibility. Carcinogenesis (2005) 2.08
Proteomic-based prognosis of brain tumor patients using direct-tissue matrix-assisted laser desorption ionization mass spectrometry. Cancer Res (2005) 2.06
Elevated male European and female African contributions to the genomes of African American individuals. Hum Genet (2006) 1.97
An application of conditional logistic regression and multifactor dimensionality reduction for detecting gene-gene interactions on risk of myocardial infarction: the importance of model validation. BMC Bioinformatics (2004) 1.95
Pathway analysis of genomic data: concepts, methods, and prospects for future development. Trends Genet (2012) 1.86
Shadows of complexity: what biological networks reveal about epistasis and pleiotropy. Bioessays (2009) 1.82
Multilocus analysis of hypertension: a hierarchical approach. Hum Hered (2004) 1.82
A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. Nat Genet (2013) 1.82
Ideal discrimination of discrete clinical endpoints using multilocus genotypes. In Silico Biol (2004) 1.81
Recurrent tissue-specific mtDNA mutations are common in humans. PLoS Genet (2013) 1.77
No-boundary thinking in bioinformatics research. BioData Min (2013) 1.76
Multifactor dimensionality reduction for graphics processing units enables genome-wide testing of epistasis in sporadic ALS. Bioinformatics (2010) 1.76
Spatially uniform relieff (SURF) for computationally-efficient filtering of gene-gene interactions. BioData Min (2009) 1.75
A gene expression fingerprint of C. elegans embryonic motor neurons. BMC Genomics (2005) 1.72
Exploiting the proteome to improve the genome-wide genetic analysis of epistasis in common human diseases. Hum Genet (2008) 1.72
Characterizing genetic interactions in human disease association studies using statistical epistasis networks. BMC Bioinformatics (2011) 1.68
A computationally efficient hypothesis testing method for epistasis analysis using multifactor dimensionality reduction. Genet Epidemiol (2009) 1.61
A case of isolated nodulus infarction presenting as a vestibular neuritis. J Neurol Sci (2004) 1.60
Gut microbial colonisation in premature neonates predicts neonatal sepsis. Arch Dis Child Fetal Neonatal Ed (2012) 1.59
Accelerating epistasis analysis in human genetics with consumer graphics hardware. BMC Res Notes (2009) 1.58
Combinatorial pharmacogenetics. Nat Rev Drug Discov (2005) 1.58
Ecogeographic genetic epidemiology. Genet Epidemiol (2009) 1.57
Genome-wide association analysis of blood-pressure traits in African-ancestry individuals reveals common associated genes in African and non-African populations. Am J Hum Genet (2013) 1.55
Single-nucleotide polymorphisms for diagnosis of salt-sensitive hypertension. Clin Chem (2006) 1.51
Tumour-infiltrating T-cell subpopulations in glioblastomas. Br J Neurosurg (2011) 1.49
Evolving hard problems: Generating human genetics datasets with a complex etiology. BioData Min (2011) 1.47
Next generation analytic tools for large scale genetic epidemiology studies of complex diseases. Genet Epidemiol (2011) 1.47
Renin-angiotensin system gene polymorphisms and coronary artery disease in a large angiographic cohort: detection of high order gene-gene interaction. Atherosclerosis (2006) 1.46
Application of Genetic Algorithms to the Discovery of Complex Models for Simulation Studies in Human Genetics. Proc Genet Evol Comput Conf (2002) 1.46
A system-level pathway-phenotype association analysis using synthetic feature random forest. Genet Epidemiol (2014) 1.46
Genome-wide association study for circulating tissue plasminogen activator levels and functional follow-up implicates endothelial STXBP5 and STX2. Arterioscler Thromb Vasc Biol (2014) 1.45
Interactive effect of obesity indexes on cognition. Dement Geriatr Cogn Disord (2004) 1.44
Bladder cancer SNP panel predicts susceptibility and survival. Hum Genet (2009) 1.43
Risk estimation using probability machines. BioData Min (2014) 1.40
GAMETES: a fast, direct algorithm for generating pure, strict, epistatic models with random architectures. BioData Min (2012) 1.40
The interaction of four genes in the inflammation pathway significantly predicts prostate cancer risk. Cancer Epidemiol Biomarkers Prev (2005) 1.39
Problems with genome-wide association studies. Science (2007) 1.39
Drinking-water arsenic exposure modulates gene expression in human lymphocytes from a U.S. population. Environ Health Perspect (2008) 1.39
Relative impact of CYP3A genotype and concomitant medication on the severity of atorvastatin-induced muscle damage. Pharmacogenet Genomics (2005) 1.38
A training-testing approach to the molecular classification of resected non-small cell lung cancer. Clin Cancer Res (2003) 1.36
Integrative functional genomics identifies an enhancer looping to the SOX9 gene disrupted by the 17q24.3 prostate cancer risk locus. Genome Res (2012) 1.35
Evidence for epistasis between SLC6A4 and ITGB3 in autism etiology and in the determination of platelet serotonin levels. Hum Genet (2007) 1.35
Detecting pathway-based gene-gene and gene-environment interactions in pancreatic cancer. Cancer Epidemiol Biomarkers Prev (2008) 1.33
Genetic Programming Neural Networks: A Powerful Bioinformatics Tool for Human Genetics. Appl Soft Comput (2007) 1.33
Enabling personal genomics with an explicit test of epistasis. Pac Symp Biocomput (2010) 1.33
Cytokine expression patterns associated with systemic adverse events following smallpox immunization. J Infect Dis (2006) 1.29
Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation. Blood (2012) 1.26
DNA repair polymorphisms modify bladder cancer risk: a multi-factor analytic strategy. Hum Hered (2007) 1.25
Genetic analysis of quantitative phenotypes in AD and MCI: imaging, cognition and biomarkers. Brain Imaging Behav (2014) 1.23
Thyroid cancer is the most common cancer in women, based on the data from population-based cancer registries, South Korea. Jpn J Clin Oncol (2013) 1.22
Guillain-Barré syndrome associated with scrub typhus. Scand J Infect Dis (2007) 1.21
A Simple and Computationally Efficient Approach to Multifactor Dimensionality Reduction Analysis of Gene-Gene Interactions for Quantitative Traits. PLoS One (2013) 1.20
Role for protein-protein interaction databases in human genetics. Expert Rev Proteomics (2009) 1.20
An information-gain approach to detecting three-way epistatic interactions in genetic association studies. J Am Med Inform Assoc (2013) 1.19
Cohort Profile: The Namwon Study and the Dong-gu Study. Int J Epidemiol (2013) 1.18
Association between bone mineral densities and serum lipid profiles of pre- and post-menopausal rural women in South Korea. Osteoporos Int (2005) 1.18
Acceleration of cardiovascular disease by a dysfunctional prostacyclin receptor mutation: potential implications for cyclooxygenase-2 inhibition. Circ Res (2008) 1.17
Transcriptional profiling in coronary artery disease: indications for novel markers of coronary collateralization. Circulation (2006) 1.17
Prevalence of osteoporosis and reference data for lumbar spine and hip bone mineral density in a Korean population. J Bone Miner Metab (2008) 1.17
The presence of stem cell marker-expressing cells is not prognostically significant in glioblastomas. Neuropathology (2011) 1.16
Layers of epistasis: genome-wide regulatory networks and network approaches to genome-wide association studies. Wiley Interdiscip Rev Syst Biol Med (2010) 1.15
A novel survival multifactor dimensionality reduction method for detecting gene-gene interactions with application to bladder cancer prognosis. Hum Genet (2010) 1.14
Admixture mapping in lupus identifies multiple functional variants within IFIH1 associated with apoptosis, inflammation, and autoantibody production. PLoS Genet (2013) 1.14
Gene expression signatures for autoimmune disease in peripheral blood mononuclear cells. Arthritis Res Ther (2004) 1.14
(1)H-MRS metabolic patterns for distinguishing between meningiomas and other brain tumors. Magn Reson Imaging (2003) 1.13
Current status of acute stroke management in Korea: a report on a multicenter, comprehensive acute stroke registry. Int J Stroke (2013) 1.13
Inverse relationship between APC gene mutation in gastric adenomas and development of adenocarcinoma. Am J Pathol (2002) 1.12
Integrated analysis of genetic, genomic and proteomic data. Expert Rev Proteomics (2004) 1.12
Reporting of model validation procedures in human studies of genetic interactions. Nutrition (2004) 1.12
Relative contribution of body composition to bone mineral density at different sites in men and women of South Korea. J Bone Miner Metab (2007) 1.09
Ability of epistatic interactions of cytokine single-nucleotide polymorphisms to predict susceptibility to disease subsets in systemic sclerosis patients. Arthritis Rheum (2008) 1.09
Impaired differentiation and cytotoxicity of natural killer cells in systemic lupus erythematosus. Arthritis Rheum (2009) 1.07
A robust multifactor dimensionality reduction method for detecting gene-gene interactions with application to the genetic analysis of bladder cancer susceptibility. Ann Hum Genet (2010) 1.07
The gender-specific role of polymorphisms from the fibrinolytic, renin-angiotensin, and bradykinin systems in determining plasma t-PA and PAI-1 levels. Thromb Haemost (2006) 1.06
Effect of cardiopulmonary bypass on urea cycle intermediates and nitric oxide levels after congenital heart surgery. J Pediatr (2003) 1.05
Big data bioinformatics. J Cell Physiol (2014) 1.04
Exploratory visual analysis of pharmacogenomic results. Pac Symp Biocomput (2005) 1.04
The role of pentraxin-3 as a prognostic biomarker in paraquat poisoning. Toxicol Lett (2011) 1.02