Published in PLoS Genet on November 24, 2010
Histone methylation: a dynamic mark in health, disease and inheritance. Nat Rev Genet (2012) 5.42
Histone lysine demethylase JARID1a activates CLOCK-BMAL1 and influences the circadian clock. Science (2011) 2.28
Jarid1b targets genes regulating development and is involved in neural differentiation. EMBO J (2011) 1.50
Epigenetic regulation of ageing: linking environmental inputs to genomic stability. Nat Rev Mol Cell Biol (2015) 1.24
Histone methylation makes its mark on longevity. Trends Cell Biol (2011) 1.21
KDM2B promotes pancreatic cancer via Polycomb-dependent and -independent transcriptional programs. J Clin Invest (2013) 1.21
Therapeutic strategies to inhibit MYC. Cold Spring Harb Perspect Med (2014) 1.19
Aging and reprogramming: a two-way street. Curr Opin Cell Biol (2012) 1.14
Histone demethylase RBP2 is critical for breast cancer progression and metastasis. Cell Rep (2014) 1.04
Histone demethylase KDM5B collaborates with TFAP2C and Myc to repress the cell cycle inhibitor p21(cip) (CDKN1A). Mol Cell Biol (2012) 0.98
Transcriptional and epigenetic regulation of autophagy in aging. Autophagy (2015) 0.97
Selective targeting of histone methylation. Cell Cycle (2011) 0.92
Histone demethylase KDM5A is regulated by its reader domain through a positive-feedback mechanism. Nat Commun (2015) 0.90
dKDM5/LID regulates H3K4me3 dynamics at the transcription-start site (TSS) of actively transcribed developmental genes. Nucleic Acids Res (2012) 0.90
The PHD1 finger of KDM5B recognizes unmodified H3K4 during the demethylation of histone H3K4me2/3 by KDM5B. Protein Cell (2014) 0.89
Histone recognition and nuclear receptor co-activator functions of Drosophila cara mitad, a homolog of the N-terminal portion of mammalian MLL2 and MLL3. Development (2012) 0.88
Physical and functional interactions between the histone H3K4 demethylase KDM5A and the nucleosome remodeling and deacetylase (NuRD) complex. J Biol Chem (2014) 0.86
The Histone Demethylase KDM5 Activates Gene Expression by Recognizing Chromatin Context through Its PHD Reader Motif. Cell Rep (2015) 0.85
Epigenetics and aging. Sci Adv (2016) 0.84
The Aging Epigenome. Mol Cell (2016) 0.84
SIN3 is critical for stress resistance and modulates adult lifespan. Aging (Albany NY) (2014) 0.83
KDM5 interacts with Foxo to modulate cellular levels of oxidative stress. PLoS Genet (2014) 0.81
Identification of genetic suppressors of the Sin3A knockdown wing phenotype. PLoS One (2012) 0.81
The histone demethylase dKDM5/LID interacts with the SIN3 histone deacetylase complex and shares functional similarities with SIN3. Epigenetics Chromatin (2016) 0.80
KdmB, a Jumonji Histone H3 Demethylase, Regulates Genome-Wide H3K4 Trimethylation and Is Required for Normal Induction of Secondary Metabolism in Aspergillus nidulans. PLoS Genet (2016) 0.78
Disruption of Methionine Metabolism in Drosophila melanogaster Impacts Histone Methylation and Results in Loss of Viability. G3 (Bethesda) (2015) 0.78
Crystallization and preliminary crystallographic analysis of a PHD domain of human JARID1B. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.78
Epigenetic regulator Lid maintains germline stem cells through regulating JAK-STAT signaling pathway activity. Biol Open (2015) 0.77
Early programming of the oocyte epigenome temporally controls late prophase I transcription and chromatin remodelling. Nat Commun (2016) 0.75
Kdm5/Lid Regulates Chromosome Architecture in Meiotic Prophase I Independently of Its Histone Demethylase Activity. PLoS Genet (2016) 0.75
Catalytic-independent roles of UTX-1 in C. elegans development. Worm (2013) 0.75
Pharmacological modulation of histone demethylase activity by a small molecule isolated from subcritical water extracts of Sasa senanensis leaves prolongs the lifespan of Drosophila melanogaster. BMC Complement Altern Med (2012) 0.75
Histone lysine demethylases in Drosophila melanogaster. Fly (Austin) (2015) 0.75
Genomic maps and comparative analysis of histone modifications in human and mouse. Cell (2005) 18.96
Active genes are tri-methylated at K4 of histone H3. Nature (2002) 15.68
How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers. Nat Struct Mol Biol (2007) 10.98
ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression. Nature (2006) 9.30
Histone H3 lysine 4 methylation patterns in higher eukaryotic genes. Nat Cell Biol (2003) 8.82
Methylation of histone H3 Lys 4 in coding regions of active genes. Proc Natl Acad Sci U S A (2002) 7.67
Molecular mechanism of histone H3K4me3 recognition by plant homeodomain of ING2. Nature (2006) 7.52
The PHD finger: implications for chromatin-mediated transcriptional regulation. Trends Biochem Sci (1995) 6.97
The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases. Cell (2007) 6.04
Drosophila myc regulates cellular growth during development. Cell (1999) 5.66
Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells. Cell (2009) 5.26
Myc-binding-site recognition in the human genome is determined by chromatin context. Nat Cell Biol (2006) 4.71
Jarid2 and PRC2, partners in regulating gene expression. Genes Dev (2010) 4.65
JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells. Nature (2010) 4.35
RBP2 belongs to a family of demethylases, specific for tri-and dimethylated lysine 4 on histone 3. Cell (2007) 4.34
The retinoblastoma binding protein RBP2 is an H3K4 demethylase. Cell (2007) 3.79
PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation. Mol Cell (2007) 3.68
The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation. Nature (2007) 3.55
Structural insights into histone demethylation by JMJD2 family members. Cell (2006) 3.37
Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger. Nature (2009) 3.13
Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans. Nature (2010) 2.67
Heterochromatin formation in Drosophila is initiated through active removal of H3K4 methylation by the LSD1 homolog SU(VAR)3-3. Mol Cell (2007) 2.66
The Trithorax group protein Lid is a trimethyl histone H3K4 demethylase required for dMyc-induced cell growth. Genes Dev (2007) 2.57
JARID1B is a histone H3 lysine 4 demethylase up-regulated in prostate cancer. Proc Natl Acad Sci U S A (2007) 2.45
dKDM2 couples histone H2A ubiquitylation to histone H3 demethylation during Polycomb group silencing. Genes Dev (2008) 2.29
The trithorax-group gene in Drosophila little imaginal discs encodes a trimethylated histone H3 Lys4 demethylase. Nat Struct Mol Biol (2007) 2.05
A screen for new trithorax group genes identified little imaginal discs, the Drosophila melanogaster homologue of human retinoblastoma binding protein 2. Genetics (2000) 2.05
The trithorax-group protein Lid is a histone H3 trimethyl-Lys4 demethylase. Nat Struct Mol Biol (2007) 1.99
Genome-wide analysis of the H3K4 histone demethylase RBP2 reveals a transcriptional program controlling differentiation. Mol Cell (2008) 1.93
Mutation of Drosophila Lsd1 disrupts H3-K4 methylation, resulting in tissue-specific defects during development. Curr Biol (2007) 1.83
Histone chaperones ASF1 and NAP1 differentially modulate removal of active histone marks by LID-RPD3 complexes during NOTCH silencing. Mol Cell (2009) 1.70
ARID proteins come in from the desert. Trends Biochem Sci (2000) 1.67
Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway. Mol Cancer (2010) 1.64
Functional analysis of the transcription repressor PLU-1/JARID1B. Mol Cell Biol (2007) 1.57
The H3K4 demethylase lid associates with and inhibits histone deacetylase Rpd3. Mol Cell Biol (2008) 1.47
Histone demethylase KDM5A is an integral part of the core Notch-RBP-J repressor complex. Genes Dev (2010) 1.44
Roles of JUMONJI in mouse embryonic development. Dev Dyn (2005) 1.34
Characterization of Drosophila melanogaster JmjC+N histone demethylases. Nucleic Acids Res (2008) 1.32
The ARID domain of the H3K4 demethylase RBP2 binds to a DNA CCGCCC motif. Nat Struct Mol Biol (2008) 1.28
A Drosophila RNA helicase gene, pitchoune, is required for cell growth and proliferation and is a potential target of d-Myc. Development (1998) 1.26
JmjC enzyme KDM2A is a regulator of rRNA transcription in response to starvation. EMBO J (2010) 1.17
The transcriptional repressor dMnt is a regulator of growth in Drosophila melanogaster. Mol Cell Biol (2005) 1.11
Peroxiredoxin 5 confers protection against oxidative stress and apoptosis and also promotes longevity in Drosophila. Biochem J (2009) 1.10
Drosophila KDM2 is a H3K4me3 demethylase regulating nucleolar organization. BMC Res Notes (2009) 0.86
Myc's broad reach. Genes Dev (2008) 7.56
The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation. Proc Natl Acad Sci U S A (2004) 5.37
c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I. Nat Cell Biol (2005) 4.89
Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1. Genes Dev (2003) 4.73
Myc influences global chromatin structure. EMBO J (2006) 4.71
Genomic binding by the Drosophila Myc, Max, Mad/Mnt transcription factor network. Genes Dev (2003) 4.68
Myc-dependent regulation of ribosomal RNA synthesis during Drosophila development. Nat Cell Biol (2005) 3.80
N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation. Genes Dev (2002) 3.71
Direct activation of RNA polymerase III transcription by c-Myc. Nature (2003) 3.32
Histone sumoylation is associated with transcriptional repression. Proc Natl Acad Sci U S A (2003) 3.18
Hematopoietic stem cell function and survival depend on c-Myc and N-Myc activity. Cell Stem Cell (2008) 2.83
Nmyc plays an essential role during lung development as a dosage-sensitive regulator of progenitor cell proliferation and differentiation. Development (2005) 2.64
The Trithorax group protein Lid is a trimethyl histone H3K4 demethylase required for dMyc-induced cell growth. Genes Dev (2007) 2.57
A nucleolar isoform of the Fbw7 ubiquitin ligase regulates c-Myc and cell size. Curr Biol (2004) 2.45
Tumor suppression and normal aging in mice with constitutively high p53 activity. Genes Dev (2006) 2.35
Histone lysine demethylase JARID1a activates CLOCK-BMAL1 and influences the circadian clock. Science (2011) 2.28
Myc-regulated microRNAs attenuate embryonic stem cell differentiation. EMBO J (2009) 1.94
Quantitative proteomic analysis of Myc oncoprotein function. EMBO J (2002) 1.89
Histone deacetylase 6 binds polyubiquitin through its zinc finger (PAZ domain) and copurifies with deubiquitinating enzymes. Proc Natl Acad Sci U S A (2002) 1.89
Direct regulation of RNA polymerase III transcription by RB, p53 and c-Myc. Cell Cycle (2003) 1.73
dMyc is required for larval growth and endoreplication in Drosophila. Development (2004) 1.69
Changes in H2A.Z occupancy and DNA methylation during B-cell lymphomagenesis. Genome Res (2010) 1.69
Myc-nick: a cytoplasmic cleavage product of Myc that promotes alpha-tubulin acetylation and cell differentiation. Cell (2010) 1.67
N-myc is an essential downstream effector of Shh signaling during both normal and neoplastic cerebellar growth. Cancer Res (2006) 1.64
An overview of MYC and its interactome. Cold Spring Harb Perspect Med (2014) 1.53
The mSin3A chromatin-modifying complex is essential for embryogenesis and T-cell development. Mol Cell Biol (2005) 1.51
N-Myc and the cyclin-dependent kinase inhibitors p18Ink4c and p27Kip1 coordinately regulate cerebellar development. Proc Natl Acad Sci U S A (2006) 1.45
Modulation of T-lymphocyte development, growth and cell size by the Myc antagonist and transcriptional repressor Mad1. EMBO J (2002) 1.36
Abnormalities in cell proliferation and apico-basal cell polarity are separable in Drosophila lgl mutant clones in the developing eye. Dev Biol (2007) 1.33
Myc: a weapon of mass destruction. Cell (2004) 1.29
Myc stimulates B lymphocyte differentiation and amplifies calcium signaling. J Cell Biol (2007) 1.29
The function and regulation of the JARID1 family of histone H3 lysine 4 demethylases: the Myc connection. Cell Cycle (2007) 1.28
Zbtb4 represses transcription of P21CIP1 and controls the cellular response to p53 activation. EMBO J (2008) 1.23
HBP1 and Mad1 repressors bind the Sin3 corepressor PAH2 domain with opposite helical orientations. Nat Struct Mol Biol (2004) 1.22
Gene regulation and epigenetic remodeling in murine embryonic stem cells by c-Myc. PLoS One (2009) 1.20
Myc and Mad bHLHZ domains possess identical DNA-binding specificities but only partially overlapping functions in vivo. Proc Natl Acad Sci U S A (2002) 1.18
Quantitative proteomic analysis of myc-induced apoptosis: a direct role for Myc induction of the mitochondrial chloride ion channel, mtCLIC/CLIC4. J Biol Chem (2005) 1.18
A Myc-Groucho complex integrates EGF and Notch signaling to regulate neural development. Proc Natl Acad Sci U S A (2007) 1.16
Drosophila growth and development in the absence of dMyc and dMnt. Dev Biol (2007) 1.13
The transcriptional repressor dMnt is a regulator of growth in Drosophila melanogaster. Mol Cell Biol (2005) 1.11
A genetic screen for dominant modifiers of a cyclin E hypomorphic mutation identifies novel regulators of S-phase entry in Drosophila. Genetics (2004) 1.07
MAD1 and p27(KIP1) cooperate to promote terminal differentiation of granulocytes and to inhibit Myc expression and cyclin E-CDK2 activity. Mol Cell Biol (2002) 1.07
Quantitative proteomic analysis of chromatin-associated factors. J Am Soc Mass Spectrom (2003) 1.06
N-myc coordinates retinal growth with eye size during mouse development. Genes Dev (2008) 1.03
Identification and characterization of SAP25, a novel component of the mSin3 corepressor complex. Mol Cell Biol (2006) 1.02
Drosophila cyclin E interacts with components of the Brahma complex. EMBO J (2002) 1.00
Premetazoan ancestry of the Myc-Max network. Mol Biol Evol (2011) 0.98
N-myc controls proliferation, morphogenesis, and patterning of the inner ear. J Neurosci (2011) 0.94
Myc-dependent genome instability and lifespan in Drosophila. PLoS One (2013) 0.92
How to make stripes: deciphering the transition from non-periodic to periodic patterns in Drosophila segmentation. Development (2011) 0.88
Stress-induced cleavage of Myc promotes cancer cell survival. Genes Dev (2014) 0.87
Molecular Characteristics in MRI-Classified Group 1 Glioblastoma Multiforme. Front Oncol (2013) 0.87
Functional analysis of the Mad1-mSin3A repressor-corepressor interaction reveals determinants of specificity, affinity, and transcriptional response. Mol Cell Biol (2004) 0.87
Regulation of c-Myc Protein Abundance by a Protein Phosphatase 2A-Glycogen Synthase Kinase 3β-Negative Feedback Pathway. Genes Cancer (2012) 0.85
Post-translational control of Myc function during differentiation. Cell Cycle (2011) 0.85
The Drosophila ubiquitin-specific protease Puffyeye regulates dMyc-mediated growth. Development (2013) 0.81
Metabolomics method to comprehensively analyze amino acids in different domains. Analyst (2015) 0.81
Ratcheting Myc. Cancer Cell (2008) 0.81
Myc in stem cell behaviour: insights from Drosophila. Adv Exp Med Biol (2013) 0.79
An Integrated Genetic-Genomic Approach for the Identification of Novel Cancer Loci in Mice Sensitized to c-Myc-Induced Apoptosis. Genes Cancer (2010) 0.78
Constitutive gray hair in mice induced by melanocyte-specific deletion of c-Myc. Pigment Cell Melanoma Res (2012) 0.78