Published in Nat Cell Biol on March 01, 2005
MYC on the path to cancer. Cell (2012) 8.65
Transcriptional amplification in tumor cells with elevated c-Myc. Cell (2012) 8.24
Myc's broad reach. Genes Dev (2008) 7.56
c-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells. Cell (2012) 6.49
c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma. Genes Dev (2006) 6.19
Global mapping of c-Myc binding sites and target gene networks in human B cells. Proc Natl Acad Sci U S A (2006) 5.27
Myc stimulates nuclearly encoded mitochondrial genes and mitochondrial biogenesis. Mol Cell Biol (2005) 4.99
Myc influences global chromatin structure. EMBO J (2006) 4.71
HIF and c-Myc: sibling rivals for control of cancer cell metabolism and proliferation. Cancer Cell (2007) 4.10
MYC as a regulator of ribosome biogenesis and protein synthesis. Nat Rev Cancer (2010) 3.64
Rapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-Myc. Mol Cell Biol (2006) 2.83
The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism. Cell (2012) 2.78
The Trithorax group protein Lid is a trimethyl histone H3K4 demethylase required for dMyc-induced cell growth. Genes Dev (2007) 2.57
Nucleolus, ribosomes, and cancer. Am J Pathol (2008) 2.53
Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles. Nature (2014) 2.33
Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53. Cancer Cell (2012) 2.29
MYC, metabolism, cell growth, and tumorigenesis. Cold Spring Harb Perspect Med (2013) 2.19
Evidence for a growth-stabilizing regulatory feedback mechanism between Myc and Yorkie, the Drosophila homolog of Yap. Dev Cell (2010) 2.13
Competitive interactions between cells: death, growth, and geography. Science (2009) 2.03
Myc-regulated microRNAs attenuate embryonic stem cell differentiation. EMBO J (2009) 1.94
Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome. Mol Cell Biol (2008) 1.93
Nucleolus: the fascinating nuclear body. Histochem Cell Biol (2007) 1.87
Inhibition of c-Myc activity by ribosomal protein L11. EMBO J (2007) 1.78
Crosstalk between c-Myc and ribosome in ribosomal biogenesis and cancer. J Cell Biochem (2008) 1.77
Aurora kinases A and B are up-regulated by Myc and are essential for maintenance of the malignant state. Blood (2010) 1.76
The Myc transactivation domain promotes global phosphorylation of the RNA polymerase II carboxy-terminal domain independently of direct DNA binding. Mol Cell Biol (2007) 1.75
Transcription-independent functions of MYC: regulation of translation and DNA replication. Nat Rev Mol Cell Biol (2008) 1.72
Translational control in cancer etiology. Cold Spring Harb Perspect Biol (2013) 1.71
The ups and downs of Myc biology. Curr Opin Genet Dev (2009) 1.70
Functional genomics identifies therapeutic targets for MYC-driven cancer. Proc Natl Acad Sci U S A (2012) 1.65
Redeployment of Myc and E2f1-3 drives Rb-deficient cell cycles. Nat Cell Biol (2015) 1.61
The Myc trilogy: lord of RNA polymerases. Nat Cell Biol (2005) 1.60
Dysregulation of ribosome biogenesis and translational capacity is associated with tumor progression of human breast cancer cells. PLoS One (2009) 1.60
Genomic and proteomic analysis reveals a threshold level of MYC required for tumor maintenance. Cancer Res (2008) 1.58
The role of Myc-induced protein synthesis in cancer. Cancer Res (2009) 1.54
Cell-type independent MYC target genes reveal a primordial signature involved in biomass accumulation. PLoS One (2011) 1.53
Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription. Mol Cell Proteomics (2012) 1.49
NPM1/B23: A Multifunctional Chaperone in Ribosome Biogenesis and Chromatin Remodeling. Biochem Res Int (2010) 1.49
MYC: connecting selective transcriptional control to global RNA production. Nat Rev Cancer (2015) 1.47
The RNA polymerase I transcription machinery. Biochem Soc Symp (2006) 1.46
Recognition of histone H3K4 trimethylation by the plant homeodomain of PHF2 modulates histone demethylation. J Biol Chem (2010) 1.46
N-Myc and the cyclin-dependent kinase inhibitors p18Ink4c and p27Kip1 coordinately regulate cerebellar development. Proc Natl Acad Sci U S A (2006) 1.45
Nucleophosmin interacts directly with c-Myc and controls c-Myc-induced hyperproliferation and transformation. Proc Natl Acad Sci U S A (2008) 1.44
c-Myc mediates pre-TCR-induced proliferation but not developmental progression. Blood (2006) 1.39
The nucleolus: a model for the organization of nuclear functions. Histochem Cell Biol (2006) 1.39
TRRAP and GCN5 are used by c-Myc to activate RNA polymerase III transcription. Proc Natl Acad Sci U S A (2007) 1.39
Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer. Nat Cell Biol (2013) 1.36
Balance of Yin and Yang: ubiquitylation-mediated regulation of p53 and c-Myc. Neoplasia (2006) 1.34
c-Myc accelerates S-phase and requires WRN to avoid replication stress. PLoS One (2009) 1.32
MYC, Metabolism, and Cancer. Cancer Discov (2015) 1.29
Dysregulation of the basal RNA polymerase transcription apparatus in cancer. Nat Rev Cancer (2013) 1.26
Evolution of the holozoan ribosome biogenesis regulon. BMC Genomics (2008) 1.25
Potential roles for ubiquitin and the proteasome during ribosome biogenesis. Mol Cell Biol (2006) 1.25
Epigenetic regulation of TTF-I-mediated promoter-terminator interactions of rRNA genes. EMBO J (2008) 1.24
Importin 7 and exportin 1 link c-Myc and p53 to regulation of ribosomal biogenesis. Mol Cell (2012) 1.24
Phenotypic transcription factors epigenetically mediate cell growth control. Proc Natl Acad Sci U S A (2008) 1.21
Myc in model organisms: a view from the flyroom. Semin Cancer Biol (2006) 1.21
Gene regulation and epigenetic remodeling in murine embryonic stem cells by c-Myc. PLoS One (2009) 1.20
Taming of the beast: shaping Myc-dependent amplification. Trends Cell Biol (2014) 1.19
Integrative genomic analysis of human ribosomal DNA. Nucleic Acids Res (2011) 1.18
Autoregulatory suppression of c-Myc by miR-185-3p. J Biol Chem (2011) 1.16
Small molecules targeting c-Myc oncogene: promising anti-cancer therapeutics. Int J Biol Sci (2014) 1.16
Dysregulation of RNA polymerase I transcription during disease. Biochim Biophys Acta (2012) 1.16
Revisiting the nucleolus: from marker to dynamic integrator of cancer signaling. Sci Signal (2012) 1.15
Ribosomal protein L11 recruits miR-24/miRISC to repress c-Myc expression in response to ribosomal stress. Mol Cell Biol (2011) 1.13
Drosophila growth and development in the absence of dMyc and dMnt. Dev Biol (2007) 1.13
Alterations in nucleolar structure and gene expression programs in prostatic neoplasia are driven by the MYC oncogene. Am J Pathol (2011) 1.12
Mitochondrial structure, function and dynamics are temporally controlled by c-Myc. PLoS One (2012) 1.09
MYC and metabolism on the path to cancer. Semin Cell Dev Biol (2015) 1.09
Regulation of cell growth by Notch signaling and its differential requirement in normal vs. tumor-forming stem cells in Drosophila. Genes Dev (2011) 1.08
Search for basonuclin target genes. Biochem Biophys Res Commun (2006) 1.07
Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription. Mol Cell Proteomics (2011) 1.07
CTCF regulates the local epigenetic state of ribosomal DNA repeats. Epigenetics Chromatin (2010) 1.06
Triptolide-induced transcriptional arrest is associated with changes in nuclear substructure. Cancer Res (2008) 1.06
Interaction of nucleolin with ribosomal RNA genes and its role in RNA polymerase I transcription. Nucleic Acids Res (2012) 1.05
The shared genomic architecture of human nucleolar organizer regions. Genome Res (2013) 1.03
Viral-mediated noisy gene expression reveals biphasic E2f1 response to MYC. Mol Cell (2011) 1.03
Human c-Myc isoforms differentially regulate cell growth and apoptosis in Drosophila melanogaster. Mol Cell Biol (2005) 1.03
LAS1L interacts with the mammalian Rix1 complex to regulate ribosome biogenesis. Mol Biol Cell (2011) 1.03
Functional interactions among members of the MAX and MLX transcriptional network during oncogenesis. Biochim Biophys Acta (2014) 1.02
Feedback regulation of c-Myc by ribosomal protein L11. Cell Cycle (2007) 1.02
c-MYC coordinately regulates ribosomal gene chromatin remodeling and Pol I availability during granulocyte differentiation. Nucleic Acids Res (2010) 1.01
Nuclear β-adrenergic receptors modulate gene expression in adult rat heart. Cell Signal (2010) 1.01
Scission of the p53-MDM2 Loop by Ribosomal Proteins. Genes Cancer (2012) 1.00
Transcriptional corepressor TLE1 functions with Runx2 in epigenetic repression of ribosomal RNA genes. Proc Natl Acad Sci U S A (2010) 1.00
A non-tumor suppressor role for basal p19ARF in maintaining nucleolar structure and function. Mol Cell Biol (2007) 1.00
Overexpression of ribosomal RNA in prostate cancer is common but not linked to rDNA promoter hypomethylation. Oncogene (2011) 0.99
Ribosomal protein L11 associates with c-Myc at 5 S rRNA and tRNA genes and regulates their expression. J Biol Chem (2010) 0.99
Las1L is a nucleolar protein required for cell proliferation and ribosome biogenesis. Mol Cell Biol (2010) 0.99
The negative c-Myc target onzin affects proliferation and apoptosis via its obligate interaction with phospholipid scramblase 1. Mol Cell Biol (2006) 0.97
c-Myc affects mRNA translation, cell proliferation and progenitor cell function in the mammary gland. BMC Biol (2009) 0.96
Nuclear PI3K signaling in cell growth and tumorigenesis. Front Cell Dev Biol (2015) 0.96
Coilin participates in the suppression of RNA polymerase I in response to cisplatin-induced DNA damage. Mol Biol Cell (2011) 0.95
MYC and transcription elongation. Cold Spring Harb Perspect Med (2014) 0.95
Conserved regulators of nucleolar size revealed by global phenotypic analyses. Sci Signal (2013) 0.95
Nucleolar DNA: the host and the guests. Histochem Cell Biol (2016) 0.95
Function and assembly of a chromatin-associated RNase P that is required for efficient transcription by RNA polymerase I. PLoS One (2008) 0.94
Nucleolar retention of a translational C/EBPalpha isoform stimulates rDNA transcription and cell size. EMBO J (2010) 0.94
Basic mechanisms in RNA polymerase I transcription of the ribosomal RNA genes. Subcell Biochem (2013) 0.94
Control of vertebrate development by MYC. Cold Spring Harb Perspect Med (2013) 0.94
Myc's broad reach. Genes Dev (2008) 7.56
The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation. Proc Natl Acad Sci U S A (2004) 5.37
Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1. Genes Dev (2003) 4.73
Myc influences global chromatin structure. EMBO J (2006) 4.71
Genomic binding by the Drosophila Myc, Max, Mad/Mnt transcription factor network. Genes Dev (2003) 4.68
Non-transcriptional control of DNA replication by c-Myc. Nature (2007) 4.55
Human papillomavirus, smoking, and sexual practices in the etiology of anal cancer. Cancer (2004) 4.04
Myc-dependent regulation of ribosomal RNA synthesis during Drosophila development. Nat Cell Biol (2005) 3.80
N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation. Genes Dev (2002) 3.71
Lack of serologic evidence for prevalent simian virus 40 infection in humans. J Natl Cancer Inst (2003) 3.44
Direct activation of RNA polymerase III transcription by c-Myc. Nature (2003) 3.32
Retracted Elevated tRNA(iMet) synthesis can drive cell proliferation and oncogenic transformation. Cell (2008) 3.23
Histone sumoylation is associated with transcriptional repression. Proc Natl Acad Sci U S A (2003) 3.18
Hematopoietic stem cell function and survival depend on c-Myc and N-Myc activity. Cell Stem Cell (2008) 2.83
Penile cancer: importance of circumcision, human papillomavirus and smoking in in situ and invasive disease. Int J Cancer (2005) 2.79
Human papillomavirus type 16 and 18 variants: race-related distribution and persistence. J Natl Cancer Inst (2006) 2.67
Nmyc plays an essential role during lung development as a dosage-sensitive regulator of progenitor cell proliferation and differentiation. Development (2005) 2.64
The Trithorax group protein Lid is a trimethyl histone H3K4 demethylase required for dMyc-induced cell growth. Genes Dev (2007) 2.57
Transcriptome-wide studies of merkel cell carcinoma and validation of intratumoral CD8+ lymphocyte invasion as an independent predictor of survival. J Clin Oncol (2011) 2.52
A nucleolar isoform of the Fbw7 ubiquitin ligase regulates c-Myc and cell size. Curr Biol (2004) 2.45
Tumor suppression and normal aging in mice with constitutively high p53 activity. Genes Dev (2006) 2.35
Association of Merkel cell polyomavirus-specific antibodies with Merkel cell carcinoma. J Natl Cancer Inst (2009) 2.22
Genomic binding profiles of functionally distinct RNA polymerase III transcription complexes in human cells. Nat Struct Mol Biol (2010) 2.15
Antibodies to merkel cell polyomavirus T antigen oncoproteins reflect tumor burden in merkel cell carcinoma patients. Cancer Res (2010) 2.14
Myc-regulated microRNAs attenuate embryonic stem cell differentiation. EMBO J (2009) 1.94
Pol II and its associated epigenetic marks are present at Pol III-transcribed noncoding RNA genes. Nat Struct Mol Biol (2010) 1.93
A population-based study of squamous cell vaginal cancer: HPV and cofactors. Gynecol Oncol (2002) 1.90
Quantitative proteomic analysis of Myc oncoprotein function. EMBO J (2002) 1.89
Histone deacetylase 6 binds polyubiquitin through its zinc finger (PAZ domain) and copurifies with deubiquitinating enzymes. Proc Natl Acad Sci U S A (2002) 1.89
Mechanisms by which DNA tumor virus oncoproteins target the Rb family of pocket proteins. Carcinogenesis (2003) 1.86
Werner syndrome protein limits MYC-induced cellular senescence. Genes Dev (2003) 1.84
Direct regulation of RNA polymerase III transcription by RB, p53 and c-Myc. Cell Cycle (2003) 1.73
Papillomavirus E6 proteins. Virology (2008) 1.70
dMyc is required for larval growth and endoreplication in Drosophila. Development (2004) 1.69
Changes in H2A.Z occupancy and DNA methylation during B-cell lymphomagenesis. Genome Res (2010) 1.69
p53 represses RNA polymerase III transcription by targeting TBP and inhibiting promoter occupancy by TFIIIB. EMBO J (2003) 1.68
Myc-nick: a cytoplasmic cleavage product of Myc that promotes alpha-tubulin acetylation and cell differentiation. Cell (2010) 1.67
Human papillomavirus type 18 DNA load and 2-year cumulative diagnoses of cervical intraepithelial neoplasia grades 2-3. J Natl Cancer Inst (2009) 1.65
N-myc is an essential downstream effector of Shh signaling during both normal and neoplastic cerebellar growth. Cancer Res (2006) 1.64
Non-coding RNA production by RNA polymerase III is implicated in cancer. Nat Rev Cancer (2008) 1.62
mTOR associates with TFIIIC, is found at tRNA and 5S rRNA genes, and targets their repressor Maf1. Proc Natl Acad Sci U S A (2010) 1.57
E6 proteins from multiple human betapapillomavirus types degrade Bak and protect keratinocytes from apoptosis after UVB irradiation. J Virol (2008) 1.54
An overview of MYC and its interactome. Cold Spring Harb Perspect Med (2014) 1.53
The gain in quality-adjusted life months by switching to esomeprazole in those with continued reflux symptoms in primary care: EncomPASS--a cluster-randomized trial. Am J Gastroenterol (2010) 1.52
The mSin3A chromatin-modifying complex is essential for embryogenesis and T-cell development. Mol Cell Biol (2005) 1.51
Identification of a novel telomerase repressor that interacts with the human papillomavirus type-16 E6/E6-AP complex. Genes Dev (2004) 1.50
tRNA genes protect a reporter gene from epigenetic silencing in mouse cells. Cell Cycle (2011) 1.47
N-Myc and the cyclin-dependent kinase inhibitors p18Ink4c and p27Kip1 coordinately regulate cerebellar development. Proc Natl Acad Sci U S A (2006) 1.45
Risk for high-grade cervical intraepithelial neoplasia associated with variants of human papillomavirus types 16 and 18. Cancer Epidemiol Biomarkers Prev (2007) 1.43
Regulation of RNA polymerase III transcription during hypertrophic growth. EMBO J (2006) 1.42
Comprehensive analysis of HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 loci and squamous cell cervical cancer risk. Cancer Res (2008) 1.40
TRRAP and GCN5 are used by c-Myc to activate RNA polymerase III transcription. Proc Natl Acad Sci U S A (2007) 1.39
TFIIIB is phosphorylated, disrupted and selectively released from tRNA promoters during mitosis in vivo. EMBO J (2003) 1.36
Modulation of T-lymphocyte development, growth and cell size by the Myc antagonist and transcriptional repressor Mad1. EMBO J (2002) 1.36
Essential functions of the histone demethylase lid. PLoS Genet (2010) 1.34
Risk of cervical cancer associated with Chlamydia trachomatis antibodies by histology, HPV type and HPV cofactors. Int J Cancer (2007) 1.32
c-Myc accelerates S-phase and requires WRN to avoid replication stress. PLoS One (2009) 1.32
The mitogen-activated protein (MAP) kinase ERK induces tRNA synthesis by phosphorylating TFIIIB. EMBO J (2003) 1.31
Normal human fibroblasts are resistant to RAS-induced senescence. Mol Cell Biol (2004) 1.30
Myc: a weapon of mass destruction. Cell (2004) 1.29
Myc stimulates B lymphocyte differentiation and amplifies calcium signaling. J Cell Biol (2007) 1.29
Regulation of RNA polymerase III transcription by Maf1 in mammalian cells. J Mol Biol (2008) 1.29
The function and regulation of the JARID1 family of histone H3 lysine 4 demethylases: the Myc connection. Cell Cycle (2007) 1.28
Identification of a human papillomavirus type 16-specific epitope on the C-terminal arm of the major capsid protein L1. J Virol (2003) 1.27
Identification of an overprinting gene in Merkel cell polyomavirus provides evolutionary insight into the birth of viral genes. Proc Natl Acad Sci U S A (2013) 1.24
Activation by c-Myc of transcription by RNA polymerases I, II and III. Biochem Soc Symp (2006) 1.24
Zbtb4 represses transcription of P21CIP1 and controls the cellular response to p53 activation. EMBO J (2008) 1.23
HBP1 and Mad1 repressors bind the Sin3 corepressor PAH2 domain with opposite helical orientations. Nat Struct Mol Biol (2004) 1.22
CK2 forms a stable complex with TFIIIB and activates RNA polymerase III transcription in human cells. Mol Cell Biol (2002) 1.21
Gene regulation and epigenetic remodeling in murine embryonic stem cells by c-Myc. PLoS One (2009) 1.20
Identification of human papillomavirus type 16 L1 surface loops required for neutralization by human sera. J Virol (2006) 1.20
Myc and Mad bHLHZ domains possess identical DNA-binding specificities but only partially overlapping functions in vivo. Proc Natl Acad Sci U S A (2002) 1.18
Efficient immortalization of primary human cells by p16INK4a-specific short hairpin RNA or Bmi-1, combined with introduction of hTERT. Cancer Sci (2007) 1.18
Quantitative proteomic analysis of myc-induced apoptosis: a direct role for Myc induction of the mitochondrial chloride ion channel, mtCLIC/CLIC4. J Biol Chem (2005) 1.18
HPV 5 and 8 E6 abrogate ATR activity resulting in increased persistence of UVB induced DNA damage. PLoS Pathog (2012) 1.16
A Myc-Groucho complex integrates EGF and Notch signaling to regulate neural development. Proc Natl Acad Sci U S A (2007) 1.16
Drosophila growth and development in the absence of dMyc and dMnt. Dev Biol (2007) 1.13
Pol III binding in six mammals shows conservation among amino acid isotypes despite divergence among tRNA genes. Nat Genet (2011) 1.12
The transcriptional repressor dMnt is a regulator of growth in Drosophila melanogaster. Mol Cell Biol (2005) 1.11
Dioxin receptor and SLUG transcription factors regulate the insulator activity of B1 SINE retrotransposons via an RNA polymerase switch. Genome Res (2011) 1.10
Beta-HPV 5 and 8 E6 promote p300 degradation by blocking AKT/p300 association. PLoS Pathog (2011) 1.10
The E6 oncoproteins from human betapapillomaviruses differentially activate telomerase through an E6AP-dependent mechanism and prolong the lifespan of primary keratinocytes. J Virol (2008) 1.08
Viral load in the natural history of human papillomavirus type 16 infection: a nested case-control study. J Infect Dis (2011) 1.08
MAD1 and p27(KIP1) cooperate to promote terminal differentiation of granulocytes and to inhibit Myc expression and cyclin E-CDK2 activity. Mol Cell Biol (2002) 1.07
Quantitative proteomic analysis of chromatin-associated factors. J Am Soc Mass Spectrom (2003) 1.06
Epigenetic down-regulation of ARF expression is a selection step in immortalization of human fibroblasts by c-Myc. Mol Cancer Res (2007) 1.06
Quantitative human papillomavirus 16 and 18 levels in incident infections and cervical lesion development. J Med Virol (2009) 1.06
Antibody responses in oral fluid after administration of prophylactic human papillomavirus vaccines. J Infect Dis (2009) 1.05
Serum antibody response following genital {alpha}9 human papillomavirus infection in young men. J Infect Dis (2011) 1.05
Esomeprazole 40 mg once a day in patients with functional dyspepsia: the randomized, placebo-controlled "ENTER" trial. Am J Gastroenterol (2006) 1.04
The mechanism of aggrecan release from cartilage differs with tissue origin and the agent used to stimulate catabolism. Biochem J (2002) 1.04
N-myc coordinates retinal growth with eye size during mouse development. Genes Dev (2008) 1.03
Human leukocyte antigen class II and cervical cancer risk: a population-based study. J Infect Dis (2002) 1.03
Identification and characterization of SAP25, a novel component of the mSin3 corepressor complex. Mol Cell Biol (2006) 1.02