Published in Science on December 03, 2010
Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism. Cell (2012) 7.36
Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth. Nat Med (2011) 6.15
Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses. Science (2011) 5.72
Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics. Proc Natl Acad Sci U S A (2013) 5.68
Links between metabolism and cancer. Genes Dev (2012) 5.27
The dynamic nature of autophagy in cancer. Genes Dev (2011) 3.57
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis. Nat Chem Biol (2012) 3.40
AMPK is a negative regulator of the Warburg effect and suppresses tumor growth in vivo. Cell Metab (2012) 3.35
Phosphofructokinase 1 glycosylation regulates cell growth and metabolism. Science (2012) 3.05
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nat Genet (2012) 3.04
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Ptpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesis. Cancer Cell (2011) 2.46
Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ: visualizing the therapeutic effects of metformin in tumor tissue. Cell Cycle (2011) 2.39
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Metabolic flux and the regulation of mammalian cell growth. Cell Metab (2011) 2.27
Emerging roles of PKM2 in cell metabolism and cancer progression. Trends Endocrinol Metab (2012) 1.87
mTOR complex 2 controls glycolytic metabolism in glioblastoma through FoxO acetylation and upregulation of c-Myc. Cell Metab (2013) 1.86
Single-lineage transcriptome analysis reveals key regulatory pathways in primitive erythroid progenitors in the mouse embryo. Blood (2011) 1.79
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Essential nontranslational functions of tRNA synthetases. Nat Chem Biol (2013) 1.72
p53 regulates cell cycle and microRNAs to promote differentiation of human embryonic stem cells. PLoS Biol (2012) 1.63
Therapeutic targeting of cancer cell metabolism. J Mol Med (Berl) (2011) 1.62
TAp73 enhances the pentose phosphate pathway and supports cell proliferation. Nat Cell Biol (2013) 1.61
The down-regulation of miR-125b in chronic lymphocytic leukemias leads to metabolic adaptation of cells to a transformed state. Blood (2012) 1.60
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Translational control of mitochondrial energy production mediates neuron morphogenesis. Cell Metab (2012) 1.55
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Loss of HSulf-1 promotes altered lipid metabolism in ovarian cancer. Cancer Metab (2014) 1.48
Heat shock transcription factor 1 is a key determinant of HCC development by regulating hepatic steatosis and metabolic syndrome. Cell Metab (2011) 1.47
Pyruvate kinase triggers a metabolic feedback loop that controls redox metabolism in respiring cells. Cell Metab (2011) 1.40
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The mitochondrial chaperone TRAP1 promotes neoplastic growth by inhibiting succinate dehydrogenase. Cell Metab (2013) 1.36
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Lactate shuttles at a glance: from physiological paradigms to anti-cancer treatments. Dis Model Mech (2011) 1.35
Identification of metabolites in the normal ovary and their transformation in primary and metastatic ovarian cancer. PLoS One (2011) 1.35
Pyruvate kinase M2 regulates glucose metabolism by functioning as a coactivator for hypoxia-inducible factor 1 in cancer cells. Oncotarget (2011) 1.33
Hexokinase 2-mediated Warburg effect is required for PTEN- and p53-deficiency-driven prostate cancer growth. Cell Rep (2014) 1.29
The circadian clock in cancer development and therapy. Prog Mol Biol Transl Sci (2013) 1.28
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Role of glutamine in cancer: therapeutic and imaging implications. J Nucl Med (2011) 1.25
Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy. BMC Cancer (2011) 1.25
Genetic mechanisms and signaling pathways in autosomal dominant polycystic kidney disease. J Clin Invest (2014) 1.24
Assessment, origin, and implementation of breath volatile cancer markers. Chem Soc Rev (2013) 1.23
EGFR mutation-induced alternative splicing of Max contributes to growth of glycolytic tumors in brain cancer. Cell Metab (2013) 1.23
Glucose oxidation modulates anoikis and tumor metastasis. Mol Cell Biol (2012) 1.23
Human telomerase acts as a hTR-independent reverse transcriptase in mitochondria. Nucleic Acids Res (2011) 1.21
Stalling the engine of resistance: targeting cancer metabolism to overcome therapeutic resistance. Cancer Res (2013) 1.19
Mitochondrial localization of TIGAR under hypoxia stimulates HK2 and lowers ROS and cell death. Proc Natl Acad Sci U S A (2012) 1.19
Emerging applications of metabolomics in drug discovery and precision medicine. Nat Rev Drug Discov (2016) 1.14
A kinase inhibitor screen identifies small-molecule enhancers of reprogramming and iPS cell generation. Nat Commun (2012) 1.14
cis-Expression QTL analysis of established colorectal cancer risk variants in colon tumors and adjacent normal tissue. PLoS One (2012) 1.14
Emerging role of cancer stem cells in the biology and treatment of ovarian cancer: basic knowledge and therapeutic possibilities for an innovative approach. J Exp Clin Cancer Res (2013) 1.13
Carbon monoxide expedites metabolic exhaustion to inhibit tumor growth. Cancer Res (2013) 1.12
Tumor TP53 expression status, body mass index and prognosis in colorectal cancer. Int J Cancer (2011) 1.12
The regulation of cellular metabolism by tumor suppressor p53. Cell Biosci (2013) 1.12
Small changes huge impact: the role of protein posttranslational modifications in cellular homeostasis and disease. J Amino Acids (2011) 1.12
The Warburg effect in tumor progression: mitochondrial oxidative metabolism as an anti-metastasis mechanism. Cancer Lett (2014) 1.11
Increased sugar uptake promotes oncogenesis via EPAC/RAP1 and O-GlcNAc pathways. J Clin Invest (2013) 1.11
Selective inhibition of mutant isocitrate dehydrogenase 1 (IDH1) via disruption of a metal binding network by an allosteric small molecule. J Biol Chem (2014) 1.11
Aerobic glycolysis tunes YAP/TAZ transcriptional activity. EMBO J (2015) 1.11
Carbonic anhydrase IX, a hypoxia-induced catalytic component of the pH regulating machinery in tumors. Front Physiol (2014) 1.11
The genetic and epigenetic alterations in human hepatocellular carcinoma: a recent update. Protein Cell (2014) 1.10
Gene profile of myeloid-derived suppressive cells from the bone marrow of lysosomal acid lipase knock-out mice. PLoS One (2012) 1.09
The embryonic origins of erythropoiesis in mammals. Blood (2012) 1.09
Pla2g16 phospholipase mediates gain-of-function activities of mutant p53. Proc Natl Acad Sci U S A (2014) 1.09
The complex landscape of pancreatic cancer metabolism. Carcinogenesis (2014) 1.08
The Warburg effect: evolving interpretations of an established concept. Free Radic Biol Med (2014) 1.07
Metabolic host responses to infection by intracellular bacterial pathogens. Front Cell Infect Microbiol (2013) 1.06
mTORC1-Induced HK1-Dependent Glycolysis Regulates NLRP3 Inflammasome Activation. Cell Rep (2015) 1.06
Oxidative stress, inflammation and carcinogenesis are controlled through the pentose phosphate pathway by transaldolase. Trends Mol Med (2011) 1.06
mTORC2 in the center of cancer metabolic reprogramming. Trends Endocrinol Metab (2014) 1.05
Kinase suppressor of Ras 2 (KSR2) regulates tumor cell transformation via AMPK. Mol Cell Biol (2012) 1.05
A joint analysis of metabolomics and genetics of breast cancer. Breast Cancer Res (2014) 1.04
Targeting Epstein-Barr virus oncoprotein LMP1-mediated glycolysis sensitizes nasopharyngeal carcinoma to radiation therapy. Oncogene (2014) 1.04
Hypoxia, cancer metabolism and the therapeutic benefit of targeting lactate/H(+) symporters. J Mol Med (Berl) (2015) 1.02
Decreased mitochondrial DNA mutagenesis in human colorectal cancer. PLoS Genet (2012) 1.02
Genome-wide profiling reveals stimulus-specific functions of p53 during differentiation and DNA damage of human embryonic stem cells. Nucleic Acids Res (2013) 1.02
Metabotropic glutamate receptor 1 (Grm1) is an oncogene in epithelial cells. Oncogene (2012) 1.01
Mitochondria in cancer: at the crossroads of life and death. Chin J Cancer (2011) 1.01
Human HMGCS2 regulates mitochondrial fatty acid oxidation and FGF21 expression in HepG2 cell line. J Biol Chem (2011) 1.01
Regulation of glycolysis and the Warburg effect by estrogen-related receptors. Oncogene (2012) 1.01
Mannose-6-phosphate regulates destruction of lipid-linked oligosaccharides. Mol Biol Cell (2011) 1.01
FoxO3 coordinates metabolic pathways to maintain redox balance in neural stem cells. EMBO J (2013) 1.00
Cellular potts modeling of tumor growth, tumor invasion, and tumor evolution. Front Oncol (2013) 0.99
mRNA expression in papillary and anaplastic thyroid carcinoma: molecular anatomy of a killing switch. PLoS One (2012) 0.99
Metabolic Dependencies in RAS-Driven Cancers. Clin Cancer Res (2015) 0.98
A transcriptomic analysis of Echinococcus granulosus larval stages: implications for parasite biology and host adaptation. PLoS Negl Trop Dis (2012) 0.98
Metabolic effect of TAp63α: enhanced glycolysis and pentose phosphate pathway, resulting in increased antioxidant defense. Oncotarget (2014) 0.97
Chemotherapeutic induction of mitochondrial oxidative stress activates GSK-3α/β and Bax, leading to permeability transition pore opening and tumor cell death. Cell Death Dis (2012) 0.97
MCJ/DnaJC15, an endogenous mitochondrial repressor of the respiratory chain that controls metabolic alterations. Mol Cell Biol (2013) 0.97
Phaeochromocytoma: a catecholamine and oxidative stress disorder. Endocr Regul (2011) 0.97
Epidermal growth factor receptor (EGFR) signaling regulates global metabolic pathways in EGFR-mutated lung adenocarcinoma. J Biol Chem (2014) 0.96
The multifaceted roles of autophagy in tumors-implications for breast cancer. J Mammary Gland Biol Neoplasia (2011) 0.96
The common mechanisms of transformation by the small DNA tumor viruses: The inactivation of tumor suppressor gene products: p53. Virology (2008) 1.65
Intravesical delivery of rapamycin suppresses tumorigenesis in a mouse model of progressive bladder cancer. Cancer Prev Res (Phila) (2009) 1.22
Stem cell biology meets p53. Nat Biotechnol (2009) 1.04
The interfaces between signal transduction pathways: IGF-1/mTor, p53 and the Parkinson Disease pathway. Oncotarget (2012) 0.90
Mouse models of human bladder cancer as a tool for drug discovery. Curr Protoc Pharmacol (2010) 0.78
Why do we not yet have a human immunodeficiency virus vaccine? J Virol (2008) 0.76