Published in Oncogene on December 06, 2010
Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury. Cancer Lett (2011) 1.81
Norcantharidin induced DU145 cell apoptosis through ROS-mediated mitochondrial dysfunction and energy depletion. PLoS One (2013) 0.94
Mechanisms that enhance sustainability of p53 pulses. PLoS One (2013) 0.91
Silencing of APE1 enhances sensitivity of human hepatocellular carcinoma cells to radiotherapy in vitro and in a xenograft model. PLoS One (2013) 0.90
Influence of P53 on the radiotherapy response of hepatocellular carcinoma. Clin Mol Hepatol (2015) 0.86
Cytochrome-c mediated a bystander response dependent on inducible nitric oxide synthase in irradiated hepatoma cells. Br J Cancer (2012) 0.83
Bystander communication and cell cycle decisions after DNA damage. Front Genet (2015) 0.78
The differential role of human macrophage in triggering secondary bystander effects after either gamma-ray or carbon beam irradiation. Cancer Lett (2015) 0.78
Extracellular miR-1246 promotes lung cancer cell proliferation and enhances radioresistance by directly targeting DR5. Oncotarget (2016) 0.78
Transglutaminase 2 Inhibitor KCC009 Induces p53-Independent Radiosensitization in Lung Adenocarcinoma Cells. Med Sci Monit (2016) 0.78
P53 expression in hepatocellular carcinoma: influence on the radiotherapeutic response of the hepatocellular carcinoma. Clin Mol Hepatol (2015) 0.77
Mechanisms and biological importance of photon-induced bystander responses: do they have an impact on low-dose radiation responses. J Radiat Res (2014) 0.77
MDM4 overexpressed in acute myeloid leukemia patients with complex karyotype and wild-type TP53. PLoS One (2014) 0.75
Biological mechanisms of gold nanoparticle radiosensitization. Cancer Nanotechnol (2017) 0.75
p31comet-Induced Cell Death Is Mediated by Binding and Inactivation of Mad2. PLoS One (2015) 0.75
Protective effect of mild endoplasmic reticulum stress on radiation-induced bystander effects in hepatocyte cells. Sci Rep (2016) 0.75
Overexpression of SKP2 Inhibits the Radiation-Induced Bystander Effects of Esophageal Carcinoma. Int J Environ Res Public Health (2017) 0.75
p53 in health and disease. Nat Rev Mol Cell Biol (2007) 11.33
A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. Science (1999) 6.97
Induction of sister chromatid exchanges by extremely low doses of alpha-particles. Cancer Res (1992) 4.72
Unexpected sensitivity to the induction of mutations by very low doses of alpha-particle radiation: evidence for a bystander effect. Radiat Res (1999) 2.70
Abnormal structure and expression of p53 gene in human hepatocellular carcinoma. Proc Natl Acad Sci U S A (1990) 2.59
Aberrant expression of the p53 oncoprotein is a common feature of a wide spectrum of human malignancies. Oncogene (1991) 2.42
Alpha particles initiate biological production of superoxide anions and hydrogen peroxide in human cells. Cancer Res (1997) 2.35
Medium from irradiated human epithelial cells but not human fibroblasts reduces the clonogenic survival of unirradiated cells. Int J Radiat Biol (1997) 2.27
p53 induces apoptosis by caspase activation through mitochondrial cytochrome c release. J Biol Chem (2000) 2.14
Factors underlying the cell growth-related bystander responses to alpha particles. Cancer Res (2000) 2.00
Mechanism of radiation-induced bystander effect: role of the cyclooxygenase-2 signaling pathway. Proc Natl Acad Sci U S A (2005) 1.92
Oncogenic bystander radiation effects in Patched heterozygous mouse cerebellum. Proc Natl Acad Sci U S A (2008) 1.89
Oxidative metabolism, gap junctions and the ionizing radiation-induced bystander effect. Oncogene (2003) 1.76
Targeted cytoplasmic irradiation induces bystander responses. Proc Natl Acad Sci U S A (2004) 1.76
Mitochondrial function and nuclear factor-kappaB-mediated signaling in radiation-induced bystander effects. Cancer Res (2008) 1.61
Cytoplasmic irradiation induces mitochondrial-dependent 53BP1 protein relocalization in irradiated and bystander cells. Cancer Res (2007) 1.55
Cell fate decision mediated by p53 pulses. Proc Natl Acad Sci U S A (2009) 1.53
Role of TGF-beta1 and nitric oxide in the bystander response of irradiated glioma cells. Oncogene (2007) 1.40
Stress-induced secretion of growth inhibitors: a novel tumor suppressor function of p53. Oncogene (1998) 1.40
Induction of radioresistance by a nitric oxide-mediated bystander effect. Radiat Res (2001) 1.37
Non-targeted bystander effects induced by ionizing radiation. Mutat Res (2006) 1.35
Delayed expression of lethal mutations and genomic instability in the progeny of human epithelial cells that survived in a bystander-killing environment. Radiat Oncol Investig (1997) 1.35
Alpha particles induce the production of interleukin-8 by human cells. Radiat Res (1999) 1.30
Cytochrome c is released from mitochondria in a reactive oxygen species (ROS)-dependent fashion and can operate as a ROS scavenger and as a respiratory substrate in cerebellar neurons undergoing excitotoxic death. J Biol Chem (2000) 1.29
Role of tumor necrosis factor-alpha and TRAIL in high-dose radiation-induced bystander signaling in lung adenocarcinoma. Cancer Res (2007) 1.28
Expression of CONNEXIN43 is highly sensitive to ionizing radiation and other environmental stresses. Cancer Res (2003) 1.20
Retinoblastoma and p53 tumor suppressor genes in human hepatoma cell lines. FASEB J (1993) 1.12
p53 inhibitor pifithrin alpha can suppress heat shock and glucocorticoid signaling pathways. J Biol Chem (2003) 1.10
Mitochondria-dependent signalling pathway are involved in the early process of radiation-induced bystander effects. Br J Cancer (2008) 1.09
Bystander signaling between glioma cells and fibroblasts targeted with counted particles. Int J Cancer (2005) 1.08
Bystander effect induced by counted high-LET particles in confluent human fibroblasts: a mechanistic study. FASEB J (2003) 1.08
Dilution of irradiated cell conditioned medium and the bystander effect. Radiat Res (2008) 1.07
Approach to radiation therapy in hepatocellular carcinoma. Cancer Treat Rev (2009) 1.03
Bystander killing of breast cancer MCF-7 cells by MDA-MB-231 cells exposed to 5-fluorouracil is mediated via Fas. J Cell Biochem (2007) 1.00
Role of gap junctional intercellular communication in radiation-induced bystander effects in human fibroblasts. Radiat Res (2003) 1.00
Mitochondrial DNA point mutations and a novel deletion induced by direct low-LET radiation and by medium from irradiated cells. Mutat Res (2005) 0.99
Heavy-ion-induced bystander killing of human lung cancer cells: role of gap junctional intercellular communication. Cancer Sci (2009) 0.99
Signaling factors for irradiated glioma cells induced bystander responses in fibroblasts. Mutat Res (2007) 0.97
Antiproliferative and apoptotic effects of tetrandrine on different human hepatoma cell lines. Am J Chin Med (2006) 0.95
Superoxide-mediated clastogenesis and anticlastogenic effects of exogenous superoxide dismutase. Proc Natl Acad Sci U S A (1996) 0.95
Deficiencies of double-strand break repair factors and effects on mutagenesis in directly gamma-irradiated and medium-mediated bystander human lymphoblastoid cells. Radiat Res (2008) 0.95
Cytochrome c oxidase subunit III: a molecular marker for N-(4-hydroxyphenyl)retinamise-induced oxidative stress in hepatoma cells. J Biol Chem (2001) 0.94
Death receptor pathways mediate targeted and non-targeted effects of ionizing radiations in breast cancer cells. Carcinogenesis (2009) 0.94
Bystander effects induced by continuous low-dose-rate 125I seeds potentiate the killing action of irradiation on human lung cancer cells in vitro. Int J Radiat Oncol Biol Phys (2008) 0.93
Mitochondrial apoptosis is amplified through gap junctions. Biochem Biophys Res Commun (2009) 0.93
Bystander effect and adaptive response in C3H 10T(1/2) cells. Int J Radiat Biol (2004) 0.90
Bystander effect on cell growth stimulation in neoplastic HSGc cells induced by heavy-ion irradiation. Radiat Environ Biophys (2003) 0.89
Bystander effects in radiation-induced genomic instability. Mutat Res (2002) 0.89
Exogenous carbon monoxide protects the bystander Chinese hamster ovary cells in mixed coculture system after alpha-particle irradiation. Carcinogenesis (2009) 0.89
p53-dependent radioresistance in ovarian carcinoma cell lines. Cancer Lett (2000) 0.88
Low-dose radiation-induced senescent stromal fibroblasts render nearby breast cancer cells radioresistant. Radiat Res (2009) 0.88
Mitochondrial dysfunction resulting from loss of cytochrome c impairs radiation-induced bystander effect. Br J Cancer (2009) 0.87
A new mechanism for DNA alterations induced by alpha particles such as those emitted by radon and radon progeny. Environ Health Perspect (1997) 0.85
Ongoing activation of p53 pathway responses is a long-term consequence of radiation exposure in vivo and associates with altered macrophage activities. J Pathol (2008) 0.84
Ceramide in nitric oxide inhibition of glioma cell growth. Evidence for the involvement of ceramide traffic. J Biol Chem (2003) 0.84
Adaptive response in embryogenesis. III. Relationship to radiation-induced apoptosis and Trp53 gene status. Radiat Res (2000) 0.81
Demonstration that a human hepatoma cell line produces a specific insulin-like growth factor carrier protein. J Clin Endocrinol Metab (1983) 0.81
A role for nuclear translocation of tripeptidyl-peptidase II in reactive oxygen species-dependent DNA damage responses. Biochem Biophys Res Commun (2009) 0.78
Human hepatocellular carcinoma transplanted in nude mice: a relevant experimental model to assess tumoral destruction by alcoholization. J Surg Res (1994) 0.78
Role of nuclear factor-kappaB and P53 in radioadaptive response in Chang live cells. Mutat Res (2010) 0.78
Neurogenesis in the adult is involved in the formation of trace memories. Nature (2001) 8.13
Stimulation of bone formation in vitro and in rodents by statins. Science (1999) 5.55
Structural basis for signal transduction by the Toll/interleukin-1 receptor domains. Nature (2000) 4.36
Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections. EMBO J (1993) 3.85
Determinants of genital human papillomavirus detection in a US population. J Infect Dis (2001) 3.21
Imaging the surface of Altair. Science (2007) 3.03
Dendrimer-encapsulated metal nanoparticles: synthesis, characterization, and applications to catalysis. Acc Chem Res (2001) 2.85
Structure of the DNA repair and replication endonuclease and exonuclease FEN-1: coupling DNA and PCNA binding to FEN-1 activity. Cell (1998) 2.67
Characterization of the structure and function of the fourth member of p38 group mitogen-activated protein kinases, p38delta. J Biol Chem (1997) 2.47
PRAK, a novel protein kinase regulated by the p38 MAP kinase. EMBO J (1998) 2.44
Hodgkin disease: Hodgkin and Reed-Sternberg cells picked from histological sections show clonal immunoglobulin gene rearrangements and appear to be derived from B cells at various stages of development. Proc Natl Acad Sci U S A (1994) 2.41
Selective inhibitors of the osteoblast proteasome stimulate bone formation in vivo and in vitro. J Clin Invest (2003) 2.30
Saccharomyces cerevisiae RNase H(35) functions in RNA primer removal during lagging-strand DNA synthesis, most efficiently in cooperation with Rad27 nuclease. Mol Cell Biol (1999) 2.29
Absence of cardiolipin in the crd1 null mutant results in decreased mitochondrial membrane potential and reduced mitochondrial function. J Biol Chem (2000) 2.26
Intrinsic fluorescence from DNA can be enhanced by metallic particles. Biochem Biophys Res Commun (2001) 2.25
Cloning and characterization of a phosphopantetheinyl transferase from Streptomyces verticillus ATCC15003, the producer of the hybrid peptide-polyketide antitumor drug bleomycin. Chem Biol (2001) 2.25
Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. Genome Res (2000) 2.21
Interferon-gamma-induced oligodendrocyte cell death: implications for the pathogenesis of multiple sclerosis. Mol Med (1995) 2.15
Infliximab in ulcerative colitis is associated with an increased risk of postoperative complications after restorative proctocolectomy. Dis Colon Rectum (2008) 2.05
The recovery of cognitive function after general anesthesia in elderly patients: a comparison of desflurane and sevoflurane. Anesth Analg (2001) 1.92
The highly recombinogenic bz locus lies in an unusually gene-rich region of the maize genome. Proc Natl Acad Sci U S A (2001) 1.88
Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest. Mol Cell Biol (2000) 1.88
Sphingosine-induced apoptosis is dependent on lysosomal proteases. Biochem J (2001) 1.80
Human mesenchymal stem cells inhibit cancer cell proliferation by secreting DKK-1. Leukemia (2009) 1.77
p62(dok), a negative regulator of Ras and mitogen-activated protein kinase (MAPK) activity, opposes leukemogenesis by p210(bcr-abl). J Exp Med (2001) 1.73
A structural change occurs upon binding of syntaxin to SNAP-25. J Biol Chem (1997) 1.72
Multiple lineages of tumors express a common tumor antigen, P1A, but they are not cross-protected. J Immunol (1995) 1.68
ATR-dependent radiation-induced gamma H2AX foci in bystander primary human astrocytes and glioma cells. Oncogene (2006) 1.64
A pharmacodynamic study of sorafenib in patients with relapsed and refractory acute leukemias. Leukemia (2010) 1.61
Malonyl-coenzyme A:acyl carrier protein acyltransferase of Streptomyces glaucescens: a possible link between fatty acid and polyketide biosynthesis. Biochemistry (1995) 1.60
Construction and initial characterization of Escherichia coli strains with few or no intact chromosomal rRNA operons. J Bacteriol (1999) 1.58
Genes for production of the enediyne antitumor antibiotic C-1027 in Streptomyces globisporus are clustered with the cagA gene that encodes the C-1027 apoprotein. Antimicrob Agents Chemother (2000) 1.58
The amplitude and time course of the myoplasmic free [Ca2+] transient in fast-twitch fibers of mouse muscle. J Gen Physiol (1996) 1.58
Big mitogen-activated kinase regulates multiple members of the MEF2 protein family. J Biol Chem (2000) 1.57
A charged-particle microbeam: I. Development of an experimental system for targeting cells individually with counted particles. Int J Radiat Biol (1997) 1.57
Population differences in SLE susceptibility genes: STAT4 and BLK, but not PXK, are associated with systemic lupus erythematosus in Hong Kong Chinese. Genes Immun (2009) 1.55
Targeted therapy of spinal cord glioma with a genetically modified Salmonella typhimurium. Cell Prolif (2009) 1.55
The effects of liver transplantation on the clinical course of colitis in ulcerative colitis patients with primary sclerosing cholangitis. Aliment Pharmacol Ther (2012) 1.52
Proliferative activity of calcifying odontogenic cysts as evaluated by proliferating cell nuclear antigen labeling index. Pathol Int (1998) 1.51
Mutational spectrum analysis of RNase H(35) deficient Saccharomyces cerevisiae using fluorescence-based directed termination PCR. Nucleic Acids Res (2000) 1.50
High frequency in vivo loss of heterozygosity is primarily a consequence of mitotic recombination. Cancer Res (1997) 1.48
Tie2-mediated loss of peroxisome proliferator-activated receptor-gamma in mice causes PDGF receptor-beta-dependent pulmonary arterial muscularization. Am J Physiol Lung Cell Mol Physiol (2009) 1.47
Distinct costimulatory molecules are required for the induction of effector and memory cytotoxic T lymphocytes. J Exp Med (1997) 1.47
The effects of differing resistance training modes on the preservation of bone mineral density in postmenopausal women: a meta-analysis. Osteoporos Int (2015) 1.47
Diagnostic value of clonality of surface immunoglobulin light and heavy chains in malignant lymphoproliferative disorders. Am J Hematol (1993) 1.45
The DNA-binding and enhancer-blocking domains of the Drosophila suppressor of Hairy-wing protein. Mol Cell Biol (1996) 1.44
Searches for Lepton flavor violation in the decays tau{+/-}-->e{+/-}gamma and tau{+/-}-->mu{+/-}gamma. Phys Rev Lett (2010) 1.44
Defect in SHAP-hyaluronan complex causes severe female infertility. A study by inactivation of the bikunin gene in mice. J Biol Chem (2001) 1.42
The use of theranostic gadolinium-based nanoprobes to improve radiotherapy efficacy. Br J Radiol (2014) 1.41
Identification and characterization of an eight-cysteine repeat of the latent transforming growth factor-beta binding protein-1 that mediates bonding to the latent transforming growth factor-beta1. J Biol Chem (1996) 1.40
Role of TGF-beta1 and nitric oxide in the bystander response of irradiated glioma cells. Oncogene (2007) 1.40
Detection of clonal B cell populations in paraffin-embedded tissues by polymerase chain reaction. Am J Pathol (1993) 1.38
Diagnostic value of serum gamma-glutamyl transferase isoenzyme for hepatocellular carcinoma: a 10-year study. Am J Gastroenterol (1992) 1.37
Activated caspase-3 expression in Alzheimer's and aged control brain: correlation with Alzheimer pathology. Brain Res (2001) 1.36
Human exonuclease 1 functionally complements its yeast homologues in DNA recombination, RNA primer removal, and mutation avoidance. J Biol Chem (1999) 1.36
Hybrid peptide-polyketide natural products: biosynthesis and prospects toward engineering novel molecules. Metab Eng (2001) 1.35
Gene-targeted B-deficient mice reveal a critical role for B cells in the CD4 T cell response. Int Immunol (1995) 1.35
Histone H2AX phosphorylation as a molecular pharmacological marker for DNA interstrand crosslink cancer chemotherapy. Biochem Pharmacol (2008) 1.35
Direct evidence for a bystander effect of ionizing radiation in primary human fibroblasts. Br J Cancer (2001) 1.32
Evaluation of cytotoxicity and radiation enhancement using 1.9 nm gold particles: potential application for cancer therapy. Nanotechnology (2010) 1.31
Structural biochemistry of a type 2 RNase H: RNA primer recognition and removal during DNA replication. J Mol Biol (2001) 1.30
Concomitant over-expression of vascular endothelial growth factor and its receptors in pancreatic cancer. Int J Cancer (2000) 1.30
Low-dose hypersensitivity in Chinese hamster V79 cells targeted with counted protons using a charged-particle microbeam. Radiat Res (2001) 1.29
Identification of amino acids in the factor XI apple 3 domain required for activation of factor IX. J Biol Chem (1999) 1.28
A focused ultrasoft x-ray microbeam for targeting cells individually with submicrometer accuracy. Radiat Res (2001) 1.25
Anomalous photogalvanic effect of circularly polarized light incident on the two-dimensional electron gas in Al{x}Ga{1-x}N/GaN heterostructures at room temperature. Phys Rev Lett (2008) 1.25
Roles for beta(pat-3) integrins in development and function of Caenorhabditis elegans muscles and gonads. J Biol Chem (2001) 1.24
Integrated preclinical and clinical development of mTOR inhibitors in pancreatic cancer. Br J Cancer (2010) 1.21
Stimulation of eukaryotic flap endonuclease-1 activities by proliferating cell nuclear antigen (PCNA) is independent of its in vitro interaction via a consensus PCNA binding region. J Biol Chem (2001) 1.21
The search for structure-specific nucleic acid-interactive drugs: effects of compound structure on RNA versus DNA interaction strength. Biochemistry (1993) 1.21
Mutagenesis of structural half-cystine residues in human thioredoxin and effects on the regulation of activity by selenodiglutathione. Biochemistry (1993) 1.20
Synthesis of dicationic diaryltriazines nucleic acid binding agents. Eur J Med Chem (1994) 1.20
Targeting microRNA-30a-mediated autophagy enhances imatinib activity against human chronic myeloid leukemia cells. Leukemia (2012) 1.17
Abnormal DNA methylation in CD4+ T cells from patients with systemic lupus erythematosus, systemic sclerosis, and dermatomyositis. Scand J Rheumatol (2009) 1.17
Blockage of intermediate-conductance-Ca(2+) -activated K(+) channels inhibits progression of human endometrial cancer. Oncogene (2007) 1.17
Genetic study of indirect inguinal hernia. J Med Genet (1994) 1.16
Loss of connective tissue growth factor as an unfavorable prognosis factor activates miR-18b by PI3K/AKT/C-Jun and C-Myc and promotes cell growth in nasopharyngeal carcinoma. Cell Death Dis (2013) 1.16
Cementum engineering with three-dimensional polymer scaffolds. J Biomed Mater Res A (2003) 1.16
Association of BANK1 and TNFSF4 with systemic lupus erythematosus in Hong Kong Chinese. Genes Immun (2009) 1.15
Low-dose studies of bystander cell killing with targeted soft X rays. Radiat Res (2003) 1.15
Hemispheric asymmetries and individual differences in visual concept learning as measured by functional MRI. Neuropsychologia (2000) 1.15
Identification of the gene for a novel liver-related putative tumor suppressor at a high-frequency loss of heterozygosity region of chromosome 8p23 in human hepatocellular carcinoma. Hepatology (2000) 1.14
Oncogenic driver mutations in patients with non-small-cell lung cancer at various clinical stages. Ann Oncol (2012) 1.13
Physiological electrical fields modify cell behaviour. Bioessays (1997) 1.13
Phase I study of the histone deacetylase inhibitor entinostat in combination with 13-cis retinoic acid in patients with solid tumours. Br J Cancer (2011) 1.12
Biosynthesis of hybrid peptide-polyketide natural products. Curr Opin Drug Discov Devel (2001) 1.12
Helicobacter pylori in the natural environment. Scand J Infect Dis (1999) 1.11
The mouse ocular albinism 1 gene product is an endolysosomal protein. Exp Eye Res (2001) 1.11
Human RAD2 homolog 1 5'- to 3'-exo/endonuclease can efficiently excise a displaced DNA fragment containing a 5'-terminal abasic lesion by endonuclease activity. J Biol Chem (1996) 1.11
Bystander-induced apoptosis and premature differentiation in primary urothelial explants after charged particle microbeam irradiation. Radiat Prot Dosimetry (2002) 1.11
A charged-particle microbeam: II. A single-particle micro-collimation and detection system. Int J Radiat Biol (1997) 1.10
The protein kinases ERK1/2 and their roles in pancreatic beta cells. Acta Physiol (Oxf) (2008) 1.10
Cell cycle-dependent and DNA damage-inducible nuclear localization of FEN-1 nuclease is consistent with its dual functions in DNA replication and repair. J Biol Chem (2000) 1.09
Inhibition of phosphatidylcholine biosynthesis following induction of apoptosis in HL-60 cells. J Biol Chem (1999) 1.09
Identification and characterization of a type II peptidyl carrier protein from the bleomycin producer Streptomyces verticillus ATCC 15003. Chem Biol (1999) 1.09
Precise measurement of the e+e- --> pi+pi-(gamma) cross section with the initial state radiation method at BABAR. Phys Rev Lett (2009) 1.07
Partial functional deficiency of E160D flap endonuclease-1 mutant in vitro and in vivo is due to defective cleavage of DNA substrates. J Biol Chem (1998) 1.07
Expression of inducible nitric oxide synthase in rat pulmonary Cryptococcus neoformans granulomas. Am J Pathol (1996) 1.07
Epigenetic inactivation of paired box gene 5, a novel tumor suppressor gene, through direct upregulation of p53 is associated with prognosis in gastric cancer patients. Oncogene (2011) 1.06