The Ecology of Tumors: By perturbing the microenvironment, wounds and infection may be key to tumor development.

PubWeight™: 0.78‹?›

🔗 View Article (PMID 21132085)

Published in Scientist on April 01, 2006

Authors

Paraic A Kenny1, Celeste M Nelson, Mina J Bissell

Author Affiliations

1: Mina Bissell is distinguished scientist, and Paraic Kenny and Celeste Nelson are postdoctoral fellows in the Life Sciences Division of the Lawrence Berkeley National Laboratory.

Articles cited by this

Inflammation and cancer. Nature (2002) 53.78

Tensional homeostasis and the malignant phenotype. Cancer Cell (2005) 19.30

Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. N Engl J Med (1986) 17.64

Tumour-educated macrophages promote tumour progression and metastasis. Nat Rev Cancer (2004) 14.55

The distribution of secondary growths in cancer of the breast. 1889. Cancer Metastasis Rev (1989) 13.15

TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia. Science (2004) 10.23

Vascular channel formation by human melanoma cells in vivo and in vitro: vasculogenic mimicry. Am J Pathol (1999) 7.66

Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability. Nature (2005) 7.24

Neurofibromas in NF1: Schwann cell origin and role of tumor environment. Science (2002) 5.08

Advances in diagnostic imaging and overestimations of disease prevalence and the benefits of therapy. N Engl J Med (1993) 3.21

Microenvironmental regulators of tissue structure and function also regulate tumor induction and progression: the role of extracellular matrix and its degrading enzymes. Cold Spring Harb Symp Quant Biol (2005) 3.19

Tumor reversion: correction of malignant behavior by microenvironmental cues. Int J Cancer (2003) 3.02

Beta1 integrin inhibitory antibody induces apoptosis of breast cancer cells, inhibits growth, and distinguishes malignant from normal phenotype in three dimensional cultures and in vivo. Cancer Res (2006) 2.86

Articles by these authors

Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment. Dev Cell (2004) 16.89

Three-dimensional culture models of normal and malignant breast epithelial cells. Nat Methods (2007) 7.43

Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability. Nature (2005) 7.24

Of extracellular matrix, scaffolds, and signaling: tissue architecture regulates development, homeostasis, and cancer. Annu Rev Cell Dev Biol (2006) 6.64

Isolation, immortalization, and characterization of a human breast epithelial cell line with stem cell properties. Genes Dev (2002) 6.55

The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression. Mol Oncol (2007) 5.81

beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium. Cancer Cell (2002) 5.56

Regulation of in situ to invasive breast carcinoma transition. Cancer Cell (2008) 4.46

Normal and tumor-derived myoepithelial cells differ in their ability to interact with luminal breast epithelial cells for polarity and basement membrane deposition. J Cell Sci (2002) 4.25

Tissue geometry determines sites of mammary branching morphogenesis in organotypic cultures. Science (2006) 4.12

Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway. Cell (2012) 4.09

Evidence for a stem cell hierarchy in the adult human breast. J Cell Biol (2007) 3.76

Modeling tissue-specific signaling and organ function in three dimensions. J Cell Sci (2003) 3.52

Mechanical tugging force regulates the size of cell-cell junctions. Proc Natl Acad Sci U S A (2010) 3.44

Phenotypic reversion or death of cancer cells by altering signaling pathways in three-dimensional contexts. J Natl Cancer Inst (2002) 3.39

The perivascular niche regulates breast tumour dormancy. Nat Cell Biol (2013) 3.36

Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition. Cancer Res (2009) 3.14

Regulation of mammary gland branching morphogenesis by the extracellular matrix and its remodeling enzymes. Breast Cancer Res (2003) 3.13

Tumor reversion: correction of malignant behavior by microenvironmental cues. Int J Cancer (2003) 3.02

Polarity and proliferation are controlled by distinct signaling pathways downstream of PI3-kinase in breast epithelial tumor cells. J Cell Biol (2004) 2.93

Beta1 integrin inhibitory antibody induces apoptosis of breast cancer cells, inhibits growth, and distinguishes malignant from normal phenotype in three dimensional cultures and in vivo. Cancer Res (2006) 2.86

Site-specific inductive and inhibitory activities of MMP-2 and MMP-3 orchestrate mammary gland branching morphogenesis. J Cell Biol (2003) 2.68

Imaging tumor-stroma interactions during chemotherapy reveals contributions of the microenvironment to resistance. Cancer Cell (2012) 2.61

MYC suppresses cancer metastasis by direct transcriptional silencing of αv and β3 integrin subunits. Nat Cell Biol (2012) 2.61

Modeling dynamic reciprocity: engineering three-dimensional culture models of breast architecture, function, and neoplastic transformation. Semin Cancer Biol (2005) 2.53

Unraveling the microenvironmental influences on the normal mammary gland and breast cancer. Semin Cancer Biol (2008) 2.41

Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2. Proc Natl Acad Sci U S A (2006) 2.41

HER2 signaling pathway activation and response of breast cancer cells to HER2-targeting agents is dependent strongly on the 3D microenvironment. Breast Cancer Res Treat (2009) 2.34

Fibrosis and cancer: do myofibroblasts come also from epithelial cells via EMT? J Cell Biochem (2007) 2.32

Targeting TACE-dependent EGFR ligand shedding in breast cancer. J Clin Invest (2007) 2.29

Mechanisms of disease: epithelial-mesenchymal transition--does cellular plasticity fuel neoplastic progression? Nat Clin Pract Oncol (2008) 2.18

Simple approach to micropattern cells on common culture substrates by tuning substrate wettability. Tissue Eng (2004) 2.13

Prognostic breast cancer signature identified from 3D culture model accurately predicts clinical outcome across independent datasets. PLoS One (2008) 2.12

Epithelial to mesenchymal transition in human breast cancer can provide a nonmalignant stroma. Am J Pathol (2003) 2.06

The MAPK(ERK-1,2) pathway integrates distinct and antagonistic signals from TGFalpha and FGF7 in morphogenesis of mouse mammary epithelium. Dev Biol (2007) 1.98

Tissue architecture and function: dynamic reciprocity via extra- and intra-cellular matrices. Cancer Metastasis Rev (2009) 1.93

Myoepithelial cells: their origin and function in breast morphogenesis and neoplasia. J Mammary Gland Biol Neoplasia (2005) 1.92

Beta1 integrin inhibition dramatically enhances radiotherapy efficacy in human breast cancer xenografts. Cancer Res (2008) 1.83

Human mammary progenitor cell fate decisions are products of interactions with combinatorial microenvironments. Integr Biol (Camb) (2008) 1.82

The hyaluronan receptors CD44 and Rhamm (CD168) form complexes with ERK1,2 that sustain high basal motility in breast cancer cells. J Biol Chem (2007) 1.82

A human breast cell model of preinvasive to invasive transition. Cancer Res (2008) 1.79

The tumor microenvironment is a dominant force in multidrug resistance. Drug Resist Updat (2012) 1.77

Laminin and biomimetic extracellular elasticity enhance functional differentiation in mammary epithelia. EMBO J (2008) 1.74

The dominance of the microenvironment in breast and ovarian cancer. Semin Cancer Biol (2002) 1.73

Targeting the tumor microenvironment. Front Biosci (2007) 1.72

Gene expression signature in organized and growth-arrested mammary acini predicts good outcome in breast cancer. Cancer Res (2006) 1.69

Myoepithelial cells: good fences make good neighbors. Breast Cancer Res (2005) 1.66

A role for dystroglycan in epithelial polarization: loss of function in breast tumor cells. Cancer Res (2002) 1.65

Cell shape regulates global histone acetylation in human mammary epithelial cells. Exp Cell Res (2007) 1.64

Cancer. Respect thy neighbor! Science (2004) 1.62

E-cadherin engagement stimulates proliferation via Rac1. J Cell Biol (2006) 1.61

Breast cancer by proxy: can the microenvironment be both the cause and consequence? Trends Mol Med (2008) 1.60

Ionizing radiation predisposes nonmalignant human mammary epithelial cells to undergo transforming growth factor beta induced epithelial to mesenchymal transition. Cancer Res (2007) 1.60

Evidence for formation of DNA repair centers and dose-response nonlinearity in human cells. Proc Natl Acad Sci U S A (2011) 1.58

β1 integrin mediates an alternative survival pathway in breast cancer cells resistant to lapatinib. Breast Cancer Res (2011) 1.56

Extracellular matrix control of mammary gland morphogenesis and tumorigenesis: insights from imaging. Histochem Cell Biol (2008) 1.55

Tissue geometry patterns epithelial-mesenchymal transition via intercellular mechanotransduction. J Cell Biochem (2010) 1.53

Integrated morphodynamic signalling of the mammary gland. Nat Rev Mol Cell Biol (2011) 1.50

Dystroglycan loss disrupts polarity and beta-casein induction in mammary epithelial cells by perturbing laminin anchoring. J Cell Sci (2006) 1.49

Molecular predictors of 3D morphogenesis by breast cancer cell lines in 3D culture. PLoS Comput Biol (2010) 1.46

Extracellular matrix-regulated gene expression requires cooperation of SWI/SNF and transcription factors. J Biol Chem (2007) 1.46

Coherent angular motion in the establishment of multicellular architecture of glandular tissues. Proc Natl Acad Sci U S A (2012) 1.45

Sustained activation of STAT5 is essential for chromatin remodeling and maintenance of mammary-specific function. J Cell Biol (2009) 1.44

Lymphatic function is required prenatally for lung inflation at birth. J Exp Med (2014) 1.44

Change in cell shape is required for matrix metalloproteinase-induced epithelial-mesenchymal transition of mammary epithelial cells. J Cell Biochem (2008) 1.41

Fabrication of aligned microstructures with a single elastomeric stamp. Proc Natl Acad Sci U S A (2002) 1.38

Self-organization of engineered epithelial tubules by differential cellular motility. Proc Natl Acad Sci U S A (2009) 1.36

Splicing program of human MENA produces a previously undescribed isoform associated with invasive, mesenchymal-like breast tumors. Proc Natl Acad Sci U S A (2012) 1.36

Three-dimensional lithographically defined organotypic tissue arrays for quantitative analysis of morphogenesis and neoplastic progression. Nat Protoc (2008) 1.35

Cadherins, RhoA, and Rac1 are differentially required for stretch-mediated proliferation in endothelial versus smooth muscle cells. Circ Res (2007) 1.35

Geometrically controlled endothelial tubulogenesis in micropatterned gels. Tissue Eng Part A (2010) 1.33

Proteolytic enzymes and altered glycosylation modulate dystroglycan function in carcinoma cells. Cancer Res (2004) 1.33

Is CD133 a marker of metastatic colon cancer stem cells? J Clin Invest (2008) 1.32

Breast cancer cells in three-dimensional culture display an enhanced radioresponse after coordinate targeting of integrin alpha5beta1 and fibronectin. Cancer Res (2010) 1.32

Mapping of mechanical strains and stresses around quiescent engineered three-dimensional epithelial tissues. Biophys J (2012) 1.31

Endogenous patterns of mechanical stress are required for branching morphogenesis. Integr Biol (Camb) (2010) 1.31

Rhamm-/- fibroblasts are defective in CD44-mediated ERK1,2 motogenic signaling, leading to defective skin wound repair. J Cell Biol (2006) 1.28

Collagen-IV and laminin-1 regulate estrogen receptor alpha expression and function in mouse mammary epithelial cells. J Cell Sci (2003) 1.27

Three-dimensional culture of human breast epithelial cells: the how and the why. Methods Mol Biol (2013) 1.26

Transmembrane/cytoplasmic, rather than catalytic, domains of Mmp14 signal to MAPK activation and mammary branching morphogenesis via binding to integrin β1. Development (2013) 1.23

Rap1 integrates tissue polarity, lumen formation, and tumorigenic potential in human breast epithelial cells. Cancer Res (2007) 1.22

Tumor initiating but differentiated luminal-like breast cancer cells are highly invasive in the absence of basal-like activity. Proc Natl Acad Sci U S A (2012) 1.21

Epithelial-mesenchymal transition: general principles and pathological relevance with special emphasis on the role of matrix metalloproteinases. Cold Spring Harb Perspect Biol (2012) 1.20

Dissecting regional variations in stress fiber mechanics in living cells with laser nanosurgery. Biophys J (2010) 1.20

To create the correct microenvironment: three-dimensional heterotypic collagen assays for human breast epithelial morphogenesis and neoplasia. Methods (2003) 1.19

p53-dependent integration of telomere and growth factor deprivation signals. Proc Natl Acad Sci U S A (2007) 1.18

The organization of tight junctions in epithelia: implications for mammary gland biology and breast tumorigenesis. J Mammary Gland Biol Neoplasia (2003) 1.18

Delivering the message: epimorphin and mammary epithelial morphogenesis. Trends Cell Biol (2003) 1.18

New insights into the regulation of epithelial-mesenchymal transition and tissue fibrosis. Int Rev Cell Mol Biol (2012) 1.17

Higher-order nuclear organization in growth arrest of human mammary epithelial cells: a novel role for telomere-associated protein TIN2. J Cell Sci (2005) 1.17

Depletion of nuclear actin is a key mediator of quiescence in epithelial cells. J Cell Sci (2011) 1.16