Published in J Natl Cancer Inst on October 02, 2002
Three-dimensional culture models of normal and malignant breast epithelial cells. Nat Methods (2007) 7.43
Of extracellular matrix, scaffolds, and signaling: tissue architecture regulates development, homeostasis, and cancer. Annu Rev Cell Dev Biol (2006) 6.64
The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression. Mol Oncol (2007) 5.81
Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression. Nat Med (2011) 5.54
The organizing principle: microenvironmental influences in the normal and malignant breast. Differentiation (2002) 4.64
Context, tissue plasticity, and cancer: are tumor stem cells also regulated by the microenvironment? Cancer Cell (2005) 3.67
Modeling tissue-specific signaling and organ function in three dimensions. J Cell Sci (2003) 3.52
Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B. Nat Med (2012) 3.21
Tumor reversion: correction of malignant behavior by microenvironmental cues. Int J Cancer (2003) 3.02
Polarity and proliferation are controlled by distinct signaling pathways downstream of PI3-kinase in breast epithelial tumor cells. J Cell Biol (2004) 2.93
Tissue architecture: the ultimate regulator of breast epithelial function. Curr Opin Cell Biol (2003) 2.92
Beta1 integrin inhibitory antibody induces apoptosis of breast cancer cells, inhibits growth, and distinguishes malignant from normal phenotype in three dimensional cultures and in vivo. Cancer Res (2006) 2.86
AlphaB-crystallin is a novel oncoprotein that predicts poor clinical outcome in breast cancer. J Clin Invest (2006) 2.74
Unraveling the microenvironmental influences on the normal mammary gland and breast cancer. Semin Cancer Biol (2008) 2.41
Targeting TACE-dependent EGFR ligand shedding in breast cancer. J Clin Invest (2007) 2.29
Bim regulation of lumen formation in cultured mammary epithelial acini is targeted by oncogenes. Mol Cell Biol (2005) 2.20
Adhesion-independent mechanism for suppression of tumor cell invasion by E-cadherin. J Cell Biol (2003) 2.14
HOXA9 regulates BRCA1 expression to modulate human breast tumor phenotype. J Clin Invest (2010) 2.00
Beta1 integrins regulate mammary gland proliferation and maintain the integrity of mammary alveoli. EMBO J (2005) 1.94
Functional role of glycosphingolipids and gangliosides in control of cell adhesion, motility, and growth, through glycosynaptic microdomains. Biochim Biophys Acta (2007) 1.86
The hyaluronan receptors CD44 and Rhamm (CD168) form complexes with ERK1,2 that sustain high basal motility in breast cancer cells. J Biol Chem (2007) 1.82
The tumor microenvironment is a dominant force in multidrug resistance. Drug Resist Updat (2012) 1.77
Use of three-dimensional basement membrane cultures to model oncogene-induced changes in mammary epithelial morphogenesis. J Mammary Gland Biol Neoplasia (2004) 1.71
Down-regulation of epithelial cadherin is required to initiate metastatic outgrowth of breast cancer. Mol Biol Cell (2011) 1.66
Hyaluronan-CD44 interactions as potential targets for cancer therapy. FEBS J (2011) 1.63
Structure and function of glycosphingolipids and sphingolipids: recollections and future trends. Biochim Biophys Acta (2007) 1.62
Breast fibroblasts modulate epithelial cell proliferation in three-dimensional in vitro co-culture. Breast Cancer Res (2004) 1.58
Extracellular matrix control of mammary gland morphogenesis and tumorigenesis: insights from imaging. Histochem Cell Biol (2008) 1.55
Protein kinase D1 regulates matrix metalloproteinase expression and inhibits breast cancer cell invasion. Breast Cancer Res (2009) 1.55
Physical mechanisms redirecting cell polarity and cell shape in fission yeast. Curr Biol (2008) 1.55
Deconstructing the mechanisms and consequences of TGF-β-induced EMT during cancer progression. Cell Tissue Res (2011) 1.53
Key signalling nodes in mammary gland development and cancer. Mitogen-activated protein kinase signalling in experimental models of breast cancer progression and in mammary gland development. Breast Cancer Res (2009) 1.40
Increased tumor cell dissemination and cellular senescence in the absence of beta1-integrin function. EMBO J (2007) 1.32
Oncogenes and tumor suppressor genes. Cold Spring Harb Perspect Biol (2010) 1.31
Translating tissue engineering technology platforms into cancer research. J Cell Mol Med (2009) 1.29
Targeting of integrin beta1 and kinesin 2alpha by microRNA 183. J Biol Chem (2009) 1.28
Three-dimensional culture of human breast epithelial cells: the how and the why. Methods Mol Biol (2013) 1.26
The need for complex 3D culture models to unravel novel pathways and identify accurate biomarkers in breast cancer. Adv Drug Deliv Rev (2014) 1.25
Toward a genetics of cancer resistance. Proc Natl Acad Sci U S A (2009) 1.25
Ectopic runx2 expression in mammary epithelial cells disrupts formation of normal acini structure: implications for breast cancer progression. Cancer Res (2009) 1.23
Expression and prognostic relevance of activated extracellular-regulated kinases (ERK1/2) in breast cancer. Br J Cancer (2005) 1.22
Rap1 integrates tissue polarity, lumen formation, and tumorigenic potential in human breast epithelial cells. Cancer Res (2007) 1.22
Focal adhesion kinase controls cellular levels of p27/Kip1 and p21/Cip1 through Skp2-dependent and -independent mechanisms. Mol Cell Biol (2006) 1.20
To create the correct microenvironment: three-dimensional heterotypic collagen assays for human breast epithelial morphogenesis and neoplasia. Methods (2003) 1.19
Ganglioside GM2/GM3 complex affixed on silica nanospheres strongly inhibits cell motility through CD82/cMet-mediated pathway. Proc Natl Acad Sci U S A (2008) 1.17
The microenvironment determines the breast cancer cells' phenotype: organization of MCF7 cells in 3D cultures. BMC Cancer (2010) 1.16
β-Catenin-regulated ALDH1A1 is a target in ovarian cancer spheroids. Oncogene (2014) 1.14
Raf-induced MMP9 disrupts tissue architecture of human breast cells in three-dimensional culture and is necessary for tumor growth in vivo. Genes Dev (2010) 1.14
Three-dimensional overlay culture models of human breast cancer reveal a critical sensitivity to mitogen-activated protein kinase kinase inhibitors. J Pharmacol Exp Ther (2009) 1.14
Live cell division dynamics monitoring in 3D large spheroid tumor models using light sheet microscopy. Cell Div (2011) 1.12
Increased sugar uptake promotes oncogenesis via EPAC/RAP1 and O-GlcNAc pathways. J Clin Invest (2013) 1.11
Normal morphogenesis of epithelial tissues and progression of epithelial tumors. Wiley Interdiscip Rev Syst Biol Med (2011) 1.10
Tumor cell migration and invasion are regulated by expression of variant integrin glycoforms. Exp Cell Res (2008) 1.09
Increasingly transformed MCF-10A cells have a progressively tumor-like phenotype in three-dimensional basement membrane culture. Cancer Cell Int (2009) 1.08
Predicting clinical response to anticancer drugs using an ex vivo platform that captures tumour heterogeneity. Nat Commun (2015) 1.08
The difficulty of targeting cancer stem cell niches. Clin Cancer Res (2010) 1.08
Engineering strategies to recapitulate epithelial morphogenesis within synthetic three-dimensional extracellular matrix with tunable mechanical properties. Phys Biol (2011) 1.07
FAM83A confers EGFR-TKI resistance in breast cancer cells and in mice. J Clin Invest (2012) 1.06
p140Cap protein suppresses tumour cell properties, regulating Csk and Src kinase activity. EMBO J (2007) 1.06
Functional live-cell imaging demonstrates that beta1-integrin promotes type IV collagen degradation by breast and prostate cancer cells. Mol Imaging (2009) 1.05
miR-205 regulates basement membrane deposition in human prostate: implications for cancer development. Cell Death Differ (2012) 1.05
Restoration of E-cadherin cell-cell junctions requires both expression of E-cadherin and suppression of ERK MAP kinase activation in Ras-transformed breast epithelial cells. Neoplasia (2008) 1.04
Three-dimensional in vitro tumor models for cancer research and drug evaluation. Biotechnol Adv (2014) 1.03
Metastasis prevention by targeting the dormant niche. Nat Rev Cancer (2015) 1.03
Functional characterization of E- and P-cadherin in invasive breast cancer cells. BMC Cancer (2009) 1.02
Tumor cell plasticity in uveal melanoma: microenvironment directed dampening of the invasive and metastatic genotype and phenotype accompanies the generation of vasculogenic mimicry patterns. Am J Pathol (2006) 1.01
Endothelial cell migration and vascular endothelial growth factor expression are the result of loss of breast tissue polarity. Cancer Res (2009) 1.01
Advanced cell culture techniques for cancer drug discovery. Biology (Basel) (2014) 1.01
Mesotrypsin promotes malignant growth of breast cancer cells through shedding of CD109. Breast Cancer Res Treat (2009) 1.00
Ionizing radiation induces heritable disruption of epithelial cell interactions. Proc Natl Acad Sci U S A (2003) 0.99
P190B RhoGAP has pro-tumorigenic functions during MMTV-Neu mammary tumorigenesis and metastasis. Breast Cancer Res (2010) 0.98
BMS-536924 reverses IGF-IR-induced transformation of mammary epithelial cells and causes growth inhibition and polarization of MCF7 cells. Clin Cancer Res (2009) 0.97
Kallikrein-related peptidase 5 induces miRNA-mediated anti-oncogenic pathways in breast cancer. Oncoscience (2014) 0.96
Inhibition of ERK promotes collagen gel compaction and fibrillogenesis to amplify the osteogenesis of human mesenchymal stem cells in three-dimensional collagen I culture. Stem Cells Dev (2009) 0.96
Cellular heterogeneity profiling by hyaluronan probes reveals an invasive but slow-growing breast tumor subset. Proc Natl Acad Sci U S A (2014) 0.95
TREEGL: reverse engineering tree-evolving gene networks underlying developing biological lineages. Bioinformatics (2011) 0.95
Epigenetic reversion of breast carcinoma phenotype is accompanied by changes in DNA sequestration as measured by AluI restriction enzyme. Am J Pathol (2007) 0.94
Contributions of extracellular matrix signaling and tissue architecture to nuclear mechanisms and spatial organization of gene expression control. Biochim Biophys Acta (2009) 0.93
Three dimensional cultures: a tool to study normal acinar architecture vs. malignant transformation of breast cells. J Vis Exp (2014) 0.91
PI-3 kinase activity is necessary for ERK1/2-induced disruption of mammary epithelial architecture. Breast Cancer Res (2009) 0.90
CXCR4 drives the metastatic phenotype in breast cancer through induction of CXCR2 and activation of MEK and PI3K pathways. Mol Biol Cell (2014) 0.90
Roles for estrogen and progesterone in breast cancer prevention. Breast Cancer Res (2007) 0.89
Characterization of ΔNp73 expression and regulation in gastric and esophageal tumors. Oncogene (2010) 0.88
Label-Free, Longitudinal Visualization of PDT Response In Vitro with Optical Coherence Tomography. Isr J Chem (2012) 0.87
MicroRNA- 130b suppresses migration and invasion of colorectal cancer cells through downregulation of integrin β1 [corrected]. PLoS One (2014) 0.87
Scribble modulates the MAPK/Fra1 pathway to disrupt luminal and ductal integrity and suppress tumour formation in the mammary gland. PLoS Genet (2014) 0.86
Multiple effects of electroporation on the adhesive behaviour of breast cancer cells and fibroblasts. Cancer Cell Int (2012) 0.83
MicroRNAs as diagnostic and prognostic biomarkers in colorectal cancer. World J Gastrointest Oncol (2016) 0.82
β1 integrin deletion enhances progression of prostate cancer in the TRAMP mouse model. Sci Rep (2012) 0.82
Integrins activate trimeric G proteins via the nonreceptor protein GIV/Girdin. J Cell Biol (2015) 0.82
Inhibitors of Rho kinase (ROCK) signaling revert the malignant phenotype of breast cancer cells in 3D context. Oncotarget (2016) 0.80
Suppression of endogenous lipogenesis induces reversion of the malignant phenotype and normalized differentiation in breast cancer. Oncotarget (2016) 0.80
Microenvironmental control of the breast cancer cell cycle. Anat Rec (Hoboken) (2012) 0.80
The cell surface mucin podocalyxin regulates collective breast tumor budding. Breast Cancer Res (2016) 0.80
Imaging of homeostatic, neoplastic, and injured tissues by HA-based probes. Biomacromolecules (2011) 0.80
Modeling of hypo/hyperglycemia and their impact on breast cancer progression related molecules. PLoS One (2014) 0.78
Downregulation of AKT3 Increases Migration and Metastasis in Triple Negative Breast Cancer Cells by Upregulating S100A4. PLoS One (2016) 0.78
LRIG1 opposes epithelial-to-mesenchymal transition and inhibits invasion of basal-like breast cancer cells. Oncogene (2015) 0.78
Anisotropic forces from spatially constrained focal adhesions mediate contact guidance directed cell migration. Nat Commun (2017) 0.77
Modeling tumor microenvironments using custom-designed biomaterial scaffolds. Curr Opin Chem Eng (2016) 0.77
Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (1970) 1528.65
Cell adhesion: the molecular basis of tissue architecture and morphogenesis. Cell (1996) 14.75
Putting tumours in context. Nat Rev Cancer (2001) 12.37
Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies. J Cell Biol (1997) 10.61
Interaction with basement membrane serves to rapidly distinguish growth and differentiation pattern of normal and malignant human breast epithelial cells. Proc Natl Acad Sci U S A (1992) 8.69
Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo. Nat Med (1999) 7.97
Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression. J Cell Biol (1989) 6.55
FAK integrates growth-factor and integrin signals to promote cell migration. Nat Cell Biol (2000) 6.54
Reciprocal interactions between beta1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: a different perspective in epithelial biology. Proc Natl Acad Sci U S A (1998) 5.34
Cadherins in cancer: implications for invasion and metastasis. Curr Opin Cell Biol (1993) 5.22
Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase. J Cell Biol (1998) 4.91
N-cadherin promotes motility in human breast cancer cells regardless of their E-cadherin expression. J Cell Biol (1999) 4.20
A new diploid nontumorigenic human breast epithelial cell line isolated and propagated in chemically defined medium. In Vitro Cell Dev Biol (1987) 3.14
Tissue structure, nuclear organization, and gene expression in normal and malignant breast. Cancer Res (1999) 2.84
Activation of both MAP kinase and phosphatidylinositide 3-kinase by Ras is required for hepatocyte growth factor/scatter factor-induced adherens junction disassembly. Mol Biol Cell (1998) 2.71
EGF-R signaling through Fyn kinase disrupts the function of integrin alpha6beta4 at hemidesmosomes: role in epithelial cell migration and carcinoma invasion. J Cell Biol (2001) 2.46
Laminin polymerization induces a receptor-cytoskeleton network. J Cell Biol (1999) 2.36
Myosin light chain kinase functions downstream of Ras/ERK to promote migration of urokinase-type plasminogen activator-stimulated cells in an integrin-selective manner. J Cell Biol (1999) 2.35
Trisomy 7p and malignant transformation of human breast epithelial cells following epidermal growth factor withdrawal. Cancer Res (1996) 2.23
Misregulation of stromelysin-1 expression in mouse mammary tumor cells accompanies acquisition of stromelysin-1-dependent invasive properties. J Biol Chem (1997) 2.15
The E-cadherin/catenin complex: an important gatekeeper in breast cancer tumorigenesis and malignant progression. Breast Cancer Res (2001) 2.14
PI3-kinase in concert with Src promotes the S-phase entry of oestradiol-stimulated MCF-7 cells. EMBO J (2001) 2.14
E-cadherin regulates the function of the EphA2 receptor tyrosine kinase. Cell Growth Differ (1999) 2.01
Epidermal growth factor promotes MDA-MB-231 breast cancer cell migration through a phosphatidylinositol 3'-kinase and phospholipase C-dependent mechanism. Cancer Res (1999) 1.98
Cadherin-11 is expressed in invasive breast cancer cell lines. Cancer Res (1999) 1.97
Integrin signaling inhibits paclitaxel-induced apoptosis in breast cancer cells. Oncogene (2001) 1.96
Restoration of tight junction structure and barrier function by down-regulation of the mitogen-activated protein kinase pathway in ras-transformed Madin-Darby canine kidney cells. Mol Biol Cell (2000) 1.76
Expression of a dominant negative cadherin mutant inhibits proliferation and stimulates terminal differentiation of human epidermal keratinocytes. J Cell Sci (1996) 1.74
Epidermal growth factor receptor gene expression in estrogen receptor-positive and negative human breast cancer cell lines. Mol Endocrinol (1987) 1.72
The alpha 3 beta 1 integrin is associated with mammary carcinoma cell metastasis, invasion, and gelatinase B (MMP-9) activity. Int J Cancer (2000) 1.71
Induction of cell scattering by expression of beta1 integrins in beta1-deficient epithelial cells requires activation of members of the rho family of GTPases and downregulation of cadherin and catenin function. J Cell Biol (1999) 1.64
The epidermal growth factor receptor modulates the interaction of E-cadherin with the actin cytoskeleton. J Biol Chem (1998) 1.59
Coendocytosis of cadherin and c-Met coupled to disruption of cell-cell adhesion in MDCK cells--regulation by Rho, Rac and Rab small G proteins. Oncogene (1999) 1.57
Matrix-degrading proteases and angiogenesis during development and tumor formation. APMIS (1999) 1.49
Differentially expressed genes associated with the metastatic phenotype in breast cancer. Breast Cancer Res Treat (1999) 1.47
E-cadherin expression in human breast cancer cells suppresses the development of osteolytic bone metastases in an experimental metastasis model. Cancer Res (1996) 1.30
H-Ras activation promotes cytoplasmic accumulation and phosphoinositide 3-OH kinase association of beta-catenin in epidermal keratinocytes. J Cell Biol (1999) 1.26
Anomalous dystroglycan in carcinoma cell lines. FEBS Lett (2000) 1.20
Laminin-10 mediates basal and EGF-stimulated motility of human colon carcinoma cells via alpha(3)beta(1) and alpha(6)beta(4) integrins. Exp Cell Res (2001) 1.18
E-cadherin transfection down-regulates the epidermal growth factor receptor and reverses the invasive phenotype of human papilloma virus-transfected keratinocytes. Cancer Res (1996) 1.14
HGF/scatter factor selectively promotes cell invasion by increasing integrin avidity. FASEB J (2000) 1.13
The EGF receptor system as a target for antitumor therapy. Cancer Invest (1991) 1.11
Basal extracellular signal-regulated kinase activity modulates cell-cell and cell-matrix interactions. Mol Cell Biol (1998) 1.07
Epidermal growth factor and laminin receptors contribute to migratory and invasive properties of gliomas. Invasion Metastasis (1997) 1.04
Inhibition of mammary epithelial apoptosis and sustained phosphorylation of Akt/PKB in MMTV-IGF-II transgenic mice. Cell Death Differ (2001) 1.02
Molecular analysis of two mammary carcinoma cell lines at the transcriptional level as a model system for progression of breast cancer. Clin Exp Metastasis (1998) 0.97
Quantitative cell dispersion analysis: new test to measure tumor cell aggressiveness. Int J Cancer (2001) 0.92
Oncogenic Ras modulates epidermal growth factor responsiveness in endometrial carcinomas. Eur J Cancer (1998) 0.87
Interleukin-1 directly regulates hormone-dependent human breast cancer cell proliferation in vitro. Mol Endocrinol (1988) 0.86
Three-dimensional culture models of normal and malignant breast epithelial cells. Nat Methods (2007) 7.43
Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability. Nature (2005) 7.24
Of extracellular matrix, scaffolds, and signaling: tissue architecture regulates development, homeostasis, and cancer. Annu Rev Cell Dev Biol (2006) 6.64
Isolation, immortalization, and characterization of a human breast epithelial cell line with stem cell properties. Genes Dev (2002) 6.55
The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression. Mol Oncol (2007) 5.81
beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium. Cancer Cell (2002) 5.56
The organizing principle: microenvironmental influences in the normal and malignant breast. Differentiation (2002) 4.64
Regulation of in situ to invasive breast carcinoma transition. Cancer Cell (2008) 4.46
Normal and tumor-derived myoepithelial cells differ in their ability to interact with luminal breast epithelial cells for polarity and basement membrane deposition. J Cell Sci (2002) 4.25
Tissue geometry determines sites of mammary branching morphogenesis in organotypic cultures. Science (2006) 4.12
Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway. Cell (2012) 4.09
Evidence for a stem cell hierarchy in the adult human breast. J Cell Biol (2007) 3.76
Modeling tissue-specific signaling and organ function in three dimensions. J Cell Sci (2003) 3.52
The perivascular niche regulates breast tumour dormancy. Nat Cell Biol (2013) 3.36
Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition. Cancer Res (2009) 3.14
Regulation of mammary gland branching morphogenesis by the extracellular matrix and its remodeling enzymes. Breast Cancer Res (2003) 3.13
Tumor reversion: correction of malignant behavior by microenvironmental cues. Int J Cancer (2003) 3.02
Polarity and proliferation are controlled by distinct signaling pathways downstream of PI3-kinase in breast epithelial tumor cells. J Cell Biol (2004) 2.93
Beta1 integrin inhibitory antibody induces apoptosis of breast cancer cells, inhibits growth, and distinguishes malignant from normal phenotype in three dimensional cultures and in vivo. Cancer Res (2006) 2.86
Site-specific inductive and inhibitory activities of MMP-2 and MMP-3 orchestrate mammary gland branching morphogenesis. J Cell Biol (2003) 2.68
Her-2 overexpression increases the metastatic outgrowth of breast cancer cells in the brain. Cancer Res (2007) 2.66
Imaging tumor-stroma interactions during chemotherapy reveals contributions of the microenvironment to resistance. Cancer Cell (2012) 2.61
MYC suppresses cancer metastasis by direct transcriptional silencing of αv and β3 integrin subunits. Nat Cell Biol (2012) 2.61
Modeling dynamic reciprocity: engineering three-dimensional culture models of breast architecture, function, and neoplastic transformation. Semin Cancer Biol (2005) 2.53
Unraveling the microenvironmental influences on the normal mammary gland and breast cancer. Semin Cancer Biol (2008) 2.41
Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2. Proc Natl Acad Sci U S A (2006) 2.41
Signalling mediated by the endoplasmic reticulum stress transducer OASIS is involved in bone formation. Nat Cell Biol (2009) 2.38
HER2 signaling pathway activation and response of breast cancer cells to HER2-targeting agents is dependent strongly on the 3D microenvironment. Breast Cancer Res Treat (2009) 2.34
Models for evaluating agents intended for the prophylaxis, mitigation and treatment of radiation injuries. Report of an NCI Workshop, December 3-4, 2003. Radiat Res (2004) 2.33
Fibrosis and cancer: do myofibroblasts come also from epithelial cells via EMT? J Cell Biochem (2007) 2.32
Critical roles of c-Jun signaling in regulation of NFAT family and RANKL-regulated osteoclast differentiation. J Clin Invest (2004) 2.31
Targeting TACE-dependent EGFR ligand shedding in breast cancer. J Clin Invest (2007) 2.29
Mechanisms of disease: epithelial-mesenchymal transition--does cellular plasticity fuel neoplastic progression? Nat Clin Pract Oncol (2008) 2.18
Iterative voting for inference of structural saliency and characterization of subcellular events. IEEE Trans Image Process (2007) 2.17
BMP2 regulates Osterix through Msx2 and Runx2 during osteoblast differentiation. J Biol Chem (2008) 2.12
Prognostic breast cancer signature identified from 3D culture model accurately predicts clinical outcome across independent datasets. PLoS One (2008) 2.12
Epithelial to mesenchymal transition in human breast cancer can provide a nonmalignant stroma. Am J Pathol (2003) 2.06
Hyaluronan and homeostasis: a balancing act. J Biol Chem (2001) 2.03
The MAPK(ERK-1,2) pathway integrates distinct and antagonistic signals from TGFalpha and FGF7 in morphogenesis of mouse mammary epithelium. Dev Biol (2007) 1.98
Co-localization of cortactin and phosphotyrosine identifies active invadopodia in human breast cancer cells. Exp Cell Res (2006) 1.96
Tissue architecture and function: dynamic reciprocity via extra- and intra-cellular matrices. Cancer Metastasis Rev (2009) 1.93
Myoepithelial cells: their origin and function in breast morphogenesis and neoplasia. J Mammary Gland Biol Neoplasia (2005) 1.92
In vivo MRI of cancer cell fate at the single-cell level in a mouse model of breast cancer metastasis to the brain. Magn Reson Med (2006) 1.88
Latent transforming growth factor-beta activation in mammary gland: regulation by ovarian hormones affects ductal and alveolar proliferation. Am J Pathol (2002) 1.88
Conditional overexpression of active transforming growth factor beta1 in vivo accelerates metastases of transgenic mammary tumors. Cancer Res (2004) 1.84
Beta1 integrin inhibition dramatically enhances radiotherapy efficacy in human breast cancer xenografts. Cancer Res (2008) 1.83
Human mammary progenitor cell fate decisions are products of interactions with combinatorial microenvironments. Integr Biol (Camb) (2008) 1.82
The hyaluronan receptors CD44 and Rhamm (CD168) form complexes with ERK1,2 that sustain high basal motility in breast cancer cells. J Biol Chem (2007) 1.82
A human breast cell model of preinvasive to invasive transition. Cancer Res (2008) 1.79
Hypoxia and hypoxia-inducible factor-1 expression enhance osteolytic bone metastases of breast cancer. Cancer Res (2007) 1.77
A novel bioinformatics pipeline for identification and characterization of fusion transcripts in breast cancer and normal cell lines. Nucleic Acids Res (2011) 1.77
The tumor microenvironment is a dominant force in multidrug resistance. Drug Resist Updat (2012) 1.77
TGF-beta biology in mammary development and breast cancer. Cold Spring Harb Perspect Biol (2011) 1.75
Laminin and biomimetic extracellular elasticity enhance functional differentiation in mammary epithelia. EMBO J (2008) 1.74
Differential roles of Smad1 and p38 kinase in regulation of peroxisome proliferator-activating receptor gamma during bone morphogenetic protein 2-induced adipogenesis. Mol Biol Cell (2003) 1.73
The dominance of the microenvironment in breast and ovarian cancer. Semin Cancer Biol (2002) 1.73
Targeting the tumor microenvironment. Front Biosci (2007) 1.72
Gene expression signature in organized and growth-arrested mammary acini predicts good outcome in breast cancer. Cancer Res (2006) 1.69
Regulation of endoplasmic reticulum stress response by a BBF2H7-mediated Sec23a pathway is essential for chondrogenesis. Nat Cell Biol (2009) 1.69
The Wnt antagonist Frzb-1 regulates chondrocyte maturation and long bone development during limb skeletogenesis. Dev Biol (2002) 1.68
Myoepithelial cells: good fences make good neighbors. Breast Cancer Res (2005) 1.66
Functional gene screening system identified TRPV4 as a regulator of chondrogenic differentiation. J Biol Chem (2007) 1.66
Bone-derived IGF mediates crosstalk between bone and breast cancer cells in bony metastases. Cancer Res (2012) 1.65
A role for dystroglycan in epithelial polarization: loss of function in breast tumor cells. Cancer Res (2002) 1.65
Cell shape regulates global histone acetylation in human mammary epithelial cells. Exp Cell Res (2007) 1.64
Reciprocal roles of MSX2 in regulation of osteoblast and adipocyte differentiation. J Biol Chem (2004) 1.64
Cancer. Respect thy neighbor! Science (2004) 1.62
Breast cancer by proxy: can the microenvironment be both the cause and consequence? Trends Mol Med (2008) 1.60
Ionizing radiation predisposes nonmalignant human mammary epithelial cells to undergo transforming growth factor beta induced epithelial to mesenchymal transition. Cancer Res (2007) 1.60
Evidence for formation of DNA repair centers and dose-response nonlinearity in human cells. Proc Natl Acad Sci U S A (2011) 1.58
Ihh/Gli2 signaling promotes osteoblast differentiation by regulating Runx2 expression and function. Mol Biol Cell (2007) 1.57
β1 integrin mediates an alternative survival pathway in breast cancer cells resistant to lapatinib. Breast Cancer Res (2011) 1.56
Extracellular matrix control of mammary gland morphogenesis and tumorigenesis: insights from imaging. Histochem Cell Biol (2008) 1.55
C-SRC tyrosine kinase activity is associated with tumor colonization in bone and lung in an animal model of human breast cancer metastasis. Cancer Res (2003) 1.52
RHAMM, a receptor for hyaluronan-mediated motility, compensates for CD44 in inflamed CD44-knockout mice: a different interpretation of redundancy. Proc Natl Acad Sci U S A (2004) 1.52
Zoledronic acid inhibits visceral metastases in the 4T1/luc mouse breast cancer model. Clin Cancer Res (2004) 1.52
Dystroglycan loss disrupts polarity and beta-casein induction in mammary epithelial cells by perturbing laminin anchoring. J Cell Sci (2006) 1.49
Isoform-specific activation of latent transforming growth factor beta (LTGF-beta) by reactive oxygen species. Radiat Res (2006) 1.47
Extracellular matrix-regulated gene expression requires cooperation of SWI/SNF and transcription factors. J Biol Chem (2007) 1.46
Molecular predictors of 3D morphogenesis by breast cancer cell lines in 3D culture. PLoS Comput Biol (2010) 1.46
Coherent angular motion in the establishment of multicellular architecture of glandular tissues. Proc Natl Acad Sci U S A (2012) 1.45
Sustained activation of STAT5 is essential for chromatin remodeling and maintenance of mammary-specific function. J Cell Biol (2009) 1.44
Inhibition of transforming growth factor-beta1 signaling attenuates ataxia telangiectasia mutated activity in response to genotoxic stress. Cancer Res (2006) 1.42
Change in cell shape is required for matrix metalloproteinase-induced epithelial-mesenchymal transition of mammary epithelial cells. J Cell Biochem (2008) 1.41
Two Perspectives. Radiat Res (2015) 1.39
Tumor-derived platelet-derived growth factor-BB plays a critical role in osteosclerotic bone metastasis in an animal model of human breast cancer. Cancer Res (2002) 1.37
NAD(P)H oxidases regulate HIF-2alpha protein expression. J Biol Chem (2007) 1.37
Self-organization of engineered epithelial tubules by differential cellular motility. Proc Natl Acad Sci U S A (2009) 1.36
Splicing program of human MENA produces a previously undescribed isoform associated with invasive, mesenchymal-like breast tumors. Proc Natl Acad Sci U S A (2012) 1.36
Differential expression of a chloride intracellular channel gene, CLIC4, in transforming growth factor-beta1-mediated conversion of fibroblasts to myofibroblasts. Am J Pathol (2002) 1.36
Proliferation of estrogen receptor-alpha-positive mammary epithelial cells is restrained by transforming growth factor-beta1 in adult mice. Am J Pathol (2005) 1.35