Inflammasomes as mediators of immunity against influenza virus.

PubWeight™: 1.35‹?› | Rank: Top 10%

🔗 View Article (PMC 3017631)

Published in Trends Immunol on December 14, 2010

Authors

Iris K Pang1, Akiko Iwasaki

Author Affiliations

1: Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.

Articles citing this

Detection of prokaryotic mRNA signifies microbial viability and promotes immunity. Nature (2011) 2.93

Intrinsic antiviral immunity. Nat Immunol (2012) 2.71

Regulating the adaptive immune response to respiratory virus infection. Nat Rev Immunol (2012) 1.87

Activation of the NLRP3 inflammasome by IAV virulence protein PB1-F2 contributes to severe pathophysiology and disease. PLoS Pathog (2013) 1.39

IL-1R signaling in dendritic cells replaces pattern-recognition receptors in promoting CD8⁺ T cell responses to influenza A virus. Nat Immunol (2013) 1.28

Traditional and new influenza vaccines. Clin Microbiol Rev (2013) 1.22

Pathogenic potential of interferon αβ in acute influenza infection. Nat Commun (2014) 1.19

The Nlrp3 inflammasome promotes age-related thymic demise and immunosenescence. Cell Rep (2012) 1.14

The inflammasome in lung diseases. Am J Physiol Lung Cell Mol Physiol (2012) 1.10

Predicting Viral Infection From High-Dimensional Biomarker Trajectories. J Am Stat Assoc (2011) 1.07

Evasion of influenza A viruses from innate and adaptive immune responses. Viruses (2012) 1.06

Tissue factor, blood coagulation, and beyond: an overview. Int J Inflam (2011) 1.05

Viral infection of the lung: host response and sequelae. J Allergy Clin Immunol (2013) 1.01

Interleukin-33 upregulation in peripheral leukocytes and CNS of multiple sclerosis patients. Clin Immunol (2011) 1.01

Conserved host response to highly pathogenic avian influenza virus infection in human cell culture, mouse and macaque model systems. BMC Syst Biol (2011) 0.97

TLR7 recognition is dispensable for influenza virus A infection but important for the induction of hemagglutinin-specific antibodies in response to the 2009 pandemic split vaccine in mice. J Virol (2012) 0.97

Immunogenetic factors associated with severe respiratory illness caused by zoonotic H1N1 and H5N1 influenza viruses. Clin Dev Immunol (2011) 0.96

Highly pathogenic avian influenza viruses inhibit effective immune responses of human blood-derived macrophages. J Leukoc Biol (2012) 0.95

Activation of P2X(7) receptor by ATP plays an important role in regulating inflammatory responses during acute viral infection. PLoS One (2012) 0.94

Control of antiviral immunity by pattern recognition and the microbiome. Immunol Rev (2012) 0.93

Asparagine endopeptidase controls anti-influenza virus immune responses through TLR7 activation. PLoS Pathog (2012) 0.93

Role of aging on innate responses to viral infections. J Gerontol A Biol Sci Med Sci (2011) 0.91

The Split Virus Influenza Vaccine rapidly activates immune cells through Fcγ receptors. Vaccine (2014) 0.88

Mannose-binding lectin contributes to deleterious inflammatory response in pandemic H1N1 and avian H9N2 infection. J Infect Dis (2011) 0.88

A network integration approach to predict conserved regulators related to pathogenicity of influenza and SARS-CoV respiratory viruses. PLoS One (2013) 0.87

Towards multiscale modeling of influenza infection. J Theor Biol (2013) 0.87

Induction of innate immunity and its perturbation by influenza viruses. Protein Cell (2015) 0.82

Innate immune recognition of respiratory syncytial virus infection. BMB Rep (2014) 0.82

Virus-induced NETs--critical component of host defense or pathogenic mediator? PLoS Pathog (2015) 0.79

The effector T cell response to influenza infection. Curr Top Microbiol Immunol (2015) 0.79

Innate immune response to a H3N2 subtype swine influenza virus in newborn porcine trachea cells, alveolar macrophages, and precision-cut lung slices. Vet Res (2014) 0.78

In silico analysis of autoimmune diseases and genetic relationships to vaccination against infectious diseases. BMC Immunol (2014) 0.78

A novel systems pharmacology model for herbal medicine injection: a case using Reduning injection. BMC Complement Altern Med (2014) 0.77

Activation and measurement of NLRP3 inflammasome activity using IL-1β in human monocyte-derived dendritic cells. J Vis Exp (2014) 0.76

Immune Responses to Influenza Virus and Its Correlation to Age and Inherited Factors. Front Microbiol (2016) 0.75

Caspase-1 independent viral clearance and adaptive immunity against mucosal respiratory syncytial virus infection. Immune Netw (2015) 0.75

AIM2 Inflammasome Is Critical for Influenza-Induced Lung Injury and Mortality. J Immunol (2017) 0.75

Induction of memory cytotoxic T cells to influenza A virus and subsequent viral clearance is not modulated by PB1-F2-dependent inflammasome activation. Immunol Cell Biol (2015) 0.75

Effect of a synbiotic on the response to seasonal influenza vaccination is strongly influenced by degree of immunosenescence. Immun Ageing (2016) 0.75

Influenza and Memory T Cells: How to Awake the Force. Vaccines (Basel) (2016) 0.75

Articles cited by this

The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell (2002) 20.11

The inflammasomes. Cell (2010) 19.37

Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science (2004) 16.26

Biologic basis for interleukin-1 in disease. Blood (1996) 16.04

RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates. Science (2006) 16.00

Immunological and inflammatory functions of the interleukin-1 family. Annu Rev Immunol (2009) 14.33

Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. Nat Immunol (2007) 13.70

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature (2009) 13.23

The inflammasomes: guardians of the body. Annu Rev Immunol (2009) 12.89

Cloning of a new cytokine that induces IFN-gamma production by T cells. Nature (1995) 10.89

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. Nature (2009) 10.83

Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3. Nature (2006) 9.77

Cell type-specific involvement of RIG-I in antiviral response. Immunity (2005) 9.37

The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response. Nature (2008) 9.01

Recognition of single-stranded RNA viruses by Toll-like receptor 7. Proc Natl Acad Sci U S A (2004) 9.00

Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression. J Immunol (2009) 8.40

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome. Nat Immunol (2009) 7.93

The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses. Nat Immunol (2010) 7.47

HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA. Science (2009) 6.59

The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA. Immunity (2009) 6.37

Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA. J Biol Chem (2006) 5.92

NLRP3 inflammasome activation: The convergence of multiple signalling pathways on ROS production? Nat Rev Immunol (2010) 5.90

The AIM2 inflammasome is critical for innate immunity to Francisella tularensis. Nat Immunol (2010) 5.79

Inflammasome recognition of influenza virus is essential for adaptive immune responses. J Exp Med (2009) 5.77

Nuclear transport of influenza virus ribonucleoproteins: the viral matrix protein (M1) promotes export and inhibits import. Cell (1991) 4.97

Defective NK cell activity and Th1 response in IL-18-deficient mice. Immunity (1998) 4.70

The IL-1 family: regulators of immunity. Nat Rev Immunol (2010) 4.65

Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella. J Exp Med (2010) 4.52

The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1. Immunity (2009) 4.51

The NLRP3 inflammasome: a sensor for metabolic danger? Science (2010) 4.33

NLRs join TLRs as innate sensors of pathogens. Trends Immunol (2005) 4.12

Involvement of toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virus. J Biol Chem (2004) 3.88

Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production. Nat Immunol (2009) 3.58

An essential role for the NLRP3 inflammasome in host defense against the human fungal pathogen Candida albicans. Cell Host Microbe (2009) 3.52

The M2 proton channels of influenza A and B viruses. J Biol Chem (2005) 3.49

Influenza virus activates inflammasomes via its intracellular M2 ion channel. Nat Immunol (2010) 3.45

Cutting edge: TNF-alpha mediates sensitization to ATP and silica via the NLRP3 inflammasome in the absence of microbial stimulation. J Immunol (2009) 3.32

PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing. J Biol Chem (2002) 3.28

CD4 effector T cell subsets in the response to influenza: heterogeneity, migration, and function. J Exp Med (2002) 3.28

Differential role of TLR- and RLR-signaling in the immune responses to influenza A virus infection and vaccination. J Immunol (2007) 3.14

Interleukin-1 is responsible for acute lung immunopathology but increases survival of respiratory influenza virus infection. J Virol (2005) 3.14

IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation. Proc Natl Acad Sci U S A (2009) 3.07

Detrimental contribution of the Toll-like receptor (TLR)3 to influenza A virus-induced acute pneumonia. PLoS Pathog (2006) 3.04

Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms. Nature (2004) 2.98

Influenza a virus M2 ion channel activity is essential for efficient replication in tissue culture. J Virol (2002) 2.97

Cutting Edge: Influenza A virus activates TLR3-dependent inflammatory and RIG-I-dependent antiviral responses in human lung epithelial cells. J Immunol (2007) 2.73

The caspase-1 inflammasome: a pilot of innate immune responses. Cell Host Microbe (2008) 2.71

Protective influenza-specific CD8 T cell responses require interactions with dendritic cells in the lungs. J Exp Med (2008) 2.55

Immunity to respiratory viruses. Annu Rev Immunol (2009) 2.50

Identification of an ion channel activity of the Vpu transmembrane domain and its involvement in the regulation of virus release from HIV-1-infected cells. FEBS Lett (1996) 2.43

Temporal changes in dendritic cell subsets, cross-priming and costimulation via CD70 control CD8(+) T cell responses to influenza. Nat Immunol (2010) 2.27

Virus infection activates IL-1 beta and IL-18 production in human macrophages by a caspase-1-dependent pathway. J Immunol (1999) 2.26

Evidence that the amantadine-induced, M2-mediated conversion of influenza A virus hemagglutinin to the low pH conformation occurs in an acidic trans Golgi compartment. Virology (1992) 2.25

TLR signaling fine-tunes anti-influenza B cell responses without regulating effector T cell responses. J Immunol (2007) 2.11

TLR-independent induction of dendritic cell maturation and adaptive immunity by negative-strand RNA viruses. J Immunol (2004) 2.10

Influence of polymorphism in the genes for the interleukin (IL)-1 receptor antagonist and IL-1beta on tuberculosis. J Exp Med (1999) 1.97

Critical functions of priming and lysosomal damage for NLRP3 activation. Eur J Immunol (2010) 1.87

The ion channel activity of the influenza virus M2 protein affects transport through the Golgi apparatus. J Cell Biol (1996) 1.83

Interleukin-18 improves the early defence system against influenza virus infection by augmenting natural killer cell-mediated cytotoxicity. J Gen Virol (2004) 1.58

IL-18 up-regulates perforin-mediated NK activity without increasing perforin messenger RNA expression by binding to constitutively expressed IL-18 receptor. J Immunol (1999) 1.48

Influence of interleukin-1 receptor antagonist gene polymorphism on disease. Clin Infect Dis (2001) 1.42

Solubilization of matrix protein M1/M from virions occurs at different pH for orthomyxo- and paramyxoviruses. Virology (1990) 1.42

Proton and cation transport activity of the M2 proton channel from influenza A virus. Proc Natl Acad Sci U S A (2010) 1.24

Influenza A virus lacking M2 protein as a live attenuated vaccine. J Virol (2009) 1.16

Polymorphism in a gene coding for the inflammasome component NALP3 and recurrent vulvovaginal candidiasis in women with vulvar vestibulitis syndrome. Am J Obstet Gynecol (2009) 1.12

Cutting edge: IL-18-transgenic mice: in vivo evidence of a broad role for IL-18 in modulating immune function. J Immunol (2001) 1.11

IL-18, but not IL-12, is required for optimal cytokine production by influenza virus-specific CD8+ T cells. Eur J Immunol (2007) 1.10

IL-18 acts synergistically with IL-15 in stimulating natural killer cell proliferation. Cytokine (2006) 1.07

Viral proteins function as ion channels. Biochim Biophys Acta (2010) 1.07

A 3'UTR SNP in NLRP3 gene is associated with susceptibility to HIV-1 infection. J Acquir Immune Defic Syndr (2010) 0.98

Genetic polymorphism in an inflammasome component, cervical mycoplasma detection and female infertility in women undergoing in vitro fertilization. J Reprod Immunol (2010) 0.79

Genetics of inflammasome-associated disorders: a lesson in the guiding principals of inflammasome function. Eur J Immunol (2010) 0.77

Articles by these authors

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92

Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08

Recognition of single-stranded RNA viruses by Toll-like receptor 7. Proc Natl Acad Sci U S A (2004) 9.00

Autophagy-dependent viral recognition by plasmacytoid dendritic cells. Science (2007) 7.65

Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells. J Exp Med (2003) 7.26

Inflammasome recognition of influenza virus is essential for adaptive immune responses. J Exp Med (2009) 5.77

Microbiota regulates immune defense against respiratory tract influenza A virus infection. Proc Natl Acad Sci U S A (2011) 5.44

CD8(+) T lymphocyte mobilization to virus-infected tissue requires CD4(+) T-cell help. Nature (2009) 4.03

Vaginal submucosal dendritic cells, but not Langerhans cells, induce protective Th1 responses to herpes simplex virus-2. J Exp Med (2003) 3.86

Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling. Proc Natl Acad Sci U S A (2009) 3.84

A vaccine strategy that protects against genital herpes by establishing local memory T cells. Nature (2012) 3.65

Influenza virus activates inflammasomes via its intracellular M2 ion channel. Nat Immunol (2010) 3.45

Bifurcation of Toll-like receptor 9 signaling by adaptor protein 3. Science (2010) 3.37

In vivo requirement for Atg5 in antigen presentation by dendritic cells. Immunity (2010) 3.19

The autophagy gene ATG5 plays an essential role in B lymphocyte development. Autophagy (2007) 2.48

Expression of DC-SIGN by dendritic cells of intestinal and genital mucosae in humans and rhesus macaques. J Virol (2002) 2.46

CD301b⁺ dermal dendritic cells drive T helper 2 cell-mediated immunity. Immunity (2013) 2.31

Cutting Edge: Plasmacytoid dendritic cells provide innate immune protection against mucosal viral infection in situ. J Immunol (2006) 1.95

CD4+ T cells support cytotoxic T lymphocyte priming by controlling lymph node input. Proc Natl Acad Sci U S A (2011) 1.86

Dendritic cells and B cells maximize mucosal Th1 memory response to herpes simplex virus. J Exp Med (2008) 1.86

Dual recognition of herpes simplex viruses by TLR2 and TLR9 in dendritic cells. Proc Natl Acad Sci U S A (2006) 1.82

Induction of antiviral immunity requires Toll-like receptor signaling in both stromal and dendritic cell compartments. Proc Natl Acad Sci U S A (2004) 1.80

Differential roles of migratory and resident DCs in T cell priming after mucosal or skin HSV-1 infection. J Exp Med (2009) 1.76

Innate control of adaptive immunity via remodeling of lymph node feed arteriole. Proc Natl Acad Sci U S A (2005) 1.62

Adaptor protein-3 in dendritic cells facilitates phagosomal toll-like receptor signaling and antigen presentation to CD4(+) T cells. Immunity (2012) 1.59

CCL9 is secreted by the follicle-associated epithelium and recruits dome region Peyer's patch CD11b+ dendritic cells. J Immunol (2003) 1.54

CD11b+ Peyer's patch dendritic cells secrete IL-6 and induce IgA secretion from naive B cells. J Immunol (2003) 1.49

Recruited inflammatory monocytes stimulate antiviral Th1 immunity in infected tissue. Proc Natl Acad Sci U S A (2010) 1.47

Autophagy and antiviral immunity. Curr Opin Immunol (2008) 1.44

MyD88 signalling in colonic mononuclear phagocytes drives colitis in IL-10-deficient mice. Nat Commun (2012) 1.44

In vivo role of nectin-1 in entry of herpes simplex virus type 1 (HSV-1) and HSV-2 through the vaginal mucosa. J Virol (2004) 1.39

Genome-virome interactions: examining the role of common viral infections in complex disease. Nat Rev Microbiol (2011) 1.38

The CXC chemokine murine monokine induced by IFN-gamma (CXC chemokine ligand 9) is made by APCs, targets lymphocytes including activated B cells, and supports antibody responses to a bacterial pathogen in vivo. J Immunol (2002) 1.34

IL-1R signaling in dendritic cells replaces pattern-recognition receptors in promoting CD8⁺ T cell responses to influenza A virus. Nat Immunol (2013) 1.28

Innate control of adaptive immunity: dendritic cells and beyond. Semin Immunol (2007) 1.26

A neuron-specific role for autophagy in antiviral defense against herpes simplex virus. Cell Host Microbe (2012) 1.21

Vaginal epithelial dendritic cells renew from bone marrow precursors. Proc Natl Acad Sci U S A (2007) 1.21

CD8+ T cell responses following replication-defective adenovirus serotype 5 immunization are dependent on CD11c+ dendritic cells but show redundancy in their requirement of TLR and nucleotide-binding oligomerization domain-like receptor signaling. J Immunol (2010) 1.17

Tissue-resident memory T cells. Immunol Rev (2013) 1.16

A crucial role for plasmacytoid dendritic cells in antiviral protection by CpG ODN-based vaginal microbicide. J Clin Invest (2006) 1.16

Dendritic cells at the host-pathogen interface. Nat Immunol (2006) 1.14

Autophagy and innate recognition systems. Curr Top Microbiol Immunol (2009) 1.07

MAdCAM-1 expressing sacral lymph node in the lymphotoxin beta-deficient mouse provides a site for immune generation following vaginal herpes simplex virus-2 infection. J Immunol (2004) 1.05

Toll-like receptors regulation of viral infection and disease. Adv Drug Deliv Rev (2007) 1.04

Cholera toxin inhibits IL-12 production and CD8alpha+ dendritic cell differentiation by cAMP-mediated inhibition of IRF8 function. J Exp Med (2009) 1.03

Innate sensors of influenza virus: clues to developing better intranasal vaccines. Expert Rev Vaccines (2008) 1.01

Generating protective immunity against genital herpes. Trends Immunol (2013) 1.00

Efficient influenza A virus replication in the respiratory tract requires signals from TLR7 and RIG-I. Proc Natl Acad Sci U S A (2013) 1.00

Autophagy in the control and pathogenesis of viral infection. Curr Opin Virol (2011) 1.00

ELF4 is critical for induction of type I interferon and the host antiviral response. Nat Immunol (2013) 0.95

Involvement of dendritic cell subsets in the induction of oral tolerance and immunity. Ann N Y Acad Sci (2004) 0.95

Control of antiviral immunity by pattern recognition and the microbiome. Immunol Rev (2012) 0.93

Nonmucosal alphavirus vaccination stimulates a mucosal inductive environment in the peripheral draining lymph node. J Immunol (2008) 0.92

Phagosome as the organelle linking innate and adaptive immunity. Traffic (2012) 0.92

Mitoxosome: a mitochondrial platform for cross-talk between cellular stress and antiviral signaling. Immunol Rev (2011) 0.92

Regulation of immature dendritic cell migration by RhoA guanine nucleotide exchange factor Arhgef5. J Biol Chem (2009) 0.89

Unique features of antiviral immune system of the vaginal mucosa. Curr Opin Immunol (2012) 0.89

Autophagic control of RLR signaling. Autophagy (2009) 0.89

Local advantage: skin DCs prime; skin memory T cells protect. Nat Immunol (2009) 0.87

Cell type-dependent requirement of autophagy in HSV-1 antiviral defense. Autophagy (2012) 0.84

Parvovirus evades interferon-dependent viral control in primary mouse embryonic fibroblasts. Virology (2013) 0.84

Autophagy and selective deployment of Atg proteins in antiviral defense. Int Immunol (2012) 0.84

High-risk human papillomavirus E6 inhibits monocyte differentiation to Langerhans cells. Virology (2013) 0.83

Application of the proximity-dependent assay and fluorescence imaging approaches to study viral entry pathways. Methods Mol Biol (2015) 0.83

Love triangle between Unc93B1, TLR7, and TLR9 prevents fatal attraction. Immunity (2011) 0.82

Nitric oxide and TNFα are critical regulators of reversible lymph node vascular remodeling and adaptive immune response. PLoS One (2013) 0.80

Comparative study of perceptions of work environment and moral sensitivity among Japanese and Norwegian nurses. Nurs Health Sci (2004) 0.79

Toll-like receptor 9 in plasmacytoid dendritic cells fails to detect parvoviruses. J Virol (2013) 0.78

Different routes to the same destination. Elife (2013) 0.76

[MHC class II-presentation of antigen by autophagy]. Tanpakushitsu Kakusan Koso (2008) 0.76

Skin T(RM) mediates distributed border patrol. Cell Res (2012) 0.75

[Inflammasomes in viral infection]. Uirusu (2009) 0.75

Gastric Cancer With Primitive Enterocyte Phenotype: An Aggressive Subgroup of Intestinal-type Adenocarcinoma. Am J Surg Pathol (2017) 0.75

[Mucosal immune defense against sexually transmitted diseases]. Nihon Rinsho (2009) 0.75

Securing mucosal borders--migrant monocytes to the rescue. Cell Host Microbe (2008) 0.75