ELF4 is critical for induction of type I interferon and the host antiviral response.

PubWeight™: 0.95‹?› | Rank: Top 15%

🔗 View Article (PMC 3939855)

Published in Nat Immunol on November 03, 2013

Authors

Fuping You1, Penghua Wang, Long Yang, Guang Yang, Yang O Zhao, Feng Qian, Wendy Walker, Richard Sutton, Ruth Montgomery, Rongtuan Lin, Akiko Iwasaki, Erol Fikrig

Author Affiliations

1: Section of Infectious Diseases, Yale University School of Medicine, New Haven, Connecticut, USA.

Articles citing this

Systems immunology reveals markers of susceptibility to West Nile virus infection. Clin Vaccine Immunol (2014) 0.97

Age-related alterations in immune responses to West Nile virus infection. Clin Exp Immunol (2016) 0.91

Interferon regulatory factor 5-dependent immune responses in the draining lymph node protect against West Nile virus infection. J Virol (2014) 0.82

New insights into innate immune restriction of West Nile virus infection. Curr Opin Virol (2014) 0.81

Risk factors for West Nile virus infection and disease in populations and individuals. Expert Rev Anti Infect Ther (2015) 0.79

Innate immune escape by Dengue and West Nile viruses. Curr Opin Virol (2016) 0.77

USP18 recruits USP20 to promote innate antiviral response through deubiquitinating STING/MITA. Cell Res (2016) 0.76

NFATC3 promotes IRF7 transcriptional activity in plasmacy--toid dendritic cells. J Exp Med (2016) 0.75

AMP-activated kinase (AMPK) promotes innate immunity and antiviral defense through modulation of stimulator of interferon genes (STING) signaling. J Biol Chem (2016) 0.75

Current developments in understanding of West Nile virus central nervous system disease. Curr Opin Neurol (2014) 0.75

Mint3 potentiates TLR3/4- and RIG-I-induced IFN-β expression and antiviral immune responses. Proc Natl Acad Sci U S A (2016) 0.75

Mitochondrial Control of Innate Immunity and Inflammation. Immune Netw (2017) 0.75

STING-IRF3 Triggers Endothelial Inflammation in Response to Free Fatty Acid-Induced Mitochondrial Damage in Diet-Induced Obesity. Arterioscler Thromb Vasc Biol (2017) 0.75

Finding a fairy in the forest: ELF4, a novel and critical element of type I interferon responses. Cell Mol Immunol (2014) 0.75

Palmitic acid dysregulates the Hippo-YAP pathway and inhibits angiogenesis by inducing mitochondrial damage and activating the cytosolic DNA sensor cGAS-STING-IRF3 signaling. J Biol Chem (2017) 0.75

Articles cited by this

Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3. Cell (2005) 20.30

IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat Immunol (2005) 18.32

Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature (2005) 17.47

VISA is an adapter protein required for virus-triggered IFN-beta signaling. Mol Cell (2005) 14.20

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. Nature (2008) 10.73

Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science (2012) 10.47

Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha/beta gene induction. Immunity (2000) 10.34

RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway. Cell (2009) 10.11

Negative regulation of toll-like receptor-mediated immune responses. Nat Rev Immunol (2005) 9.70

IFI16 is an innate immune sensor for intracellular DNA. Nat Immunol (2010) 8.97

The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation. Immunity (2008) 7.60

Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis. Nat Med (2004) 7.49

Innate immunity to virus infection. Immunol Rev (2009) 7.04

Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo. EMBO J (2010) 4.78

ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization. Proc Natl Acad Sci U S A (2009) 4.46

The N-ethyl-N-nitrosourea-induced Goldenticket mouse mutant reveals an essential function of Sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides. Infect Immun (2010) 3.89

Role of CD8+ T cells in control of West Nile virus infection. J Virol (2004) 3.40

PKR and RNase L contribute to protection against lethal West Nile Virus infection by controlling early viral spread in the periphery and replication in neurons. J Virol (2006) 3.13

Cytoplasmic DNA innate immune pathways. Immunol Rev (2011) 2.84

Innate and adaptive immune responses determine protection against disseminated infection by West Nile encephalitis virus. Viral Immunol (2003) 2.69

IPS-1 is essential for the control of West Nile virus infection and immunity. PLoS Pathog (2010) 2.39

A genomic regulatory element that directs assembly and function of immune-specific AP-1-IRF complexes. Science (2012) 2.30

Compensatory dendritic cell development mediated by BATF-IRF interactions. Nature (2012) 2.25

The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response. Nat Immunol (2012) 2.11

Activation of STAT6 by STING is critical for antiviral innate immunity. Cell (2011) 2.08

PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4. Nat Immunol (2009) 2.07

Crystal structure of ATF-2/c-Jun and IRF-3 bound to the interferon-beta enhancer. EMBO J (2004) 2.01

When Ets transcription factors meet their partners. Bioessays (2002) 1.99

Induction of IFN-beta and the innate antiviral response in myeloid cells occurs through an IPS-1-dependent signal that does not require IRF-3 and IRF-7. PLoS Pathog (2009) 1.95

Dysregulation of TLR3 impairs the innate immune response to West Nile virus in the elderly. J Virol (2008) 1.93

Transcription factor ELF4 controls the proliferation and homing of CD8+ T cells via the Krüppel-like factors KLF4 and KLF2. Nat Immunol (2009) 1.73

The ETS protein MEF plays a critical role in perforin gene expression and the development of natural killer and NK-T cells. Immunity (2002) 1.70

IRF-3, IRF-5, and IRF-7 coordinately regulate the type I IFN response in myeloid dendritic cells downstream of MAVS signaling. PLoS Pathog (2013) 1.67

NF-AT-AP-1 and Rel-bZIP: hybrid vigor and binding under the influence. Cell (1994) 1.43

Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias. Mol Cell Biol (1999) 1.40

Modulation of T-cell function by type I interferon. Immunol Cell Biol (2012) 1.21

Activation of the JNK-AP-1 signal transduction pathway is associated with pathogenesis and progression of human osteosarcomas. Bone (2003) 1.14

Tumor promoting properties of the ETS protein MEF in ovarian cancer. Oncogene (2007) 1.10

ELF4/MEF activates MDM2 expression and blocks oncogene-induced p16 activation to promote transformation. Mol Cell Biol (2009) 1.09

Specific binding of high-mobility-group I (HMGI) protein and histone H1 to the upstream AT-rich region of the murine beta interferon promoter: HMGI protein acts as a potential antirepressor of the promoter. Mol Cell Biol (1999) 1.06

Regulation of endothelial cell development by ETS transcription factors. Semin Cell Dev Biol (2011) 1.04

Caspase-12 controls West Nile virus infection via the viral RNA receptor RIG-I. Nat Immunol (2010) 1.04

TANK-binding kinase-1 plays an important role during in vitro and in vivo type I IFN responses to DNA virus infections. J Immunol (2009) 1.04

Regulation of human beta 2-microglobulin transactivation in hematopoietic cells. Blood (2002) 1.00

Changes of natural killer cell activity in different mouse lines by acute and asymptomatic flavivirus infections. Acta Virol (1986) 0.95

Overexpression of p65/RelA potentiates curcumin-induced apoptosis in HCT116 human colon cancer cells. Carcinogenesis (2006) 0.95

Inducible histamine protects mice from P. acnes-primed and LPS-induced hepatitis through H2-receptor stimulation. Gastroenterology (2004) 0.87

Functional dissection of the ETS transcription factor MEF. Biochim Biophys Acta (2002) 0.83

The transcription factor E74-like factor controls quiescence of endothelial cells and their resistance to myeloablative treatments in bone marrow. Arterioscler Thromb Vasc Biol (2011) 0.78

Articles by these authors

The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements. Nat Biotechnol (2006) 30.90

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92

Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08

Triggering the interferon antiviral response through an IKK-related pathway. Science (2003) 11.62

ATP mediates rapid microglial response to local brain injury in vivo. Nat Neurosci (2005) 11.55

Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer. Proc Natl Acad Sci U S A (2005) 10.89

Recognition of single-stranded RNA viruses by Toll-like receptor 7. Proc Natl Acad Sci U S A (2004) 9.00

Guidelines for the diagnosis and management of syncope (version 2009). Eur Heart J (2009) 8.25

The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus. Cell (2009) 7.88

Autophagy-dependent viral recognition by plasmacytoid dendritic cells. Science (2007) 7.65

Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis. Nat Med (2004) 7.49

Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells. J Exp Med (2003) 7.26

The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models. Nat Biotechnol (2010) 7.08

2013 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy: the Task Force on cardiac pacing and resynchronization therapy of the European Society of Cardiology (ESC). Developed in collaboration with the European Heart Rhythm Association (EHRA). Eur Heart J (2013) 6.17

Inflammasome recognition of influenza virus is essential for adaptive immune responses. J Exp Med (2009) 5.77

Microbiota regulates immune defense against respiratory tract influenza A virus infection. Proc Natl Acad Sci U S A (2011) 5.44

Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus. Nature (2013) 5.35

RNA interference screen for human genes associated with West Nile virus infection. Nature (2008) 4.93

The P2Y12 receptor regulates microglial activation by extracellular nucleotides. Nat Neurosci (2006) 4.93

Transcriptional profiling of interferon regulatory factor 3 target genes: direct involvement in the regulation of interferon-stimulated genes. J Virol (2002) 4.31

MYD88 L265P somatic mutation in Waldenström's macroglobulinemia. N Engl J Med (2012) 4.26

Guidelines for cardiac pacing and cardiac resynchronization therapy: The Task Force for Cardiac Pacing and Cardiac Resynchronization Therapy of the European Society of Cardiology. Developed in collaboration with the European Heart Rhythm Association. Eur Heart J (2007) 4.15

2013 ESC guidelines on cardiac pacing and cardiac resynchronization therapy: the task force on cardiac pacing and resynchronization therapy of the European Society of Cardiology (ESC). Developed in collaboration with the European Heart Rhythm Association (EHRA). Europace (2013) 4.07

CD8(+) T lymphocyte mobilization to virus-infected tissue requires CD4(+) T-cell help. Nature (2009) 4.03

Choice of cranial window type for in vivo imaging affects dendritic spine turnover in the cortex. Nat Neurosci (2007) 3.92

Vaginal submucosal dendritic cells, but not Langerhans cells, induce protective Th1 responses to herpes simplex virus-2. J Exp Med (2003) 3.86

Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling. Proc Natl Acad Sci U S A (2009) 3.84

Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma. J Invest Dermatol (2004) 3.80

A vaccine strategy that protects against genital herpes by establishing local memory T cells. Nature (2012) 3.65

STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity. Proc Natl Acad Sci U S A (2003) 3.46

Influenza virus activates inflammasomes via its intracellular M2 ion channel. Nat Immunol (2010) 3.45

The circadian clock controls toll-like receptor 9-mediated innate and adaptive immunity. Immunity (2012) 3.43

Long-term sensory deprivation prevents dendritic spine loss in primary somatosensory cortex. Nature (2005) 3.41

OspC facilitates Borrelia burgdorferi invasion of Ixodes scapularis salivary glands. J Clin Invest (2004) 3.38

Bifurcation of Toll-like receptor 9 signaling by adaptor protein 3. Science (2010) 3.37

The Surgical Mortality Probability Model: derivation and validation of a simple risk prediction rule for noncardiac surgery. Ann Surg (2012) 3.20

In vivo requirement for Atg5 in antigen presentation by dendritic cells. Immunity (2010) 3.19

Tumor-infiltrating NY-ESO-1-specific CD8+ T cells are negatively regulated by LAG-3 and PD-1 in human ovarian cancer. Proc Natl Acad Sci U S A (2010) 3.12

PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2. Cell (2002) 3.09

Essential role for OspA/B in the life cycle of the Lyme disease spirochete. J Exp Med (2004) 3.02

The NEMO adaptor bridges the nuclear factor-kappaB and interferon regulatory factor signaling pathways. Nat Immunol (2007) 2.91

Magnetic resonance imaging in patients with a pacemaker system designed for the magnetic resonance environment. Heart Rhythm (2010) 2.89

The Lyme disease agent exploits a tick protein to infect the mammalian host. Nature (2005) 2.82

Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice. Nat Med (2002) 2.77

High levels of phosphorylated form of Akt-1 in prostate cancer and non-neoplastic prostate tissues are strong predictors of biochemical recurrence. Clin Cancer Res (2004) 2.75

Toll-like receptor 7 mitigates lethal West Nile encephalitis via interleukin 23-dependent immune cell infiltration and homing. Immunity (2009) 2.66

Age-associated decrease in TLR function in primary human dendritic cells predicts influenza vaccine response. J Immunol (2010) 2.63

TROSPA, an Ixodes scapularis receptor for Borrelia burgdorferi. Cell (2004) 2.62

Vaccination with an NY-ESO-1 peptide of HLA class I/II specificities induces integrated humoral and T cell responses in ovarian cancer. Proc Natl Acad Sci U S A (2007) 2.61

Guidelines for cardiac pacing and cardiac resynchronization therapy. The Task Force for Cardiac Pacing and Cardiac Resynchronization Therapy of the European Society of Cardiology. Developed in collaboration with the European Heart Rhythm Association. Europace (2007) 2.58

Identification of the minimal phosphoacceptor site required for in vivo activation of interferon regulatory factor 3 in response to virus and double-stranded RNA. J Biol Chem (2003) 2.57

The balance of reproducibility, sensitivity, and specificity of lists of differentially expressed genes in microarray studies. BMC Bioinformatics (2008) 2.54

NY-ESO-1 and LAGE-1 cancer-testis antigens are potential targets for immunotherapy in epithelial ovarian cancer. Cancer Res (2003) 2.53

Pacemaker therapy in patients with neurally mediated syncope and documented asystole: Third International Study on Syncope of Uncertain Etiology (ISSUE-3): a randomized trial. Circulation (2012) 2.53

A Smac mimetic rescue screen reveals roles for inhibitor of apoptosis proteins in tumor necrosis factor-alpha signaling. Cancer Res (2007) 2.52

Molecular adaptation of Borrelia burgdorferi in the murine host. J Exp Med (2002) 2.49

The autophagy gene ATG5 plays an essential role in B lymphocyte development. Autophagy (2007) 2.48

Guidelines on management (diagnosis and treatment) of syncope--update 2004. Europace (2004) 2.47

Expression of DC-SIGN by dendritic cells of intestinal and genital mucosae in humans and rhesus macaques. J Virol (2002) 2.46

Transforming growth factor-beta-regulated miR-24 promotes skeletal muscle differentiation. Nucleic Acids Res (2008) 2.44

2010 Focused Update of ESC Guidelines on device therapy in heart failure: an update of the 2008 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure and the 2007 ESC guidelines for cardiac and resynchronization therapy. Developed with the special contribution of the Heart Failure Association and the European Heart Rhythm Association. Eur Heart J (2010) 2.36

CD301b⁺ dermal dendritic cells drive T helper 2 cell-mediated immunity. Immunity (2013) 2.31

MasterCARD: a priceless link to innate immunity. Trends Mol Med (2006) 2.29

Bruton tyrosine kinase inhibition is a novel therapeutic strategy targeting tumor in the bone marrow microenvironment in multiple myeloma. Blood (2012) 2.29

Negative regulation of the retinoic acid-inducible gene I-induced antiviral state by the ubiquitin-editing protein A20. J Biol Chem (2005) 2.27

Defective neuromuscular synapses in mice lacking amyloid precursor protein (APP) and APP-Like protein 2. J Neurosci (2005) 2.21

Crystal structure of west nile virus envelope glycoprotein reveals viral surface epitopes. J Virol (2006) 2.20

Age-associated defect in human TLR-1/2 function. J Immunol (2007) 2.20

A tick antioxidant facilitates the Lyme disease agent's successful migration from the mammalian host to the arthropod vector. Cell Host Microbe (2007) 2.17

Dissociation of a MAVS/IPS-1/VISA/Cardif-IKKepsilon molecular complex from the mitochondrial outer membrane by hepatitis C virus NS3-4A proteolytic cleavage. J Virol (2006) 2.15

A heterozygous moth genome provides insights into herbivory and detoxification. Nat Genet (2013) 2.13

Rab 5 is required for the cellular entry of dengue and West Nile viruses. J Virol (2007) 2.12

Human Borrelia miyamotoi infection in the United States. N Engl J Med (2013) 2.11

Heme oxygenase-1 protein localizes to the nucleus and activates transcription factors important in oxidative stress. J Biol Chem (2007) 2.08

Engraftment of sorted/expanded human central nervous system stem cells from fetal brain. J Neurosci Res (2002) 2.07

Medium-term effects of septal and apical pacing in pacemaker-dependent patients: a double-blind prospective randomized study. Pacing Clin Electrophysiol (2013) 2.07

Regulation of IRF-3-dependent innate immunity by the papain-like protease domain of the severe acute respiratory syndrome coronavirus. J Biol Chem (2007) 2.07

Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity. J Virol (2004) 2.06

Ibrutinib in previously treated Waldenström's macroglobulinemia. N Engl J Med (2015) 2.04

Recognition of the measles virus nucleocapsid as a mechanism of IRF-3 activation. J Virol (2002) 2.04

AML1-ETO and C-KIT mutation/overexpression in t(8;21) leukemia: implication in stepwise leukemogenesis and response to Gleevec. Proc Natl Acad Sci U S A (2005) 2.03

IFN-gamma-producing gamma delta T cells help control murine West Nile virus infection. J Immunol (2003) 2.03

Methylation of Tat by PRMT6 regulates human immunodeficiency virus type 1 gene expression. J Virol (2005) 2.02

Guidelines on management (diagnosis and treatment) of syncope-update 2004. Executive Summary. Eur Heart J (2004) 2.01

Human innate immunosenescence: causes and consequences for immunity in old age. Trends Immunol (2009) 2.00

A functional floxed allele of Pkd1 that can be conditionally inactivated in vivo. J Am Soc Nephrol (2004) 1.97

Cutting Edge: Plasmacytoid dendritic cells provide innate immune protection against mucosal viral infection in situ. J Immunol (2006) 1.95

Coordinated loading of IRG resistance GTPases on to the Toxoplasma gondii parasitophorous vacuole. Cell Microbiol (2010) 1.94

Dysregulation of TLR3 impairs the innate immune response to West Nile virus in the elderly. J Virol (2008) 1.93

Linear ubiquitination of NEMO negatively regulates the interferon antiviral response through disruption of the MAVS-TRAF3 complex. Cell Host Microbe (2012) 1.93

Altered adipose and plasma sphingolipid metabolism in obesity: a potential mechanism for cardiovascular and metabolic risk. Diabetes (2006) 1.91

Chromatin-remodelling factor BRG1 selectively activates a subset of interferon-alpha-inducible genes. Nat Cell Biol (2002) 1.91

Why certain dyes are useful for localizing the sentinel lymph node. J Nucl Med (2002) 1.89

Somatic mutations in MYD88 and CXCR4 are determinants of clinical presentation and overall survival in Waldenstrom macroglobulinemia. Blood (2014) 1.89

CD4+ T cells support cytotoxic T lymphocyte priming by controlling lymph node input. Proc Natl Acad Sci U S A (2011) 1.86