Published in Carcinogenesis on February 03, 2010
Homologous recombination and its regulation. Nucleic Acids Res (2012) 2.44
A dual role for A-type lamins in DNA double-strand break repair. Cell Cycle (2011) 1.80
DNA double-strand break repair as determinant of cellular radiosensitivity to killing and target in radiation therapy. Front Oncol (2013) 1.30
The mTOR inhibitor rapamycin suppresses DNA double-strand break repair. Radiat Res (2010) 1.25
DNA2 and EXO1 in replication-coupled, homology-directed repair and in the interplay between HDR and the FA/BRCA network. Cell Cycle (2012) 1.23
Two distinct modes of ATR activation orchestrated by Rad17 and Nbs1. Cell Rep (2013) 1.19
RPA-coated single-stranded DNA as a platform for post-translational modifications in the DNA damage response. Cell Res (2014) 1.10
Controlling DNA-end resection: a new task for CDKs. Front Genet (2013) 1.09
DNA-PK, ATM and ATR collaboratively regulate p53-RPA interaction to facilitate homologous recombination DNA repair. Oncogene (2012) 1.07
A dual role of BRCA1 in two distinct homologous recombination mediated repair in response to replication arrest. Nucleic Acids Res (2011) 1.06
The role of BRCA1 in homologous recombination repair in response to replication stress: significance in tumorigenesis and cancer therapy. Cell Biosci (2013) 1.02
Okazaki fragment processing-independent role for human Dna2 enzyme during DNA replication. J Biol Chem (2012) 0.98
Combined inhibition of Wee1 and PARP1/2 for radiosensitization in pancreatic cancer. Clin Cancer Res (2014) 0.96
RFWD3-Dependent Ubiquitination of RPA Regulates Repair at Stalled Replication Forks. Mol Cell (2015) 0.93
Inhibiting the DNA damage response as a therapeutic manoeuvre in cancer. Br J Pharmacol (2013) 0.93
DNA-PK phosphorylation of RPA32 Ser4/Ser8 regulates replication stress checkpoint activation, fork restart, homologous recombination and mitotic catastrophe. DNA Repair (Amst) (2014) 0.92
DNA structure-specific priming of ATR activation by DNA-PKcs. J Cell Biol (2013) 0.91
Human single-stranded DNA binding proteins are essential for maintaining genomic stability. BMC Mol Biol (2013) 0.91
Chk1 suppressed cell death. Cell Div (2010) 0.90
RING finger and WD repeat domain 3 (RFWD3) associates with replication protein A (RPA) and facilitates RPA-mediated DNA damage response. J Biol Chem (2011) 0.90
TRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism. Nat Genet (2015) 0.85
PARG is dispensable for recovery from transient replicative stress but required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress. Nucleic Acids Res (2014) 0.85
53BP1 promotes microhomology-mediated end-joining in G1-phase cells. Nucleic Acids Res (2015) 0.83
RNF126 promotes homologous recombination via regulation of E2F1-mediated BRCA1 expression. Oncogene (2015) 0.81
Cdk5 promotes DNA replication stress checkpoint activation through RPA-32 phosphorylation, and impacts on metastasis free survival in breast cancer patients. Cell Cycle (2015) 0.79
p53 suppresses hyper-recombination by modulating BRCA1 function. DNA Repair (Amst) (2015) 0.79
The DNA damage response and checkpoint adaptation in Saccharomyces cerevisiae: distinct roles for the replication protein A2 (Rfa2) N-terminus. Genetics (2015) 0.77
Dual inhibition of ATR and ATM potentiates the activity of trabectedin and lurbinectedin by perturbing the DNA damage response and homologous recombination repair. Oncotarget (2016) 0.76
Targeting radioresistant breast cancer cells by single agent CHK1 inhibitor via enhancing replication stress. Oncotarget (2016) 0.75
Managing Single-Stranded DNA during Replication Stress in Fission Yeast. Biomolecules (2015) 0.75
Replication-mediated disassociation of replication protein A-XPA complex upon DNA damage: implications for RPA handing off. Cell Biol Int (2012) 0.75
Phosphorylation and cellular function of the human Rpa2 N-terminus in the budding yeast Saccharomyces cerevisiae. Exp Cell Res (2014) 0.75
Extensive RPA2 hyperphosphorylation promotes apoptosis in response to DNA replication stress in CHK1 inhibited cells. Nucleic Acids Res (2015) 0.75
A phosphorylation-and-ubiquitylation circuitry driving ATR activation and homologous recombination. Nucleic Acids Res (2017) 0.75
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science (2003) 18.29
Human CtIP promotes DNA end resection. Nature (2007) 10.63
Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism. Annu Rev Biochem (1997) 9.83
XRCC3 promotes homology-directed repair of DNA damage in mammalian cells. Genes Dev (1999) 9.50
Rad51-deficient vertebrate cells accumulate chromosomal breaks prior to cell death. EMBO J (1998) 6.65
Recombinant replication protein A: expression, complex formation, and functional characterization. J Biol Chem (1994) 6.41
DNA double-strand break repair: all's well that ends well. Annu Rev Genet (2006) 5.59
Sister chromatid gene conversion is a prominent double-strand break repair pathway in mammalian cells. EMBO J (2000) 4.94
The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair. Nat Cell Biol (2005) 4.62
Heterogeneity in radiation-induced DNA damage and repair in tumor and normal cells measured using the "comet" assay. Radiat Res (1990) 4.60
A dynamic model for replication protein A (RPA) function in DNA processing pathways. Nucleic Acids Res (2006) 4.49
Multiple mechanisms control chromosome integrity after replication fork uncoupling and restart at irreparable UV lesions. Mol Cell (2006) 4.44
DNA double-strand break repair: from mechanistic understanding to cancer treatment. DNA Repair (Amst) (2007) 3.69
Nuclear foci of mammalian recombination proteins are located at single-stranded DNA regions formed after DNA damage. Proc Natl Acad Sci U S A (1999) 3.68
The role of double-strand break repair - insights from human genetics. Nat Rev Genet (2006) 3.25
Spontaneous homologous recombination is induced by collapsed replication forks that are caused by endogenous DNA single-strand breaks. Mol Cell Biol (2005) 3.10
Replisome assembly and the direct restart of stalled replication forks. Nat Rev Mol Cell Biol (2006) 3.00
Characterization of homologous recombination induced by replication inhibition in mammalian cells. EMBO J (2001) 2.98
Replication protein A phosphorylation and the cellular response to DNA damage. DNA Repair (Amst) (2004) 2.92
The structure-specific endonuclease Mus81-Eme1 promotes conversion of interstrand DNA crosslinks into double-strands breaks. EMBO J (2006) 2.89
Fanconi anemia (cross)linked to DNA repair. Cell (2005) 2.78
Different roles for nonhomologous end joining and homologous recombination following replication arrest in mammalian cells. Mol Cell Biol (2002) 2.73
Rad52 protein associates with replication protein A (RPA)-single-stranded DNA to accelerate Rad51-mediated displacement of RPA and presynaptic complex formation. J Biol Chem (2002) 2.35
The crystal structure of the complex of replication protein A subunits RPA32 and RPA14 reveals a mechanism for single-stranded DNA binding. EMBO J (1999) 2.15
Cell cycle regulated phosphorylation of RPA-32 occurs within the replication initiation complex. EMBO J (1992) 2.13
The ionizing radiation-induced replication protein A phosphorylation response differs between ataxia telangiectasia and normal human cells. Mol Cell Biol (1993) 2.01
Sequential and synergistic modification of human RPA stimulates chromosomal DNA repair. J Biol Chem (2007) 1.94
Replication fork bypass of a pyrimidine dimer blocking leading strand DNA synthesis. J Biol Chem (1997) 1.90
Replication protein A (RPA) phosphorylation prevents RPA association with replication centers. Mol Cell Biol (2004) 1.89
Sites of UV-induced phosphorylation of the p34 subunit of replication protein A from HeLa cells. J Biol Chem (1997) 1.84
Differential replication of a single, UV-induced lesion in the leading or lagging strand by a human cell extract: fork uncoupling or gap formation. Proc Natl Acad Sci U S A (1995) 1.82
The human Rad51 protein: polarity of strand transfer and stimulation by hRP-A. EMBO J (1997) 1.80
RPA2 is a direct downstream target for ATR to regulate the S-phase checkpoint. J Biol Chem (2006) 1.79
Tracing the network connecting BRCA and Fanconi anaemia proteins. Nat Rev Cancer (2004) 1.76
Exploring the roles of Mus81-Eme1/Mms4 at perturbed replication forks. DNA Repair (Amst) (2007) 1.76
Unwind and slow down: checkpoint activation by helicase and polymerase uncoupling. Genes Dev (2005) 1.71
Claspin and the activated form of ATR-ATRIP collaborate in the activation of Chk1. J Biol Chem (2004) 1.70
Analysis of DNA replication forks encountering a pyrimidine dimer in the template to the leading strand. J Mol Biol (1999) 1.69
RPA phosphorylation in mitosis alters DNA binding and protein-protein interactions. Biochemistry (2003) 1.63
MDC1 interacts with Rad51 and facilitates homologous recombination. Nat Struct Mol Biol (2005) 1.61
ATRIP associates with replication protein A-coated ssDNA through multiple interactions. Proc Natl Acad Sci U S A (2006) 1.55
BRCA1 promotes induction of ssDNA by ionizing radiation. Cancer Res (2006) 1.55
The phosphorylation domain of the 32-kDa subunit of replication protein A (RPA) modulates RPA-DNA interactions. Evidence for an intersubunit interaction. J Biol Chem (2003) 1.51
scid cells are deficient in Ku and replication protein A phosphorylation by the DNA-dependent protein kinase. Mol Cell Biol (1995) 1.49
ATM is required for the cellular response to thymidine induced replication fork stress. Hum Mol Genet (2004) 1.46
Mapping of amino acid residues in the p34 subunit of human single-stranded DNA-binding protein phosphorylated by DNA-dependent protein kinase and Cdc2 kinase in vitro. J Biol Chem (1997) 1.43
A mutant allele of MRE11 found in mismatch repair-deficient tumor cells suppresses the cellular response to DNA replication fork stress in a dominant negative manner. Mol Biol Cell (2008) 1.34
The 32- and 14-kilodalton subunits of replication protein A are responsible for species-specific interactions with single-stranded DNA. Biochemistry (1998) 1.30
Modulation of replication protein A function by its hyperphosphorylation-induced conformational change involving DNA binding domain B. J Biol Chem (2005) 1.29
Preferential localization of hyperphosphorylated replication protein A to double-strand break repair and checkpoint complexes upon DNA damage. Biochem J (2005) 1.28
The MRX complex stabilizes the replisome independently of the S phase checkpoint during replication stress. EMBO J (2009) 1.26
RNA interference inhibition of Mus81 reduces mitotic recombination in human cells. Mol Biol Cell (2003) 1.17
Mechanisms of replication fork restart in Escherichia coli. Philos Trans R Soc Lond B Biol Sci (2004) 1.17
DNA damage induced hyperphosphorylation of replication protein A. 1. Identification of novel sites of phosphorylation in response to DNA damage. Biochemistry (2005) 1.16
RPA phosphorylation facilitates mitotic exit in response to mitotic DNA damage. Proc Natl Acad Sci U S A (2008) 1.14
Enhanced DNA-PK-mediated RPA2 hyperphosphorylation in DNA polymerase eta-deficient human cells treated with cisplatin and oxaliplatin. DNA Repair (Amst) (2008) 1.12
Inhibition of mammalian cell DNA synthesis by ionizing radiation. Int J Radiat Biol Relat Stud Phys Chem Med (1986) 1.06
Pol eta is required for DNA replication during nucleotide deprivation by hydroxyurea. Oncogene (2007) 1.06
Replication of simian virus 40 DNA after UV irradiation: evidence of growing fork blockage and single-stranded gaps in daughter strands. J Virol (1988) 1.04
Ionizing radiation-dependent and independent phosphorylation of the 32-kDa subunit of replication protein A during mitosis. Nucleic Acids Res (2009) 1.00
Phosphorylation of replication protein A by S-phase checkpoint kinases. DNA Repair (Amst) (2006) 0.98
Requirement for RecFOR-mediated recombination in priA mutant. Mol Microbiol (2004) 0.98
Connecting replication and recombination. Mol Cell (2003) 0.94
Protein phosphatase 2A-dependent dephosphorylation of replication protein A is required for the repair of DNA breaks induced by replication stress. Mol Cell Biol (2009) 0.94
Hyperphosphorylation of replication protein A in cisplatin-resistant and -sensitive head and neck squamous cell carcinoma cell lines. Head Neck (2010) 0.90
BRCA1 and BRCA2: different roles in a common pathway of genome protection. Nat Rev Cancer (2011) 3.85
Cell cycle-dependent complex formation of BRCA1.CtIP.MRN is important for DNA double-strand break repair. J Biol Chem (2008) 3.52
BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ. Cancer Cell (2005) 3.44
Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair. Mol Cell Biol (2004) 2.67
A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases. Nat Struct Mol Biol (2008) 2.43
The SCF(Skp2) ubiquitin ligase complex interacts with the human replication licensing factor Cdt1 and regulates Cdt1 degradation. J Biol Chem (2003) 2.36
The histone H3K79 methyltransferase Dot1L is essential for mammalian development and heterochromatin structure. PLoS Genet (2008) 2.35
Cell cycle checkpoint defects contribute to genomic instability in PTEN deficient cells independent of DNA DSB repair. Cell Cycle (2009) 2.31
A miR-200 microRNA cluster as prognostic marker in advanced ovarian cancer. Gynecol Oncol (2009) 2.26
Suv4-20h deficiency results in telomere elongation and derepression of telomere recombination. J Cell Biol (2007) 2.24
Androgen receptor signaling regulates DNA repair in prostate cancers. Cancer Discov (2013) 2.15
Accelerated partial breast irradiation with low-dose-rate interstitial implant brachytherapy after wide local excision: 12-year outcomes from a prospective trial. Int J Radiat Oncol Biol Phys (2011) 2.06
Cyclin-dependent kinases phosphorylate human Cdt1 and induce its degradation. J Biol Chem (2004) 1.96
Rad52 inactivation is synthetically lethal with BRCA2 deficiency. Proc Natl Acad Sci U S A (2010) 1.94
The role of the BRCA1 tumor suppressor in DNA double-strand break repair. Mol Cancer Res (2005) 1.93
Mammalian Rad9 plays a role in telomere stability, S- and G2-phase-specific cell survival, and homologous recombinational repair. Mol Cell Biol (2006) 1.84
Novel roles for A-type lamins in telomere biology and the DNA damage response pathway. EMBO J (2009) 1.83
A dual role for A-type lamins in DNA double-strand break repair. Cell Cycle (2011) 1.80
RPA2 is a direct downstream target for ATR to regulate the S-phase checkpoint. J Biol Chem (2006) 1.79
Helical tomotherapy planning for left-sided breast cancer patients with positive lymph nodes: comparison to conventional multiport breast technique. Int J Radiat Oncol Biol Phys (2009) 1.79
H2AX prevents CtIP-mediated DNA end resection and aberrant repair in G1-phase lymphocytes. Nature (2010) 1.78
Fractionation for whole breast irradiation: an American Society for Radiation Oncology (ASTRO) evidence-based guideline. Int J Radiat Oncol Biol Phys (2010) 1.76
Expression of the proto-oncogene Fos after exposure to radiofrequency radiation relevant to wireless communications. Radiat Res (2005) 1.73
Response of human REV1 to different DNA damage: preferential dCMP insertion opposite the lesion. Nucleic Acids Res (2002) 1.63
Microhomology-mediated End Joining and Homologous Recombination share the initial end resection step to repair DNA double-strand breaks in mammalian cells. Proc Natl Acad Sci U S A (2013) 1.62
MDC1 interacts with Rad51 and facilitates homologous recombination. Nat Struct Mol Biol (2005) 1.61
ATR affecting cell radiosensitivity is dependent on homologous recombination repair but independent of nonhomologous end joining. Cancer Res (2004) 1.60
Diabetes reduces basal retinal insulin receptor signaling: reversal with systemic and local insulin. Diabetes (2006) 1.58
Risk of lymphedema after regional nodal irradiation with breast conservation therapy. Int J Radiat Oncol Biol Phys (2003) 1.57
The CD44 receptor interacts with P-glycoprotein to promote cell migration and invasion in cancer. Cancer Res (2005) 1.57
A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases. Nat Struct Mol Biol (2008) 1.51
Paclitaxel decreases the interstitial fluid pressure and improves oxygenation in breast cancers in patients treated with neoadjuvant chemotherapy: clinical implications. J Clin Oncol (2005) 1.48
Hyperthermia activates a subset of ataxia-telangiectasia mutated effectors independent of DNA strand breaks and heat shock protein 70 status. Cancer Res (2007) 1.47
Telomere recombination requires the MUS81 endonuclease. Nat Cell Biol (2009) 1.45
BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage. J Biol Chem (2004) 1.45
Transcription-dependent degradation of topoisomerase I-DNA covalent complexes. Mol Cell Biol (2003) 1.43
Overexpression of extracellular matrix metalloproteinase inducer in multidrug resistant cancer cells. Mol Cancer Res (2003) 1.39
The Mre11-Rad50-Nbs1 complex acts both upstream and downstream of ataxia telangiectasia mutated and Rad3-related protein (ATR) to regulate the S-phase checkpoint following UV treatment. J Biol Chem (2007) 1.39
The Mre11 complex mediates the S-phase checkpoint through an interaction with replication protein A. Mol Cell Biol (2007) 1.38
Checkpoint kinase 2-mediated phosphorylation of BRCA1 regulates the fidelity of nonhomologous end-joining. Cancer Res (2006) 1.38
Utility of DNA repair protein foci for the detection of putative BRCA1 pathway defects in breast cancer biopsies. Mol Cancer Res (2009) 1.37
Activities of human DNA polymerase kappa in response to the major benzo[a]pyrene DNA adduct: error-free lesion bypass and extension synthesis from opposite the lesion. DNA Repair (Amst) (2002) 1.37
Negative Regulation of AKT Activation by BRCA1. Cancer Res (2008) 1.34
Direct-current electrical field guides neuronal stem/progenitor cell migration. Stem Cells (2008) 1.34
Novel chemical enhancers of heat shock increase thermal radiosensitization through a mitotic catastrophe pathway. Cancer Res (2007) 1.32
The interaction of CtIP and Nbs1 connects CDK and ATM to regulate HR-mediated double-strand break repair. PLoS Genet (2013) 1.27
Collection, cryopreservation, and characterization of human dental pulp-derived mesenchymal stem cells for banking and clinical use. Tissue Eng Part C Methods (2008) 1.26
The mTOR inhibitor rapamycin suppresses DNA double-strand break repair. Radiat Res (2010) 1.25
Neurofibromin is a novel regulator of RAS-induced signals in primary vascular smooth muscle cells. Hum Mol Genet (2006) 1.24
Rad51 paralog complexes BCDX2 and CX3 act at different stages in the BRCA1-BRCA2-dependent homologous recombination pathway. Mol Cell Biol (2012) 1.21
BRCA1- and BRCA2-deficient cells are sensitive to etoposide-induced DNA double-strand breaks via topoisomerase II. Cancer Res (2007) 1.21
Mesenchymal stem/progenitor cells promote the reconstitution of exogenous hematopoietic stem cells in Fancg-/- mice in vivo. Blood (2009) 1.20
Erk1 positively regulates osteoclast differentiation and bone resorptive activity. PLoS One (2011) 1.19
A role for the Rb family of proteins in controlling telomere length. Nat Genet (2002) 1.19
The biphasic role of NF-kappaB in progression and chemoresistance of ovarian cancer. Clin Cancer Res (2011) 1.19
Suppression of insulin receptor substrate 1 (IRS-1) promotes mammary tumor metastasis. Mol Cell Biol (2006) 1.19
Multiple increased osteoclast functions in individuals with neurofibromatosis type 1. Am J Med Genet A (2011) 1.18
DNA damage induces p53-dependent BRCA1 nuclear export. J Biol Chem (2004) 1.18
The ATR-mediated S phase checkpoint prevents rereplication in mammalian cells when licensing control is disrupted. J Cell Biol (2007) 1.17
The interaction of p53 with replication protein A mediates suppression of homologous recombination. Oncogene (2004) 1.16
Clinical experience with a 3D surface patient setup system for alignment of partial-breast irradiation patients. Int J Radiat Oncol Biol Phys (2006) 1.16
Radical abdominal trachelectomy for cervical malignancies: surgical, oncological and fertility outcomes in 62 patients. Gynecol Oncol (2011) 1.14
Determination of lead in water samples by graphite furnace atomic absorption spectrometry after cloud point extraction. Talanta (2005) 1.14
Accelerated partial-breast irradiation using proton beams: initial clinical experience. Int J Radiat Oncol Biol Phys (2006) 1.13
Nonhomologous end-joining of site-specific but not of radiation-induced DNA double-strand breaks is reduced in the presence of wild-type p53. Oncogene (2005) 1.13
BRCA1 loss activates cathepsin L-mediated degradation of 53BP1 in breast cancer cells. J Cell Biol (2013) 1.12
A SNP and SSR based genetic map of asparagus bean (Vigna. unguiculata ssp. sesquipedialis) and comparison with the broader species. PLoS One (2011) 1.12
A new pathway that regulates 53BP1 stability implicates cathepsin L and vitamin D in DNA repair. EMBO J (2011) 1.12
Prevention of DNA re-replication in eukaryotic cells. J Mol Cell Biol (2011) 1.12
Fhit and CHK1 have opposing effects on homologous recombination repair. Cancer Res (2005) 1.11
Favorable prognosis in patients with T1a/T1bN0 triple-negative breast cancers treated with multimodality therapy. Cancer (2012) 1.11
Molecular pathways: understanding the role of Rad52 in homologous recombination for therapeutic advancement. Clin Cancer Res (2012) 1.11
Radiosensitizing and anti-proliferative effects of resveratrol in two human cervical tumor cell lines. Cancer Lett (2002) 1.10
Low-density lipoprotein receptor-related protein 1 is an essential receptor for myelin phagocytosis. J Cell Sci (2009) 1.09
Loss of A-type lamins and genomic instability. Cell Cycle (2009) 1.09
CtIP protein dimerization is critical for its recruitment to chromosomal DNA double-stranded breaks. J Biol Chem (2012) 1.08